Gene

KWMTBOMO00201

Pre Gene Modal

BGIBMGA000628

Annotation

bestrophin_2_[Spodoptera_littoralis]

Location

Bomo_Chr1(+):6281373-6331221      View in EpiBrowser

Full name

Bestrophin homolog      

Location in the cell

PlasmaMembrane   Reliability : 2.804

CDS

ATGACTATATCGTACGCCGGTGAAGTACCAAACGGCAGCAGTTTTGGTTGTTTCTGGAGGATCCTCTGCAAATGGAGAGGCAGCGTCTACAAGCTGGTGTGGCGCGAGCTGCTAGCATACCTATTGCTTTACTATACAATAAACTTATTGTATCGCTTCGCACTCACAGAACAGCAACAAAGGGTGTTCGAGAAGGTTCGGCAGTATTTCGGAGCACAGAGCGAATCTATTCCGATGTCGTTCGTGCTCGGTTTCTACGTAAGTCTCGTCGTGAAGCGTTGGTGGGAACAGTACAAGCTCCTTCCGTGGCCTGATACGCTCGCGCTGTTCATCTCTGCAGGCATACCTGGAGCGGACGAGACGGGCCGATTAATGAGAAGAAATATTGTAAGATATGCTATCCTCGCCTACGTCATCACGCTACAGAGGGTGTCTCTTAGGGTAAAAAGAAGATTTCCAACATGGCAACACGTAGTTGACTCTGGTCTTATGTTGGAAAGCGAGAGAAAAGTTTTTGAAAAGATGGACGGCAAGAGTCCTATGTCCAAGTATTGGATGCCGTTAGTATGGGCGACGAATATAATAAACAGAGCCAGGAAAGAAGGCCTAATAACCAGTGACCACATAGTGCAAACGTTGTTGGTGGAGCTATCTGACATAAGACGAAGATTGGGGGCGCTCATTGGTTATGACACCGTTTGCGTACCACTCGTTTATACGCAGGTGGTAACTTTGTCCCTGTACACTTATTTCGTTGCGGCATTGATGGGCCGTCAACTGGTCCCTCCGGCGCCCGGAAGTACCTCCAAGTACGAACCTGACGTATACTTTCCGCTCTTCACAGCTTTACAGTTCTGCTTTTACGTGGGATGGTTGAAAGTAGCTGAAGTTTTAATTAATCCTTTCGGAGAAGATGACGATGACATCGAACTAAATTGGCTTATTGACAGGCACATAAAGGCAGCCTATATGATAGTTGACGAGATGCACGAAGAGCATCCTGAACTGCTGAAAGATCAATACTGGGAAGAGGTGGTCCCCAAAGATTTACCGTACACCGTAGCCTCAGAACATTACCGTCGCCATGAGCCCCCTTGCTCAGCTGACCACTACAAAGTAAAAGCAGAGGACGCTGTCTATGCTAACGTTCAAGCACCCAGAAAGAGTCATGATGAAACTTACGCTGATTACGAAAGTGTGGACACTCCCTTAGTTGAAAGGCGAAAAAATTGGTTCCAGCGACAAATATCGAGGATGGGCTCGGTACGGTCCGCTTCAACGGCGTATTCATCGGGAGGCCTCTTTGGACGAAATCGACACAATTCTGTTGTCTATTCGAGTCCTGAAGCAGGCCAGCCCGTGGCGCCACCTCCCCCGCACCACAAGATGTCTTTATATGAGCGACTTGTTGGTCGCAAATCGGGCAGAGGGCAGCATCGACAAAATTCAAGACACGGTGGCCAAAAAAGTAATGGATCCGCCGTTCCTATTACCCTGCGGAACAGACCTCGTATACCCACACCGGACGTGACGAAAGAGGTCATGGACCGTGAAAATCGTATCGCAATGGGTATGCAGAACATGGGTGTAATAATGGCTCACCAAGGCTATCAAAATGAAGTTCCCGTATTAGGTGCACTGGTCTTATCGCCTATACAGGAATTGGATAGTGGTTCCGTGAACAACACATTACACGCAGGGCAGCCTGGCACCACGGCTCTAGCGCAAGCAGTGCTGGCACCCGGTGGACTAACACCAATGCTCACTACTGCACCTGTTAACTTAACACCGATGGGTGTATCCCAGCTCACAACTATAGTGAGCTCAGCGCCATCGACGCCACGAGCTGAGCGTGGCCCAGCAGATGGCTCCGGTGGTTCACCGCAATCTCCAAGAGCGACCATTACAGAGCTCCCTCCATCGGATCGTGAAAGTAATCATAGCGGCACACCTCCAGATTTCGCGAGGAAACCAGGTTCTAAAAGAGGAGAGAGCAACGCGACTGACACAATTGAAGGAACTTCATTCGAACCAAGCGAAGAGCTCGTATCAGATGTTGAATGA

