Gene

KWMTBOMO00349

Pre Gene Modal

BGIBMGA000705

Annotation

PREDICTED:_potassium_channel_subfamily_T_member_2_[Amyelois_transitella]

Location

Bomo_Chr1(+):10482873-10524564      View in EpiBrowser

Full name

Potassium channel subfamily T member 1      

Alternative Name

KCa4.1
Sequence like a calcium-activated potassium channel subunit

Location in the cell

PlasmaMembrane   Reliability : 4.447

CDS

ATGGCAGGTGTCAGTAGATATAGTTCATACAATTGTTTGACTGGCTGGGACAGCTATGACAAGATACCCAGAGTAAGGGTGGAGTTCTACGTCAACGAGAACACTTTTAAGGAAAGACTGCAATTATATTTTATTAAAAATCAACGATCGAGTTTACGCATTAGGATAGCGAATCTATTTTTCAAACTTTTGACCTGCGTGCTGTATATATTTCGTGTGTGTACTGAAGGAGATCCTATAGCTGCGACTTGTTATGGATGTAAGCTTGGAAACAAGACTGACTTCCAACATTCTGCCAATTTGACGGAAGAAGAGTTCCAAGAGCACCCGTTAATTAATTGGGACGCAATAATATGGGTCAACCGACCTTTATATCTATGGATAGTGCAAGTACTCCTGGCATTGGTGTCTTTCACCGAAGCATTATTACTTGCCTACTTGGGCTATAAGGGCAACATTTGGCAGCAAGTGTTATCATTCCACTTCATCTTGGAAATGGTGAACACTATACCCTTTGCGTTAACCCTGACATTTCCTCCATTACGAAATCTATTTATACCGGTCTTTCTGAATTGTTGGCTCGCAAAAAGATCACTTGAAAATATGTTTAACGATTTACATCGAGCTATGCAAAAGTCGCAATCAGCTTTATCACAACAATTAATGATATTATGCGTTACGCTACTCTGTCTCGTCTTTACTAGTGTCTGCGGTATTCAACACTTTCAACGAGCTGGACATCGACACCTTAATCTTTTCCAAGCCACTTATTTTGTCGTAGTGACATTTTCAACAGTGGGCTATGGCGATTTTGTTCCGGACATATGGCCCTCTCAATTGTTCATGGTTGTCATGATTGGAGTTGCGCTGGTTGTTCTTCCAACACAGTTTGAACAATTGGCCTTTACTTGGATGGAAAGACAGAAATTGGGAGGATCATATTCTTCTCACCGAGCACAGTCTGAAAAACATGTAGTAGTATGTTCAACAACTTTACATGCCGACACTATCATGGACTTCTTGAACGAATTCTACGCACATCCACTACTTCAAGACTATTATGTTGTATTGCTGTCGCCGATGGAACTCGATACTACTATGCGTATGATTCTGCAGGTACCGATTTGGGCTCAACGTGTAATTTACGTTCAAGGCTCATGCCTAAAAGATACGGATTTGATTAGAGCTCGTATGAACGAAGCTGAAGCCTGTTTCATCTTGGCCGCCAGAAATTATGCCGACAAAACCGCTGCAGACGAACATACAATTTTACGATCATGGGCCGTTAAAGATTTCGCACCAAAAGTTGCACAATATGTACAAATATTTAGACCAGAAAATAAGCTACATGTAAAATTTGCTGAATTCGTGGTATGTGAAGATGAATTTAAATATGCTTTGTTGGCTAACAACTGTACCTGTCCAGGAGCGTCAACTTTAGTAACTCTCCTGCTTCACACAAGCAGAGGACAAGAAGGACAACAATCGCCTGAAGAATGGCACCGCCTTTATGGAAAATGTTCCGGAAATGAAATATACCACATCGTTCTGGGAGACAGCAGATTTTTCGGAGAATATGAAGGAAAAAGTTTTACTTACGCTAGTTTTCACTCACACCGAAAGTATGGAGTCGCTTTAGTTGGTGTTCGGCCCGCTGAATTACCTGAATTTTATGAAGATACAATATTGCTTAATCCGGGACCTCGGCATATAATGAAAAGCACCGATACGTGTTATTATATGAGTATAACAAAAGAAGAGAATTCCGCTTTTGTTGTTTCTGATAAACAGGCTGTACCAAACCCTACGATACCAAAAGACCAAACAGCATGCAGCTTCCTTTCAAACGAGAGGAATCCAGACGAAGGCAGTACAAGCCAGCAGAAGAAACCAGACGCTAAATTAGCCGATCGCTCTACCTCCGAATCAAGGACCTGCTTAAAAGAATCACCAGGAATCGAAAGTGTTGTTGACAGTCATTTACTTTTACCGAAACCTGAAACCAGCAATTTCTTAAGTCCGGACACACTGAGTCATCGTGGAGGAAATAGCAGGAGGCCATCGATACTTCCTGTTCCAGATATGGTCACCAGTAGTTTAACTTTAACAAATGACAATCAAGATGAAGAAGCTGAAATTGATGAGAGCGAAGATGAGCTAGATGACGATGTTCCTTGGCGATCCCCATCAGAAAAAATTGCAGATGACTTCACTACAAGCAGTTTCTCCTCGCTGGCTGCCAGTGATAACGCACACAGCGCTTGGCGCAACGATTTTGCAAGAATCGTCAAAGGATTCCCGCCTGTGTCACCTTTTATTGGAGTCAGCCCAACTCTCTGTTTTCTGCTAAAGGAAAAGAAACCTCTTTGCTGCTTACAACTGGCCCAAGTCTGTGAACACTGCGCCTATAGAAATGCCAAGGAATATCAATGGCAAAATAAAACGATTATTCTTGCTGCCGACTATGCTTCTAATGGAATTTACAATTTTATTATTCCGCTAAGAGCTCATTTTCGGTCTAAAACAACTTTAAACCCTATTATTTTGCTTCTCGAGCGACGGCCAGATGTTGCATTTCTAGATGCCATATCTTATTTCCCTCTGGTTTATTGGATGTTGGGCACTATTGATTGCTTGGATGATCTGCTTCGAGCTGGAATAACATTAGCTGAAAACGTTGTAGTTGTGAACAAAGAGCTATCAAATTCTGCTGAGGAAGATAGCCTTGCTGATTGCAATACAATTGTAGCAGTACAGACAATGTTCAAGTTCTTCCCTTCAATAAGGTCCATAACAGAACTATCTCAATCATCAAATATGAGATTTATGCAATTCCGTGCTCACGATAAATATGCTTTACATCTTTCTAAGATGGAAAAGCGAGAAAAAGAAAGGGGCTCACACATTTCCTATATGTTTCGATTGCCTTTCGCGGCCGGATCAGTTTTCTCTGCCTCAATGTTGGACACGTTACTTTATCAAGCCTTTGTTAAAGATTACATGATTACTTTTGTGCGACTATTATTGGGAATAGATCAGGCGCCCGGATCTGGATTTTTAGCGTCGATAAAAATTACCAAAGAAGATATGTGGATTCGTACCTATGGTCGTTTATACCAAAAACTATGTTCGACCTCATGTGAAATCCCAATTGGGATATATCGCACACAAGATACAAGCATGGCCGATGCATCTCACCACCAGGAGGAGCTTGATGGAGGAGATTTCCCGGCGTGCGGGCGTCAAGAGGCAACTAGCTGCCTTGGTGGTTGCTACGGAGAACGCACGCCGGTGTACTCTACAAGTCTGGCAGATGAAGCTCGCGACAATCACATTCAGCAAATTGAAAGAGCTGAAATAGCCAACTTGGTTCGTTCCAGGATGGAATCTCTAAATCTAACTGGGGTAGATTACGATGATGTAAGCGAAAAACGAAATAGTTTATCTTATGTCATAATCAATCCAAGCTGCGACTTAAATTTGCAAGAAGGAGACATCATTTATCTTGTGCGCCCTTCTCCATTTTCTGCACAAAAAACATTTGAAAGGCATAACAGTCGTCGAAAATCAAATATAAGCTTCTGTTCTCAAGCCTTAATCCAAGCGCAGGGAGGGAGCAGACGAGGTTCAGGAATGGCAGCAACTTTTGCTCAATCACGGGCTCCACCTCTTTCCACTACCAAGGCTAATTCGTTGTCTTTACCCGATAGCCCAACAATCATTACAGATTTCAGAGGTCGCTCTAATTCACTGCGTGTAGTGGATGATATTTTACTACGACGATCAAATTCTTTACGTCAGGGCATAAGCGGAACAGGATCCCGACGTCGCAAAAGCAGTTTAGAAGAAATAGGCATATCGCACTTCAATTCCTTGCTTCAACATCAGCAGCAACAGCAGGAGCAAGATGCTATAAAATTAGGACTAAGCAGCATTGGCCTAAGAATTACACCACCGGAAGAAACTCCTCGAATGGCTTTAGAGCCATTCCAGGACATAGCAGCAGCACTACCATCTACATCAGGTGGATCCACCATGCCAGTCAATGTAACTCCTGACCCACAACATCTTCAGGGTACAATCGTGTGA

