Gene

KWMTBOMO00227

Pre Gene Modal

BGIBMGA000570

Annotation

PREDICTED:_JNK-interacting_protein_1_[Plutella_xylostella]

Location

Bomo_Chr1(-):7512341-7521947      View in EpiBrowser

Full name

JNK-interacting protein 1      

Alternative Name

APP-like-interacting protein 1
Protein eye developmental SP512

Location in the cell

Nuclear   Reliability : 3.849

CDS

ATGGCCGATAGCGAGTTTGAAGAATTTCGACGAGTTTTTGATAGACTACCGCAACACATTAAGGCCCCAACGCCTTTTTACTCATTAGTGCCAAATGTTGGATTCGAAGATGAGTCACCTTCCTCGAAAAGTGAAGGTAGCCCCGAAGAAGACAGAGGATGTGTAGGCGAAACCGATGGTCGGTCATCTATTCCGGAAAATCCGGAGTCTCCACCGCCACCGGCAGACGCAGCAGACACACAACGCAGTCCTCGTCACCAGACGTTTACAAATGGCGAAAGGCGAAGGAGAAAACTCCCTGAGATCCCGAAACATAAAAAATCATCTATTCTAGCATGTGGCCAACCAGCATCTCTAGCTGATGAACTTGGGGCTCTAACCGGGATGCTCGTAAGACCAGGATGTCACAGCAGACCACTGCTCGTGCTAAAATGTGGCTATCTCCTCGACGAAGACTCCAGCCCAGATTCGGAGAGACTGCAAAGCTTGGGAGATGTCGACAGTGGACACAGCACCGCACATTCCCCTATCGACACGGGTCCAAAGAGTTTGTCGCCAATACCCTTACAGCAAAACGTGTCGCCCTCGTCCAGTTGCAGTATCAGTGGAATGAATTTTGCAGGAAATATGACCACAGTACCTCATAGTCAACTAGAAATGCTTGAAGCAACCCACAGAGGCCTACATAAATTTAACCCTAGGCATCACGATGAAATCGAGGTGGAAATAGGGGACCCTATTTATGTTCAAAAAGAAGCAGAAGATCTATGGTGCGAAGGTGTAAATTTACGAACAGGACAGCAAGGAATCTTTCCCTCCGCCTACGCAGTCGATATGGATTACAACGACTTCGACCCAGCAAATGCCAAAGTAAAAAGGGAACGATATTTATTAGGGTATATGGGCTCCGTAGAAACTTTAGCCCATAAAGGTACAGGTGTCGTTTGCCAAGCTGTAAAAAAGATTGTCGGTGAATGCAGCACTGAACCTACCATTCAGCCTTGTATTCTTGAAGTATCTGATCAGGGGCTTCGTATGGTTGACCGTTCCAAGCCAGAGAGAAATCGCAACGGACCCTGTATCGATTACTTTTACTCGCTGAAGAACGTATCGTTTTGCGCTTTCCATCCTCGAGATCATCGTTACCTGGGTTTCATCACAAAACACCCGACCCTTCAACGATTCGCTTGCCACGTATTTCGAGGACAGGAGTCTACCAGGCCAGTCGCAGAAGCAGTCGGGAGAGCTTTTCAAAGATTTTATCAGAAGTTTATCGAGACAGCGTACCCAATTGAGGACATCTACATAGAATAG

Protein

MADSEFEEFRRVFDRLPQHIKAPTPFYSLVPNVGFEDESPSSKSEGSPEEDRGCVGETDGRSSIPENPESPPPPADAADTQRSPRHQTFTNGERRRRKLPEIPKHKKSSILACGQPASLADELGALTGMLVRPGCHSRPLLVLKCGYLLDEDSSPDSERLQSLGDVDSGHSTAHSPIDTGPKSLSPIPLQQNVSPSSSCSISGMNFAGNMTTVPHSQLEMLEATHRGLHKFNPRHHDEIEVEIGDPIYVQKEAEDLWCEGVNLRTGQQGIFPSAYAVDMDYNDFDPANAKVKRERYLLGYMGSVETLAHKGTGVVCQAVKKIVGECSTEPTIQPCILEVSDQGLRMVDRSKPERNRNGPCIDYFYSLKNVSFCAFHPRDHRYLGFITKHPTLQRFACHVFRGQESTRPVAEAVGRAFQRFYQKFIETAYPIEDIYIE

Description

The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity).

Subunit

Forms homo- and heterooligomeric complexes. Binds Hep, a dual specificity protein kinase in the JNK pathway, but not its downstream target bsk. The C-terminal region interacts with the kinesin light chain protein, Klc, and the C-terminal PTY motif of amyloid-beta protein precursor-like protein, Appl.

Similarity

Belongs to the JIP scaffold family.

Keywords

3D-structure   Alternative splicing   Complete proteome   Cytoplasm   Developmental protein   Reference proteome   SH3 domain  

Feature

chain  JNK-interacting protein 1
splice variant  In isoform A.

