Gene

KWMTBOMO00228

Pre Gene Modal

BGIBMGA000642

Annotation

tryptophan_5-hydroxylase_1_[Bombyx_mori]

Location

Bomo_Chr1(+):7529008-7540472      View in EpiBrowser

Location in the cell

Nuclear   Reliability : 2.511

CDS

ATGAGTGGTTCGGGAAAAGGTCTTCTAGGTCTTTGGCTCTATAGAAACGGTTCTGATTGGCAAGTAAAGAATGAATCTCCACACCATCCTAAGCTCGGAGAGCTTCATGCAGCAAGAGTCCAGGCTCAAGCAGAAAGCGAACGTATTTCGGTGATGTTTACATTGAAAAACCAAGTTGGCGGACTAGTTCGGGCCTTATCCGTTTTCCAAGACTTGGGTATTAACGTTCTCCACATTGAATCCAGAAAATCTATGACTGAAGTTTCATCTGCCGACATCCTCGTGGACGTGGAGTGTGATCCCCAAAGAATGGAGCAACTGAAGAGGATGCTAAAACGAGAAGTCCAAGACTTTGAGGTTGTACCACCGCAGACTGGTGATGAGTTTCCTCCTCCAACGCCTATGTCTGCTGCGGCAAGCTTCGATTTCGGTGAGATGCCCTGGTTTCCACGAAAGATATCTGACTTGGACCGCGCCCAAAACGTCCTCATGTATGGTTCGGAACTGGACGCCGATCACCCTGGCTTCAAAGACCCGATATATAGGAAACGCCGTGAACAGTTTGCGGCAATCGCCAATAACTATAAGTATGGCCATCCGATCCCGAAGGTGCAGTATACTGAAACAGAAATCAAAACATGGGGAATTGTGTTCCGTGAGCTTCACAAACTTTACCAGAAACACGCTTGTCCTGAGTACTTAGAGAACTGGCCCCAACTTGTCAAGTACTGCGGCTACAGGGAGGACAACTTGCCTCAGCTAGAAGATGTGAGTTCATTCTTGAAACGAAAAACTGGCTTTCAATTGCGCCCTGTTGCCGGCTATCTCTCGCCGAGGGACTTTTTATCGGGTCTTGCTTTCCGTGTTTTCCACTGCACCCAATACATTCGTCACTCGTCTGATCCTTTCTACACTCCGGAACCCGATTGCTGCCATGAACTTCTCGGGCACATGCCGCTGCTAGCTAATCCAAGTTTCGCGCAATTCTCTCAAGAACTCGGCTTGGCGTCTCTCGGCGCGTCTGATGCAGACATAGATAAATTGGCTACCTTGTATTTCTTCACGGTTGAATTTGGCTTGTGTCGTCAACCGGATGGCTCTTTTTGCGTTTACGGAGCTGGACTGCTTTCGTCTGTGGCTGAACTCCAACATGCCCTCACTACGCCGGAAAAAATAAAGCGTTTCGACCCCGATATTACTGTACATGAAGAATGCATCATCACTTCATACCAAAACGCTTATTATTATACCGATTCCTTTGAAGAGGCGAAGGAGAAAATGAGAGCATTTGCTGAAAGCATACAACGCCCTTTTGGAGTCAGATACAATCCATACACTCAAAGCGTCGAGGTACTGAGTAATGCACAGAAGATTACTGCTCTGGTCTCTGAGTTACGAGGAGATTTGTGCATTGTGTCTTCGGCTATAAAGAAAATATCAGCTCAGGATTCGACATTAGATGTAGAGTCGATTGCTAATATGCTTCATACTGGTCTTCAGGTTCACGATCGGAGTCCACAGAGCACGTCTGGAGCGAGCACTCCTAATTCTGAACGCGGTACTTCGCCAGCAAGGCTAGAGAAAACCGAAGAAACTCTTAAAACCGACGAAGAAAAACCAACTAAAAACTAA

