Gene

KWMTBOMO00375  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA000715

Annotation

probable_medium-chain_specific_acyl-CoA_dehydrogenase?_mitochondrial_[Papilio_xuthus]

Location

Bomo_Chr1(+):11156068-11179575      View in EpiBrowser

Full name

Probable medium-chain specific acyl-CoA dehydrogenase, mitochondrial      

Location in the cell

Mitochondrial   Reliability : 2.485

CDS

ATGAACCCGTTGGCGCAGATTGTTCGTGCCACTCGCCCTATTTACAGGAAATTATCAACAACTGCAACAACTGCTTCTGCTGCAAAGCCAATACCGACAACAGGCTTTTGTTTCGAATTAACCGATGAGCAGAAAGCGCTTCAGGAACTAGCGCGTAAATTCACGAAGGATGAAATCATTCCTGTGGCGGGTCAATATGATAAGACGGGGGAGTACCCGTGGCCCGTTGTAAAGAAGGCTTGGGAAGTTGGCCTAATGAACGGACACATTCCAGAACATTGCGGGGGCATAGGGAATTTTGGCGTCTTCGAAGAGTGCATCGTAGCGGACGAACTTGCGTTTGGATGTACTGGCATCACGACAGCTATTGGGGGCACGTCCTTAGGACAAACTCCCATCATTATTGCTGGAAATAAGGAGCAGCAGAAGAAATATCTGGGTAGACTAATCGACGAACCATTAGTCGCTGCCTATGGGGTGACCGAACCTGGTGCTGGATCCGATGTAGCCGGTATAAAGACGAGAGCGGAGAAGAAAGGCGACGAATGGATCCTGAACGGTCAGAAAATGTGGATCACCAACGGTGGTGTTGCCAACTGGTACTTTGTATTGGCTCGTACGAATCCGGACCCTAAATGTCCGGCCAGCAAAGCATTCACCGGCTTCATCGTCGAACGGGAATGGCCTGGGGTCACTCCAGGGCGAAAGGAACAAAACATGGGTCAGCGTGCTTCGGACACCCGAGGTATCACGTTTGAAGATGTGCGTATCCCCAAAGAAAATGTGCTTATTGGCGAAGGAGCTGGATTCAAGATCGCCATGGGAGCCTTTGACAAGACTCGTCCTCCGGTAGCGGCTGGTGCTACTGGGTTGGCTCAACGGGCTCTCCACGAAGCCACCAAGTACTCGTTGGAACGCAAAACGTTCGGAGTGCCCATAGCGAGACACCAGGCGGTAGCGTTCATGCTTGCCGACATGGCGATAGGAGTGGAGACCGCTCGTATCGCATGGCAACGCGCCGCATGGATGGTTGACCACGGACAAAAGAATACAGTTATGGCGTCAGTGGCCAAGTGTCACGCTTCGGAAATCGCTAACAAGGCAGCCACTGATGCGGTCCAAGTGTTCGGAGGAAACGGCTTCAACACCGAATACCCAGTCGAGAAACTGATGCGGGACGCCAAGATATACCAAATCTACGAAGGAACCTCGCAGATTCAAAGGCTCATCATATCAAGAGAGATCCTCACCGCAGCAACTCAAACCAACTGA

Protein

MNPLAQIVRATRPIYRKLSTTATTASAAKPIPTTGFCFELTDEQKALQELARKFTKDEIIPVAGQYDKTGEYPWPVVKKAWEVGLMNGHIPEHCGGIGNFGVFEECIVADELAFGCTGITTAIGGTSLGQTPIIIAGNKEQQKKYLGRLIDEPLVAAYGVTEPGAGSDVAGIKTRAEKKGDEWILNGQKMWITNGGVANWYFVLARTNPDPKCPASKAFTGFIVEREWPGVTPGRKEQNMGQRASDTRGITFEDVRIPKENVLIGEGAGFKIAMGAFDKTRPPVAAGATGLAQRALHEATKYSLERKTFGVPIARHQAVAFMLADMAIGVETARIAWQRAAWMVDHGQKNTVMASVAKCHASEIANKAATDAVQVFGGNGFNTEYPVEKLMRDAKIYQIYEGTSQIQRLIISREILTAATQTN

Description

This enzyme is specific for acyl chain lengths of 4 to 16.

Catalytic Activity

a medium-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = a medium-chain trans-(2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]

Cofactor

FAD

Subunit

Homotetramer.