Protein

MTISYAGEVPNGSSFGCFWRILCKWRGSVYKLVWRELLAYLLLYYTINLLYRFALTEQQQRVFEKVRQYFGAQSESIPMSFVLGFYVSLVVKRWWEQYKLLPWPDTLALFISAGIPGADETGRLMRRNIVRYAILAYVITLQRVSLRVKRRFPTWQHVVDSGLMLESERKVFEKMDGKSPMSKYWMPLVWATNIINRARKEGLITSDHIVQTLLVELSDIRRRLGALIGYDTVCVPLVYTQVVTLSLYTYFVAALMGRQLVPPAPGSTSKYEPDVYFPLFTALQFCFYVGWLKVAEVLINPFGEDDDDIELNWLIDRHIKAAYMIVDEMHEEHPELLKDQYWEEVVPKDLPYTVASEHYRRHEPPCSADHYKVKAEDAVYANVQAPRKSHDETYADYESVDTPLVERRKNWFQRQISRMGSVRSASTAYSSGGLFGRNRHNSVVYSSPEAGQPVAPPPPHHKMSLYERLVGRKSGRGQHRQNSRHGGQKSNGSAVPITLRNRPRIPTPDVTKEVMDRENRIAMGMQNMGVIMAHQGYQNEVPVLGALVLSPIQELDSGSVNNTLHAGQPGTTALAQAVLAPGGLTPMLTTAPVNLTPMGVSQLTTIVSSAPSTPRAERGPADGSGGSPQSPRATITELPPSDRESNHSGTPPDFARKPGSKRGESNATDTIEGTSFEPSEELVSDVE

Description

Forms chloride channels.

Similarity

Belongs to the bestrophin family.

Uniprot

I6XZ71   A0A2A4JER2   A0A2A4JDB2   A0A2W1BJG2   A0A212FMA6   A0A194PTX5   + More
A0A194QUH4   H9ITP8   A0A2H1VSW4   A0A139WKD3   A0A1Y1MQW5   A0A1L8DF52   A0A088A9S5   U5ETV9   A0A154NZ73   A0A0L7QZT4   A0A195CUG9   A0A0L0CPV1   A0A151IVZ2   A0A026W780   A0A158NQ03   A0A1B0GME3   A0A1B0G266   Q16KY4   A0A1A9XJI8   K7J614   A0A023EW33   A0A1Q3G4Z1   A0A1Q3G4Y9   A0A182FDZ8   A0A182WCU5   A0A182R0G2   A0A182NNJ4   B4N3X8   A0A182HXQ6   A0A1B6FHL1   A0A182YBS6   A0A1B6IYJ9   Q5TSK2   A0A182RKJ1   A0A0K8VPW4   A0A2M4A4M6   A0A182J9S7   A0A1B0A6L1   A0A084VXI9   W5J5D1   A0A2M3YZW2   A0A2M3YZU5   A0A1I8MK18   A0A2M4BE00   A0A2M4BE02   B3NGG8   Q9VRW4   B4HUT2   B4QJD0   B4PJN1   B4LI87   Q7YU35   A0A1W4V9D2   B3M9Z2   A0A182JP97   B4IXY4   A0A1B0AY46   A0A151XG23   A0A1B6KF69   A0A1A9UJ92   B4KVQ1   A0A146KT61   A0A1B6LGZ4   A0A195FND4   A0A195BI48   A0A1B6KR18   A0A182MLT6   A0A1B6LCH1   A0A182PSZ0   A0A182S870   A0A0P8YC90   A0A182LHZ9   A0A0J9RPT4   A0A1W4UXH2   A0A0Q5U493   A0A0Q9WJG1   A0A3B0KFP7   A0A182XNL5   A0A0R1DXQ5   B5DP29   A0A069DWF1   A0A0P4VMQ9   A0A1I8NQ24   A0A0K8UV58   A0A0K8WHV1   A0A023F3F5   J9JWQ3   A0A0V0G7D3   A0A0K8V2B3   A0A1B0G267   E0W1P6   A0A1J1IQX1  

