Gene

KWMTBOMO00179

Pre Gene Modal

BGIBMGA000600

Annotation

PREDICTED:_phospholipase_C_gamma_isoform_X2_[Bombyx_mori]

Location

Bomo_Chr1(-):5661390-5667652      View in EpiBrowser

Full name

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma       + More
Phosphoinositide phospholipase C      

Location in the cell

Nuclear   Reliability : 3.333

CDS

ATGAAGTCGGTCTGCTTCAACGGGGCCAAAGATAGGCTCATACACGAGGCAGACCAGCTTATCTCCTACATAGAAAGAGGCTCTACCGTTTTAAAATTCTTCCCTCGTAAGAGACCCGAAAGGCGTGCACTTTGCGTGAGAAGAGAGACCCATCAAGTTCTTTGGTCTCGAATCAATGCCCCTCAGAGACAGGGCTACGAAGGGGCTCTCGATATCCGTGATGTCAAAGAAGTTCGCACTGGAAAATCATCCAAAGACTTTGAGCGTTGGCCTGAAGAAACCAAACGTCTTGAAAGTTCAAAATGCTTTACCATTTATTATGGAACTGAATTTAAACTTCGCTGTGCATCATTTGTTGCTCAAACAGATAAAGAGTGTGAAGCTTGGGTGAAAGGTGTACTGTATCTAATAGCAGAAGCTGTCAGTGCATCATATCCTCTACAGATTGAAAGATGGCTCCGGAAAGAATTCTATTCTATTGAAAACTCCCATGAAAAAATAACATTAAAAGAGGTCAAAGCTTTTCTACCAAAAATTAATTGTAAAATTTCAACAAGTAAGCTTCGAGATGTATTCCAAGATGTTGACACTGAAAAAAGAGGGGAGATTGGCTTTGATGATTTTGCTGTTCTTTATCAGAAGCTAATTTTTGATGAGAATAATGTTCAGGACATATTTGATAAATACTCAGTCTATTGTTCTAATGGTACTACTATTACTCTTAGAGAGTTTCAAAATTTCCTTAGAGATGAACAGCATGATAACCTTGGTGATGATGAAGTACAAGCCTCACAGTTCATCCGTGATTACTTAAGAGATCCACAAAGAGACATCTATGAACCTTATTTCACTTTAAGCGAGTTTGTCGAGATGCTGTACTCCAAGCAGAATTCCATCTATGACAGTCAGTATGATAAGGTTACACAAGATATGACCAGGCCTTTGTCACACTATTGGATATCTTCTTCTCATAACACGTATCTGACAGGTGACCAGTTTTCAAGTGAATCATCACTGGAGGCCTACGTGCGGTGCTTGAGGTCAGGCTGTCGTTGTATTGAGCTAGATTGTTGGGATGGTCCTGACGGCACACCTTTTATTTATCACGGGCACACACTGACAACGAAAATAAGGTTTATGGATGTACTGCGAACAATAAAAGAACATGCATTCATCACATCTGAATATCCATTAATTTTGTCTATCGAAGACAACTGCTCACTCCCACAGCAAAGACGAATGGCGAGCGCATTTCAAGACGTATTCGGTGACCTTCTTCTTGTTCATCCAATGGATAAGAATGAAACATCACTTCCCTCTCCTCATGACTTACGCAGAAAAATAATCCTGAAACATAAAAAATTACCTGAAGGTGCTGAAGAAAGTTCTTTCGCAGTACGTCAAGAAGAAGGAAAAGATTTAGACCTACGAAATTCGATCAAAAATGGTATATTGCATTTGGAAGATCCTGTCGACAAAGAATGGAAGCCTCACGCCTTCGTGCTCACCGAGAACAAACTTTACTATACAGAGAGCTACAACAGTCAAGAAGAAACCGACACTGAAAGTGACGGAGACTCAGATGCGGAAAACGCTATTGTACCACAAGATGAATTACATTTCGCAGAATGTTGGTTCCACGGGAAGCTGGCAGGGAATCGACAAGAAGCCGAAGATTTGCTGAGAGCCCACGCCCATCTTGGCGATGGAACCTTTCTGGTGAGGGAGAGCGTTACTTTTGTCGGTGACTACTGTCTATCATTCTGGCGGCAAGGGAAAGTAAATCACTGCCGCATCAAGCTCAAACAGGAACGGGGGGTCACCAAGTTCTATCTGATAGATAGTATGTGTTTCGACAGCCTGTACAACCTCATCACCCATTATAGGTCACATCCTCTGAGGAGTCAAGAGTTCCTGATAACGTTAAAGGAGCCAGTGCCTCAGCCTAACAAGCATGAAGGCAAGGAATGGTTCCACGCGCACTGCACGCGTACTCAAGCCGAAGAATTACTGCGGAAGACCAACACCGACGGCGCTTTCCTAGTACGCCCCAGCGAAAAGGAACAAGGGAGCTTCGCAATTAGTTTCAGGACTGAGAAGGAGATAAAGCATTGCAGGGTTAAACAAGAGGGTCGCCTGTACACAATCGCGAAGAAACCGTCAGAAGACTTGTCTCTGTAA

