Gene

KWMTBOMO00178

Pre Gene Modal

BGIBMGA000600

Annotation

PREDICTED:_phospholipase_C_gamma_isoform_X1_[Bombyx_mori]

Location

Bomo_Chr1(-):5651470-5661002      View in EpiBrowser

Full name

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma       + More
Phosphoinositide phospholipase C      

Location in the cell

Cytoplasmic   Reliability : 1.958

CDS

ATGGATCCCACGTCATTCACGTCCAAGGTGACCGTTAAAGCGCTTTACGATTATCGGGCTCGTCAAGATGACGAGTTGTCCTTCTGCAAGCACGCCATCATTACAAACGTCGACAAGCCGGACGAGGGCTGGTGGCGGGGCGACTACGGCGGCAAACGTCATCACTGGTTCCCGGCCAACTACGTGCTTGAGATTGAGGTTCCACACACACCCGACGTGACCAGCGGTCTAGAAAACGAATCAGCCGCCCTGGGATCGTTGCAGAAAGGCGTGCTGGACGTGCTCGGCGCTATCGTTGAATTGGTGGTGGGCGACGGGGGAGGCGCGGCGCGGTGGCTGGTGCGTGTCCAGAGCCCCGCCATGTACTCGCCGTTCGACATGGCAGCCGCCACCCGCGAGTCCGCGCTCGAATGGCTCTCGGCCATCGAAGAGGCCGCGCACAGTGCTAGCGCTCGCTCGCTCCACCACAGGAAAATGGAACGAACATGGCGCATCGCCAAAGAGATATCGGACCTCATCATCTACTGCCGCTCAGTCACCTTCAACATCGAACGTCTACGCATCAAGGGCTTTGTTTACAACGAGATGTCCTCGTTTCCCGAGACCAAAGCCGAACGCCTTATGTCTCAGCAAGAGAACACGTTCTTCGTCAAGTACCACACGACGCAACTTAGCCGTATCTACCCTAAAGGCCAGAGAATCGATTCGTCGAACTACAATCCGGTGCCGTTCTGGAACTGCGGCTCTCAAATGGTCGCTTTGAATTACCAAACGCCCGACAAACCGATGCAGGTCAACATGGGCAAGTTTAAACAGAACGGCGGCTGTGGCTTTATCTTGAAGCCACAGTTTATGTTCGAGGAAGGATACAATCCGTGCGATAAAAAATCGATCGAGGGCAAAGTGAAGCCGGTAACTGTGATGTTGCGTGTTATCGGGGCGAGGCATCTGTGCAAGACGGGTCGCGGCACGGCCAGTCCCTTTGTAGAAGTCGAGATCATCGGGGCGGACTACGACAGCGGCGTCAAACTCGTCACTAAAACAGTGTCTGATAACGGACTGAACCCTTTGTGGAACGACATCTGCGAGTTCGAAGTTGCGAACCCAGAACTGGCCTTGATCCGTTTCGTGGTACAAGACGAAGATATATTTGGCGAGCCGAACTTCATAGGTCAAGCGACTTTCCCGCTGTTGTGCCTGCGTAAAGGATACCGAAGCGTGCCTCTCACTAACGCATTCTCCGAAGAACTGGAACTATCCACACTGATGGTTCACTTGTCAATTATAACAGACGGTTGA

Protein

MDPTSFTSKVTVKALYDYRARQDDELSFCKHAIITNVDKPDEGWWRGDYGGKRHHWFPANYVLEIEVPHTPDVTSGLENESAALGSLQKGVLDVLGAIVELVVGDGGGAARWLVRVQSPAMYSPFDMAAATRESALEWLSAIEEAAHSASARSLHHRKMERTWRIAKEISDLIIYCRSVTFNIERLRIKGFVYNEMSSFPETKAERLMSQQENTFFVKYHTTQLSRIYPKGQRIDSSNYNPVPFWNCGSQMVALNYQTPDKPMQVNMGKFKQNGGCGFILKPQFMFEEGYNPCDKKSIEGKVKPVTVMLRVIGARHLCKTGRGTASPFVEVEIIGADYDSGVKLVTKTVSDNGLNPLWNDICEFEVANPELALIRFVVQDEDIFGEPNFIGQATFPLLCLRKGYRSVPLTNAFSEELELSTLMVHLSIITDG

Description

Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.

