Gene

KWMTBOMO00216

Pre Gene Modal

BGIBMGA000577

Annotation

PREDICTED:_cyclic_nucleotide-gated_cation_channel_subunit_A-like_[Bombyx_mori]

Location

Bomo_Chr1(-):6910528-6958874      View in EpiBrowser

Full name

Cyclic nucleotide-gated cation channel subunit A      

Alternative Name

Cyclic nucleotide-gated ion channel subunit A

Location in the cell

PlasmaMembrane   Reliability : 3.069

CDS

ATGTCCGACAACCAATTGAACACCCACGGCAGCAGCAAAATATTCACCATGTCGAATTCCGGCAGTTCTAATCCTGGTCCTTCAGGACTGAACACAAACTCTGCCGAGATCTCCAAAGATACGGAGAAATCAATCGAGAGCAACGCGCACAGCTCCATCCATATAGCTCCCGATGATAAAGAACCGCAGAACCAAGTCGTTGAACACTATGGAGAGGCTGTGACGGAATCGAACGCCAACAACAACTGGATCCAGCGGCAATTCTCGCGTCTGACGAAGAACTGGCGGTTCCGTATCAAAAATGAAGGTCGCGCCAAGCCCCCCGATTGGTTCCTGGACAAATTCGCTGCACAAACGTTCACCGACCCCGAAGAACCGCTCTACCAGGCACAACGTTCCAAGCTACTCTGCGGGATGAAATTAGCCTTCGACCCAACCTTACCAACTCATTATAACTGGTTGGCGGTTGTTTCCCTGGCTATCCTGTACAACGTGGTGTTTGTGATCGGACGAGCGGTGTTCTGGGAACTAGACAACTTGACCTCTGTCTGGTTCGTCCTGGATTATCTATGCGACTTCGTTTATCTCGTCGACACCGTTATACATATACACGAAGGCTATCTCGAACAAGGACTGATGGTTAAAGATGCGAAGATGCTCAGACACCACTATCTAAAGTCGAGCTCTTGGAAATATGACCTGCTTTCATTGATACCGACCGATATAGCGTACTATTGGTGGCCTCCGGGATCGTGCGATCATATGCATTTGCCGTGCCCGGTTATCGTGCGGTTAAATCGACTTCTCCGCCTGCCTCGCATGTGGGAATGGTTTGATAGAACAGAGACAGCCACAAGTTATCCGAACGCTTTCAGAATTTGCAAGGTTGTGATGGCGATACTAGTTCTTATCCACTGGAACGCTTGCCTATACTTTGCTATCAGCTATGCTATCGGTTTCGGTACCGACAATTGGGTATACAATTTGACAGGCTCTCGCAACGGTTCTTTGACGCATCAATATATCTATAGTTTTTATTGGTCAACTTTGACTCTGACGACCATCGGTGAAACACCACAACCGGAAAAGGACGCCGAGTATTTGTTTGTCGTGGCTGACTTTTTGGCGGGAGTTCTGATCTTCGCCACAATCGTAGGGAACATTGGCTCGATGATTTCAAACATGAACGTTGCCAGAGTTGAATTCCAGAATAAAATGGACGGCGTGAAACAGTATATGGCCTTTAGAAAAGTAAGCGGTGAACTTGAAGCCAGAGTCATACGTTGGTTCGCTTACACTTGGGCACAGAGCGGTGCATTAGATGAAGAAAACGTATTGTCATCTCTCCCTGATAAATTAAAAGCTGAAATCGCTATAAGGGTACATTTGGACACATTACGAGAAGTTCGCATATTTCAAGATTGTGAACCTGGTTTATTGGAGGCATTGGTCCTAAAGCTAAAGCTGCAAGTGTTCAGCCCAGGAGATTACATTTGCAGAAAAGGAGATGTTGGCAAGGAAATGTATATTGTGAAGAGAGGACGACTGCAAGTCGTTGCTGATGATGGAAAGACTGTATTAGCTACTTTGAGTGCAGGCTCTGTATTTGGAGAAGTGAGTGTCCTGGAAATCGCCGGTAACAGAACCGGTAATCGACGAACTGCTAATGTACGAGCTTTGGGATACTCTGACCTATTTTGTCTCGCTAAAAGGGATCTCTGGGAGGCTCTAGGTGACTACCCTGATGCAAGAAATACACTCACTGAACGCGGCTGTCAATTGCTTAGAAAGGATGGACTACTTGATGAAGCTTTGTTTGAAAGCGCACAAACTACCCAACAAAGCATAGAAGAAACTGTTCACAAATTGGAGACCACCGTAGAAATGCTAAATAATCGTCTACAAGGCCTTTTGGCAGACGTAGGCGAGGAACAAGCTGAAATGAAACAAAGGATGAACAATATAGAAGTTAGGATGCTGGAAGATGAAGTCGATGAACTGCCCTCGGATGACGATGTGACCTCATCCGATGCTTCAGAGTTGAAAAGTGAAATTGCCAAAGATCTAGCTTCAGGATACAGCGAGGCTCCGATGACTTACATGAATGAGATTCAAAGAGTGATAAAACAGGAAGGCAGTGTTGAAATTTTGCAGTGTTTTAGCATTTACGCGACGTATTGGGACAAAAAGACAACCGGTGTCAATGGAATGTGGCTTTAA

