SGID Silkworm Genome Informatics Database
Gene
KWMTBOMO00303  Validated by peptides from experiments
Pre Gene Modal
BGIBMGA000540
Annotation
PREDICTED:_ecotropic_viral_integration_site_5_ortholog_isoform_X5_[Bombyx_mori]
Full name
Ecotropic viral integration site 5 ortholog      
Location in the cell
Cytoplasmic   Reliability : 1.964 Nuclear   Reliability : 1.344
 

Sequence

CDS
ATGACCGATCGGGCTTCAACTGAAAAATCTCCGGAGCTCAATCCAAACGCAGACTGCCGAATCCCGACAAGTGAAACTATCCCGACGCCCGACCGGGCGCTTCTCGCCAAGCTGGAGGAAGAAAACCGTCGTATCGAGGCTGATGCGAAGAACGCCTCGCTCACTACCGTCCACAGTCGGAAGAGCTCCGACACATCACTGATATCCCTCGCTTCCGCCACAAGCTCAAGTCATGAGGTCGAAACGCGCCCAACTCCTGGGACTAATGGAGAAGAGGATCTTTGGAGCCTCTGGGGTCGCCTCGTCAGCAACTGGGAATCGGAATGGAAACGTCGAAACCAATGGGTCCGCGACCTTGTTCGACAGGGTGTCCCACATCATTTCAGAGGCATCGTATGGCAGCTACTGGCAGGCGTAGACACGTCGCCCGAAAAGAAGTTATACGCCTCATATATTAAGGCGAAATCAGCCTGCGAGAAGGTCATACGTCGTGACATCGCTCGCACATATCCCGAACACGATTTCTTCAAAGAGAAGGATGGCCTCGGCCAGGAGTCTTTATTCAATGTGATGAAGGCGTATTCTTTGCACGATCGAGAAGTCGGCTACTGTCAAGGCTCAGGATTTATCGTCGGCTTATTACTAATGCAGATGCCGGAAGAGGAAGCGTTCGCTGTTTTAGTTAAAATAATGCAACAACATCGCATGCGGGACATGTTCAAACCGAGCATGGCGGAACTGGGACTCTGCATGTTTCAGCTGGAGAACTTGGTACAGGAACTGTTGCCTGACTTGCATGTTCACTTCCAATCTCAGAGCTTCAGCACGTCTCTGTACGCTAGTAGTTGGTTCCTGACTTTGTTTACAACAACACTATCACTTCCGCTCGCTTGCCGTATAATGGATGTGTTTCTCTCTGAAGGAATCGAAATTGTTTTCAAAGTCGCCCTAGCGTTGCTTACTTTAGGAAAAAACGATCTCTTATCGCTCGATATGGAGAGCATTTTGAAGTACATACAGAAAGAACTGCCCTTGAAAGCTGAAGCGGATCAAGCCGCTTTCATGAACTTGGCGTATTCAGTCAAAGTTAATCCGAAAAAGATGAAGAAACTCGAAAAGGAGTACACGGTTATAAAAACAAAGGAGCAAGGTGATATTGCCGTGCTCAGGTGTCTTCGTCAAGAGAACCGTCTCCTCAAGCAACGCGTAGAACTGCTGGAGAAGGAAAGTTCCGCTCTAGCAGAGCGTCTGGTCCGAGGTCAAGTGGACCGCGCTGAAGGAGAAGAAGAAACCTTTGCATTGGATCGAGAGGTCCAAGCGTTGCGTCGAGCTAACGTAGACATGCAGCAGCGGCTGGCCGTTGCTTTAGATGAGATAAGATCTCTCGAGATGACTATCGCCGAGAATAACTCGAGGCAGTCGTCGCTGGAGGGCACCGAAAGCGCCAGCGGTCAGAAACACGAGGAACTAGCGCGCTGCCTGCAGAGGGAGCTAGTGCGGGCGCGTCTACACGCAGCGGAACGCGAGGCCGCCGAACGCGAACTGACGGCTCGCATCGACGAACTCGAGAACGAGAACAAGAGCCTCAGGAGACAGCGCGTCGACAACAATGTCGCACACTTACAGGACGAGCTGATAGCCGTAAAGTTGCGTGAAGCTGAAGCTAATCTCTCGTTGAAGGACTTAAGGCAGCGGGTCTCGGAGCTGTCAGAATCGTGGCAACGACATTTGCAGGAGCACAAGCAGGAAGCACCCGCTGCTCCAGTTCAGTCGAATGTAGTATCAGACATCATGGCGACCCCGAAGAAACTGCTGCGAGCTTGGGAAGGGAGGTCGGCTGATATGCTCAAACTGGACGAGGAACTCATGACCACCAGGATCAGGGAGGTCGAGGCCTTGACCGAATTAAAGGAGTTAAGACTGAAGGTAATGGAACTAGAGACTCAAGTTCAAGTGTCGACAAATCAGCTCCGAAGACAGGACGAGGAAGCTCGGCTGTTACGCGAGAATCTAGATGCGGCCCTCCAACGTGAACGAGCTCTCCAAACGAGACAGAGAGAGTTCCAGCACAAATACGCTGATTTAGAGAGCAAGGCCAAGTATGAATCGATGCAAGCTAACATTCGAAACATGGAAGACGCGCAAAGAATAGCCGAACTGGAGACAGAAGTGTCTGAATATAAATTAAAGAATGAAGTCATGGCAACCGAAGGTGAACTAAGGAACAATAATATGGACGACTCCGACAGAGTACGTGAATTGCAAGAGCAAGTCGCCGAGCTAAAAGCGGAGATCATGAGGTTAGAGGCGTGGAAATCTCGGGCTCTCGGTCACACGGAGCTCAGCCGCGCCATATCCCTGGAGGACGATTTGGAAGAAGACGAGAAACTCAAGTTGACACTGCGCCGAGAATCTTCTACATCATTAGAATTTACAACAACCTCACGCAAACCTTCGTAG
Protein
MTDRASTEKSPELNPNADCRIPTSETIPTPDRALLAKLEEENRRIEADAKNASLTTVHSRKSSDTSLISLASATSSSHEVETRPTPGTNGEEDLWSLWGRLVSNWESEWKRRNQWVRDLVRQGVPHHFRGIVWQLLAGVDTSPEKKLYASYIKAKSACEKVIRRDIARTYPEHDFFKEKDGLGQESLFNVMKAYSLHDREVGYCQGSGFIVGLLLMQMPEEEAFAVLVKIMQQHRMRDMFKPSMAELGLCMFQLENLVQELLPDLHVHFQSQSFSTSLYASSWFLTLFTTTLSLPLACRIMDVFLSEGIEIVFKVALALLTLGKNDLLSLDMESILKYIQKELPLKAEADQAAFMNLAYSVKVNPKKMKKLEKEYTVIKTKEQGDIAVLRCLRQENRLLKQRVELLEKESSALAERLVRGQVDRAEGEEETFALDREVQALRRANVDMQQRLAVALDEIRSLEMTIAENNSRQSSLEGTESASGQKHEELARCLQRELVRARLHAAEREAAERELTARIDELENENKSLRRQRVDNNVAHLQDELIAVKLREAEANLSLKDLRQRVSELSESWQRHLQEHKQEAPAAPVQSNVVSDIMATPKKLLRAWEGRSADMLKLDEELMTTRIREVEALTELKELRLKVMELETQVQVSTNQLRRQDEEARLLRENLDAALQRERALQTRQREFQHKYADLESKAKYESMQANIRNMEDAQRIAELETEVSEYKLKNEVMATEGELRNNNMDDSDRVRELQEQVAELKAEIMRLEAWKSRALGHTELSRAISLEDDLEEDEKLKLTLRRESSTSLEFTTTSRKPS