Protein

MKSVCFNGAKDRLIHEADQLISYIERGSTVLKFFPRKRPERRALCVRRETHQVLWSRINAPQRQGYEGALDIRDVKEVRTGKSSKDFERWPEETKRLESSKCFTIYYGTEFKLRCASFVAQTDKECEAWVKGVLYLIAEAVSASYPLQIERWLRKEFYSIENSHEKITLKEVKAFLPKINCKISTSKLRDVFQDVDTEKRGEIGFDDFAVLYQKLIFDENNVQDIFDKYSVYCSNGTTITLREFQNFLRDEQHDNLGDDEVQASQFIRDYLRDPQRDIYEPYFTLSEFVEMLYSKQNSIYDSQYDKVTQDMTRPLSHYWISSSHNTYLTGDQFSSESSLEAYVRCLRSGCRCIELDCWDGPDGTPFIYHGHTLTTKIRFMDVLRTIKEHAFITSEYPLILSIEDNCSLPQQRRMASAFQDVFGDLLLVHPMDKNETSLPSPHDLRRKIILKHKKLPEGAEESSFAVRQEEGKDLDLRNSIKNGILHLEDPVDKEWKPHAFVLTENKLYYTESYNSQEETDTESDGDSDAENAIVPQDELHFAECWFHGKLAGNRQEAEDLLRAHAHLGDGTFLVRESVTFVGDYCLSFWRQGKVNHCRIKLKQERGVTKFYLIDSMCFDSLYNLITHYRSHPLRSQEFLITLKEPVPQPNKHEGKEWFHAHCTRTQAEELLRKTNTDGAFLVRPSEKEQGSFAISFRTEKEIKHCRVKQEGRLYTIAKKPSEDLSL

Description

Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.

Catalytic Activity

a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)

Similarity

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

Uniprot

H9ITM0   D2XZ03   A0A2A4K1A7   A0A060BIC2   A0A2H1V5J9   A0A194QW69   + More
A0A212EMM4   A0A194PRV4   A0A0N1IN36   A0A2J7QPE5   A0A067R4V5   A0A0N0U461   A0A151JQT3   A0A0L7QR48   A0A158NTI1   A0A195C3N1   A0A151HZR5   A0A151X826   A0A026VXP9   A0A3L8D6S6   A0A195FTF0   A0A232F3Z6   A0A2A3EAE0   A0A1B6HJU2   A0A1Y1KG69   A0A1W4XCL1   A0A154P0V9   A0A224X547   A0A023F3P4   A0A310SPU7   A0A0A9X474   A0A139W9D8   D7ELR5   A0A087ZXW1   B0WL59   A0A1S4F7L8   Q17CT3   A0A1Q3F8M6   A0A1Q3F8K4   A0A084VHS7   A0A182QRY2   A0A2R5L918   A0A182RW64   A0A182VF99   A0A182JGV8   A0A182N2B2   A0A131XWM3   A0A182K268   A0A182WDJ1   A0A182KL33   Q7QHE3   A0A182FKL3   A0A182M1X0   A0A182NZM7   A0A182YB20   W5JCJ5   A0A2M4A9Q3   A0A2M4BA71   U4UD37   N6UAF3   B7P4X9   T1IHK2   A0A336LNZ2   A0A182HWB9   A0A182X5M9   A0A224X5R9   A0A1J1IE99   A0A1B0GIU0   A0A1L8DYI1   A0A2M4BAP5   A0A2M4BAQ3   L7MKR7   A0A0P6GX85   A0A0P5Y732   A0A0N8BB53   A0A0P5K5M3   A0A0P6GQA6   A0A182HCQ0   A0A0P5HQ05   A0A1I8NY27   A0A0P5H5I7   A0A0A1WF15   A0A1D2NCI0   W8BW99   A0A1B0FA29   A0A1B0API1   A0A0L0BNN5   A0A1A9ULC6   A0A1A9XWX6   A0A1I8M0T8   A0A1B0AE86   A0A1A9W621   A0A0K8VME4   A0A034WI99   A0A2T7NHX7   T1PIV1   Q86RA6   B4JKL8   A0A2C9JPF0   A2IB48  

