Gene

KWMTBOMO00268

Pre Gene Modal

BGIBMGA000667

Annotation

PREDICTED:_insulin-like_peptide_isoform_X1_[Bombyx_mori]

Location

Bomo_Chr1(+):8698646-8702438      View in EpiBrowser

Full name

Bombyxin B       + More
Bombyxin B-5      
Bombyxin A-2 homolog      
Bombyxin B-11      
Bombyxin A-3      
Bombyxin B-2      
Bombyxin B-9      
Bombyxin B-1      
Bombyxin E-1      
Bombyxin B-7      
Bombyxin A-8      
Bombyxin B-3      
Bombyxin B-12      
Bombyxin A-9      
Bombyxin A-2      
Bombyxin B-4      
Bombyxin A-4      
Bombyxin A-1 homolog      
Bombyxin A-5      
Bombyxin A-1      
Bombyxin A-7      
Bombyxin B-10      
Bombyxin A-6      
Bombyxin A-3 homolog      
Insulin-related peptide 2      
Bombyxin A      
Bombyxin G-1      
Bombyxin D-1      
Bombyxin B-6      
Bombyxin B-8      
Insulin-related peptide 1      
Insulin      

Alternative Name

4K-prothoracicotropic hormone
4K-prothoracicotropic hormone IV
Bombyxin IV
Bombyxin-II

Location in the cell

Extracellular   Reliability : 3.813

CDS

ATGTTTCTGCTGTATTTCCTGATCGTTGTGGCGCTGGTGAGTGCTGACGTCCACGACAAAGAGTTGAAAATTGAGGAAAATCCTCGGGTCTATTGCGGACGTCATTTGGCCAACGCACGCATGGTACTCTGCTATGACACTGTCGAGAAGAGAGCCCAATCTTATCTCGACGCAAACATTATTTCGGCGGGAGATTTGAGCTCCTGGCCTGGCCTGTCTTCCCAGTACGCCAAGACTCGCGCTTTTGCTCTCGCCGAGAAATCTAAACGCGGCCCTGGCTTAGTCGACGAATGTTGCCTTAAGCCCTGTTACACCTATGATCTACTTAATTACTGCTGA

Protein

MFLLYFLIVVALVSADVHDKELKIEENPRVYCGRHLANARMVLCYDTVEKRAQSYLDANIISAGDLSSWPGLSSQYAKTRAFALAEKSKRGPGLVDECCLKPCYTYDLLNYC

Description

Brain peptide responsible for activation of prothoracic glands to produce ecdysone in insects.
Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.

Subunit

Heterodimer of a B chain and an A chain linked by two disulfide bonds.

Miscellaneous

Silk worm has two kinds of PTTH: 4K-PTTH and 22K-PTTH; there are many forms of 4K-PTTH.
Silk worm has two kinds of PTTH: 4K-PTTH and 22K-PTTH; there are four forms of 4K-PTTH.

Similarity

Belongs to the insulin family.

Keywords

Cleavage on pair of basic residues   Complete proteome   Disulfide bond   Hormone   Reference proteome   Secreted   Signal   Pyrrolidone carboxylic acid   Direct protein sequencing   3D-structure   Amidation   Neuropeptide   Carbohydrate metabolism   Glucose metabolism  