Uniprot

H9ITJ0   A0A2H1VFP4   A0A2A4JMC5   A0A2W1BLU3   A0A212EMR1   A0A194QUK2   + More
A0A194Q4Z5   A0A0L7LIZ5   Q17KB6   A0A182NKC8   A0A182QM22   A0A0M4EDC6   A0A182KFM5   A0A182YCW8   A0A182IKQ4   A0A182WKJ4   A0A1W4VVN9   A0A182RPF3   Q7Q664   A0A182U4N4   B3M553   A0A084W0Q7   A0A182MUH6   B3NJF3   A0A1Q3FR19   A0A0J9RLW7   Q9W0K0   A0A182I1Q8   A0A182V079   A0A182X775   W5JJI4   A0A1J1I7K8   B4HVN6   A0A182PJJ0   A0A1W4W6Q3   B4IZR1   A0A0Q5U2J0   Q9W0K0-2   A0A0J9RLI6   A0A0P8XTN4   B4PCR5   A0A1I8P0L8   A0A1I8M857   B4KWR3   B4HCQ1   A0A0Q9WIT1   A0A034WPY1   A0A0R3P6Q9   B4HCQ2   B4MM35   A0A3B0KFR2   B4IQZ3   A0A0Q9XBA9   B4HCW6   B4HDF4   A0A0R1DUW6   A0A1I8P0H5   B4LGY8   W8BRE1   B4IQW7   T1PBA5   A0A1I8M853   A0A0L0BVD0   Q29DP0   A0A182FCQ8   A0A034WN93   A0A087ZZD8   D6WHK0   A0A2A3EIS7   B4IR04   W8BAV8   A0A0M9ABH9   A0A1A9Y2A3   B4HD56   A0A1B0GCQ7   A0A1B0C6B2   A0A1B0AD19   B4HCQ3   A0A182SIN2   A0A1W4XE28   A0A195DBW7   A0A151XFP5   A0A195FPZ8   E2AD08   A0A0L7R962   E9IJ96   F4WGX4   A0A195BCD9   A0A158NFE7   B4HDB5   A0A026WKC6   A0A336LRJ2   A0A182GWY6   K7IMD1   E2BF34   A0A0T6B2P9   A0A1B6LGG6   A0A023F351  

Pubmed

19121390    28756777    22118469    26354079    26227816    17510324    + More
25244985    12364791    14747013    17210077    17994087    24438588    22936249    11912189    10731132    12537572    12537569    20920257    23761445    17550304    25315136    25348373    15632085    24495485    26108605    18362917    19820115    20798317    21282665    21719571    21347285    24508170    30249741    26483478    20075255    25474469   

EMBL

BABH01006872    ODYU01002299    SOQ39606.1    NWSH01001075    PCG72734.1    KZ149977    + More
PZC75888.1    AGBW02013810    OWR42774.1    KQ461108    KPJ09147.1    KQ459463    KPJ00612.1    JTDY01000892    KOB75533.1    CH477226    EAT47131.1    AXCN02000407    CP012525    ALC43584.1    AAAB01008960    EAA11484.4    CH902618    EDV39532.1    ATLV01019151    KE525263    KFB43801.1    AXCM01004843    CH954178    EDV50115.1    GFDL01005026    JAV30019.1    CM002912    KMY96757.1    AF220194    AF231037    AE014296    AY051495    BT001795    APCN01000088    ADMH02001054    ETN64301.1    CVRI01000042    CRK95722.1    CH480817    EDW50001.1    CH916366    EDV95646.1    KQS43051.1    KMY96756.1    KPU78081.1    CM000159    EDW92788.1    CH933809    EDW17510.1    CH479388    EDW29629.1    CH940647    KRF83862.1    GAKP01003144    JAC55808.1    CH379070    KRT08874.1    EDW29630.1    CH963847    EDW73044.2    OUUW01000012    SPP87200.1    CH690070    EDW26662.1    KRG05581.1    CH479486    EDW32958.1    CH480208    EDW26922.1    KRK00719.1    EDW68458.1    GAMC01010744    JAB95811.1    CH689783    EDW39417.1    KA645258    AFP59887.1    JRES01001279    KNC23976.1    EAL30374.1    GAKP01003145    JAC55807.1    KQ971331    EEZ99727.1    KZ288230    PBC31588.1    CH690177    EDW27183.1    GAMC01010743    JAB95812.1    KQ435691    KOX81147.1    CH479720    EDW37585.1    CCAG010002190    JXJN01026526    EDW29631.1    KQ981063    KYN09919.1    KQ982182    KYQ59155.1    KQ981340    KYN42538.1    GL438633    EFN68681.1    KQ414627    KOC67407.1    GL763739    EFZ19364.1    GL888147    EGI66593.1    KQ976514    KYM82226.1    ADTU01014378    ADTU01014379    CH479999    EDW25262.1    KK107199    QOIP01000009    EZA55549.1    RLU18972.1    UFQT01000067    SSX19333.1    JXUM01019983    KQ560561    KXJ81888.1    GL447910    EFN85712.1    LJIG01016061    KRT81731.1    GEBQ01017186    GEBQ01013559    JAT22791.1    JAT26418.1    GBBI01002892    JAC15820.1   