Protein

MSGSGKGLLGLWLYRNGSDWQVKNESPHHPKLGELHAARVQAQAESERISVMFTLKNQVGGLVRALSVFQDLGINVLHIESRKSMTEVSSADILVDVECDPQRMEQLKRMLKREVQDFEVVPPQTGDEFPPPTPMSAAASFDFGEMPWFPRKISDLDRAQNVLMYGSELDADHPGFKDPIYRKRREQFAAIANNYKYGHPIPKVQYTETEIKTWGIVFRELHKLYQKHACPEYLENWPQLVKYCGYREDNLPQLEDVSSFLKRKTGFQLRPVAGYLSPRDFLSGLAFRVFHCTQYIRHSSDPFYTPEPDCCHELLGHMPLLANPSFAQFSQELGLASLGASDADIDKLATLYFFTVEFGLCRQPDGSFCVYGAGLLSSVAELQHALTTPEKIKRFDPDITVHEECIITSYQNAYYYTDSFEEAKEKMRAFAESIQRPFGVRYNPYTQSVEVLSNAQKITALVSELRGDLCIVSSAIKKISAQDSTLDVESIANMLHTGLQVHDRSPQSTSGASTPNSERGTSPARLEKTEETLKTDEEKPTKN

Cofactor

Fe(2+)

Uniprot

A0A0A0QIF7   H9ITR2   A0A2H1VFH5   A0A2A4JKX5   A0A194QZX5   A0A212EMQ3   + More
A0A0G3VJK8   A0A142F422   A0A194QB12   A0A084W0Q8   A0A182IYT9   A0A1S4G590   J9E928   A0A182I1Q9   A0A182YCW9   A0A182KBJ1   A0A182PJI9   A0A182WKJ5   A0A182FCQ7   A0A182KPE9   A0A182RPF4   A0A1J1I820   A0A182GEG7   A0A336LM66   A0A182NKC7   Q7Q665   W5JIU7   A0A182SWG0   D6WHK1   B0XK29   A0A1B0CQB7   A0A2H8TWM4   A0A1I8P648   A0A1I8MZC1   J9JJ41   E9RJU9   A0A2A3EIN8   A0A1W4X3N3   W8C3W8   A0A0K8VBY4   B4KWR4   R9S2K6   A0A034WR65   E2AD07   A0A3B0KPT3   B4MM34   A0A0R3P6T9   A0A1A9Y2A1   A0A1B0B9H9   A0A195DAI2   A0A087ZZK7   B3M555   E2BF35   Q29DP1   A0A0L7R9H6   A0A158NFE8   B4IZR0   A0A310SIY1   B4HVN4   A0A1B0AD17   A0A1W4W6M0   B4LGY7   A0A0J9RMW1   B4PCR3   A0A0L0BV79   Q9W0K2   B4QLX4   B3NJF1   A0A182ME81   A0A182QL96   A0A195BDE8   A0A067QRH3   A0A182X774   A0A151IHU0   F2ZBU1   A0A182UZZ4   A0A1A9X2W7   K7IMD2   E0VZU7   B4HDG7   T1I7M5   A0A1D2MRD4   A0A0N0BKX3   A0A226DK15   A0A1B0GCQ6   A0A0C9QF55   N6U2M6   A0A026WHP4   A0A0P5FLH1   A0A0P6AWJ1   A0A0P5YZL0   E9G1D2   T1KEU9   T1J5F7   A0A1S3JT92   A0A210QFD6   V3ZXB0  

Pubmed

19121390    26354079    22118469    26974346    24438588    17510324    + More
25244985    20966253    26483478    12364791    20920257    23761445    18362917    19820115    25315136    24495485    17994087    25348373    20798317    15632085    21347285    22936249    17550304    26108605    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    24845553    20075255    20566863    27289101    23537049    24508170    30249741    21292972    28812685    23254933   