Feature

chain  Bombyxin B
peptide  Bombyxin B-5 B chain
propeptide  C peptide like

Uniprot

H9ITT7   F8WTP8   A0A212EZ83   A0A0S1U0R4   F6KMX3   A0A2H1V286   + More
A0A194QKH9   A0A2A4JGH3   A0A385H8W5   I3VNA0   A0A194PJ20   A0A2S2Q9T5   A0A2H1X245   Q53X51   P26739   A0A2A4J1N6   A0A194Q7C8   A0A1B6BZF9   P33719   Q17196   M4QG01   P26726   P26734   J9JRU5   A0A0L7KP19   P26743   P26733   H9JY78   A0A212F2W7   P21808   P26741   P26731   H9JY77   P26737   P29519   P26732   H9JR12   A0A0L7L7G8   P15411   J9LQE8   H9JRY4   P26738   A0A194Q5I3   B4HAE6   P26727   P33718   P26728   J9M6G9   Q17192   P26730   Q17194   P26729   A0A1B6DZA5   Q2LZ97   A0A0K0PRT2   P33720   C0HKS4   A0A194RKP6   H9JQX3   A0A3B0JZE9   O61271   P26736   A0A194RG26   M4QC54   A0A194Q039   A0A2S2PL00   A0A0C9RE29   A0A0D6DR34   A0A0C9QS78   P26740   P26742   A0A2H1WPT3   A0A0K2TC75   A0A194PZA6   A0A385H8W3   H9JQX2   A0A385H8X0   C0HKS3   P01335   T1GAC2   A0A2H1WZM1   A0A3B3XJ76   A0A194RFD7   A0A212EI08   A0A0S2IKM6   M4QEN0   A0A2A4JKR2   A0A087YIN9   H9JY76   A0A3B5QHU8   A0A0S7IR20   A0A3N0Y3H4   M4QNU1   A0A0K0PQM2   A0A212EPD8   A0A0H3UYJ9   A0A315V6M5   A0A2P0XJ57   A0A2D1CG01   A0A0K0PQK4  

Pubmed

19121390    22118469    17559850    26354079    30171635    8683595    + More
1601275    2674935    26227816    9253178    1515030    16593744    2708384    7473749    17994087    15632085    26812356    29466015    9732555    6306593    7037403    23542700    29703783   

EMBL

BABH01006963    AB661462    BAK57501.1    AGBW02011334    OWR46809.1    KT005974    + More
ALM30325.1    HQ451073    AEE43937.1    ODYU01000348    SOQ34957.1    KQ461198    KPJ06073.1    NWSH01001540    PCG70919.1    MH028098    AXY04267.1    JQ864199    AFK81937.1    KQ459606    KPI91080.1    GGMS01005107    MBY74310.1    ODYU01012871    SOQ59389.1    D00786    BAA00682.1    D00780    NWSH01003834    PCG65779.1    KQ459324    KPJ01447.1    GEDC01030647    JAS06651.1    D13924    D00788    KC340943    AGH25575.1    M26069    ABLF02029157    JTDY01007633    JTDY01000351    KOB65058.1    KOB77585.1    D00785    M26068    BABH01042456    AGBW02013861    AGBW02010668    OWR42608.1    OWR48079.1    D78138    D00782    D00783    D00774    D00775    BABH01042454    D00778    D00789    D00776    BABH01028595    JTDY01002420    KOB71447.1    J04727    ABLF02029626    BABH01016939    D00779    KQ459583    KPI98655.1    CH479240    EDW37544.1    D00769    D13923    D00770    ABLF02024498    D00340    D00772    D00773    D00787    D00771    GEDC01006304    JAS30994.1    CH379069    EAL29611.3    KP696397    AKQ48976.1    D13925    KQ460211    KPJ16546.1    OUUW01000012    SPP87457.1    AB010380    AB010381    D00797    AB003905    KPJ16547.1    KC340940    AGH25572.1    KPI98658.1    GGMR01017319    MBY29938.1    GBYB01006610    GBYB01006611    JAG76377.1    JAG76378.1    HG972850    LT984754    CDO67721.1    SPC71615.1    GBYB01006609    JAG76376.1    D00781    D00784    ODYU01010158    SOQ55080.1    HACA01006252    CDW23613.1    KPI98656.1    MH028095    AXY04264.1    BABH01028597    MH028093    AXY04262.1    X00989    CAQQ02093058    ODYU01012310    SOQ58560.1    KPJ16543.1    AGBW02014744    OWR41114.1    KT071542    ALO24192.1    KC340942    AGH25574.1    NWSH01001233    PCG72023.1    AYCK01023274    GBYX01425763    JAO55487.1    RJVU01053127    ROL40679.1    KC340941    AGH25573.1    KP696395    AKQ48974.1    AGBW02013503    OWR43321.1    KP177518    AIZ50368.1    NHOQ01002811    PWA14592.1    KY763987    AVA30823.1    KX951416    ATN38177.1    KP696394    AKQ48973.1   

Proteomes

UP000005204    UP000007151    UP000053240    UP000218220    UP000053268    UP000007819    + More
UP000037510    UP000008744    UP000001819    UP000268350    UP000015102    UP000261480    UP000028760    UP000002852   