Protein

MSDNQLNTHGSSKIFTMSNSGSSNPGPSGLNTNSAEISKDTEKSIESNAHSSIHIAPDDKEPQNQVVEHYGEAVTESNANNNWIQRQFSRLTKNWRFRIKNEGRAKPPDWFLDKFAAQTFTDPEEPLYQAQRSKLLCGMKLAFDPTLPTHYNWLAVVSLAILYNVVFVIGRAVFWELDNLTSVWFVLDYLCDFVYLVDTVIHIHEGYLEQGLMVKDAKMLRHHYLKSSSWKYDLLSLIPTDIAYYWWPPGSCDHMHLPCPVIVRLNRLLRLPRMWEWFDRTETATSYPNAFRICKVVMAILVLIHWNACLYFAISYAIGFGTDNWVYNLTGSRNGSLTHQYIYSFYWSTLTLTTIGETPQPEKDAEYLFVVADFLAGVLIFATIVGNIGSMISNMNVARVEFQNKMDGVKQYMAFRKVSGELEARVIRWFAYTWAQSGALDEENVLSSLPDKLKAEIAIRVHLDTLREVRIFQDCEPGLLEALVLKLKLQVFSPGDYICRKGDVGKEMYIVKRGRLQVVADDGKTVLATLSAGSVFGEVSVLEIAGNRTGNRRTANVRALGYSDLFCLAKRDLWEALGDYPDARNTLTERGCQLLRKDGLLDEALFESAQTTQQSIEETVHKLETTVEMLNNRLQGLLADVGEEQAEMKQRMNNIEVRMLEDEVDELPSDDDVTSSDASELKSEIAKDLASGYSEAPMTYMNEIQRVIKQEGSVEILQCFSIYATYWDKKTTGVNGMWL

Description

Approximately 50-fold more sensitive to cGMP than to cAMP. May be involved in transduction cascades of both invertebrate photoreceptors and olfactory sensillae.

Similarity

Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family.

Keywords

cGMP   cGMP-binding   Complete proteome   Glycoprotein   Ion channel   Ion transport   Ligand-gated ion channel   Membrane   Nucleotide-binding   Reference proteome   Transmembrane   Transmembrane helix   Transport  

