Gene

KWMTBOMO00238  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA000648

Annotation

imaginal_disk_growth_factor_[Bombyx_mori]

Location

Bomo_Chr1(+):8035471-8055380      View in EpiBrowser

Full name

Chitinase-like protein EN03       + More
Chitinase-like protein Idgf4      

Alternative Name

Imaginal disk growth factor-like protein
Imaginal disk growth factor protein 4

Location in the cell

Mitochondrial   Reliability : 0.954

CDS

ATGAAGCTATTTATCGCTCTAGTCGGGCTCTTGGCCCTCGCTAAGGCCCTACCTGCGGTAACCCACAGCAAAGTACTTTGTTACTACGACAGCAGGAGCTATGTCAGAGAATCTCAAGCCCGCATGCTGCCGTTGGACCTCGATCCCGCTCTGTCGTTCTGCACCCACTTGCTGTACGGCTATGCCGGTATCCAGCCTGACACCTATAAGCTGGTGTCCTTAAACGAGAACCTGGACATAGACCGAACACACGACAACTACCGTGCGATCACCAGCTTGAAAGCCAAGTACCCTGGTCTCACTGTATTATTATCTGTTGGTGGCGACGCTGATACCGAAGAACCAGAAAAATATAACCTTCTGCTGGAATCGCAGCAAGCCCGTACTGCTTTCATTAATTCCGGAGTGCTGTTGGCTGAACAATATGGTTTCGATGGAATTGACCTCGCCTGGCAGTTCCCAAGAGTTAAGCCTAAGAAGATCCGCTCGACCTGGGGATCGCTTTGGCATGGAATTAAGAAGACATTCGGCACCACGCCAGTCGATGAGAAGGAATCTGAGCACCGTGAAGGTTTCACTGCCCTTGTTCGTGAATTGAAACAGGCCCTTATCCACAAGCCTAAGATGCAGCTCGGCGTGACTGTTTTGCCCAACGTTAATTCTACAATTTACCACGACGTGCCCGCCATCATTAACTTAGTTGACTATGTAAACGTTGGCGCTTACGATTATTACACTCCGACACGCAACAACAAAGAAGCTGATTACACAGCTCCTATTTACACCCCACAAAATCGCAACCCACTGCAGAACGCCGACGCCGCTGTCACATACTGGCTCACGAGCGGTGCTCCAAGCCAAAAGATAGTATTGTCTATCGCGACCTTCGGTCGTACCTGGAAACTGGACGCTGACAGCGAAATTGCGGGAGTCCCTCCAATCCACACTGATGGTCCCGGCGAAGCTGGACCATACGTTAAGACTGAAGGTTTGCTCAGTTACCCAGAAGTCTGCGGTAAGTTGATCAACCCCAACCAGCAGAAGGGAATGCGTCCTCACCTCAGGAAGGTTACTGACCCCAGCAAGCGTTTCGGAACATACGCCTTCCGTCTTCCTGATGACAACGGTGAGGGTGGCATTTGGGTATCATACGAGGATCCTGATACTGCTGGCCAGAAAGCTGCTTACGTCAAGTCAAAGAATCTCGGTGGTGTCGCTATTGTGGACCTATCATTGGATGACTTCCGCGGTCTCTGTACCGGAGACAAGTATCCAATCCTTAGGGCCGCTAAATACCGTCTCTAA

Protein

MKLFIALVGLLALAKALPAVTHSKVLCYYDSRSYVRESQARMLPLDLDPALSFCTHLLYGYAGIQPDTYKLVSLNENLDIDRTHDNYRAITSLKAKYPGLTVLLSVGGDADTEEPEKYNLLLESQQARTAFINSGVLLAEQYGFDGIDLAWQFPRVKPKKIRSTWGSLWHGIKKTFGTTPVDEKESEHREGFTALVRELKQALIHKPKMQLGVTVLPNVNSTIYHDVPAIINLVDYVNVGAYDYYTPTRNNKEADYTAPIYTPQNRNPLQNADAAVTYWLTSGAPSQKIVLSIATFGRTWKLDADSEIAGVPPIHTDGPGEAGPYVKTEGLLSYPEVCGKLINPNQQKGMRPHLRKVTDPSKRFGTYAFRLPDDNGEGGIWVSYEDPDTAGQKAAYVKSKNLGGVAIVDLSLDDFRGLCTGDKYPILRAAKYRL