Similarity

Belongs to the acyl-CoA dehydrogenase family.

Keywords

Complete proteome   FAD   Fatty acid metabolism   Flavoprotein   Lipid metabolism   Mitochondrion   Oxidoreductase   Reference proteome   Transit peptide  

Feature

chain  Probable medium-chain specific acyl-CoA dehydrogenase, mitochondrial

Uniprot

I4DJ33   A0A194PLJ7   A0A212EGL0   A0A068FRF0   D2XMK9   H9ITY5   + More
A0A194QMX3   A0A0M4E8L7   B3M619   B4N6W6   A0A1W4WYU1   A0A3B0KHR1   Q2M113   B4GQT6   B4PCA8   A0A1W4VNC1   B3NF95   V5G253   V5I8N3   A0A182WIG5   B4IX89   G3KKP7   Q9VSA3   B4L0Z8   B4LGR7   A0A0J9RR61   B4HIV1   A0A182KGT3   A0A1I8MQB6   A0A2J7PW45   A0A2J7PW54   A0A2J7PW50   A0A182PHN8   A0A182Q9A6   A0A182MS61   A0A2J7PW57   Q16GA1   B4QKX0   A0A0L0CHL3   A0A1L8EE47   A0A182UV67   A0A182XMV3   A0A182LJ14   Q7PNP8   A0A182HWQ9   A0A182UAW2   A0A182RFA8   A0A1I8NNJ1   A0A023ERV4   A0A182Y1B6   A0A182NGY1   A0A1Q3FJJ8   A0A023F9Y8   A0A067QLW6   A0A182GQZ1   D6WFZ1   A0A182IJX2   A0A1A9WG17   A0A084W486   B0WLI6   A0A2R7WI88   A0A1A9UPF3   A0A034WER3   A0A1I9WLC3   A0A1A9XCG3   A0A1B0B8Q9   A0A3B0JW24   A0A2M4A5A9   A0A067QSV4   Q1HQM4   T1E7Y7   A0A1A9ZBP0   A0A182FH31   A0A069DUA7   A0A0K8W6D8   D3TNV6   A0A1L8E2A5   U5EWS3   W8BI95   T1PAW1   A0A2M4CT55   A0A2M4A6I5   A0A2M4BP80   A0A0P4VYB9   A0A2M4BPB6   R4G3Z8   A0A2M3ZFS0   B5DG29   A0A2M4A7U1   A0A1Y1MQH3   A0A0A1X935   A0A1L8E2S6   A0A2J7QMR2   A0A2M3Z061   A0A060YMD9   A0A0A9ZCR3   A0A0K8TTW8   A0A1B6GZ82   D6WEK6   A0A0P5FQZ8  

EC Number

1.3.8.7

Pubmed

22651552    26354079    22118469    26385554    20074338    19121390    + More
17994087    15632085    17550304    10731132    12537572    12537569    18057021    22936249    25315136    17510324    26108605    20966253    12364791    14747013    17210077    24945155    26483478    25244985    25474469    24845553    18362917    19820115    24438588    25348373    27538518    17204158    26334808    20353571    24495485    27129103    19878547    20433749    28004739    25830018    24755649    25401762    26823975    26369729   

