Gene

KWMTBOMO00200  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA000627

Annotation

Ubiquitin_conjugating_enzyme_4_[Operophtera_brumata]

Location

Bomo_Chr1(+):6273243-6278029      View in EpiBrowser

Full name

Ubiquitin-conjugating enzyme E2-22 kDa      

Alternative Name

E2 ubiquitin-conjugating enzyme 4
Ubiquitin carrier protein
Ubiquitin-protein ligase

Location in the cell

Cytoplasmic   Reliability : 3.038

CDS

ATGGCAAATATAGCAGCCAAACGTATAAAAAGAGAGTTCAAAGAGATAATGAAAAGTGAAGAGGTGATTGGTGGCTCCATAAAATTGGGACTCGTGAATGAGAATTGGACTGAACTCAAAGGCGAGATAGCTGGTCCTGTTGATACTCCTTATGAAGGTGGGACCTTCCTCCTTGAAATTAAAGTTCCCGAAACTTATCCTTTCAATCCTCCTAAGATACGCTTTTTGACCAAGATCTGGCATCCGAACGTGTCCTCAGTCACCGGTGCCATATGTTTAGACATCTTGAAAGACCAATGGGCAGCAGCTTTAACATTGCGTACAGTTCTATTGTCGTTGCAAGCATTACTGTCAGCAGGTGAACCTAATGATCCACAAGATGCTGTGGTCGCCAAACAGTTCAGAGAGAATCCTCGTTTATTCACTATGACGGCACGACATTGGACCAATGTTTATGCTGGTGGGCCAAATATAGTACACGAATGCAATAGCAAAGTGCAGCGTATGCTGGACATGGGTATTGATGAACATCAGGCCAGAGTAGCTCTCTCCTCATATGATTGGGACTTAGAGCGTGCCACTGAGCAACTTTTTGGCTAG

Protein

MANIAAKRIKREFKEIMKSEEVIGGSIKLGLVNENWTELKGEIAGPVDTPYEGGTFLLEIKVPETYPFNPPKIRFLTKIWHPNVSSVTGAICLDILKDQWAAALTLRTVLLSLQALLSAGEPNDPQDAVVAKQFRENPRLFTMTARHWTNVYAGGPNIVHECNSKVQRMLDMGIDEHQARVALSSYDWDLERATEQLFG

Description

Catalyzes the covalent attachment of ubiquitin to other proteins.

Catalytic Activity

S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.

Subunit

Interacts with Rpn10.

Similarity

Belongs to the ubiquitin-conjugating enzyme family.

Keywords

ATP-binding   Complete proteome   Nucleotide-binding   Reference proteome   Transferase   Ubl conjugation pathway  

Feature

chain  Ubiquitin-conjugating enzyme E2-22 kDa

Uniprot

Q8T0Z6   A0A1E1W876   A0A0L7KYN0   A0A2H1WHE2   A0A194RGV5   A0A2A4JF65   + More
A0A2W1BTZ3   A0A194PM80   A0A212FM86   A0A1S4EA37   C4WVG8   A0A2S2NUM0   A0A0T6BAJ7   A0A1B6GEW3   A0A1B6JGT5   D6WGK1   A0A2S2QG15   A0A1Y1LHY7   A0A1B6CT36   A0A1W4XA67   N6U4U5   S4PHK9   A0A2J7PHJ2   A0A067QP56   A0A069DX27   A0A0P4VMG1   R4FPS9   A0A288SHV2   A0A131YB07   A0A224ZAS5   A0A131YS71   A0A023FXB8   L7MGD7   G3MH11   A0A034WW32   A0A0M8ZT06   V5GS58   V9IKI5   A0A087ZTN9   A0A0A9XGU5   A0A1E1XJ69   A0A1A9Y0R4   A0A1B0AI33   D3TPZ5   A0A0A1WU50   A0A0K8TPI4   A0A293MWY4   A0A2R5L3U6   U5EZB4   A0A1Z5LFN4   A0A1A9XFL7   A0A1A9V7I0   T1GGG3   W8C779   E2BGT9   T1J400   A0A1I8MCC2   B4IYA2   A0A1B0BWT6   B4LHQ5   A0A026VVJ0   A0A1I8PBZ5   A0A158NTP5   B4KVV0   A0A0M4EIH9   A0A1A9WTM6   A0A023FGI9   A0A1W4UMD5   B3NGK2   B4PED8   X2JAX3   P52486   B3MAQ5   B4MMS2   Q29D46   B4H7Z7   A0A1A9X065   F4WIZ4   A0A3B0K1R4   A0A0J9RTW9   B4HL92   E2B1Y5   B4QNA9   A0A087UVX9   A0A2M3ZJP3   A0A2M4ASV0   A0A2M4C057   A0A084VXI0   A0A3B0KAV2   A0A182JJW8   A0A2L2XZ26   W5J539   A0A1Q3F225   B0WC59   K1R3M6   A0A182NNI8   A0A182Q5J2   Q0IFU0   A0A023EI28   A0A3M7Q0N4  