Proteomes

UP000005204    UP000218220    UP000007151    UP000053240    UP000053268    UP000037510    + More
UP000008820    UP000075884    UP000075886    UP000092553    UP000075881    UP000076408    UP000075880    UP000075920    UP000192221    UP000075900    UP000007062    UP000075902    UP000007801    UP000030765    UP000075883    UP000008711    UP000000803    UP000075840    UP000075903    UP000076407    UP000000673    UP000183832    UP000001292    UP000075885    UP000001070    UP000002282    UP000095300    UP000095301    UP000009192    UP000008744    UP000008792    UP000001819    UP000007798    UP000268350    UP000037069    UP000069272    UP000005203    UP000007266    UP000242457    UP000053105    UP000092443    UP000092444    UP000092460    UP000092445    UP000075901    UP000192223    UP000078492    UP000075809    UP000078541    UP000000311    UP000053825    UP000007755    UP000078540    UP000005205    UP000053097    UP000279307    UP000069940    UP000249989    UP000002358    UP000008237   

PRIDE

H9ITJ0    Q9W0K0   

Pfam

PF00640   PID        + More
PF14604   SH3_9

Interpro

IPR001452   SH3_domain        + More
IPR006020   PTB/PI_dom       
IPR036028   SH3-like_dom_sf       
IPR011993   PH-like_dom_sf       

SUPFAM

SSF50044   SSF50044       

Gene 3D

2.30.29.30    

ProteinModelPortal

H9ITJ0   A0A2H1VFP4   A0A2A4JMC5   A0A2W1BLU3   A0A212EMR1   A0A194QUK2   + More
A0A194Q4Z5   A0A0L7LIZ5   Q17KB6   A0A182NKC8   A0A182QM22   A0A0M4EDC6   A0A182KFM5   A0A182YCW8   A0A182IKQ4   A0A182WKJ4   A0A1W4VVN9   A0A182RPF3   Q7Q664   A0A182U4N4   B3M553   A0A084W0Q7   A0A182MUH6   B3NJF3   A0A1Q3FR19   A0A0J9RLW7   Q9W0K0   A0A182I1Q8   A0A182V079   A0A182X775   W5JJI4   A0A1J1I7K8   B4HVN6   A0A182PJJ0   A0A1W4W6Q3   B4IZR1   A0A0Q5U2J0   Q9W0K0-2   A0A0J9RLI6   A0A0P8XTN4   B4PCR5   A0A1I8P0L8   A0A1I8M857   B4KWR3   B4HCQ1   A0A0Q9WIT1   A0A034WPY1   A0A0R3P6Q9   B4HCQ2   B4MM35   A0A3B0KFR2   B4IQZ3   A0A0Q9XBA9   B4HCW6   B4HDF4   A0A0R1DUW6   A0A1I8P0H5   B4LGY8   W8BRE1   B4IQW7   T1PBA5   A0A1I8M853   A0A0L0BVD0   Q29DP0   A0A182FCQ8   A0A034WN93   A0A087ZZD8   D6WHK0   A0A2A3EIS7   B4IR04   W8BAV8   A0A0M9ABH9   A0A1A9Y2A3   B4HD56   A0A1B0GCQ7   A0A1B0C6B2   A0A1B0AD19   B4HCQ3   A0A182SIN2   A0A1W4XE28   A0A195DBW7   A0A151XFP5   A0A195FPZ8   E2AD08   A0A0L7R962   E9IJ96   F4WGX4   A0A195BCD9   A0A158NFE7   B4HDB5   A0A026WKC6   A0A336LRJ2   A0A182GWY6   K7IMD1   E2BF34   A0A0T6B2P9   A0A1B6LGG6   A0A023F351  

PDB

2FPE     E-value=2.46276e-13,     Score=183

KEGG

101745296    no KO assigned | (RefSeq) JNK-interacting protein 1

GO

GO:0019896   GO:0019901   GO:2000331   GO:0046328   GO:0019894   GO:0048490   GO:0005078   GO:1904115   GO:0048491   GO:0042802   GO:0007254   GO:0007275   GO:0030424   GO:0005515   GO:0016020   GO:0016021   GO:0005230   GO:0006810   GO:0004890   GO:0005216   GO:0006508   GO:0007169  

Subcellular location

Cytoplasm  

Length:

437

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.000460000000000001

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00213

outside

1  -  437

 

 

Pi

5.873898

Theta

13.098943

Tajima's D

-1.55012

CLR

0

CSRT

0.0527973601319934

Interpretation

Uncertain