Gene

KWMTBOMO00191  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA000624

Annotation

titin2_[Bombyx_mori]

Location

Bomo_Chr1(+):6126863-6147892      View in EpiBrowser

Full name

Titin      

Alternative Name

D-Titin
Kettin

Location in the cell

Nuclear   Reliability : 3.198

CDS

ATGGCTATCGGTTGTCCGGCTAACATGGCCAGCCCATTGCCACCTCAGCTAACTAATTTGCTGTGCTATGTCTATAGCTCGCTGAGCGACTTTAAGCTTGTAGATCAGCCCAACCATGCTGAATTTAAACCTATAACAGAAGTAATGAAACCTAAAAGTAATGAAAAAGAAGTTCTGAGTGATTCCAGCGAGGACAAAATTATACCTCCGGAAGAACAAAAATCTGAGCCAAAGTTATTATTAAATAATAAAAAAAGTAAAGATAAACCAATTCTCCGAAAACTTCAAATTGAAGAACTAGAAAGTAGTAAACCTCAGCATCCAGAAGAAATGACCGTGCCGCAATTCTCTAAACTGAAACTAAAAAAATCTTCTGTTTTACCTAAACAAGAGCCTGCAGTTGTTAAACTTCCTAAATTCCAACTAAAAAGTCGCATTAAATTCATAAGAGACTGGCCACCTCAAGAAATGAAACCAATAGTTACTTATCTAGGCAGTATTAAACAAAATGGAGAGTTATCGAGAAACGTAAAAGAAGCAAATAAAATCAAAAAGAAAAAGCTGAAACTGCCCAAAATTCCCGACTTAGAAAGAGTGACATTGGAAAAATCGGACTTATTTGATTCCCAAGAGGATGAATCAAAACCAGATGTGAGTCAACCGCCCCAAAATATAATTGAAGAAGCGAAAAGCGAACCAAAACTAATAGAAGAATCCGAACAACCAATTGCAAAAACATCAGAAATTGACAATGAAGTACCAGAAAAAATAAATGTTCCTGATGATAAAGAAACTTCACAAACTCCTACTTCATTTAACAAGAGATCTAAACTCACCCCTATTAAAATAGAGCGAAAAGAAATGGAAGTAAGTACACCACAACACGCAGAAACTGTAGATGGGCCTCAATTCACCCTGCCTAAATTGAAGAAAACTGCAGTAAAACCCAAAAAGGAAACTAGCCTTGTTAAATTACCTAAATTTCAATTAAAAAGCAGAATTAAATATATTACTAGCTGGCCCCCTGAATCCATCAAACCTCTTATTTCATACATGGGTAGCATAAAACAAAATGGAATTTTATCGAGAAATATAAAAGAGGCCGCCAAAGTTAAAAAACAAGTGTTCGTACCTCCAAAATTGCCCGATGTAGAAAAAACAGAATTAGAACAACCGTTATTTAGTTATGAAGACATTGTAGAAAGTAAAAAAGATGAAAATGAAATTATTCAAGAAAAACAAACTCTTGAGGAATTGCCTAAAGAAGATGTGCCTGAACAGTATACTATAACTCCTAGAAAATCAAGCGCACAAAAGATTGATGAGATAGTAGATGAAGTAACTATTAAAAAGAGATTGAAACCCGTTCGAAAATCTTCTGTAACTTTACCTGAAATAACAGAACCTGAAGTAGTAACATTTAGGCCAAAAATTACGAAAACCAAAGAAGATGTGGAGCAGGAATTTAACATCCAGTTAGACTCTTATGCTGAAGAAGAAATTTCAATGTCAAGCAAAGTAAAACTAAAGCCTCAAAAACAACTGACATTTAAAGAAGAAGATGCTGAAACATCTATTCAATTTTATGAGAAAGGCCAAGACGAAAGTCCAGAAATAATTGAAATAGTAGACAGTGACGTTGAAAAAGAAGAATCAGAATCAGCCAACATTATGATACCGCTCAAGAAAAAGCTTGAAACTAAGAATGTCTTAGAAACCGTTGAATCTGTAGTGACTTTATCTAAACCTAAGCTACAAAACGATAATGAAATATCCGAAGTTGTATGTATTGAACTAGAGAAAAAGCCAAAGTACATCGTAGATGACCAAGATGAAGTGCAATTTGAAGTAAAACCTCGTGCTACCGAAGTTACTACCTTTTCAAGCAATATTAAAGTTAAGCCGAAAAAGAAAATGTCAATTATAGAAGCTGCAGATGAAACTTTGTTGCAAATCCATAAGGAAATTGATGATGAAAGTCAACCTGAAGAAATTATCATGAGTGATGGTGACACTGAAGAAAACATCGAAATGATTATAAAAAGAAAACCGAAAAAACCAACATACGAAATAAGCGAAGTGGAAGAACTAAGCGTCGAATTCAAACCAAAACAAATGAAGGATGAAAATAATGAAGGTGAACTTACTATTTCAACAAAACGAAAACCAAAGTCTCTTATAATACAAGAAGCTGACGCGACGATGAGTATTTCGCGAGAACAAGAATTCCCAGATACGCCCGTTGAAGTCCGCTGTGGTGACACAGTATTTGCTGTATATTCGTACGTGGCAGAAACTGATGAAGCTATAAATCTTGTTGAGGGCGAACGACTATATATCCTTGACACTTCCAATCAAGATTGGTGGTACGTACAAAAACATTTAACGGAAGAGAAAGGCTGGGTACCTGCACAATATCTCATGGATGAAAATAATTACACGCAATATCTGCAGAAAAAATTGAACGAGAAAATAGATAAACTACCTGTTTTCGAAAAACCGACGTCAGAAGAACAATCCATGGCTCCAATATTTGTTGAGAAATTACGTCCAAAACATACTCCCGATGGATCAACAGTGCAATTCGAATGTCAAGTTGAAGGTTATCCTAGGCCACAGATAACATGGTTCCGACAAACAGCTATAATCAAGCCTTCGCAGGATTTCCAAATGTATTATGATGATGATAACGTGGCTACATTGGTAATTCGTGAGGTGTTCCCTGAAGATGCCGGTACTTTTACATGCGTAGCGAAGAATGCGGCAGGATTTGCTTCCAGCACTACAGAACTAATTGTGGAAGCTCCTCTTTCTGATCACGGTTCTGAAATGACTGTATTATCAAGGAAAAGCTTATCTAGAGAATCATCGTTGGCTGATATTTTGGAAGGGATACCACCAACCTTTTCTAAAAAACCAAAAGCACAATACGTTGATGAAGGATCGGATATATTATTAGAATGTAGACTTGTGGCTATACCAGAGCCAGATATAGCGTGGTTATTCAAAGGCGAAGAAATAGTACCCGATGAAAATATCTCTGTAGCCATAGAGTCCGATATGCACATGTACTGCAGTGTTCTAAAAATAACAAATGTTAAAAAATTCCAAGAGGGTACTTATACTGTGGTGGCCGTCAATAGAGAAGGCGAAGCCAGTCTTCCTATTGTTCTAAAAATTAAAACGGGAGAAAAAGAACCGCCTCAAGTTATTGAGCCGCTAAAAAGCATGATTGTTAGACAAGGTGAAAGTGTTATACTATCAGCACAAGTGGTTGGTAATCCCCGACCAACAATTACCTGGTGTAAAAATAATAAACCTGTTAAGGCCTTGCCAACCAAATCAGATGGTGATACACACAGTATAACAATTCTTAAGCCAAAGAAAGTTAAAGATGAAGGGGTTTATACATTAAAAGCTGAGAATTCTGAAGGTATTGCGGAAACCAGTGCTGTTATTACTGTTGAAGAACCAACAGAGGAAAATGCTGAACCCCCACTTTTTATTAATCGATTCCAAGAAATCACGGTGAAAGAAAAGGGTACCATAAAATTAGTCGCTAGAGTAACAGGGAATCCAGTTCCATCAATAACGTGGTATAGAAACAATGAAATTATTAGCCCATCGGAAACGATTACTCAAAACTTTGACGGTGAAAATATTGAGCTTGTTATAACAAACGTAGATTCAGAGATTGATTCAGGCGATTATAAATGTGTTGCCTCGAACAGTGCTGGTAAATCATCTCACGGAGCCCGAGTCACTATCGATGTTGAGAAAGTAACATTCGTTAAGCATCTACAGAAATCTTACGAAACCGAGGAAGGTAAAACTGTGATTTTAGAATGTCAAACATCGCATACTGTTTCTACAAAATGGTATCACAACAAAAAAGAAATTAGTGGAATGGACCACAGAGAAATAATTCAGGAAGGTAGAATTCATAAATTAAAAATAAAGAAAACTAAGCTTACTGATGTTGGTGTTATAAAATGTATCGTAAAAGATCAAGAGACAAGCACAATGTTAGTTGTAAAAGAAACCATTCCTGAATTTATACGAAAACTTCAAGACTTCGAAGTTAAAGAAAAGGACGTAGCTATTTTGGAAGTTGAAATTAATTCTGAAACTGCTGATGTCGTATGGGAAAGAGACGGCGAAATAATAAAACCAAAGAAAAATAAATATGATTTTGAAAAACGAGGTCATATTCGCAAACTTTATATTAGAAACACTTCTGTTCATGATGAGGGTGAATATTCATGCATTTTGCGTGACGAATCTTGTACTGCTGAAGTAACAGTAGTGGAACTACCCCCTGAAATCATTACACGCCTACAAAATCAGAAGGTAAACAAAGGTAACAAAGCAACATTTGAAATAGAGCTGACCAAAGGCGATGCTCTAGTGAGGTGGTTTAAAGATGGCTCTGAAATTCAATTTTCTAATCACATACAGTTAACCATAGATGGTAAAAAACAAAAACTGAAGATATACGACTGTGATTTAGATGACGCAGGGGAATATTCTTGTGAGGTTGGAAACAGTAAATGCACAGCGATACTTACAGTAGAAGAACCTTCTATCAACTTTACTCTGCGACTTCCAGAATTTATACTGGTTCCAGCAAATACAGACGCCTATTTGACAGTTGAAATTCCTGATGAAACATTAGATGTAACATGGTACAAAAAGAAATCCGTAATCGAAGATACTGAAAAGTTCACTCTAATATCAGATGTAAAGAAGCGAACATTAATTATAAGAAAATGTACAGAGGATGATCAATGCGAATATACGTGTGTACTACTCGATGCGAAGAGCTCTACAAAATTAAAAGTAGAAGTGGTTGAGTTTCCTCCAAAAATTGTTGATTATGAACGAGAATATAGAATTAAACGGGGAAGCGACGTCACTCTACTTGTGGACTATCAAGCTTTCCCACAACCAAATGACGAATGGATCGTAAACTCTAAAATAATAAAGAAATGTAAACATACTAAGCCAAGTATAGATTCAAAATCGGCAAGCTTGACAATTAAAAAAGTAGAAAACACTGATGCTGGTATCTACAAACTACGTCTTGAAAATAATTGTGGTCATGCTGATGTTGAAATGAATGTGACAATACTTGATAAACCATCTCCGCCAGGGAAACCTAATATTTTAGAAATAGATTCTAGTTCGATTAACATATGTTGGGACGAACCAGAAAATACAGGAAATTCAACTATCATATACTATGTTGTCGAATATCAGGAAATTGATACAACAGAGTGGATATCGGTTAAAAATATAACCAAAACGCAAACCTCTATTCAGAACTTGAAAACAAACTCCTCATATAGATTCCGTGCTTATGCCGTAAATGAAGTGGACATTAGTGATGCTTCAGAAACAACAGAATATTATAAAGTAATAAAAGAAACGAAAATCCAATCTCCGACTGTAGAAAAACCATTGAAAAATATAACAACGGAACCAAATGAGGATATTGAACTAACGTGTATTTTCGGTGGAGTTCCTCAACCTAAGGTTACATGGTACAGAGACGGAAAGAAACTTAAAACTGCTAAAGCAACATATGAAAACAGAGTAGCAACATTAGTTGTAACTGTAACTGAAACAACTATTGGAACCTACAAATGTATAGCTTTTAATGATCATGGAGAAGTTGAAACGTCTTGCGTCGTTGGAATACAACAAAAACCTGTAATTACCATTTCTAATGAGGATATCAAACAGAAGCATAAAGTTGGAGATGAATGGTTGGTAACAGCTGTAATAGAAGGAATACCGCCACCTGAAGTAATATGGTATAAGAATGGAAATAAATTAGAAAATGATAAAGAATATAATATAACAACAAAAGAAAAAACTAGCGTAATTCGAATTAAAGAATTGAAGCGCTCTCATTCAAGTAAATATACTATTGAAGCTTCCAATACCGCTGGAACTTCTTCAGTTGAGGTCACACTAAAGGTCTACGATAAACCTAGTAAACCAGAAGGCCCTGTTATAATGCGCGAAATAAGTCGTGAATCAGTTACAATTGAATGGAAACCACCTTTAGATGACGGAGGTCTAGAGCTAACAAAATACGCCATCGAAAAACATGAACCCGATAATAATCGATGGATAAAAGTGGCAGATGTAGACAGAGACGTCGAAACATATTGCATACAAAAACTCAATGAAAACTGTGAATATATGTTCCGCGTTATAGCACAAAACCCTGTTGGATTTTCGGAAGCTCTTGAAAGTGAACCGATTGTTATAAAAACTGCATTAGACGTTCCTTCGCCGCCACTGGGCCCACTAGGTTTGTATGGTATCGATAATGAATCCGTGTATATAACATGGTTCCCGTCTGAGAAAAACGGCGGATCACCAATAATCGATTACAAGGTTGAAATAAAACAAGAAGGGAAGAAATGGAAAACCATCACAACTGTTACTGAAACAACAGCTAGAATCCAAAAGTTATCGATAAACACTACATATCAGTTCAGAATATACGCTAGAAACGAAATCGGAACGAGTCTTCCGTACACATCAGATGACAAAATAACAATTGGAAAAACGCTAACACCGCCGTCCCAGCCACGGAATTTCGTAGTGAGTGAGTCTACGTCACGATCAGTAACGCTAAAATGGACAGAGCCAGAGAGTAATGGCGGCAGTCCAATTACCAACTATATAATTGAATTTAAGACAGTCAAAGGAAAATCGTGGACTAAAATAGTCACCGTAGGTGGTTCAGTTCATGAACATTGTATTGAAAATATTAAGGAAAAAGATGAAATAATCTTCCGAATCTCAGCAGAAAATACTGTTGGTGTTAGTTTGCCAACAGAATCACAATCAGTACGATTAGAGAAACATGCAACTGTGCCATCGCCGCCGACGGCTCCTCTTGAAATAAGAATGGTTGGTAGCAACATCGTTATGACTTCATGGGGTACACCAGAATGGGATGGTGGGGCTCCACTTCTCGGTTACAACATCGCTATCAGGGATGTTACAAAAACAATGTGGATGGAAGTTGGAAAAGTCGATGTCAACACGCTTAAATTCAACATTAGAGATTTGAGCGAAAACCACACCTACATGATCAGAATCTACGCACGAAATGAGATTGGTCTCAGCGAGCCCCTGGAGTCAGATGAACCCTTTAAAGTTATACCAGGAGAAGGTTCCCATGCCGACGAGGAGCCAGGCGAACAGACTGAGGTCACGGAGCCAACATCGTTCAGTACTCAGACCACGACTTCGTGGCTGCGGGAGCACAACATGGATGCTGATATACGATCGTACGCGCGCGGTTCCCTGCTACGTCGCGACGAATACTTCTTTAGAATATGGCACTACGCTAAACAGCTATTTAAGTGA

