Gene

KWMTBOMO00244  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA000563

Annotation

tyrosine_hydroxylase_[Bombyx_mori]

Location

Bomo_Chr1(-):8299632-8307450      View in EpiBrowser

Full name

Tyrosine 3-monooxygenase      

Alternative Name

Protein Pale
Tyrosine 3-hydroxylase

Location in the cell

Cytoplasmic   Reliability : 1.911 Nuclear   Reliability : 2.406

CDS

ATGGCAGTCGCAGCAGCCCAGAAGAACCGCGAAATGTTCGCCATCAAGAAATCCTACAGTATCGAGAACGGTTACCCATCTCGCCGTCGTTCCTTGGTTGATGACGCCCGCTTCGAAACACTGGTAGTCAAACAAACCAAGCAGAGCGTACTTGAAGAGGCTCGCGCCCGAGCCAATGACTCTGGCTTGGAATCTGATTTCATCCAAGATGGAGTGCATATTGGTAACGGTGATAATTCTCCAACCGTTGAAGATGGGACCCAGCAAGATGAAACGAAAAATGGTCACCTCGCTGATGCTGATATAGGCGATGACGATGCGAAGGGTGACGAGGATTATACGCTGACCGAAGAAGAAGTGATCTTGCAAAATGCTGCTAGTGAATCTTCTGAAGCGGAACAAGCTCTCCAACAAGCTGCCCTTTTATTGCATATGCGCGATGGAATGGGATCCCTCGCACGCATTCTGAAAACCATCGACAATTATAAAGGATGCGTTCAGCACCTTGAGACTCGCCCTTCCCAAGTCACTGGAGTCCAATTCGATGCTCTAGTTAAAGTCAGCATGACTCGTATTAATCTTATCCAGCTAATTAGATCCTTGCGTCAGTCAACCGCGTTTGCTGGTGTTAACCTTCTGACCGAAAATAACATCTCGAGCAAGACACCTTGGTTCCCGCGCCACGCTTCTGATCTCGATAACTGTAACCATCTCATGACCAAGTACGAACCCGAATTAGACATGAACCATCCTGGTTTCGCGGACAAAGATTACAGGGAACGCAGAAAACAGATTGCGGAAATCGCTTTCGCTTACAAATACGGTGACCCGATTCCGTCTATCGCATACACTGAAATCGAGAATGGCACTTGGCAACGAGTGTTCAACACCGTGCTTGATTTGATGCCCAAACACGCGTGCAGAGAGTACAAGGCTGCGTTCGAGAAACTACAGGCAGCAGACATATTCGTACCTCATCGTATTCCACAACTGGAAGATGTCAGTAGCTTCTTGCGTAAGCACACTGGCTTTACCCTGCGACCGGCTGCTGGTCTTCTGACGGCACGTGACTTCCTCGCCTCGCTTGCCTTCCGCGTATTCCAATCGACACAATACGTACGCCACAACAATTCGCCTTTCCACACACCTGAACCTGACTGTATTCACGAGCTTCTTGGTCATATACCATTATTGGCTGACCCCAGCTTCGCCCAATTTTCGCAAGAAATTGGCCTTGCATCCCTCGGCGCTTCGGATTCTGAAATCGAAAAACTATCTACTGTCTACTGGTTTACGGTTGAGTTCGGACTGTGCAAAGAGAACCAGCAACTGAAAGCTTATGGTGCAGCTCTTTTGTCTTCGATCGGAGAACTGCTTCATGCTCTTAGTGACAAGCCTGAGCTGAGACCGTTCGAGCCTGCATCCACATCCGTGCAACCCTACCAAGACCAGGAGTACCAGCCCATCTATTACGTAGCTGAGACCTTCGAAGATGCCAAAGACAAATTCAGACGCTGGGTGTCAACCATGTCGCGACCGTTCGAAGTGCGCTTCAACCCTCACACAGAGCGCGTAGAGGTGCTCGACTCCGTTGATAAGCTGGAAACTCTCATCTGGCAGCTCAACACCGAGATGTTGCATCTCACCAACGCCGTTAAGAAGCTCAAGGGCTCACACTTCGAGTGA