Catalytic Activity

a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)

Uniprot

H9ITM0   D2XZ03   A0A2H1V5J9   A0A2A4K1A7   A0A194QW69   A0A060BIC2   + More
A0A194PRV4   A0A212EMM4   A0A087ZXW1   A0A158NTI1   A0A310SPU7   E2BZZ7   A0A151X826   A0A232F3Z6   A0A0N0U461   A0A2J7QPE5   A0A0A9X474   A0A026VXP9   E0V9R3   A0A2P8XD80   E2AZU2   A0A1B6CI00   A0A0L7QR48   A0A0V0GED2   F4WEY9   A0A0J7K5Q9   A0A139W9F8   A0A2A3EAE0   A0A224X5R9   A0A0C9QV50   T1HV24   A0A195FTF0   A0A1W4XCL1   A0A023F3P4   A0A224X547   A0A3L8D6S6   A0A067R4V5   A0A151JQT3   A0A195C3N1   D7ELR5   A0A2H8TLT2   A0A182HCQ0   A0A154P0V9   A0A1Y1KG69   A0A336LNZ2   A0A1S4F7L8   J9JQK0   A0A1Q3F8K4   A0A1Q3F8M6   B0WL59   A0A182U1Z9   V5HV23   Q17CT3   A0A2M4ABK3   A0A1E1XAI8   A0A2M4BAP5   A0A2M4BAQ3   A0A131XWM3   A0A2M4BA71   A0A1J1IAL8   A0A182M1X0   W5JCJ5   A0A293M8T2   A0A182WDJ1   A0A1J1IE99   A0A182FKL3   A0A182K268   A0A182JGV8   A0A182VF99   A0A2M4A9Q3   A0A182RW64   Q7QHE3   A0A182X5M9   A0A2R5L918   A0A182HWB9   A0A182NZM7   A0A182N2B2   U4UD37   N6UAF3   A0A182YB20   A0A182QRY2   W4XRL3   A0A084VHS7   A0A151HZR5   A0A1S3H5X7   B7P4X9   A0A0P4VK22   A0A1V9XNV8   A0A1L8DYI1   A0A2G8LRB6   A2IB48   A0A0P5MT73   A0A0P4XLN7   A0A2T7NHX7   A0A0P4YRU7   A0A0P5LIS7   A0A0N8BKM6   A0A0N8BFL3   A0A0P5H5I7   A0A0N8BB53  

EC Number

3.1.4.11

Pubmed

19121390    26354079    22118469    21347285    20798317    28648823    + More
25401762    26823975    24508170    20566863    29403074    21719571    18362917    19820115    25474469    30249741    24845553    26483478    28004739    25765539    17510324    28503490    20920257    23761445    12364791    14747013    17210077    23537049    25244985    24438588    27129103    28327890    29023486    18951372   