Description

Cooperates with insulin-like peptides to stimulate the proliferation, polarization and motility of imaginal disk cells. May act by stabilizing the binding of insulin-like peptides to its receptor through a simultaneous interaction with both molecules to form a multiprotein signaling complex (By similarity).
Cooperates with insulin-like peptides to stimulate the proliferation, polarization and motility of imaginal disk cells. May act by stabilizing the binding of insulin-like peptides to its receptor through a simultaneous interaction with both molecules to form a multiprotein signaling complex.

Miscellaneous

Lacks the typical Glu active site in position 152 that is replaced by a Gln residue, preventing the hydrolase activity. Its precise function remains unclear.
Lacks the typical Glu active site in position 158 that is replaced by a Gln residue, preventing the hydrolase activity. Its precise function remains unclear.
Lacks the typical Glu active site in position 156 that is replaced by a Gln residue, preventing the hydrolase activity. Its precise function remains unclear.

Similarity

Belongs to the glycosyl hydrolase 18 family.
Belongs to the glycosyl hydrolase 18 family. IDGF subfamily.

Keywords

Complete proteome   Direct protein sequencing   Disulfide bond   Glycoprotein   Reference proteome   Secreted   Signal   Developmental protein  

Feature

chain  Chitinase-like protein EN03

Uniprot

A7BEX9   Q9GV28   H9ITR8   A0A2A4J8G1   D0EJV6   Q0QJJ5   + More
A0A212FDU6   Q6IWP3   A0A2H1V6B4   T1WFZ2   S4NT73   A0A194QB02   I4DM57   A0A2W1BNW3   A0A194QZW8   A0A3G1T182   I4DJ57   A0JCK4   A0A1W4X8W6   U5EUT6   A0A1W4WZG9   A0A182TSA9   A0A182UUX7   A0NF62   A0A182JLL9   A0A182L1N9   Q6JEK4   A0A2C9GR73   A0A182QFT6   A0A182LRE7   A0A1B0EZB9   A0A182T6F3   A0A1A9WS71   V5I8T0   A0A2C9GR77   Q7Q3V3   A0A182G3Y5   Q6JEK5   A0A182VLG6   A0A023ESA4   A0A182TM46   A0A182L1N7   A0A0L0C2Z8   A0A2M3Z1L3   A0A182WU84   A0A1S4F0F9   A0A023ES96   A0A2M3ZEW9   A0A023ES78   A0A182P4X1   A0A023EUI5   A0A182JP37   A0A1L8E1S0   A0A1A9UEB2   A0A182Y035   A0A084VNB3   A0A182J7A7   A0A2I6Q778   A0A3B0J863   A0A1B0BCD4   T1DSM7   A0A1L8E1W9   Q17JL4   D3TLB4   Q2PQM7   A0A182NU84   A0A2P0P9I2   A0A1A9YS97   A0A2Z2Z1A0   A0A182RC98   B4JIS9   Q29FW8   A0A034W3G0   W8B3T8   A0A1B0ADI8   A0A182MPR3   A0A0K8V176   A0A0A1WM01   B4L2Y9   T1PF14   A0A2M4BQD2   B4M255   A0A182W789   B0W7I9   W5JAF2   X2JEB6   Q9W303   Q0Z935   A0A0M5J2Z6   Q0Z936   B4PXD8   A0A182G3Y4   A0A1W4VHQ8   A0A084VNB4   A0A2M4AAV2   T1EAM6   A0A2M4BMS1   A0A1Q3FJM1   A0A1B0FNT6   B3NT34  