PRIDE

H9ITT7    F8WTP8    P26739    P33719    Q17196    P26726    + More
P26734    P26743    P26733    H9JY78    P21808    P26741    P26731    H9JY77    P26737    P29519    P26732    H9JR12    P15411    H9JRY4    P26738    P26727    P26728    P26730    Q17194    P26729    H9JQX3    O61271    P26736    P26740    P26742    H9JQX2    H9JY76   

Pfam

PF00049   Insulin        + More
PF04756   OST3_OST6

Interpro

IPR016179   Insulin-like        + More
IPR036438   Insulin-like_sf       
IPR022352   Insulin_family       
IPR016724   Insulin-rel_pep       
IPR022353   Insulin_CS       
IPR040228   Insulin-relat-peptide_inver       
IPR021149   OligosaccharylTrfase_OST3/OST6       
IPR036249   Thioredoxin-like_sf       
IPR027285   Bombyxin_B       
IPR017097   Bombyxin       
IPR030680   Bombyxin_A       
IPR004825   Insulin       

SUPFAM

SSF56994   SSF56994        + More
SSF52833   SSF52833       

ProteinModelPortal

H9ITT7   F8WTP8   A0A212EZ83   A0A0S1U0R4   F6KMX3   A0A2H1V286   + More
A0A194QKH9   A0A2A4JGH3   A0A385H8W5   I3VNA0   A0A194PJ20   A0A2S2Q9T5   A0A2H1X245   Q53X51   P26739   A0A2A4J1N6   A0A194Q7C8   A0A1B6BZF9   P33719   Q17196   M4QG01   P26726   P26734   J9JRU5   A0A0L7KP19   P26743   P26733   H9JY78   A0A212F2W7   P21808   P26741   P26731   H9JY77   P26737   P29519   P26732   H9JR12   A0A0L7L7G8   P15411   J9LQE8   H9JRY4   P26738   A0A194Q5I3   B4HAE6   P26727   P33718   P26728   J9M6G9   Q17192   P26730   Q17194   P26729   A0A1B6DZA5   Q2LZ97   A0A0K0PRT2   P33720   C0HKS4   A0A194RKP6   H9JQX3   A0A3B0JZE9   O61271   P26736   A0A194RG26   M4QC54   A0A194Q039   A0A2S2PL00   A0A0C9RE29   A0A0D6DR34   A0A0C9QS78   P26740   P26742   A0A2H1WPT3   A0A0K2TC75   A0A194PZA6   A0A385H8W3   H9JQX2   A0A385H8X0   C0HKS3   P01335   T1GAC2   A0A2H1WZM1   A0A3B3XJ76   A0A194RFD7   A0A212EI08   A0A0S2IKM6   M4QEN0   A0A2A4JKR2   A0A087YIN9   H9JY76   A0A3B5QHU8   A0A0S7IR20   A0A3N0Y3H4   M4QNU1   A0A0K0PQM2   A0A212EPD8   A0A0H3UYJ9   A0A315V6M5   A0A2P0XJ57   A0A2D1CG01   A0A0K0PQK4  

PDB

6BFC     E-value=0.0427207,     Score=79

KEGG

100653512    K04526 insulin | (RefSeq) BmILP; insulin-like peptide

PATHWAY

04068    FoxO signaling pathway - Bombyx mori (domestic silkworm)
04140    Autophagy - animal - Bombyx mori (domestic silkworm)
04150    mTOR signaling pathway - Bombyx mori (domestic silkworm)
04213    Longevity regulating pathway - multiple species - Bombyx mori (domestic silkworm)

GO

GO:0005576   GO:0005179   GO:0016021   GO:0008083   GO:0005615   GO:0007218   GO:0006006   GO:2000252   GO:0031667   GO:2000228   GO:0003309   GO:0009749   GO:0008270   GO:0006096   GO:0005506   GO:0009072   GO:0006810   GO:0007169  

PANTHER

PTHR13647   PTHR12692  

Subcellular location

Secreted  

SignalP

Position:   1 - 15,         Likelihood:  0.997007

 

 

Length:

112

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.06399

Exp number, first 60 AAs:

0.06357

Total prob of N-in:

0.02219

outside

1  -  112

 

 

Pi

19.194482

Theta

17.385789

Tajima's D

0.608789

CLR

0.031091

CSRT

0.560021998900055

Interpretation

Uncertain