EMBL

BABH01006728    BABH01006729    BABH01006730    BABH01006731    GU266212    ADB25315.1    + More
ODYU01000800    SOQ36125.1    NWSH01000326    PCG77422.1    KQ461108    KPJ09210.1    KF800735    AIA77273.1    KQ459594    KPI96176.1    AGBW02013811    OWR42742.1    ADTU01002746    ADTU01002747    KQ761834    OAD56687.1    GL451708    EFN78774.1    KQ982431    KYQ56438.1    NNAY01001051    OXU25332.1    KQ435834    KOX71582.1    NEVH01012091    PNF30464.1    GBHO01028815    GDHC01018996    JAG14789.1    JAP99632.1    KK107796    EZA47604.1    DS234996    EEB10119.1    PYGN01002794    PSN29961.1    GL444277    EFN61071.1    GEDC01024230    JAS13068.1    KQ414784    KOC61102.1    GECL01000429    JAP05695.1    GL888112    EGI67260.1    LBMM01013349    KMQ85692.1    KQ972349    KXZ75917.1    KZ288308    PBC28697.1    GFTR01008591    JAW07835.1    GBYB01004537    JAG74304.1    ACPB03018902    KQ981268    KYN43890.1    GBBI01002697    JAC16015.1    GFTR01008801    JAW07625.1    QOIP01000013    RLU15548.1    KK852891    KDR14243.1    KQ978627    KYN29563.1    KQ978344    KYM94788.1    EFA12319.2    GFXV01003299    MBW15104.1    JXUM01033613    JXUM01033614    JXUM01033615    JXUM01033616    KQ434796    KZC05565.1    GEZM01084973    JAV60354.1    UFQT01000094    SSX19640.1    ABLF02012330    ABLF02012332    GFDL01011186    JAV23859.1    GFDL01011149    JAV23896.1    DS231980    EDS30232.1    GANP01004416    JAB80052.1    CH477304    EAT44189.1    GGFK01004850    MBW38171.1    GFAC01002966    JAT96222.1    GGFJ01000965    MBW50106.1    GGFJ01000966    MBW50107.1    GEFM01005730    GEGO01006352    JAP70066.1    JAR89052.1    GGFJ01000788    MBW49929.1    CVRI01000047    CRK97327.1    AXCM01007440    ADMH02001908    ETN60549.1    GFWV01011762    MAA36491.1    CRK97326.1    GGFK01004174    MBW37495.1    AAAB01008816    EAA05135.4    GGLE01001829    MBY05955.1    APCN01001484    KB632225    ERL90238.1    APGK01036671    KB740941    ENN77611.1    AXCN02001729    AAGJ04060113    ATLV01013225    ATLV01013226    ATLV01013227    ATLV01013228    KE524847    KFB37521.1    KQ976693    KYM77666.1    ABJB010334257    ABJB010359695    ABJB011028291    DS637651    EEC01651.1    GDKW01003776    JAI52819.1    MNPL01006676    OQR75200.1    GFDF01002563    JAV11521.1    MRZV01000006    PIK62764.1    EF185302    ABM55782.1    GDIQ01152210    JAK99515.1    GDIP01240811    JAI82590.1    PZQS01000012    PVD20783.1    GDIP01224509    JAI98892.1    GDIQ01169006    JAK82719.1    GDIQ01168451    JAK83274.1    GDIQ01182555    JAK69170.1    GDIQ01237785    GDIQ01237784    JAK13941.1    GDIQ01195035    JAK56690.1   

Proteomes

UP000005204    UP000218220    UP000053240    UP000053268    UP000007151    UP000005203    + More
UP000005205    UP000008237    UP000075809    UP000215335    UP000053105    UP000235965    UP000053097    UP000009046    UP000245037    UP000000311    UP000053825    UP000007755    UP000036403    UP000007266    UP000242457    UP000015103    UP000078541    UP000192223    UP000279307    UP000027135    UP000078492    UP000078542    UP000069940    UP000076502    UP000007819    UP000002320    UP000075902    UP000008820    UP000183832    UP000075883    UP000000673    UP000075920    UP000069272    UP000075881    UP000075880    UP000075903    UP000075900    UP000007062    UP000076407    UP000075840    UP000075885    UP000075884    UP000030742    UP000019118    UP000076408    UP000075886    UP000007110    UP000030765    UP000078540    UP000085678    UP000001555    UP000192247    UP000230750    UP000245119   

PRIDE

H9ITM0    D2XZ03   

Pfam

PF00387   PI-PLC-Y        + More
PF00168   C2
PF00388   PI-PLC-X
PF00017   SH2
PF00018   SH3_1
PF14604   SH3_9
PF06966   DUF1295
PF09279   EF-hand_like
PF00169   PH