Protein

MAIGCPANMASPLPPQLTNLLCYVYSSLSDFKLVDQPNHAEFKPITEVMKPKSNEKEVLSDSSEDKIIPPEEQKSEPKLLLNNKKSKDKPILRKLQIEELESSKPQHPEEMTVPQFSKLKLKKSSVLPKQEPAVVKLPKFQLKSRIKFIRDWPPQEMKPIVTYLGSIKQNGELSRNVKEANKIKKKKLKLPKIPDLERVTLEKSDLFDSQEDESKPDVSQPPQNIIEEAKSEPKLIEESEQPIAKTSEIDNEVPEKINVPDDKETSQTPTSFNKRSKLTPIKIERKEMEVSTPQHAETVDGPQFTLPKLKKTAVKPKKETSLVKLPKFQLKSRIKYITSWPPESIKPLISYMGSIKQNGILSRNIKEAAKVKKQVFVPPKLPDVEKTELEQPLFSYEDIVESKKDENEIIQEKQTLEELPKEDVPEQYTITPRKSSAQKIDEIVDEVTIKKRLKPVRKSSVTLPEITEPEVVTFRPKITKTKEDVEQEFNIQLDSYAEEEISMSSKVKLKPQKQLTFKEEDAETSIQFYEKGQDESPEIIEIVDSDVEKEESESANIMIPLKKKLETKNVLETVESVVTLSKPKLQNDNEISEVVCIELEKKPKYIVDDQDEVQFEVKPRATEVTTFSSNIKVKPKKKMSIIEAADETLLQIHKEIDDESQPEEIIMSDGDTEENIEMIIKRKPKKPTYEISEVEELSVEFKPKQMKDENNEGELTISTKRKPKSLIIQEADATMSISREQEFPDTPVEVRCGDTVFAVYSYVAETDEAINLVEGERLYILDTSNQDWWYVQKHLTEEKGWVPAQYLMDENNYTQYLQKKLNEKIDKLPVFEKPTSEEQSMAPIFVEKLRPKHTPDGSTVQFECQVEGYPRPQITWFRQTAIIKPSQDFQMYYDDDNVATLVIREVFPEDAGTFTCVAKNAAGFASSTTELIVEAPLSDHGSEMTVLSRKSLSRESSLADILEGIPPTFSKKPKAQYVDEGSDILLECRLVAIPEPDIAWLFKGEEIVPDENISVAIESDMHMYCSVLKITNVKKFQEGTYTVVAVNREGEASLPIVLKIKTGEKEPPQVIEPLKSMIVRQGESVILSAQVVGNPRPTITWCKNNKPVKALPTKSDGDTHSITILKPKKVKDEGVYTLKAENSEGIAETSAVITVEEPTEENAEPPLFINRFQEITVKEKGTIKLVARVTGNPVPSITWYRNNEIISPSETITQNFDGENIELVITNVDSEIDSGDYKCVASNSAGKSSHGARVTIDVEKVTFVKHLQKSYETEEGKTVILECQTSHTVSTKWYHNKKEISGMDHREIIQEGRIHKLKIKKTKLTDVGVIKCIVKDQETSTMLVVKETIPEFIRKLQDFEVKEKDVAILEVEINSETADVVWERDGEIIKPKKNKYDFEKRGHIRKLYIRNTSVHDEGEYSCILRDESCTAEVTVVELPPEIITRLQNQKVNKGNKATFEIELTKGDALVRWFKDGSEIQFSNHIQLTIDGKKQKLKIYDCDLDDAGEYSCEVGNSKCTAILTVEEPSINFTLRLPEFILVPANTDAYLTVEIPDETLDVTWYKKKSVIEDTEKFTLISDVKKRTLIIRKCTEDDQCEYTCVLLDAKSSTKLKVEVVEFPPKIVDYEREYRIKRGSDVTLLVDYQAFPQPNDEWIVNSKIIKKCKHTKPSIDSKSASLTIKKVENTDAGIYKLRLENNCGHADVEMNVTILDKPSPPGKPNILEIDSSSINICWDEPENTGNSTIIYYVVEYQEIDTTEWISVKNITKTQTSIQNLKTNSSYRFRAYAVNEVDISDASETTEYYKVIKETKIQSPTVEKPLKNITTEPNEDIELTCIFGGVPQPKVTWYRDGKKLKTAKATYENRVATLVVTVTETTIGTYKCIAFNDHGEVETSCVVGIQQKPVITISNEDIKQKHKVGDEWLVTAVIEGIPPPEVIWYKNGNKLENDKEYNITTKEKTSVIRIKELKRSHSSKYTIEASNTAGTSSVEVTLKVYDKPSKPEGPVIMREISRESVTIEWKPPLDDGGLELTKYAIEKHEPDNNRWIKVADVDRDVETYCIQKLNENCEYMFRVIAQNPVGFSEALESEPIVIKTALDVPSPPLGPLGLYGIDNESVYITWFPSEKNGGSPIIDYKVEIKQEGKKWKTITTVTETTARIQKLSINTTYQFRIYARNEIGTSLPYTSDDKITIGKTLTPPSQPRNFVVSESTSRSVTLKWTEPESNGGSPITNYIIEFKTVKGKSWTKIVTVGGSVHEHCIENIKEKDEIIFRISAENTVGVSLPTESQSVRLEKHATVPSPPTAPLEIRMVGSNIVMTSWGTPEWDGGAPLLGYNIAIRDVTKTMWMEVGKVDVNTLKFNIRDLSENHTYMIRIYARNEIGLSEPLESDEPFKVIPGEGSHADEEPGEQTEVTEPTSFSTQTTTSWLREHNMDADIRSYARGSLLRRDEYFFRIWHYAKQLFK