EC Number

3.1.4.11

Pubmed

19121390    26354079    22118469    24845553    21347285    24508170    + More
30249741    28648823    28004739    25474469    25401762    26823975    18362917    19820115    17510324    24438588    20966253    12364791    14747013    17210077    25244985    20920257    23761445    23537049    25576852    26483478    25830018    27289101    24495485    26108605    25315136    25348373    12807765    17994087    18057021    15562597    18951372   

EMBL

BABH01006728    BABH01006729    BABH01006730    BABH01006731    GU266212    ADB25315.1    + More
NWSH01000326    PCG77422.1    KF800735    AIA77273.1    ODYU01000800    SOQ36125.1    KQ461108    KPJ09210.1    AGBW02013811    OWR42742.1    KQ459594    KPI96176.1    KQ459285    KPJ02044.1    NEVH01012091    PNF30464.1    KK852891    KDR14243.1    KQ435834    KOX71582.1    KQ978627    KYN29563.1    KQ414784    KOC61102.1    ADTU01002746    ADTU01002747    KQ978344    KYM94788.1    KQ976693    KYM77666.1    KQ982431    KYQ56438.1    KK107796    EZA47604.1    QOIP01000013    RLU15548.1    KQ981268    KYN43890.1    NNAY01001051    OXU25332.1    KZ288308    PBC28697.1    GECU01032726    JAS74980.1    GEZM01084973    JAV60354.1    KQ434796    KZC05565.1    GFTR01008801    JAW07625.1    GBBI01002697    JAC16015.1    KQ761834    OAD56687.1    GBHO01028815    GDHC01018996    JAG14789.1    JAP99632.1    KQ972349    KXZ75916.1    EFA12319.2    DS231980    EDS30232.1    CH477304    EAT44189.1    GFDL01011149    JAV23896.1    GFDL01011186    JAV23859.1    ATLV01013225    ATLV01013226    ATLV01013227    ATLV01013228    KE524847    KFB37521.1    AXCN02001729    GGLE01001829    MBY05955.1    GEFM01005730    GEGO01006352    JAP70066.1    JAR89052.1    AAAB01008816    EAA05135.4    AXCM01007440    ADMH02001908    ETN60549.1    GGFK01004174    MBW37495.1    GGFJ01000788    MBW49929.1    KB632225    ERL90238.1    APGK01036671    KB740941    ENN77611.1    ABJB010334257    ABJB010359695    ABJB011028291    DS637651    EEC01651.1    JH429910    UFQT01000094    SSX19640.1    APCN01001484    GFTR01008591    JAW07835.1    CVRI01000047    CRK97326.1    AJWK01017652    AJWK01017653    AJWK01017654    GFDF01002563    JAV11521.1    GGFJ01000965    MBW50106.1    GGFJ01000966    MBW50107.1    GACK01000489    JAA64545.1    GDIQ01027654    JAN67083.1    GDIP01063285    LRGB01000512    JAM40430.1    KZS18530.1    GDIQ01195035    JAK56690.1    GDIQ01249526    GDIQ01247932    GDIQ01244786    GDIQ01244785    GDIQ01244784    GDIQ01233177    GDIQ01231433    GDIQ01205290    GDIQ01203629    GDIQ01190495    GDIQ01187843    GDIQ01171695    GDIQ01163660    GDIQ01162303    GDIQ01160901    GDIQ01140665    GDIQ01138515    GDIQ01130969    GDIQ01126968    GDIQ01125268    GDIQ01123316    GDIQ01116817    GDIQ01116816    GDIQ01096920    GDIP01131328    GDIQ01084279    GDIQ01063042    GDIQ01046045    GDIQ01044407    GDIQ01033749    GDIQ01032297    GDIQ01030610    JAK61230.1    JAL72386.1    GDIQ01030314    JAN64423.1    JXUM01033613    JXUM01033614    JXUM01033615    JXUM01033616    GDIQ01223973    JAK27752.1    GDIQ01237785    GDIQ01237784    JAK13941.1    GBXI01017227    JAC97064.1    LJIJ01000091    ODN02952.1    GAMC01013111    JAB93444.1    CCAG010004929    JXJN01001447    JRES01001597    KNC21621.1    GDHF01012286    JAI40028.1    GAKP01003676    JAC55276.1    PZQS01000012    PVD20783.1    KA648696    AFP63325.1    AF543827    CH940651    AAN39331.1    EDW65634.1    CH916370    EDW00121.1    EF185302    ABM55782.1   