EC Number

2.3.2.23

Pubmed

12715162    19121390    26227816    26354079    28756777    22118469    + More
18362917    19820115    28004739    23537049    23622113    24845553    26334808    27129103    28797301    26830274    25576852    22216098    25348373    25765539    25401762    29209593    20353571    25830018    26369729    28528879    24495485    20798317    25315136    17994087    24508170    21347285    17550304    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    11862484    12537569    15632085    21719571    22936249    24438588    26561354    20920257    23761445    22992520    17510324    24945155    26483478    30375419   

EMBL

BABH01006766    AB079872    AB090308    BAB85203.1    GDQN01007895    JAT83159.1    + More
JTDY01004453    KOB68146.1    ODYU01008358    SOQ51884.1    KQ460398    KPJ15161.1    NWSH01001804    PCG70073.1    KZ150006    PZC75213.1    KQ459601    KPI93844.1    AGBW02007654    OWR54874.1    ABLF02024379    AK341509    BAH71888.1    GGMR01008294    MBY20913.1    LJIG01002831    KRT84109.1    GECZ01031850    GECZ01022545    GECZ01008823    JAS37919.1    JAS47224.1    JAS60946.1    GECU01024323    GECU01009312    JAS83383.1    JAS98394.1    KQ971321    EFA00574.1    GGMS01006919    MBY76122.1    GEZM01058993    JAV71585.1    GEDC01020668    JAS16630.1    APGK01049653    KB741156    KB631725    ENN73582.1    ERL85603.1    GAIX01005760    JAA86800.1    NEVH01025136    PNF15794.1    KK853182    KDR10179.1    GBGD01003010    JAC85879.1    GDKW01000871    JAI55724.1    ACPB03000249    GAHY01000729    JAA76781.1    KX982001    APQ43054.1    GEFM01000176    JAP75620.1    GFPF01013097    MAA24243.1    GEDV01007129    JAP81428.1    GBBL01001927    JAC25393.1    GACK01001768    JAA63266.1    JO841162    AEO32779.1    GAKP01000939    JAC58013.1    KQ435891    KOX69376.1    GANP01011208    JAB73260.1    JR049586    AEY61011.1    GBHO01027299    GBRD01002044    JAG16305.1    JAG63777.1    GFAA01004082    JAT99352.1    CCAG010000249    EZ423497    ADD19773.1    GBXI01012126    JAD02166.1    GDAI01001798    JAI15805.1    GFWV01019700    MAA44428.1    GGLE01000052    MBY04178.1    GANO01001097    JAB58774.1    GFJQ02000767    JAW06203.1    CAQQ02027324    CAQQ02027325    CAQQ02027326    CAQQ02027327    CAQQ02027328    CAQQ02027329    GAMC01000707    JAC05849.1    GL448228    EFN85071.1    JH431832    CH916366    EDV96552.1    JXJN01021963    CH940647    EDW69608.1    KK108166    EZA46849.1    ADTU01026082    CH933809    EDW18474.1    CP012525    ALC43676.1    GBBK01003835    JAC20647.1    CH954178    EDV51238.1    CM000159    EDW92976.1    AE014296    AHN58038.1    AHN58039.1    X92838    Y11349    AY060381    CH902618    EDV39139.1    CH963847    EDW73478.1    CH379070    EAL30568.1    CH479219    EDW34787.1    GL888181    EGI65764.1    OUUW01000002    SPP77328.1    CM002912    KMY98734.1    CH480815    EDW40911.1    GL445000    EFN60302.1    CM000363    EDX09892.1    KK121912    KFM81518.1    GGFM01007929    MBW28680.1    GGFK01010519    MBW43840.1    GGFJ01009542    MBW58683.1    ATLV01018074    KE525212    KFB42674.1    OUUW01000007    SPP83229.1    IAAA01007170    LAA00085.1    ADMH02002184    ETN57965.1    GFDL01013458    JAV21587.1    DS231885    EDS43211.1    JH816453    EKC28471.1    AXCN02001913    CH477294    EAT44442.1    JXUM01054187    JXUM01054188    JXUM01054189    GAPW01004565    KQ561809    JAC09033.1    KXJ77467.1    REGN01007961    RNA04782.1   