Description

Key component in the assembly and functioning of adult and embryonic striated muscles and muscle tendons. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The size and extensibility of the cross-links are the main determinants of sarcomere extensibility properties of muscle. In non-muscle cells, seems to play a role in chromosome condensation and chromosome segregation during mitosis. Might link the lamina network to chromatin or nuclear actin, or both during interphase.

Similarity

Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.

Keywords

Alternative splicing   Cell cycle   Cell division   Chromosome   Coiled coil   Complete proteome   Cytoplasm   Developmental protein   Disulfide bond   Immunoglobulin domain   Mitosis   Muscle protein   Nucleus   Reference proteome   Repeat   SH3 domain   TPR repeat  

Feature

chain  Titin
splice variant  In isoform B.

Uniprot

Q8T101   Q8MMJ9   A0A2W1BR33   A0A2A4JA34   A0A2A4JBM0   A0A2H1WA57   + More
A0A194R013   A0A194PRX9   A0A212EMM0   A0A0L7LK08   A0A088A9C6   A0A026VUD4   E2BM24   A0A154PJP5   A0A2J7QZK4   A0A195FZ63   A0A2J7QZK5   A0A0N0BEG5   A0A151I9J5   A0A1B6DP09   A0A151WT55   F4X806   A0A1S4FA74   Q17AF2   A0A336LNI7   A0A336LSE4   A0A182JZ59   A0A336LRC6   A0A182RB00   A0A158NVR6   A0A182MBM1   A0A182WJ12   A0A182GES9   A0A182FI83   A0A182XZ30   A0A0K8UMT2   W5JCS9   A0A146M3F4   A0A0K8VP60   A0A034V2U6   A0A0A1XPH8   E0VZZ8   A0A084VEZ0   A0A034V0P5   A0A2P8Z6P9   A0A0Q9WW89   A0A0P8XSQ8   A0A0Q9WIS3   A0A0P8Y833   A0A0Q9WIY4   A0A069DY97   A0A3B0KJX7   A0A224X960   A0A0P8XSF0   B4N316   A0A0P9AID6   A0A1W4W593   A0A0M5J037   A0A146LRT9   A0A310S8S3   A0A0R1DUN8   M9PDZ6   M9PGZ0   M9PBJ0   B4QN22   M9PDS3   M9PDZ9   M9PBI9   M9PEA5   A0A0R1E0V7   M9PEA0   A0A0J9RMQ2   A0A0R1DUV4   A0A0J9RNP6   A0A0R1DY47   M9PDS8   A0A1A9XBG4   Q9I7U4-5   A0A1A9WLT4   Q9I7U4   A0A0Q5UH56   Q9I7U4-4   A0A0J9UCP5   A0A0J9RM79   A0A0R1DWF4   A0A0R1DUJ0   A0A1A9UCU1   A0A0R1DUI7   A0A1A9Z6R8   A0A0J9RNQ2   A0A0Q5U8V9   A0A0J9RNP1  

Pubmed

12715162    28756777    26354079    22118469    26227816    24508170    + More
20798317    21719571    17510324    21347285    26483478    25244985    20920257    23761445    26823975    25348373    25830018    20566863    24438588    29403074    17994087    26334808    17550304    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    22936249    10629221    10934048    9548712    10669599    9917396    8335002    11062264    12537569    22467859    26251439   