Pubmed

11222941    11280994    19121390    7949257    16835019    22118469    + More
15288202    23622113    26354079    22651552    28756777    30578597    12364791    14747013    17210077    20966253    15271211    26483478    24945155    26108605    25244985    24438588    29236932    17510324    20353571    16907828    17994087    15632085    25348373    24495485    25830018    25315136    20920257    23761445    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    9847235    12537569    18342250    18362917    19820115    17550304   

EMBL

AB183872    BAF73623.1    AB041634    BAB16695.1    BABH01006915    BABH01006916    + More
NWSH01002459    PCG68251.1    GQ843826    ACW82749.1    DQ355162    ABC79625.1    AGBW02008997    OWR51911.1    AY616136    AAT36640.1    ODYU01000916    SOQ36395.1    KF040475    AGU16453.1    GAIX01012296    JAA80264.1    KQ459463    KPJ00601.1    AK402375    BAM18997.1    KZ150110    PZC73363.1    KQ461108    KPJ09136.1    MG846880    AXY94732.1    AK401325    BAM17947.1    MH899224    AB282642    AZS52300.1    BAF36822.1    GANO01002177    JAB57694.1    AAAB01008964    EAU76358.1    AY496421    AAS80138.1    APCN01002479    AXCN02000772    AXCM01008455    AJVK01007194    GALX01004150    JAB64316.1    EAA12233.3    JXUM01041493    KQ561285    KXJ79101.1    AY496420    AAS80137.1    GAPW01001475    JAC12123.1    JRES01001070    KNC25789.1    GGFM01001671    MBW22422.1    GAPW01001473    JAC12125.1    GGFM01006229    MBW26980.1    GAPW01001498    JAC12100.1    GAPW01001474    JAC12124.1    GFDF01001437    JAV12647.1    ATLV01014736    KE524984    KFB39457.1    KY274439    AUM84824.1    OUUW01000003    SPP78025.1    JXJN01011956    GAMD01001409    JAB00182.1    GFDF01001438    JAV12646.1    CH477232    EAT46826.1    EZ422216    ADD18492.1    DQ307196    KU739373    ARA90550.1    KY681046    AUP42573.1    CH916370    EDW00526.1    CH379065    EAL31461.3    GAKP01010100    MH250169    JAC48852.1    QAV56502.1    GAMC01010745    JAB95810.1    GDHF01019989    JAI32325.1    GBXI01014213    JAD00079.1    CH933810    EDW07875.2    KA646478    AFP61107.1    GGFJ01005837    MBW54978.1    CH940651    EDW65759.2    DS231854    EDS38024.1    ADMH02002034    ETN59840.1    AE014298    AHN59538.1    AF102239    AY070943    BT003236    DQ659254    KQ971342    ABG47452.1    EFA03804.1    CP012528    ALC48324.1    DQ659253    ABG47451.1    EFA03805.1    CM000162    EDX02889.1    JXUM01041491    JXUM01041492    KXJ79100.1    KFB39458.1    GGFK01004584    MBW37905.1    GAMD01000908    JAB00683.1    GGFJ01005181    MBW54322.1    GFDL01007276    JAV27769.1    CCAG010019910    CH954180    EDV46214.1   

Proteomes

UP000005204    UP000218220    UP000007151    UP000053268    UP000053240    UP000192223    + More
UP000075902    UP000075903    UP000007062    UP000075880    UP000075882    UP000075840    UP000075886    UP000075883    UP000092462    UP000075901    UP000091820    UP000069940    UP000249989    UP000037069    UP000076407    UP000075885    UP000075881    UP000078200    UP000076408    UP000030765    UP000268350    UP000092460    UP000008820    UP000092444    UP000075884    UP000092443    UP000075900    UP000001070    UP000001819    UP000092445    UP000009192    UP000095301    UP000008792    UP000075920    UP000002320    UP000000673    UP000000803    UP000007266    UP000092553    UP000002282    UP000192221    UP000008711   