Proteomes

UP000005204    UP000218220    UP000053240    UP000007151    UP000053268    UP000235965    + More
UP000027135    UP000053105    UP000078492    UP000053825    UP000005205    UP000078542    UP000078540    UP000075809    UP000053097    UP000279307    UP000078541    UP000215335    UP000242457    UP000192223    UP000076502    UP000007266    UP000005203    UP000002320    UP000008820    UP000030765    UP000075886    UP000075900    UP000075903    UP000075880    UP000075884    UP000075881    UP000075920    UP000075882    UP000007062    UP000069272    UP000075883    UP000075885    UP000076408    UP000000673    UP000030742    UP000019118    UP000001555    UP000075840    UP000076407    UP000183832    UP000092461    UP000076858    UP000069940    UP000095300    UP000094527    UP000092444    UP000092460    UP000037069    UP000078200    UP000092443    UP000095301    UP000092445    UP000091820    UP000245119    UP000008792    UP000001070    UP000076420   

PRIDE

H9ITM0    D2XZ03    L7MKR7   

Pfam

PF00387   PI-PLC-Y        + More
PF00168   C2
PF00388   PI-PLC-X
PF00017   SH2
PF00018   SH3_1
PF14604   SH3_9
PF06966   DUF1295
PF09279   EF-hand_like
PF00225   Kinesin
PF13833   EF-hand_8
PF16457   PH_12

Interpro

IPR035024   PLC-gamma_N-SH2        + More
IPR016279   PLC-gamma       
IPR017946   PLC-like_Pdiesterase_TIM-brl       
IPR000909   PLipase_C_PInositol-sp_X_dom       
IPR001452   SH3_domain       
IPR036028   SH3-like_dom_sf       
IPR001849   PH_domain       
IPR001192   PI-PLC_fam       
IPR001711   PLipase_C_Pinositol-sp_Y       
IPR036860   SH2_dom_sf       
IPR035892   C2_domain_sf       
IPR000980   SH2       
IPR002048   EF_hand_dom       
IPR000008   C2_dom       
IPR011992   EF-hand-dom_pair       
IPR035023   PLC-gamma_C-SH2       
IPR011993   PH-like_dom_sf       
IPR010721   DUF1295       
IPR001104   3-oxo-5_a-steroid_4-DH_C       
IPR015359   PLC_EF-hand-like       
IPR027417   P-loop_NTPase       
IPR036961   Kinesin_motor_dom_sf       
IPR001752   Kinesin_motor_dom       