EMBL

AK401301    BAM17923.1    KQ459605    KPI91980.1    AGBW02015069    OWR40617.1    + More
KJ622080    AID66670.1    GU205155    ADB57042.1    BABH01007168    BABH01007169    KQ461196    KPJ06320.1    CP012525    ALC43241.1    CH902618    EDV40735.1    CH964168    EDW80105.1    OUUW01000009    SPP84641.1    CH379069    EAL30764.1    CH479188    EDW40121.1    CM000159    EDW93793.1    CH954178    EDV50437.1    GALX01004386    JAB64080.1    GALX01004385    JAB64081.1    CH916366    EDV97421.1    JN252151    JN252152    JN252153    JN252154    JN252155    JN252156    JN252157    JN252158    JN252159    JN252160    JN252161    JN252162    JN252163    JN252164    JN252165    JN252166    JN252167    JN252168    JN252169    JN252170    JN252171    JN252172    AEO11957.1    AEO11958.1    AEO11959.1    AEO11960.1    AEO11961.1    AEO11962.1    AEO11963.1    AEO11964.1    AEO11965.1    AEO11966.1    AEO11967.1    AEO11968.1    AEO11969.1    AEO11970.1    AEO11971.1    AEO11972.1    AEO11973.1    AEO11974.1    AEO11975.1    AEO11976.1    AEO11977.1    AEO11978.1    AE014296    AY089546    CH933809    EDW18155.1    CH941131    CH940647    EDW57380.1    EDW70532.1    CM002912    KMY98197.1    CH480815    EDW40605.1    NEVH01020938    PNF20562.1    PNF20564.1    PNF20565.1    AXCN02000356    AXCM01017076    PNF20561.1    CH478303    EAT33262.1    CM000363    EDX09603.1    JRES01000375    KNC31868.1    GFDG01001812    JAV16987.1    AAAB01008960    EAA11811.3    APCN01001526    JXUM01094639    JXUM01094640    JXUM01094641    GAPW01001641    KQ564143    JAC11957.1    KXJ72689.1    GFDL01007288    JAV27757.1    GBBI01000898    JAC17814.1    KK853183    KDR10129.1    JXUM01081493    JXUM01081494    JXUM01081495    KQ563250    KXJ74210.1    KQ971328    EEZ99771.1    ATLV01020289    KE525297    KFB45030.1    DS231986    EDS30505.1    KK854849    PTY19219.1    GAKP01006155    JAC52797.1    KU932307    APA33943.1    JXJN01010041    SPP84642.1    GGFK01002675    MBW35996.1    KK853058    KDR11928.1    DQ440420    ABF18453.1    GAMD01003228    JAA98362.1    GBGD01001597    JAC87292.1    GDHF01005623    JAI46691.1    CCAG010020781    EZ423108    ADD19384.1    GFDF01001211    JAV12873.1    GANO01001282    JAB58589.1    GAMC01005590    JAC00966.1    KA645068    AFP59697.1    GGFL01004358    MBW68536.1    GGFK01003092    MBW36413.1    GGFJ01005681    MBW54822.1    GDKW01002026    JAI54569.1    GGFJ01005682    MBW54823.1    ACPB03023307    GAHY01001780    JAA75730.1    GGFM01006655    MBW27406.1    BT043588    BT059085    ACH70703.1    ACN10798.1    GGFK01003387    MBW36708.1    GEZM01027474    JAV86725.1    GBXI01006881    JAD07411.1    GFDF01001212    JAV12872.1    NEVH01013204    PNF29880.1    GGFM01001125    MBW21876.1    FR914393    CDQ93058.1    GBHO01021106    GBHO01021081    GBHO01020140    GBHO01011724    GBHO01011716    GBHO01001910    GBHO01001909    GBHO01001908    GBHO01001905    GBHO01001902    GBRD01015497    GBRD01015496    GBRD01015495    GBRD01015494    GBRD01015493    GBRD01015492    GBRD01015491    GBRD01005481    GBRD01005477    GBRD01005476    GBRD01005475    GBRD01005474    GBRD01005473    GBRD01005472    GBRD01000743    GDHC01019813    JAG22498.1    JAG22523.1    JAG23464.1    JAG31880.1    JAG31888.1    JAG41694.1    JAG41695.1    JAG41696.1    JAG41699.1    JAG41702.1    JAG50329.1    JAP98815.1    GDAI01000208    JAI17395.1    GECZ01002038    JAS67731.1    KQ971318    EFA00426.1    GDIQ01253302    GDIP01140198    JAJ98422.1    JAL63516.1   

Proteomes

UP000053268    UP000007151    UP000005204    UP000053240    UP000092553    UP000007801    + More
UP000007798    UP000192223    UP000268350    UP000001819    UP000008744    UP000002282    UP000192221    UP000008711    UP000075920    UP000001070    UP000000803    UP000009192    UP000008792    UP000001292    UP000075881    UP000095301    UP000235965    UP000075885    UP000075886    UP000075883    UP000008820    UP000000304    UP000037069    UP000075903    UP000076407    UP000075882    UP000007062    UP000075840    UP000075902    UP000075900    UP000095300    UP000069940    UP000249989    UP000076408    UP000075884    UP000027135    UP000007266    UP000075880    UP000091820    UP000030765    UP000002320    UP000078200    UP000092443    UP000092460    UP000092445    UP000069272    UP000092444    UP000015103    UP000087266    UP000193380   

PRIDE

D2XMK9    H9ITY5    B3M619    B4N6W6    B4GQT6    B4PCA8    + More
B3NF95    B4IX89    G3KKP7    Q9VSA3    B4L0Z8    B4LGR7    B4HIV1    Q16GA1    B4QKX0    D6WFZ1    B0WLI6    Q1HQM4    D3TNV6   