Pubmed

23300744    28756777    22118469    26354079    19121390    18362917    + More
19820115    28004739    26108605    24508170    30249741    21347285    17510324    20075255    24945155    17994087    25244985    12364791    14747013    17210077    24438588    20920257    23761445    25315136    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    22936249    17550304    18057021    26823975    20966253    15632085    26334808    27129103    25474469    20566863   

EMBL

JQ968535    AFN57625.1    NWSH01001804    PCG70074.1    PCG70075.1    KZ150006    + More
PZC75212.1    AGBW02007654    OWR54873.1    KQ459594    KPI96209.1    KQ461108    KPJ09178.1    BABH01006768    ODYU01004250    SOQ43923.1    KQ971331    KYB28301.1    GEZM01024027    JAV88049.1    GFDF01009069    JAV05015.1    GANO01002604    JAB57267.1    KQ434783    KZC04891.1    KQ414676    KOC64072.1    KQ977279    KYN04331.1    JRES01000089    KNC34222.1    KQ980880    KYN11995.1    KK107388    QOIP01000001    EZA51476.1    RLU26758.1    ADTU01022825    ADTU01022826    ADTU01022827    ADTU01022828    ADTU01022829    AJVK01011427    AJVK01011428    AJVK01011429    CCAG010019771    CH477932    CH477829    EAT34965.1    EAT35845.1    GAPW01000282    JAC13316.1    GFDL01000174    JAV34871.1    GFDL01000177    JAV34868.1    AXCN02001915    CH964095    EDW79333.1    APCN01005336    GECZ01020081    JAS49688.1    GECU01015713    JAS91993.1    AAAB01008905    EAL40404.3    GDHF01011402    JAI40912.1    GGFK01002351    MBW35672.1    ATLV01018075    ATLV01018076    KE525212    KFB42683.1    ADMH02002184    ETN57959.1    GGFM01001059    MBW21810.1    GGFM01001036    MBW21787.1    GGFJ01002135    MBW51276.1    GGFJ01002134    MBW51275.1    CH954178    EDV51134.1    AE014296    BT099579    AAF50668.2    ACU43541.1    CH480817    EDW50703.1    CM000363    CM002912    EDX09439.1    KMY97910.1    CM000159    EDW93630.1    CH940647    EDW69654.1    KRF84497.1    BT010012    AAQ22481.1    CH902618    EDV41212.1    KPU79004.1    CH916366    EDV96505.1    JXJN01005545    JXJN01005546    KQ982182    KYQ59230.1    GEBQ01029912    JAT10065.1    CH933809    EDW18425.2    GDHC01018945    JAP99683.1    GEBQ01017001    JAT22976.1    KQ981382    KYN42075.1    KQ976464    KYM84500.1    GEBQ01026102    JAT13875.1    AXCM01012182    GEBQ01018579    JAT21398.1    KPU79003.1    KMY97911.1    KQS43675.1    KRF84498.1    OUUW01000009    SPP85149.1    KRK01278.1    CH379067    EDY73280.2    GBGD01000649    JAC88240.1    GDKW01002984    JAI53611.1    GDHF01021730    JAI30584.1    GDHF01001665    JAI50649.1    GBBI01002864    JAC15848.1    ABLF02030258    ABLF02030261    ABLF02062784    GECL01002090    JAP04034.1    GDHF01019381    GDHF01017132    JAI32933.1    JAI35182.1    DS235873    EEB19628.1    CVRI01000058    CRL02637.1   