Protein

MAGVSRYSSYNCLTGWDSYDKIPRVRVEFYVNENTFKERLQLYFIKNQRSSLRIRIANLFFKLLTCVLYIFRVCTEGDPIAATCYGCKLGNKTDFQHSANLTEEEFQEHPLINWDAIIWVNRPLYLWIVQVLLALVSFTEALLLAYLGYKGNIWQQVLSFHFILEMVNTIPFALTLTFPPLRNLFIPVFLNCWLAKRSLENMFNDLHRAMQKSQSALSQQLMILCVTLLCLVFTSVCGIQHFQRAGHRHLNLFQATYFVVVTFSTVGYGDFVPDIWPSQLFMVVMIGVALVVLPTQFEQLAFTWMERQKLGGSYSSHRAQSEKHVVVCSTTLHADTIMDFLNEFYAHPLLQDYYVVLLSPMELDTTMRMILQVPIWAQRVIYVQGSCLKDTDLIRARMNEAEACFILAARNYADKTAADEHTILRSWAVKDFAPKVAQYVQIFRPENKLHVKFAEFVVCEDEFKYALLANNCTCPGASTLVTLLLHTSRGQEGQQSPEEWHRLYGKCSGNEIYHIVLGDSRFFGEYEGKSFTYASFHSHRKYGVALVGVRPAELPEFYEDTILLNPGPRHIMKSTDTCYYMSITKEENSAFVVSDKQAVPNPTIPKDQTACSFLSNERNPDEGSTSQQKKPDAKLADRSTSESRTCLKESPGIESVVDSHLLLPKPETSNFLSPDTLSHRGGNSRRPSILPVPDMVTSSLTLTNDNQDEEAEIDESEDELDDDVPWRSPSEKIADDFTTSSFSSLAASDNAHSAWRNDFARIVKGFPPVSPFIGVSPTLCFLLKEKKPLCCLQLAQVCEHCAYRNAKEYQWQNKTIILAADYASNGIYNFIIPLRAHFRSKTTLNPIILLLERRPDVAFLDAISYFPLVYWMLGTIDCLDDLLRAGITLAENVVVVNKELSNSAEEDSLADCNTIVAVQTMFKFFPSIRSITELSQSSNMRFMQFRAHDKYALHLSKMEKREKERGSHISYMFRLPFAAGSVFSASMLDTLLYQAFVKDYMITFVRLLLGIDQAPGSGFLASIKITKEDMWIRTYGRLYQKLCSTSCEIPIGIYRTQDTSMADASHHQEELDGGDFPACGRQEATSCLGGCYGERTPVYSTSLADEARDNHIQQIERAEIANLVRSRMESLNLTGVDYDDVSEKRNSLSYVIINPSCDLNLQEGDIIYLVRPSPFSAQKTFERHNSRRKSNISFCSQALIQAQGGSRRGSGMAATFAQSRAPPLSTTKANSLSLPDSPTIITDFRGRSNSLRVVDDILLRRSNSLRQGISGTGSRRRKSSLEEIGISHFNSLLQHQQQQQEQDAIKLGLSSIGLRITPPEETPRMALEPFQDIAAALPSTSGGSTMPVNVTPDPQHLQGTIV