Protein

MAVAAAQKNREMFAIKKSYSIENGYPSRRRSLVDDARFETLVVKQTKQSVLEEARARANDSGLESDFIQDGVHIGNGDNSPTVEDGTQQDETKNGHLADADIGDDDAKGDEDYTLTEEEVILQNAASESSEAEQALQQAALLLHMRDGMGSLARILKTIDNYKGCVQHLETRPSQVTGVQFDALVKVSMTRINLIQLIRSLRQSTAFAGVNLLTENNISSKTPWFPRHASDLDNCNHLMTKYEPELDMNHPGFADKDYRERRKQIAEIAFAYKYGDPIPSIAYTEIENGTWQRVFNTVLDLMPKHACREYKAAFEKLQAADIFVPHRIPQLEDVSSFLRKHTGFTLRPAAGLLTARDFLASLAFRVFQSTQYVRHNNSPFHTPEPDCIHELLGHIPLLADPSFAQFSQEIGLASLGASDSEIEKLSTVYWFTVEFGLCKENQQLKAYGAALLSSIGELLHALSDKPELRPFEPASTSVQPYQDQEYQPIYYVAETFEDAKDKFRRWVSTMSRPFEVRFNPHTERVEVLDSVDKLETLIWQLNTEMLHLTNAVKKLKGSHFE

Catalytic Activity

(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-dopa

Cofactor

Fe(2+)

Similarity

Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.

Keywords

Alternative splicing   Catecholamine biosynthesis   Complete proteome   Iron   Metal-binding   Monooxygenase   Neurotransmitter biosynthesis   Oxidoreductase   Reference proteome  

Feature

chain  Tyrosine 3-monooxygenase
splice variant  In isoform Hypodermal.

Uniprot

B7XAK2   E9L3G5   E9L3H1   E9L3J0   E9L3H7   E9L3J1   + More
E9L3J2   E9L3G7   E9L3G4   E9L3H0   E9L3H5   E9L3H6   E9L3H8   E9L3I0   E7CZD7   A0A2H1VJX9   A5YVV1   A0A2W1BU82   M4GVG2   A0A2A4K6A9   A0A0G3VI81   Q402L8   D5MRL1   Q0E9S3   A0A194PT63   D5MRK5   D5LPT9   A6BLY5   F2VLL9   A0A212FDY4   D9IX57   A0A0L7L763   T1TCT2   A0A0G3VFY8   Q0E9S2   A0A182QXT4   A0A182WKJ2   A0A182RPF1   A0A182YQC3   A0A182V967   A0A182KPE6   A0A182X777   Q7PII7   A0A182I1Q6   A0A195BCD3   E2BF32   T1DPG9   Q29DR7   B4N2X5   B4H7A4   A0A182IZD0   A0A026WHN9   A0A3B0KGP5   A0A158NFE6   A0A1W4UXG4   E9IJ93   A0A182PJJ2   A0A0L0CQQ4   B4J096   A0A182FDH1   B4KW72   A0A084W0Q1   F4WGX8   A0A1Q3FU03   A5YVV2   A0A154P317   B4LHH8   B5X0J4   P18459   A0A1A9XWL5   F8J2H7   A0A1B0B587   B3M9H5   A0A336LN07   A0A1B0FBP0   E2A6B6   B3NFM6   A0A1A9Z3A0   A0A1A9VYP6   A0A0J9RQ65   B4PJR3   A0A2P8YCA1   B4QJT1   A0A0C9RB22   T1PBG7   G8E099   A0A1Y1M337   W5JBY1   A0A0Q9X3P9   W8BHQ1   A0A0A9WVH7   A0A034VJ95   A0A2R8G1S9   A0A0A1XT79   A0A0J7L2G0   A0A1W4VAQ6   A0A0K8VQZ7   D6WHA4   A0A1L8E390   C8CE48  

EC Number

1.14.16.2

Pubmed

18854583    19121390    21212153    17967351    28756777    16133568    + More
26354079    18178496    22118469    26227816    25244985    20966253    12364791    14747013    17210077    20798317    15632085    17994087    24508170    30249741    21347285    21282665    26108605    24438588    27416870    21719571    20080183    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    2483109    12537569    22936249    17550304    29403074    25315136    28004739    20920257    23761445    24495485    25401762    26823975    25348373    28941310    25830018    18362917    19820115   