SUPFAM

SSF47473   SSF47473        + More
SSF50044   SSF50044       
SSF51695   SSF51695       
SSF55550   SSF55550       
SSF52540   SSF52540       

Gene 3D

2.30.29.30     2.60.40.150     3.20.20.190     3.30.505.10     3.40.850.10    

CDD

cd10341  SH2_N-SH2_PLC_gamma_like
cd09932  SH2_C-SH2_PLC_gamma_like

ProteinModelPortal

H9ITM0   D2XZ03   A0A2A4K1A7   A0A060BIC2   A0A2H1V5J9   A0A194QW69   + More
A0A212EMM4   A0A194PRV4   A0A0N1IN36   A0A2J7QPE5   A0A067R4V5   A0A0N0U461   A0A151JQT3   A0A0L7QR48   A0A158NTI1   A0A195C3N1   A0A151HZR5   A0A151X826   A0A026VXP9   A0A3L8D6S6   A0A195FTF0   A0A232F3Z6   A0A2A3EAE0   A0A1B6HJU2   A0A1Y1KG69   A0A1W4XCL1   A0A154P0V9   A0A224X547   A0A023F3P4   A0A310SPU7   A0A0A9X474   A0A139W9D8   D7ELR5   A0A087ZXW1   B0WL59   A0A1S4F7L8   Q17CT3   A0A1Q3F8M6   A0A1Q3F8K4   A0A084VHS7   A0A182QRY2   A0A2R5L918   A0A182RW64   A0A182VF99   A0A182JGV8   A0A182N2B2   A0A131XWM3   A0A182K268   A0A182WDJ1   A0A182KL33   Q7QHE3   A0A182FKL3   A0A182M1X0   A0A182NZM7   A0A182YB20   W5JCJ5   A0A2M4A9Q3   A0A2M4BA71   U4UD37   N6UAF3   B7P4X9   T1IHK2   A0A336LNZ2   A0A182HWB9   A0A182X5M9   A0A224X5R9   A0A1J1IE99   A0A1B0GIU0   A0A1L8DYI1   A0A2M4BAP5   A0A2M4BAQ3   L7MKR7   A0A0P6GX85   A0A0P5Y732   A0A0N8BB53   A0A0P5K5M3   A0A0P6GQA6   A0A182HCQ0   A0A0P5HQ05   A0A1I8NY27   A0A0P5H5I7   A0A0A1WF15   A0A1D2NCI0   W8BW99   A0A1B0FA29   A0A1B0API1   A0A0L0BNN5   A0A1A9ULC6   A0A1A9XWX6   A0A1I8M0T8   A0A1B0AE86   A0A1A9W621   A0A0K8VME4   A0A034WI99   A0A2T7NHX7   T1PIV1   Q86RA6   B4JKL8   A0A2C9JPF0   A2IB48  

PDB

4EY0     E-value=2.51302e-51,     Score=513

KEGG

100329155    K01116 phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11] | (RefSeq) PLCg; phospholipase C

PATHWAY

00562    Inositol phosphate metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)
04070    Phosphatidylinositol signaling system - Bombyx mori (domestic silkworm)
04933    AGE-RAGE signaling pathway in diabetic complications - Bombyx mori (domestic silkworm)

GO

GO:0035556   GO:0004435   GO:0005509   GO:0009395   GO:0016042   GO:0016021   GO:0007165   GO:0016627   GO:0051209   GO:0048015   GO:0032959   GO:0010634   GO:0005886   GO:0007018   GO:0008017   GO:0003777   GO:0005524   GO:0070373   GO:0045873   GO:0042059   GO:0007298   GO:0032868   GO:0030307   GO:0006629   GO:0008081   GO:0005515   GO:0004713   GO:0004672   GO:0003707   GO:0007169  

PANTHER

PTHR10336  

Length:

726

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.05639

Exp number, first 60 AAs:

0.00018

Total prob of N-in:

0.00293

outside

1  -  726

 

 

Pi

0.231142

Theta

1.333538

Tajima's D

-1.898084

CLR

0.838361

CSRT

0.0100994950252487

Interpretation

Possibly Positive selection