Summary

Description
Functions as a GTPase-activating protein (GAP). During border cell migration in the ovary, acts as a GAP for Rab11 and is necessary for the maintenance of active receptor tyrosine kinases at the leading edge.
Subunit
Interacts with Rab11.
Keywords
Alternative splicing   Coiled coil   Complete proteome   Cytoplasm   Endosome   GTPase activation   Phosphoprotein   Reference proteome  
Feature
chain  Ecotropic viral integration site 5 ortholog
splice variant  In isoform C and isoform D.
EMBL
BABH01007029    BABH01007030    NWSH01003131    PCG66899.1    PCG66900.1    GDQN01007299    + More
JAT83755.1    AGBW02012593    OWR44781.1    ODYU01007655    SOQ50622.1    PCG66897.1    KQ459594    KPI96110.1    KQ461108    KPJ09273.1    NEVH01002994    PNF40912.1    ADTU01011953    KQ976396    KYM92988.1    KQ981727    KYN36971.1    KK852685    KDR18482.1    GL440682    EFN65572.1    PNF40910.1    QOIP01000010    RLU18055.1    GEBQ01024317    GEBQ01003623    JAT15660.1    JAT36354.1    KQ435922    KOX68640.1    KZ288232    PBC31530.1    KQ982490    KYQ55788.1    KQ414632    KOC67123.1    NNAY01001051    OXU25331.1    GL449158    EFN83192.1    GEDC01030221    JAS07077.1    AAZX01000334    GEBQ01026154    GEBQ01024264    JAT13823.1    JAT15713.1    KK107167    EZA56367.1    KQ971327    EFA01267.1    GFTR01007979    JAW08447.1    GEDC01000906    JAS36392.1    ABLF02040575    ABLF02040576    GL764129    EFZ18387.1    GEZM01076826    JAV63615.1    APGK01043126    APGK01043127    APGK01043128    APGK01043129    KB741011    ENN75573.1    GBYB01011036    JAG80803.1    KB631957    ERL87468.1    GDHC01020521    JAP98107.1    CVRI01000059    CRL03768.1    AAAB01008859    EAA08217.5    GDHC01016241    JAQ02388.1    CRL03769.1    APCN01000435    EGK96918.1    GECL01001202    JAP04922.1    GGMR01005871    MBY18490.1    GDHC01010247    JAQ08382.1    GGFJ01002226    MBW51367.1    ADMH02001618    ETN61773.1    GGFM01001288    MBW22039.1    ATLV01013859    KE524905    KFB38212.1    AXCN02000052    GEBQ01031355    GEBQ01005695    JAT08622.1    JAT34282.1    GEDC01001382    JAS35916.1    GL888417    EGI61310.1    ACPB03020531    CH933810    KRF94026.1    GGFK01003230    MBW36551.1    KRF94025.1    KRF94027.1    GANO01001893    JAB57978.1    CH940660    KRF78087.1    GDAI01000983    JAI16620.1    EDW07387.1    GGFK01003449    MBW36770.1    AJWK01018121    AJWK01018122    GGFJ01002495    MBW51636.1    EDW58047.2    AE014298    AY061021    AY118309    BT099930    BT099932    BT126034    CH963925    KRF98851.1    CH954180    KQS29802.1    GEDC01018942    JAS18356.1    CM000162    KRK06485.1    DS235873    EEB19620.1    GFDF01003611    JAV10473.1    CH916370    EDV99533.1    EDV46049.2    GAPW01000244    JAC13354.1    CH478033    EAT34274.1    OUUW01000039    SPP89913.1    EDX01971.2    GFDL01014463    JAV20582.1    EDW78327.1   
Pfam
PF00566   RabGAP-TBC
Interpro
IPR035969   Rab-GTPase_TBC_sf        + More
IPR031214   Evi5       
IPR000195   Rab-GTPase-TBC_dom       
SUPFAM
SSF47923   SSF47923       
PDB
3HZJ     E-value=1.32037e-55,     Score=551

Ontologies

Topology

Subcellular location
Cytoplasm  
Endosome  
Length:
819
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
2.68957
Exp number, first 60 AAs:
0
Total prob of N-in:
0.06810
outside
1  -  819
 
 

Population Genetic Test Statistics

Pi
19.120682
Theta
17.329432
Tajima's D
-1.234414
CLR
0.004277
CSRT
0.0978951052447378
Interpretation
Uncertain
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