Proteomes

UP000218220    UP000007151    UP000053268    UP000053240    UP000005204    UP000007266    + More
UP000005203    UP000076502    UP000053825    UP000078542    UP000037069    UP000078492    UP000053097    UP000279307    UP000005205    UP000092462    UP000092444    UP000008820    UP000092443    UP000002358    UP000069272    UP000075920    UP000075886    UP000075884    UP000007798    UP000075840    UP000076408    UP000007062    UP000075900    UP000075880    UP000092445    UP000030765    UP000000673    UP000095301    UP000008711    UP000000803    UP000001292    UP000000304    UP000002282    UP000008792    UP000192221    UP000007801    UP000075881    UP000001070    UP000092460    UP000075809    UP000078200    UP000009192    UP000078541    UP000078540    UP000075883    UP000075885    UP000075901    UP000075882    UP000268350    UP000076407    UP000001819    UP000095300    UP000007819    UP000009046    UP000183832   

PRIDE

H9ITP8    Q7YU35   

Pfam

PF01062   Bestrophin

Interpro

IPR021134   Bestrophin/UPF0187        + More
IPR000615   Bestrophin       

ProteinModelPortal

I6XZ71   A0A2A4JER2   A0A2A4JDB2   A0A2W1BJG2   A0A212FMA6   A0A194PTX5   + More
A0A194QUH4   H9ITP8   A0A2H1VSW4   A0A139WKD3   A0A1Y1MQW5   A0A1L8DF52   A0A088A9S5   U5ETV9   A0A154NZ73   A0A0L7QZT4   A0A195CUG9   A0A0L0CPV1   A0A151IVZ2   A0A026W780   A0A158NQ03   A0A1B0GME3   A0A1B0G266   Q16KY4   A0A1A9XJI8   K7J614   A0A023EW33   A0A1Q3G4Z1   A0A1Q3G4Y9   A0A182FDZ8   A0A182WCU5   A0A182R0G2   A0A182NNJ4   B4N3X8   A0A182HXQ6   A0A1B6FHL1   A0A182YBS6   A0A1B6IYJ9   Q5TSK2   A0A182RKJ1   A0A0K8VPW4   A0A2M4A4M6   A0A182J9S7   A0A1B0A6L1   A0A084VXI9   W5J5D1   A0A2M3YZW2   A0A2M3YZU5   A0A1I8MK18   A0A2M4BE00   A0A2M4BE02   B3NGG8   Q9VRW4   B4HUT2   B4QJD0   B4PJN1   B4LI87   Q7YU35   A0A1W4V9D2   B3M9Z2   A0A182JP97   B4IXY4   A0A1B0AY46   A0A151XG23   A0A1B6KF69   A0A1A9UJ92   B4KVQ1   A0A146KT61   A0A1B6LGZ4   A0A195FND4   A0A195BI48   A0A1B6KR18   A0A182MLT6   A0A1B6LCH1   A0A182PSZ0   A0A182S870   A0A0P8YC90   A0A182LHZ9   A0A0J9RPT4   A0A1W4UXH2   A0A0Q5U493   A0A0Q9WJG1   A0A3B0KFP7   A0A182XNL5   A0A0R1DXQ5   B5DP29   A0A069DWF1   A0A0P4VMQ9   A0A1I8NQ24   A0A0K8UV58   A0A0K8WHV1   A0A023F3F5   J9JWQ3   A0A0V0G7D3   A0A0K8V2B3   A0A1B0G267   E0W1P6   A0A1J1IQX1  

PDB

6N23     E-value=6.48456e-96,     Score=898

KEGG

101743037    K22204 bestrophin, other | (RefSeq) bestrophin-4

GO

GO:0034707   GO:0005254   GO:0005886   GO:0016021   GO:0005777   GO:0006821   GO:0005887  

PANTHER

PTHR10736  

Subcellular location

Cell membrane  

Length:

687

Number of predicted TMHs:

3

Exp number of AAs in TMHs:

71.8834700000002

Exp number, first 60 AAs:

21.32043

Total prob of N-in:

0.48224

POSSIBLE N-term signal

sequence

inside

1  -  31

TMhelix

32  -  54

outside

55  -  68

TMhelix

69  -  91

inside

92  -  128

TMhelix

129  -  146

outside

147  -  687

 

 

Pi

15.29601

Theta

17.944571

Tajima's D

-1.19496

CLR

0.071496

CSRT

0.102844857757112

Interpretation

Possibly Positive selection