EMBL

KF650639    AIL94234.1    BABH01006872    ODYU01002299    SOQ39610.1    NWSH01001075    + More
PCG72735.1    KQ461108    KPJ09146.1    AGBW02013810    OWR42775.1    KP657632    RSAL01000121    AKL78857.1    RVE46690.1    KT946792    AMQ67551.1    KQ459463    KPJ00611.1    ATLV01019151    ATLV01019152    KE525263    KFB43802.1    CH477226    EJY57396.1    APCN01000088    CVRI01000042    CRK95724.1    JXUM01059094    KQ562035    KXJ76846.1    UFQS01000067    UFQT01000067    SSW98952.1    SSX19334.1    AAAB01008960    EAA11742.3    ADMH02001054    ETN64302.1    KQ971331    EFA01002.1    DS233689    EDS31126.1    AJWK01023383    AJWK01023384    AJWK01023385    AJWK01023386    GFXV01006888    MBW18693.1    ABLF02030381    AB618095    BAJ83476.1    KZ288230    PBC31587.1    GAMC01002602    JAC03954.1    GDHF01015972    JAI36342.1    CH933809    EDW17511.1    KC699559    AGN03862.1    GAKP01000871    JAC58081.1    GL438633    EFN68680.1    OUUW01000012    SPP87201.1    CH963847    EDW73043.1    CH379070    KRT08873.1    JXJN01010387    JXJN01010388    KQ981063    KYN09920.1    CH902618    EDV39534.1    GL447910    EFN85713.1    EAL30373.2    KQ414627    KOC67406.1    ADTU01014379    ADTU01014380    CH916366    EDV95645.1    KQ767065    OAD53510.1    CH480817    EDW49999.1    CH940647    EDW68457.2    CM002912    KMY96754.1    CM000159    EDW92786.1    JRES01001279    KNC23970.1    AE014296    BT001418    AAF47444.1    AAN71173.1    CM000363    EDX08760.1    CH954178    EDV50113.1    AXCM01011779    AXCN02000407    KQ976514    KYM82227.1    KK853024    KDR12331.1    KQ977578    KYN01817.1    AB626809    BAK19479.1    DS235854    EEB18903.1    CH480298    EDW27421.1    ACPB03000182    ACPB03000183    LJIJ01000646    ODM95603.1    KQ435691    KOX81148.1    LNIX01000017    OXA45573.1    CCAG010002190    GBYB01013133    JAG82900.1    APGK01041859    KB740998    ENN75820.1    KK107199    QOIP01000009    EZA55550.1    RLU18973.1    GDIQ01259517    JAJ92207.1    GDIP01029905    LRGB01000084    JAM73810.1    KZS20986.1    GDIP01064301    JAM39414.1    GL732529    EFX86644.1    CAEY01000029    JH431861    NEDP02003883    OWF47473.1    KB202953    ESO87260.1   

Proteomes

UP000005204    UP000218220    UP000053240    UP000007151    UP000283053    UP000053268    + More
UP000030765    UP000075880    UP000008820    UP000075840    UP000076408    UP000075881    UP000075885    UP000075920    UP000069272    UP000075882    UP000075900    UP000183832    UP000069940    UP000249989    UP000075884    UP000007062    UP000000673    UP000075901    UP000007266    UP000002320    UP000092461    UP000095300    UP000095301    UP000007819    UP000242457    UP000192223    UP000009192    UP000000311    UP000268350    UP000007798    UP000001819    UP000092443    UP000092460    UP000078492    UP000005203    UP000007801    UP000008237    UP000053825    UP000005205    UP000001070    UP000001292    UP000092445    UP000192221    UP000008792    UP000002282    UP000037069    UP000000803    UP000000304    UP000008711    UP000075883    UP000075886    UP000078540    UP000027135    UP000076407    UP000078542    UP000075903    UP000091820    UP000002358    UP000009046    UP000008744    UP000015103    UP000094527    UP000053105    UP000198287    UP000092444    UP000019118    UP000053097    UP000279307    UP000076858    UP000000305    UP000015104    UP000085678    UP000242188    UP000030746   

PRIDE

H9ITR2    Q9W0K2   

Pfam

PF00351   Biopterin_H        + More
PF01842   ACT
PF13844   Glyco_transf_41
PF00515   TPR_1