Description

Outwardly rectifying potassium channel subunit that may coassemble with other Slo-type channel subunits. Activated by high intracellular sodium or chloride levels. Activated upon stimulation of G-protein coupled receptors, such as CHRM1 and GRIA1. May be regulated by calcium in the absence of sodium ions (in vitro) (By similarity).
Generates outwardly rectifying currents that are suppressed by elevation of intracellular calcium.

Subunit

Interacts (via C-terminus) with FMR1; this interaction alters gating properties of KCNT1 (PubMed:20512134). Interacts with CRBN via its cytoplasmic C-terminus (By similarity).

Similarity

Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. KCa4.1/KCNT1 sub-subfamily.

Keywords

Alternative splicing   Calcium   Cell membrane   Complete proteome   Disease mutation   Epilepsy   Glycoprotein   Ion channel   Ion transport   Membrane   Phosphoprotein   Potassium   Potassium channel   Potassium transport   Reference proteome   Transmembrane   Transmembrane helix   Transport   3D-structure  

Feature

chain  Potassium channel subfamily T member 1
splice variant  In isoform 2 and isoform 3.
sequence variant  In EIEE14; dbSNP:rs587777264.

Uniprot

A0A212EY19   A0A194QWH0   A0A194PY46   A0A139WLY1   A0A139WM47   A7UR92   + More
A0A182IR49   A0A3B0JKV1   A0A1W4XHF4   A0A3B0JLH8   J9K6K2   A0A336LSZ5   A0A336LTP8   A0A336LUK8   A0A336LQC2   A0A336LQ39   A0A336LPP9   A0A1J1ITI9   A0A1Y1NBK9   A0A336LPT4   A0A1Y1NE12   A0A2S2NZ98   A0A336LPM5   A0A1J1IRM2   E0W0S8   A0A336M243   A0A0P5ZTV5   A0A162QJ56   A0A0P5ZX15   A0A0P6CR92   A0A0P5B3Q8   A0A0P5XMA2   A0A0P6A468   N6UDZ1   A0A0P5DU19   E9HEH7   A0A0P5WSA0   A0A0P5AC24   A0A0L7QTU4   A0A0P6IQA5   A0A0P6ATN0   A0A1B0CHQ2   U4TUR2   U4UE65   A0A1C9TA78   K1PSX5   A0A0L8G7B1   A0A0L8G6V3   A0A3B3I015   A0A336LPL1   A0A267EGF8   A0A3B4VM99   A0A3B4ZIJ9   A0A336LTT0   A0A2K5RPJ3   I3N3P6   A0A2I3S2J6   A0A2K5CTR7   Q5JUK3-3   H0WYR9   A0A2J8UIJ8   A0A2K6GK25   A0A2K6K4N9   A0A2K6NPW6   A0A146VBH1   A0A0K2GMW5   A0A3P8XE41   A0A3P9KR47   A0A3B4VM72   A0A3P8XB84   E1BW18   Q8QFV0   A0A3P9IIP2   A0A2K6DE59   A0A1W5ACB6   A0A3B4VIR6   A0A2K5RPF5   A0A2K5CTT5   A0A2I3T3B9   A0A3P8XB73   A0A2I2YBE5   A0A2K5RPK7   A0A287D7E5   A0A2J8NA34   A0A3B3RM10   A0A2K5CTS9   Q5JUK3-2   A0A2K6K4Q0   A0A0D9SFC8   A0A2I2YX38   G3QR87   A0A2J8UIP1   A0A2J8UIN6   A0A3B4EPN9   A0A2K5CTS6   A0A2K6GK47   A0A3B3RND9   A0A2K6K4M7   A0A2K6NPX6   A0A146VC13  