Interpro

IPR035024   PLC-gamma_N-SH2        + More
IPR016279   PLC-gamma       
IPR017946   PLC-like_Pdiesterase_TIM-brl       
IPR000909   PLipase_C_PInositol-sp_X_dom       
IPR001452   SH3_domain       
IPR036028   SH3-like_dom_sf       
IPR001849   PH_domain       
IPR001192   PI-PLC_fam       
IPR001711   PLipase_C_Pinositol-sp_Y       
IPR036860   SH2_dom_sf       
IPR035892   C2_domain_sf       
IPR000980   SH2       
IPR002048   EF_hand_dom       
IPR000008   C2_dom       
IPR011992   EF-hand-dom_pair       
IPR035023   PLC-gamma_C-SH2       
IPR011993   PH-like_dom_sf       
IPR010721   DUF1295       
IPR001104   3-oxo-5_a-steroid_4-DH_C       
IPR015359   PLC_EF-hand-like       
IPR036352   Semap_dom_sf       

SUPFAM

SSF47473   SSF47473        + More
SSF50044   SSF50044       
SSF51695   SSF51695       
SSF55550   SSF55550       
SSF101912   SSF101912       

Gene 3D

2.30.29.30     2.60.40.150     3.20.20.190     3.30.505.10    

CDD

cd10341  SH2_N-SH2_PLC_gamma_like
cd09932  SH2_C-SH2_PLC_gamma_like

ProteinModelPortal

H9ITM0   D2XZ03   A0A2H1V5J9   A0A2A4K1A7   A0A194QW69   A0A060BIC2   + More
A0A194PRV4   A0A212EMM4   A0A087ZXW1   A0A158NTI1   A0A310SPU7   E2BZZ7   A0A151X826   A0A232F3Z6   A0A0N0U461   A0A2J7QPE5   A0A0A9X474   A0A026VXP9   E0V9R3   A0A2P8XD80   E2AZU2   A0A1B6CI00   A0A0L7QR48   A0A0V0GED2   F4WEY9   A0A0J7K5Q9   A0A139W9F8   A0A2A3EAE0   A0A224X5R9   A0A0C9QV50   T1HV24   A0A195FTF0   A0A1W4XCL1   A0A023F3P4   A0A224X547   A0A3L8D6S6   A0A067R4V5   A0A151JQT3   A0A195C3N1   D7ELR5   A0A2H8TLT2   A0A182HCQ0   A0A154P0V9   A0A1Y1KG69   A0A336LNZ2   A0A1S4F7L8   J9JQK0   A0A1Q3F8K4   A0A1Q3F8M6   B0WL59   A0A182U1Z9   V5HV23   Q17CT3   A0A2M4ABK3   A0A1E1XAI8   A0A2M4BAP5   A0A2M4BAQ3   A0A131XWM3   A0A2M4BA71   A0A1J1IAL8   A0A182M1X0   W5JCJ5   A0A293M8T2   A0A182WDJ1   A0A1J1IE99   A0A182FKL3   A0A182K268   A0A182JGV8   A0A182VF99   A0A2M4A9Q3   A0A182RW64   Q7QHE3   A0A182X5M9   A0A2R5L918   A0A182HWB9   A0A182NZM7   A0A182N2B2   U4UD37   N6UAF3   A0A182YB20   A0A182QRY2   W4XRL3   A0A084VHS7   A0A151HZR5   A0A1S3H5X7   B7P4X9   A0A0P4VK22   A0A1V9XNV8   A0A1L8DYI1   A0A2G8LRB6   A2IB48   A0A0P5MT73   A0A0P4XLN7   A0A2T7NHX7   A0A0P4YRU7   A0A0P5LIS7   A0A0N8BKM6   A0A0N8BFL3   A0A0P5H5I7   A0A0N8BB53  

PDB

1QAT     E-value=5.25318e-52,     Score=517

KEGG

100329155    K01116 phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11] | (RefSeq) PLCg; phospholipase C

GO

GO:0035556   GO:0004435   GO:0005509   GO:0009395   GO:0016042   GO:0016021   GO:0016627   GO:0007165   GO:0051209   GO:0048015   GO:0032959   GO:0010634   GO:0005886   GO:0006629   GO:0005515   GO:0008081   GO:0004713   GO:0004672   GO:0003707   GO:0007169  

PANTHER

PTHR10336  

Length:

432

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.0191

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00531

outside

1  -  432

 

 

Pi

0.394486

Theta

3.324862

Tajima's D

-2.317899

CLR

3.089034

CSRT

0.00129993500324984

Interpretation

Uncertain