Feature

chain  Cyclic nucleotide-gated cation channel subunit A

Uniprot

A0A2H1W1V5   A0A194PSE0   A0A194QZZ0   A0A2A4JXB5   A0A2A4JWL9   A0A212EMQ9   + More
A0A2W1BM45   A0A182Q981   A0A182VSK7   A0A182V7R4   A0A182RWG3   A0A182UFR1   A0A182F3M6   A0A182HZ08   A0A1S4H003   A0A182X870   A0A084VYA6   Q7PW88   A0A1J1IJT5   B4MQE1   A0A182YMU7   B3MF73   B4HSU3   A0A1W4UL93   B4P6A9   B4QHI0   A0A1W4UY60   A0A0R1DSW8   A0A0Q5W0Z9   B3NPM3   A0A0J9U3H3   A0A0P9AGQ2   Q24278   A0A1W4UZS7   A0A0B4JCU4   Q291Q9   A0A0R3NSP1   A0A0A1WI12   A0A3B0J1W5   A0A1I8P1B8   A0A0M3QVJ7   A0A1I8P178   W8BHT5   B4KP74   A0A139WLV3   B4GAE2   A0A034WPK3   B4LIQ9   A0A1I8NBE3   A0A1A9X4Y9   B4J454   A0A1B0BU28   A0A1B0AF10   A0A336LHJ4   A0A336JW06   A0A2J7PU74   A0A1Y1N611   A0A0T6B6C6   T1HIQ7   A0A2S2N6U4   A0A0K8T6T5   A0A2S2QEB0   A0A2S2P0B6   A0A2H8THY8   A0A1B3P5V9   A0A1B3P991   A0A226E8G5   T1IPJ9   E9FQW8   A0A165A4M6   A0A0N8DU53   A0A0K2T1J1   A0A2T7PLN4   A0A2C9KAH1   A0A1S3HU00   V4AXB6   A0A1V9XH82   A0A210QJK9   U3K9G0   H0Z7Q5   F6TBQ4   A0A1L8HGU0  

Pubmed

26354079    22118469    28756777    12364791    24438588    17994087    + More
25244985    17550304    22936249    7957070    10731132    12537572    12537568    12537573    12537574    16110336    17569856    17569867    15632085    25830018    24495485    18362917    19820115    25348373    18057021    25315136    28004739    21292972    15562597    23254933    28327890    28812685    20360741    20431018    27762356   

EMBL

ODYU01005804    SOQ47059.1    KQ459594    KPI96227.1    KQ461108    KPJ09161.1    + More
NWSH01000439    PCG76416.1    PCG76417.1    AGBW02013811    OWR42759.1    KZ149973    PZC75998.1    AXCN02000670    AXCN02000671    APCN01005837    AAAB01008984    ATLV01018352    KE525231    KFB42950.1    EAA14765.5    CVRI01000054    CRL00491.1    CH963849    EDW74330.1    CH902619    EDV37701.1    CH480816    EDW48107.1    CM000158    EDW91959.1    CM000362    CM002911    EDX07325.1    KMY94219.1    KRK00221.1    CH954179    KQS62463.1    EDV55790.1    KMY94220.1    KMY94221.1    KPU76994.1    X89601    AE013599    ADV37206.1    CM000071    EAL25053.1    KRT01811.1    GBXI01016259    JAC98032.1    OUUW01000001    SPP72873.1    CP012524    ALC42513.1    GAMC01017286    JAB89269.1    CH933808    EDW09050.2    KQ971319    KYB28873.1    CH479181    EDW31894.1    GAKP01002378    JAC56574.1    CH940648    EDW61412.2    KRF79976.1    CH916367    EDW02660.1    JXJN01020459    UFQS01000004    UFQT01000004    SSW96813.1    SSX17200.1    SSW96814.1    SSX17201.1    NEVH01021207    PNF19879.1    GEZM01011990    JAV93311.1    LJIG01009591    KRT82773.1    ACPB03001509    GGMR01000231    MBY12850.1    GBRD01004711    GBRD01004710    GBRD01004707    JAG61111.1    GGMS01006329    MBY75532.1    GGMR01010322    MBY22941.1    GFXV01001073    MBW12878.1    KU712075    AOG13007.1    KU716098    AOG14382.1    LNIX01000006    OXA53317.1    JH431263    GL732523    EFX90296.1    LRGB01000642    KZS17172.1    GDIP01000623    JAN03093.1    HACA01002344    CDW19705.1    PZQS01000003    PVD34297.1    KB200329    ESP02218.1    MNPL01010851    OQR72895.1    NEDP02003345    OWF48920.1    AGTO01000816    ABQF01012365    ABQF01012366    ABQF01012367    AAMC01003096    CM004468    OCT95322.1   