Pubmed

22118469    26354079    18362917    19820115    12364791    28004739    + More
20566863    23537049    21292972    22992520    17554307    16136131    14702039    15164053    15489334    10718198    20512134    23086396    23086397    24029078    23708187    24463883    26993267    27864847    25362486    25069045    15592404    22398555    29240929   

EMBL

AGBW02011631    OWR46385.1    KQ461108    KPJ09310.1    KQ459594    KPI96070.1    + More
KQ971314    KYB29019.1    KYB29020.1    AAAB01008807    EDO64534.2    OUUW01000001    SPP74099.1    SPP74096.1    ABLF02039742    ABLF02039754    ABLF02047215    UFQT01000105    SSX20041.1    SSX20043.1    SSX20037.1    SSX20045.1    SSX20040.1    SSX20036.1    CVRI01000058    CRL02892.1    GEZM01007528    JAV95109.1    SSX20042.1    GEZM01007527    JAV95110.1    GGMR01009773    MBY22392.1    SSX20044.1    CRL02893.1    DS235862    EEB19234.1    SSX20038.1    GDIP01039686    JAM64029.1    LRGB01000327    KZS19731.1    GDIP01038538    JAM65177.1    GDIP01000470    JAN03246.1    GDIP01190159    JAJ33243.1    GDIP01082322    JAM21393.1    GDIP01035246    JAM68469.1    APGK01026655    APGK01026656    APGK01026657    APGK01026658    APGK01026659    KB740635    ENN79925.1    GDIP01152820    JAJ70582.1    GL732629    EFX69876.1    GDIP01082323    JAM21392.1    GDIP01202063    JAJ21339.1    KQ414736    KOC62087.1    GDIQ01001674    JAN93063.1    GDIP01038537    JAM65178.1    AJWK01012580    AJWK01012581    AJWK01012582    AJWK01012583    AJWK01012584    AJWK01012585    KB630556    ERL83673.1    KB632107    ERL88866.1    KU681442    AOR07222.1    JH818227    EKC24758.1    KQ423495    KOF72763.1    KOF72762.1    SSX20034.1    NIVC01002133    PAA60613.1    SSX20039.1    AGTP01090746    AGTP01090747    AGTP01090748    AACZ04057952    NBAG03000232    PNI68601.1    AK127272    AL158822    CH471090    BC136618    BC171770    AB037843    AAQR03116405    AAQR03116406    AAQR03116407    NDHI03003456    PNJ45115.1    GCES01071539    JAR14784.1    KP869068    ALA62333.1    AADN04000037    AY093434    PNI68606.1    CABD030067347    CABD030067348    CABD030067349    PNI68608.1    PNJ45120.1    PNJ45122.1    GCES01071535    JAR14788.1   

Proteomes

UP000007151    UP000053240    UP000053268    UP000007266    UP000007062    UP000075880    + More
UP000268350    UP000192223    UP000007819    UP000183832    UP000009046    UP000076858    UP000019118    UP000000305    UP000053825    UP000092461    UP000030742    UP000005408    UP000053454    UP000001038    UP000215902    UP000261420    UP000261400    UP000233040    UP000005215    UP000002277    UP000233020    UP000005640    UP000005225    UP000233160    UP000233180    UP000233200    UP000265000    UP000265140    UP000265180    UP000000539    UP000265200    UP000233120    UP000192224    UP000001519    UP000261540    UP000261440   