PRIDE

A7BEX9    Q9GV28    H9ITR8    Q2PQM7    X2JEB6    Q9W303    + More

Pfam

PF00704   Glyco_hydro_18

Interpro

IPR001223   Glyco_hydro18_cat        + More
IPR029070   Chitinase_insertion_sf       
IPR011583   Chitinase_II       
IPR015520   IDGF       
IPR017853   Glycoside_hydrolase_SF       

SUPFAM

SSF51445   SSF51445        + More
SSF54556   SSF54556       

Gene 3D

3.10.50.10    

CDD

cd02873  GH18_IDGF

ProteinModelPortal

A7BEX9   Q9GV28   H9ITR8   A0A2A4J8G1   D0EJV6   Q0QJJ5   + More
A0A212FDU6   Q6IWP3   A0A2H1V6B4   T1WFZ2   S4NT73   A0A194QB02   I4DM57   A0A2W1BNW3   A0A194QZW8   A0A3G1T182   I4DJ57   A0JCK4   A0A1W4X8W6   U5EUT6   A0A1W4WZG9   A0A182TSA9   A0A182UUX7   A0NF62   A0A182JLL9   A0A182L1N9   Q6JEK4   A0A2C9GR73   A0A182QFT6   A0A182LRE7   A0A1B0EZB9   A0A182T6F3   A0A1A9WS71   V5I8T0   A0A2C9GR77   Q7Q3V3   A0A182G3Y5   Q6JEK5   A0A182VLG6   A0A023ESA4   A0A182TM46   A0A182L1N7   A0A0L0C2Z8   A0A2M3Z1L3   A0A182WU84   A0A1S4F0F9   A0A023ES96   A0A2M3ZEW9   A0A023ES78   A0A182P4X1   A0A023EUI5   A0A182JP37   A0A1L8E1S0   A0A1A9UEB2   A0A182Y035   A0A084VNB3   A0A182J7A7   A0A2I6Q778   A0A3B0J863   A0A1B0BCD4   T1DSM7   A0A1L8E1W9   Q17JL4   D3TLB4   Q2PQM7   A0A182NU84   A0A2P0P9I2   A0A1A9YS97   A0A2Z2Z1A0   A0A182RC98   B4JIS9   Q29FW8   A0A034W3G0   W8B3T8   A0A1B0ADI8   A0A182MPR3   A0A0K8V176   A0A0A1WM01   B4L2Y9   T1PF14   A0A2M4BQD2   B4M255   A0A182W789   B0W7I9   W5JAF2   X2JEB6   Q9W303   Q0Z935   A0A0M5J2Z6   Q0Z936   B4PXD8   A0A182G3Y4   A0A1W4VHQ8   A0A084VNB4   A0A2M4AAV2   T1EAM6   A0A2M4BMS1   A0A1Q3FJM1   A0A1B0FNT6   B3NT34  

PDB

1JNE     E-value=1.68266e-115,     Score=1064

KEGG

692387    no KO assigned | (RefSeq) Idgf, En03; imaginal disk growth factor

GO

GO:0008061   GO:0005975   GO:0005576   GO:0007275   GO:0042060   GO:0040003   GO:0008084   GO:0018990   GO:0007444   GO:0004568   GO:0016787   GO:0006032   GO:0004553   GO:0005216   GO:0006811   GO:0006810   GO:0009072   GO:0007169   GO:0016021  

PANTHER

PTHR11177:SF235  

Subcellular location

Secreted  

SignalP

Position:   1 - 16,         Likelihood:  0.998295

 

 

Length:

434

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.745189999999999

Exp number, first 60 AAs:

0.7265

Total prob of N-in:

0.02397

outside

1  -  434

 

 

Pi

0.714414

Theta

4.758097

Tajima's D

-2.452972

CLR

0.014224

CSRT

0.000299985000749962

Interpretation

Possibly Positive selection