Pfam

PF02770   Acyl-CoA_dh_M        + More
PF02771   Acyl-CoA_dh_N
PF00441   Acyl-CoA_dh_1

Interpro

IPR009100   AcylCoA_DH/oxidase_NM_dom        + More
IPR006091   Acyl-CoA_Oxase/DH_cen-dom       
IPR009075   AcylCo_DH/oxidase_C       
IPR006089   Acyl-CoA_DH_CS       
IPR013786   AcylCoA_DH/ox_N       
IPR036250   AcylCo_DH-like_C       
IPR037069   AcylCoA_DH/ox_N_sf       
IPR034180   MCAD       

SUPFAM

SSF56645   SSF56645        + More
SSF47203   SSF47203       

Gene 3D

1.10.540.10    

CDD

cd01157  MCAD

ProteinModelPortal

I4DJ33   A0A194PLJ7   A0A212EGL0   A0A068FRF0   D2XMK9   H9ITY5   + More
A0A194QMX3   A0A0M4E8L7   B3M619   B4N6W6   A0A1W4WYU1   A0A3B0KHR1   Q2M113   B4GQT6   B4PCA8   A0A1W4VNC1   B3NF95   V5G253   V5I8N3   A0A182WIG5   B4IX89   G3KKP7   Q9VSA3   B4L0Z8   B4LGR7   A0A0J9RR61   B4HIV1   A0A182KGT3   A0A1I8MQB6   A0A2J7PW45   A0A2J7PW54   A0A2J7PW50   A0A182PHN8   A0A182Q9A6   A0A182MS61   A0A2J7PW57   Q16GA1   B4QKX0   A0A0L0CHL3   A0A1L8EE47   A0A182UV67   A0A182XMV3   A0A182LJ14   Q7PNP8   A0A182HWQ9   A0A182UAW2   A0A182RFA8   A0A1I8NNJ1   A0A023ERV4   A0A182Y1B6   A0A182NGY1   A0A1Q3FJJ8   A0A023F9Y8   A0A067QLW6   A0A182GQZ1   D6WFZ1   A0A182IJX2   A0A1A9WG17   A0A084W486   B0WLI6   A0A2R7WI88   A0A1A9UPF3   A0A034WER3   A0A1I9WLC3   A0A1A9XCG3   A0A1B0B8Q9   A0A3B0JW24   A0A2M4A5A9   A0A067QSV4   Q1HQM4   T1E7Y7   A0A1A9ZBP0   A0A182FH31   A0A069DUA7   A0A0K8W6D8   D3TNV6   A0A1L8E2A5   U5EWS3   W8BI95   T1PAW1   A0A2M4CT55   A0A2M4A6I5   A0A2M4BP80   A0A0P4VYB9   A0A2M4BPB6   R4G3Z8   A0A2M3ZFS0   B5DG29   A0A2M4A7U1   A0A1Y1MQH3   A0A0A1X935   A0A1L8E2S6   A0A2J7QMR2   A0A2M3Z061   A0A060YMD9   A0A0A9ZCR3   A0A0K8TTW8   A0A1B6GZ82   D6WEK6   A0A0P5FQZ8  

PDB

2A1T     E-value=4.43854e-161,     Score=1457

KEGG

101746258    K00249 acyl-CoA dehydrogenase [EC:1.3.8.7] | (RefSeq) probable medium-chain specific acyl-CoA dehydr

PATHWAY

00071    Fatty acid degradation - Bombyx mori (domestic silkworm)
00280    Valine, leucine and isoleucine degradation - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)
01212    Fatty acid metabolism - Bombyx mori (domestic silkworm)

GO

GO:0050660   GO:0003995   GO:0005739   GO:0006635   GO:0070991   GO:0005759   GO:0051793   GO:0016021   GO:0016627   GO:0008152   GO:0030286   GO:0006813   GO:0006810   GO:0009072   GO:0007169   GO:0055114  

Subcellular location

Mitochondrion matrix  

Length:

423

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.13667

Exp number, first 60 AAs:

0.00217

Total prob of N-in:

0.00976

outside

1  -  423

 

 

Pi

16.448881

Theta

20.779237

Tajima's D

-0.89607

CLR

0.150119

CSRT

0.154792260386981

Interpretation

Uncertain