PRIDE

Q5JUK3    Q8QFV0   

Pfam

PF07885   Ion_trans_2        + More
PF03493   BK_channel_a

Interpro

IPR003929   K_chnl_BK_asu        + More
IPR013099   K_chnl_dom       
IPR036291   NAD(P)-bd_dom_sf       
IPR002052   DNA_methylase_N6_adenine_CS       

SUPFAM

SSF51735   SSF51735       

ProteinModelPortal

A0A212EY19   A0A194QWH0   A0A194PY46   A0A139WLY1   A0A139WM47   A7UR92   + More
A0A182IR49   A0A3B0JKV1   A0A1W4XHF4   A0A3B0JLH8   J9K6K2   A0A336LSZ5   A0A336LTP8   A0A336LUK8   A0A336LQC2   A0A336LQ39   A0A336LPP9   A0A1J1ITI9   A0A1Y1NBK9   A0A336LPT4   A0A1Y1NE12   A0A2S2NZ98   A0A336LPM5   A0A1J1IRM2   E0W0S8   A0A336M243   A0A0P5ZTV5   A0A162QJ56   A0A0P5ZX15   A0A0P6CR92   A0A0P5B3Q8   A0A0P5XMA2   A0A0P6A468   N6UDZ1   A0A0P5DU19   E9HEH7   A0A0P5WSA0   A0A0P5AC24   A0A0L7QTU4   A0A0P6IQA5   A0A0P6ATN0   A0A1B0CHQ2   U4TUR2   U4UE65   A0A1C9TA78   K1PSX5   A0A0L8G7B1   A0A0L8G6V3   A0A3B3I015   A0A336LPL1   A0A267EGF8   A0A3B4VM99   A0A3B4ZIJ9   A0A336LTT0   A0A2K5RPJ3   I3N3P6   A0A2I3S2J6   A0A2K5CTR7   Q5JUK3-3   H0WYR9   A0A2J8UIJ8   A0A2K6GK25   A0A2K6K4N9   A0A2K6NPW6   A0A146VBH1   A0A0K2GMW5   A0A3P8XE41   A0A3P9KR47   A0A3B4VM72   A0A3P8XB84   E1BW18   Q8QFV0   A0A3P9IIP2   A0A2K6DE59   A0A1W5ACB6   A0A3B4VIR6   A0A2K5RPF5   A0A2K5CTT5   A0A2I3T3B9   A0A3P8XB73   A0A2I2YBE5   A0A2K5RPK7   A0A287D7E5   A0A2J8NA34   A0A3B3RM10   A0A2K5CTS9   Q5JUK3-2   A0A2K6K4Q0   A0A0D9SFC8   A0A2I2YX38   G3QR87   A0A2J8UIP1   A0A2J8UIN6   A0A3B4EPN9   A0A2K5CTS6   A0A2K6GK47   A0A3B3RND9   A0A2K6K4M7   A0A2K6NPX6   A0A146VC13  

PDB

5U76     E-value=0,     Score=3137

KEGG

101745297    K04946 potassium channel subfamily T member 1 | (RefSeq) potassium channel subfamily T member 2

GO

GO:0016021   GO:0006813   GO:0005886   GO:0042391   GO:0015271   GO:0005228   GO:0016020   GO:0008168   GO:0003676   GO:0015269   GO:0016491   GO:0030286   GO:0006810   GO:0009072   GO:0007169  

Subcellular location

Cell membrane  

Length:

1362

Number of predicted TMHs:

5

Exp number of AAs in TMHs:

122.88911

Exp number, first 60 AAs:

6.52533

Total prob of N-in:

0.94245

inside

1  -  55

TMhelix

56  -  73

outside

74  -  125

TMhelix

126  -  148

inside

149  -  156

TMhelix

157  -  179

outside

180  -  215

TMhelix

216  -  238

inside

239  -  249

TMhelix

250  -  272

outside

273  -  1362

 

 

Pi

18.460882

Theta

18.22277

Tajima's D

0.300062

CLR

0.087142

CSRT

0.464626768661567

Interpretation

Uncertain