Proteomes

UP000053268    UP000053240    UP000218220    UP000007151    UP000075886    UP000075920    + More
UP000075903    UP000075900    UP000075902    UP000069272    UP000075840    UP000076407    UP000030765    UP000007062    UP000183832    UP000007798    UP000076408    UP000007801    UP000001292    UP000192221    UP000002282    UP000000304    UP000008711    UP000000803    UP000001819    UP000268350    UP000095300    UP000092553    UP000009192    UP000007266    UP000008744    UP000008792    UP000095301    UP000091820    UP000001070    UP000092460    UP000092445    UP000235965    UP000015103    UP000198287    UP000000305    UP000076858    UP000245119    UP000076420    UP000085678    UP000030746    UP000192247    UP000242188    UP000016665    UP000007754    UP000008143    UP000186698   

PRIDE

Q24278   

Pfam

PF00027   cNMP_binding        + More
PF16526   CLZ
PF00520   Ion_trans

Interpro

IPR018488   cNMP-bd_CS        + More
IPR000595   cNMP-bd_dom       
IPR005821   Ion_trans_dom       
IPR018490   cNMP-bd-like       
IPR014710   RmlC-like_jellyroll       
IPR032406   CLZ_dom       
IPR027359   Volt_channel_dom_sf       
IPR003938   K_chnl_volt-dep_EAG/ELK/ERG       

SUPFAM

SSF51206   SSF51206       

Gene 3D

2.60.120.10     1.20.120.350    

CDD

cd00038  CAP_ED

ProteinModelPortal

A0A2H1W1V5   A0A194PSE0   A0A194QZZ0   A0A2A4JXB5   A0A2A4JWL9   A0A212EMQ9   + More
A0A2W1BM45   A0A182Q981   A0A182VSK7   A0A182V7R4   A0A182RWG3   A0A182UFR1   A0A182F3M6   A0A182HZ08   A0A1S4H003   A0A182X870   A0A084VYA6   Q7PW88   A0A1J1IJT5   B4MQE1   A0A182YMU7   B3MF73   B4HSU3   A0A1W4UL93   B4P6A9   B4QHI0   A0A1W4UY60   A0A0R1DSW8   A0A0Q5W0Z9   B3NPM3   A0A0J9U3H3   A0A0P9AGQ2   Q24278   A0A1W4UZS7   A0A0B4JCU4   Q291Q9   A0A0R3NSP1   A0A0A1WI12   A0A3B0J1W5   A0A1I8P1B8   A0A0M3QVJ7   A0A1I8P178   W8BHT5   B4KP74   A0A139WLV3   B4GAE2   A0A034WPK3   B4LIQ9   A0A1I8NBE3   A0A1A9X4Y9   B4J454   A0A1B0BU28   A0A1B0AF10   A0A336LHJ4   A0A336JW06   A0A2J7PU74   A0A1Y1N611   A0A0T6B6C6   T1HIQ7   A0A2S2N6U4   A0A0K8T6T5   A0A2S2QEB0   A0A2S2P0B6   A0A2H8THY8   A0A1B3P5V9   A0A1B3P991   A0A226E8G5   T1IPJ9   E9FQW8   A0A165A4M6   A0A0N8DU53   A0A0K2T1J1   A0A2T7PLN4   A0A2C9KAH1   A0A1S3HU00   V4AXB6   A0A1V9XH82   A0A210QJK9   U3K9G0   H0Z7Q5   F6TBQ4   A0A1L8HGU0  

PDB

5H3O     E-value=6.25526e-144,     Score=1312

KEGG

101740153    K04950 cyclic nucleotide gated channel alpha 3 | (RefSeq) cyclic nucleotide-gated cation channel sub

GO

GO:0005216   GO:0016021   GO:0030553   GO:0005223   GO:0005222   GO:0017071   GO:0005221   GO:0019934   GO:0006812   GO:0001666   GO:0005249   GO:0007608   GO:0006811   GO:0016020   GO:0005524   GO:0005622   GO:0030145   GO:0006508   GO:0007169   GO:0055085  

Subcellular location

Membrane  

Length:

739

Number of predicted TMHs:

3

Exp number of AAs in TMHs:

85.2328500000002

Exp number, first 60 AAs:

0.00017

Total prob of N-in:

0.43723

outside

1  -  152

TMhelix

153  -  175

inside

176  -  295

TMhelix

296  -  318

outside

319  -  366

TMhelix

367  -  389

inside

390  -  739

 

 

Pi

21.346868

Theta

23.455026

Tajima's D

-1.318519

CLR

0.015766

CSRT

0.0821958902054897

Interpretation

Uncertain