EMBL

AB079867    BAB85198.1    AB090308    BAC10620.1    KZ150006    PZC75220.1    + More
NWSH01002247    PCG68831.1    PCG68830.1    ODYU01007290    SOQ49940.1    KQ461108    KPJ09186.1    KQ459594    KPI96201.1    AGBW02013811    OWR42750.1    JTDY01000849    KOB75679.1    KK107899    EZA47270.1    GL449100    EFN83273.1    KQ434938    KZC12045.1    NEVH01009068    PNF34018.1    KQ981193    KYN45099.1    PNF34017.1    KQ435828    KOX71854.1    KQ978274    KYM95733.1    GEDC01009890    JAS27408.1    KQ982761    KYQ51092.1    GL888900    EGI57423.1    CH477336    EAT43208.1    UFQT01000086    SSX19500.1    SSX19499.1    SSX19501.1    ADTU01027389    ADTU01027390    ADTU01027391    ADTU01027392    ADTU01027393    ADTU01027394    ADTU01027395    ADTU01027396    ADTU01027397    ADTU01027398    AXCM01005178    JXUM01058620    KQ562010    KXJ76922.1    GDHF01024639    GDHF01014413    GDHF01003054    JAI27675.1    JAI37901.1    JAI49260.1    ADMH02001532    ETN62157.1    GDHC01004325    JAQ14304.1    GDHF01011647    JAI40667.1    GAKP01022123    JAC36829.1    GBXI01001522    JAD12770.1    DS235854    EEB18954.1    ATLV01012355    KE524785    KFB36534.1    GAKP01022121    JAC36831.1    PYGN01000172    PSN52174.1    CH940647    KRF84565.1    CH902618    KPU77609.1    KRF84569.1    KPU77605.1    KRF84568.1    GBGD01000009    JAC88880.1    OUUW01000009    SPP85451.1    GFTR01008992    JAW07434.1    KPU77608.1    CH964062    EDW78755.2    KPU77607.1    CP012525    ALC42874.1    GDHC01009173    JAQ09456.1    KQ769940    OAD52761.1    CM000159    KRK00825.1    AE014296    AGB94000.1    AGB94006.1    AGB94007.1    CM000363    EDX08904.1    AGB94003.1    AGB94005.1    AGB94002.1    AGB94004.1    KRK00839.1    AGB93999.1    CM002912    KMY97017.1    KRK00829.1    KMY97014.1    KRK00835.1    AGB94008.1    AB026845    AJ238575    AJ238577    AJ271740    AJ400900    AJ400901    AJ400902    AF045775    AF045776    AF045777    AF045778    AJ245406    AJ012279    AJ012280    AF135062    AF135167    AF241648    AF241649    BK000146    AY094749    AAC23966.1    AAF47604.1    AAG40155.1    AAM11102.1    BAA90301.2    CAA09971.1    CAB76253.1    CAB93524.1    CAB96426.1    DAA00021.1    CH954178    KQS43158.1    KMY97025.1    KMY97018.1    KRK00830.1    KRK00832.1    KRK00827.1    KMY97019.1    KQS43149.1    KMY97009.1   

Proteomes

UP000218220    UP000053240    UP000053268    UP000007151    UP000037510    UP000005203    + More
UP000053097    UP000008237    UP000076502    UP000235965    UP000078541    UP000053105    UP000078542    UP000075809    UP000007755    UP000008820    UP000075881    UP000075900    UP000005205    UP000075883    UP000075920    UP000069940    UP000249989    UP000069272    UP000076408    UP000000673    UP000009046    UP000030765    UP000245037    UP000008792    UP000007801    UP000268350    UP000007798    UP000192221    UP000092553    UP000002282    UP000000803    UP000000304    UP000092443    UP000091820    UP000008711    UP000078200    UP000092445   

PRIDE

Q8T101    Q8MMJ9    M9PDS3    M9PBI9    M9PEA5    M9PDS8    + More
Q9I7U4   

Pfam

PF14604   SH3_9        + More
PF00041   fn3
PF07679   I-set
PF06582   Titin_Ig-rpts
PF00018   SH3_1

Interpro

IPR001452   SH3_domain        + More
IPR003598   Ig_sub2       
IPR036179   Ig-like_dom_sf       
IPR003961   FN3_dom       
IPR039696   MFAP3-like       
IPR003599   Ig_sub       
IPR007110   Ig-like_dom       
IPR013783   Ig-like_fold       
IPR036028   SH3-like_dom_sf       
IPR036116   FN3_sf       
IPR013098   Ig_I-set       
IPR010939   Titin-rpts       
IPR006623   THEG       
IPR018159   Spectrin/alpha-actinin       
IPR013106   Ig_V-set       