EMBL

BABH01006925    GQ387061    HM545522    HM545524    HM545525    HM545526    + More
HM545527    HM545528    HM545529    HM545530    HM545531    HM545532    AB439286    ACU82844.1    ADV56717.1    ADV56719.1    ADV56720.1    ADV56721.1    ADV56722.1    ADV56723.1    ADV56724.1    ADV56725.1    ADV56726.1    ADV56727.1    BAH11148.1    HM545508    HM545509    HM545511    HM545512    HM545515    HM545516    HM545517    HM545536    ADV56703.1    ADV56704.1    ADV56706.1    ADV56707.1    ADV56710.1    ADV56711.1    ADV56712.1    ADV56731.1    HM545514    ADV56709.1    HM545533    ADV56728.1    HM545520    ADV56715.1    HM545534    ADV56729.1    HM545535    ADV56730.1    HM545510    ADV56705.1    HM545507    ADV56702.1    HM545513    ADV56708.1    HM545518    ADV56713.1    HM545519    ADV56714.1    HM545521    ADV56716.1    HM545523    ADV56718.1    HM856623    ADV32917.1    ODYU01002965    SOQ41135.1    EF592177    ABQ95973.1    MF440319    KZ149961    ASS36971.1    PZC76340.1    JF795467    JF795468    AFG25778.1    AFG25779.1    NWSH01000125    PCG79303.1    KP657623    RSAL01000039    AKL78848.1    RVE51020.1    AB178006    BAE43824.1    AB525743    BAJ07593.1    AB274834    BAF32573.1    KQ459594    KPI96158.1    AB525737    KQ461108    BAJ07587.1    KPJ09226.1    GU953229    ADF43213.1    AB288228    BAF64534.1    GU386339    ADU32895.1    AGBW02008997    OWR51918.1    HM215247    JN410829    ADK12633.1    AEP25405.1    JTDY01002569    KOB71174.1    KC996753    AGT62463.1    KP657624    AKL78849.1    AB274835    BAF32574.1    AXCN02000407    AAAB01008960    EAA44132.3    APCN01000085    KQ976514    KYM82221.1    GL447910    EFN85710.1    GAMD01003344    JAA98246.1    CH379070    EAL30347.2    CH964062    EDW78714.1    CH479217    EDW33710.1    KK107199    QOIP01000009    EZA55545.1    RLU18977.1    OUUW01000012    SPP87590.1    ADTU01014360    GL763739    EFZ19360.1    JRES01000036    KNC34688.1    CH916366    EDV95697.1    CH933809    EDW17460.1    ATLV01019149    KU886220    KE525263    AMZ03511.1    KFB43795.1    GL888147    EGI66597.1    GFDL01003971    JAV31074.1    EF592178    ABQ95974.1    KQ434795    KZC05530.1    CH940647    EDW68508.1    BT044563    AE014296    ACI15758.1    AHN57980.1    U14395    X76209    AY071698    FJ830627    ACZ06878.1    JXJN01008642    JXJN01008643    CH902618    EDV41188.1    UFQS01000067    UFQT01000067    SSW98948.1    SSX19330.1    CCAG010001557    GL437123    EFN71001.1    CH954178    EDV50568.1    CM002912    KMY97958.1    CM000159    EDW93662.1    PYGN01000708    PSN41889.1    CM000363    EDX09472.1    GBYB01013689    JAG83456.1    KA646004    AFP60633.1    JF499654    AEC14314.1    GEZM01042393    JAV79891.1    ADMH02001663    ETN61516.1    KRF98935.1    GAMC01017321    JAB89234.1    GBHO01032173    GBRD01000651    GDHC01016939    JAG11431.1    JAG65170.1    JAQ01690.1    GAKP01016775    JAC42177.1    KY911196    AVP73886.1    GBXI01000132    JAD14160.1    LBMM01001144    KMQ96828.1    GDHF01011012    JAI41302.1    KQ971331    EEZ99729.1    GFDF01001119    JAV12965.1    GQ390366    ACU77882.2   

Proteomes

UP000005204    UP000218220    UP000283053    UP000053268    UP000053240    UP000007151    + More
UP000037510    UP000075886    UP000075920    UP000075900    UP000076408    UP000075903    UP000075882    UP000076407    UP000007062    UP000075840    UP000078540    UP000008237    UP000001819    UP000007798    UP000008744    UP000075880    UP000053097    UP000279307    UP000268350    UP000005205    UP000192221    UP000075885    UP000037069    UP000001070    UP000069272    UP000009192    UP000030765    UP000007755    UP000076502    UP000008792    UP000000803    UP000092443    UP000092460    UP000007801    UP000092444    UP000000311    UP000008711    UP000092445    UP000078200    UP000002282    UP000245037    UP000000304    UP000095301    UP000000673    UP000036403    UP000007266   