Interpro

IPR036329   Aro-AA_hydroxylase_C_sf        + More
IPR019773   Tyrosine_3-monooxygenase-like       
IPR001273   ArAA_hydroxylase       
IPR002912   ACT_dom       
IPR018301   ArAA_hydroxylase_Fe/CU_BS       
IPR041904   TrpOH_cat       
IPR005963   Trp_5_mOase       
IPR019774   Aromatic-AA_hydroxylase_C       
IPR036951   ArAA_hydroxylase_sf       
IPR011990   TPR-like_helical_dom_sf       
IPR019734   TPR_repeat       
IPR001440   TPR_1       
IPR037919   OGT       
IPR013026   TPR-contain_dom       
IPR029489   OGT/SEC/SPY_C       

SUPFAM

SSF56534   SSF56534        + More
SSF48452   SSF48452       

Gene 3D

1.10.800.10     1.25.40.10    

CDD

cd03346  eu_TrpOH

ProteinModelPortal

A0A0A0QIF7   H9ITR2   A0A2H1VFH5   A0A2A4JKX5   A0A194QZX5   A0A212EMQ3   + More
A0A0G3VJK8   A0A142F422   A0A194QB12   A0A084W0Q8   A0A182IYT9   A0A1S4G590   J9E928   A0A182I1Q9   A0A182YCW9   A0A182KBJ1   A0A182PJI9   A0A182WKJ5   A0A182FCQ7   A0A182KPE9   A0A182RPF4   A0A1J1I820   A0A182GEG7   A0A336LM66   A0A182NKC7   Q7Q665   W5JIU7   A0A182SWG0   D6WHK1   B0XK29   A0A1B0CQB7   A0A2H8TWM4   A0A1I8P648   A0A1I8MZC1   J9JJ41   E9RJU9   A0A2A3EIN8   A0A1W4X3N3   W8C3W8   A0A0K8VBY4   B4KWR4   R9S2K6   A0A034WR65   E2AD07   A0A3B0KPT3   B4MM34   A0A0R3P6T9   A0A1A9Y2A1   A0A1B0B9H9   A0A195DAI2   A0A087ZZK7   B3M555   E2BF35   Q29DP1   A0A0L7R9H6   A0A158NFE8   B4IZR0   A0A310SIY1   B4HVN4   A0A1B0AD17   A0A1W4W6M0   B4LGY7   A0A0J9RMW1   B4PCR3   A0A0L0BV79   Q9W0K2   B4QLX4   B3NJF1   A0A182ME81   A0A182QL96   A0A195BDE8   A0A067QRH3   A0A182X774   A0A151IHU0   F2ZBU1   A0A182UZZ4   A0A1A9X2W7   K7IMD2   E0VZU7   B4HDG7   T1I7M5   A0A1D2MRD4   A0A0N0BKX3   A0A226DK15   A0A1B0GCQ6   A0A0C9QF55   N6U2M6   A0A026WHP4   A0A0P5FLH1   A0A0P6AWJ1   A0A0P5YZL0   E9G1D2   T1KEU9   T1J5F7   A0A1S3JT92   A0A210QFD6   V3ZXB0  

PDB

5L01     E-value=3.12103e-159,     Score=1443

KEGG

101740691    K00502 tryptophan 5-monooxygenase [EC:1.14.16.4] | (RefSeq) tryptophan 5-hydroxylase 1

PATHWAY

00380    Tryptophan metabolism - Bombyx mori (domestic silkworm)
00790    Folate biosynthesis - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0009072   GO:0004510   GO:0042427   GO:0005506   GO:0016714   GO:0006493   GO:0016757   GO:0016021   GO:0043005   GO:0045187   GO:0030431   GO:0004505   GO:0008152   GO:0016597   GO:0004497   GO:0007169   GO:0055114  

PANTHER

PTHR11473   PTHR44366  

Length:

543

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00262

Exp number, first 60 AAs:

0.00018

Total prob of N-in:

0.00025

outside

1  -  543

 

 

Pi

19.510695

Theta

22.287126

Tajima's D

-1.190263

CLR

0.098028

CSRT

0.106244687765612

Interpretation

Uncertain