SUPFAM

SSF48726   SSF48726        + More
SSF50044   SSF50044       
SSF49265   SSF49265       

Gene 3D

2.60.40.10    

CDD

cd00063  FN3

ProteinModelPortal

Q8T101   Q8MMJ9   A0A2W1BR33   A0A2A4JA34   A0A2A4JBM0   A0A2H1WA57   + More
A0A194R013   A0A194PRX9   A0A212EMM0   A0A0L7LK08   A0A088A9C6   A0A026VUD4   E2BM24   A0A154PJP5   A0A2J7QZK4   A0A195FZ63   A0A2J7QZK5   A0A0N0BEG5   A0A151I9J5   A0A1B6DP09   A0A151WT55   F4X806   A0A1S4FA74   Q17AF2   A0A336LNI7   A0A336LSE4   A0A182JZ59   A0A336LRC6   A0A182RB00   A0A158NVR6   A0A182MBM1   A0A182WJ12   A0A182GES9   A0A182FI83   A0A182XZ30   A0A0K8UMT2   W5JCS9   A0A146M3F4   A0A0K8VP60   A0A034V2U6   A0A0A1XPH8   E0VZZ8   A0A084VEZ0   A0A034V0P5   A0A2P8Z6P9   A0A0Q9WW89   A0A0P8XSQ8   A0A0Q9WIS3   A0A0P8Y833   A0A0Q9WIY4   A0A069DY97   A0A3B0KJX7   A0A224X960   A0A0P8XSF0   B4N316   A0A0P9AID6   A0A1W4W593   A0A0M5J037   A0A146LRT9   A0A310S8S3   A0A0R1DUN8   M9PDZ6   M9PGZ0   M9PBJ0   B4QN22   M9PDS3   M9PDZ9   M9PBI9   M9PEA5   A0A0R1E0V7   M9PEA0   A0A0J9RMQ2   A0A0R1DUV4   A0A0J9RNP6   A0A0R1DY47   M9PDS8   A0A1A9XBG4   Q9I7U4-5   A0A1A9WLT4   Q9I7U4   A0A0Q5UH56   Q9I7U4-4   A0A0J9UCP5   A0A0J9RM79   A0A0R1DWF4   A0A0R1DUJ0   A0A1A9UCU1   A0A0R1DUI7   A0A1A9Z6R8   A0A0J9RNQ2   A0A0Q5U8V9   A0A0J9RNP1  

PDB

6FWX     E-value=8.94448e-40,     Score=418

KEGG

100049060    no KO assigned | (RefSeq) Titin2, Bmtitin2; titin-like protein

GO

GO:0016301   GO:0016787   GO:0051301   GO:0007498   GO:0040011   GO:0000794   GO:0045214   GO:0007520   GO:0007517   GO:0007076   GO:0031674   GO:0007525   GO:0003779   GO:0016203   GO:0007519   GO:0008307   GO:0030018   GO:0005863   GO:0030017   GO:0035206   GO:0007062   GO:0007522   GO:0005515   GO:0004177   GO:0005737   GO:0008235   GO:0019538   GO:0030145   GO:0005622   GO:0006508   GO:0007169   GO:0016021  

PANTHER

PTHR14340  

Subcellular location

Cytoplasm  
Nucleus  
Chromosome  
   Colocalizes with ball and mask in Z-lines of indirect flight muscle (PubMed:26251439). In the embryo, localizes across the muscles in a striped pattern positioned at the sites at which muscles are attached to the epidermis. In the larval body wall muscles, localizes to the Z line and is still present as a doublet at the muscle-epidermal attachment sites. During pupa development, progressively forms broad striations at the Z line which become more defined after the pupa eclosion.   With evidence from 12 publications.

Length:

2463

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00978

Exp number, first 60 AAs:

0.00266

Total prob of N-in:

0.00013

outside

1  -  2463

 

 

Pi

0.502203

Theta

2.556556

Tajima's D

-2.260229

CLR

1.370248

CSRT

0.000999950002499875

Interpretation

Possibly Positive selection