Proteomes

UP000005204    UP000037510    UP000053240    UP000218220    UP000053268    UP000007151    + More
UP000079169    UP000007819    UP000007266    UP000192223    UP000019118    UP000030742    UP000235965    UP000027135    UP000015103    UP000053105    UP000005203    UP000092443    UP000092445    UP000092444    UP000078200    UP000015102    UP000008237    UP000095301    UP000001070    UP000092460    UP000008792    UP000053097    UP000095300    UP000005205    UP000009192    UP000092553    UP000091820    UP000192221    UP000008711    UP000002282    UP000000803    UP000007801    UP000007798    UP000001819    UP000008744    UP000007755    UP000268350    UP000001292    UP000000311    UP000000304    UP000054359    UP000030765    UP000075880    UP000000673    UP000002320    UP000005408    UP000075884    UP000075886    UP000008820    UP000069940    UP000249989    UP000276133   

PRIDE

Q8T0Z6    P52486   

Pfam

PF00179   UQ_con        + More
PF00627   UBA

Interpro

IPR009060   UBA-like_sf        + More
IPR016135   UBQ-conjugating_enzyme/RWD       
IPR000608   UBQ-conjugat_E2       
IPR015940   UBA       
IPR023313   UBQ-conjugating_AS       

SUPFAM

SSF46934   SSF46934        + More
SSF54495   SSF54495       

Gene 3D

3.10.110.10    

CDD

cd00195  UBCc

ProteinModelPortal

Q8T0Z6   A0A1E1W876   A0A0L7KYN0   A0A2H1WHE2   A0A194RGV5   A0A2A4JF65   + More
A0A2W1BTZ3   A0A194PM80   A0A212FM86   A0A1S4EA37   C4WVG8   A0A2S2NUM0   A0A0T6BAJ7   A0A1B6GEW3   A0A1B6JGT5   D6WGK1   A0A2S2QG15   A0A1Y1LHY7   A0A1B6CT36   A0A1W4XA67   N6U4U5   S4PHK9   A0A2J7PHJ2   A0A067QP56   A0A069DX27   A0A0P4VMG1   R4FPS9   A0A288SHV2   A0A131YB07   A0A224ZAS5   A0A131YS71   A0A023FXB8   L7MGD7   G3MH11   A0A034WW32   A0A0M8ZT06   V5GS58   V9IKI5   A0A087ZTN9   A0A0A9XGU5   A0A1E1XJ69   A0A1A9Y0R4   A0A1B0AI33   D3TPZ5   A0A0A1WU50   A0A0K8TPI4   A0A293MWY4   A0A2R5L3U6   U5EZB4   A0A1Z5LFN4   A0A1A9XFL7   A0A1A9V7I0   T1GGG3   W8C779   E2BGT9   T1J400   A0A1I8MCC2   B4IYA2   A0A1B0BWT6   B4LHQ5   A0A026VVJ0   A0A1I8PBZ5   A0A158NTP5   B4KVV0   A0A0M4EIH9   A0A1A9WTM6   A0A023FGI9   A0A1W4UMD5   B3NGK2   B4PED8   X2JAX3   P52486   B3MAQ5   B4MMS2   Q29D46   B4H7Z7   A0A1A9X065   F4WIZ4   A0A3B0K1R4   A0A0J9RTW9   B4HL92   E2B1Y5   B4QNA9   A0A087UVX9   A0A2M3ZJP3   A0A2M4ASV0   A0A2M4C057   A0A084VXI0   A0A3B0KAV2   A0A182JJW8   A0A2L2XZ26   W5J539   A0A1Q3F225   B0WC59   K1R3M6   A0A182NNI8   A0A182Q5J2   Q0IFU0   A0A023EI28   A0A3M7Q0N4  

PDB

3K9P     E-value=5.91988e-71,     Score=676

KEGG

100141465    K04649 ubiquitin-conjugating enzyme (huntingtin interacting protein 2) [EC:2.3.2.23] | (RefSeq) Ubcd

PATHWAY

04120    Ubiquitin mediated proteolysis - Bombyx mori (domestic silkworm)

GO

GO:0016740   GO:0005524   GO:0005634   GO:0061631   GO:0016874   GO:0031625   GO:0070628   GO:0004842   GO:0000209   GO:0005515   GO:0006468   GO:0004672   GO:0005622   GO:0030145   GO:0006508   GO:0007169   GO:0016021  

Length:

199

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.03462

Exp number, first 60 AAs:

0.00017

Total prob of N-in:

0.35576

outside

1  -  199

 

 

Pi

13.958078

Theta

17.573426

Tajima's D

-1.190674

CLR

0.010479

CSRT

0.102694865256737

Interpretation

Uncertain