PRIDE

B7XAK2    E9L3H7    E9L3H5    E9L3H6    E9L3H8    E9L3I0    + More
B5X0J4    P18459   

Pfam

PF00351   Biopterin_H        + More
PF00071   Ras

Interpro

IPR005962   Tyr_3_mOase        + More
IPR036329   Aro-AA_hydroxylase_C_sf       
IPR019773   Tyrosine_3-monooxygenase-like       
IPR001273   ArAA_hydroxylase       
IPR019774   Aromatic-AA_hydroxylase_C       
IPR036951   ArAA_hydroxylase_sf       
IPR018301   ArAA_hydroxylase_Fe/CU_BS       
IPR002912   ACT_dom       
IPR041903   Eu_TyrOH_cat       
IPR005225   Small_GTP-bd_dom       
IPR001806   Small_GTPase       
IPR027417   P-loop_NTPase       
IPR020849   Small_GTPase_Ras-type       

SUPFAM

SSF56534   SSF56534        + More
SSF52540   SSF52540       

Gene 3D

1.10.800.10    

CDD

cd03345  eu_TyrOH

ProteinModelPortal

B7XAK2   E9L3G5   E9L3H1   E9L3J0   E9L3H7   E9L3J1   + More
E9L3J2   E9L3G7   E9L3G4   E9L3H0   E9L3H5   E9L3H6   E9L3H8   E9L3I0   E7CZD7   A0A2H1VJX9   A5YVV1   A0A2W1BU82   M4GVG2   A0A2A4K6A9   A0A0G3VI81   Q402L8   D5MRL1   Q0E9S3   A0A194PT63   D5MRK5   D5LPT9   A6BLY5   F2VLL9   A0A212FDY4   D9IX57   A0A0L7L763   T1TCT2   A0A0G3VFY8   Q0E9S2   A0A182QXT4   A0A182WKJ2   A0A182RPF1   A0A182YQC3   A0A182V967   A0A182KPE6   A0A182X777   Q7PII7   A0A182I1Q6   A0A195BCD3   E2BF32   T1DPG9   Q29DR7   B4N2X5   B4H7A4   A0A182IZD0   A0A026WHN9   A0A3B0KGP5   A0A158NFE6   A0A1W4UXG4   E9IJ93   A0A182PJJ2   A0A0L0CQQ4   B4J096   A0A182FDH1   B4KW72   A0A084W0Q1   F4WGX8   A0A1Q3FU03   A5YVV2   A0A154P317   B4LHH8   B5X0J4   P18459   A0A1A9XWL5   F8J2H7   A0A1B0B587   B3M9H5   A0A336LN07   A0A1B0FBP0   E2A6B6   B3NFM6   A0A1A9Z3A0   A0A1A9VYP6   A0A0J9RQ65   B4PJR3   A0A2P8YCA1   B4QJT1   A0A0C9RB22   T1PBG7   G8E099   A0A1Y1M337   W5JBY1   A0A0Q9X3P9   W8BHQ1   A0A0A9WVH7   A0A034VJ95   A0A2R8G1S9   A0A0A1XT79   A0A0J7L2G0   A0A1W4VAQ6   A0A0K8VQZ7   D6WHA4   A0A1L8E390   C8CE48  

PDB

1TOH     E-value=1.12025e-122,     Score=1127

KEGG

100270767    K00501 tyrosine 3-monooxygenase [EC:1.14.16.2] | (RefSeq) Th; tyrosine hydroxylase

PATHWAY

00350    Tyrosine metabolism - Bombyx mori (domestic silkworm)
00790    Folate biosynthesis - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0009072   GO:0042423   GO:0005506   GO:0004511   GO:0007165   GO:0003924   GO:0005525   GO:0016020   GO:0048085   GO:0048082   GO:0008049   GO:0035220   GO:0009611   GO:2000274   GO:0043052   GO:0040040   GO:0008344   GO:0042542   GO:0042416   GO:0042417   GO:0048066   GO:0006584   GO:0048067   GO:0042136   GO:0007619   GO:0030424   GO:0043204   GO:0005737   GO:0006585   GO:0016714   GO:0004497   GO:0006810   GO:0007169   GO:0016021   GO:0055114  

PANTHER

PTHR11473  

Length:

561

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.01204

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00625

outside

1  -  561

 

 

Pi

0.651827

Theta

5.993226

Tajima's D

-2.530351

CLR

18.693244

CSRT

0.000149992500374981

Interpretation

Possibly Positive selection