Gene

KWMTBOMO00177

Pre Gene Modal

BGIBMGA000601

Annotation

PREDICTED:_TGF-beta_receptor_type-1_isoform_X2_[Bombyx_mori]

Location

Bomo_Chr1(-):5623734-5644852      View in EpiBrowser

Full name

Serine/threonine-protein kinase receptor       + More
Receptor protein serine/threonine kinase      

Location in the cell

Nuclear   Reliability : 1.317

CDS

ATGTGCAATCGAGAGATACTCCAGGAGCTGCATCCGAAGCCGCCAGAGACGAGCCCGACCGCGACGGCATGGCAGGTTGTGCCTTGGATCATGGGACTTGTTGTATTCGCCATATGCGTCGCTTTAAGTCTGTGGTGGGCGAAGAAATGGCGAGCCGACGGGAAACGACCGCCACGGCCTTACCCGGATGAGGACGAGACCAAACACATACTTAATACACCCACCACCACTATCAGAGATATGATTGAACTAACGACGTCTGGCTCTGGATCTGGATTACCGCTTCTGGTGCAGCGAAGTATCGCACGCCAGATCCAACTGGTGGACATAATTGGAAAGGGTCGTTTCGGCGAGGTGTGGCGTGGTCGTTGGAGGGGTGAGAACGTCGCGGTTAAGATATTTTCATCTCGCGAGGAATGTTCTTGGTTCCGGGAAGCGGAAATTTACCAGACCGTGATGTTGCGGCATGAAAATATCCTTGGGTTCATTGCGGCTGATAATAAAGATAATGGGACGTGGACTCAGTTATGGTTGATAACTGATTATCATGAAAATGGTTCTCTATTTGATTTCCTTACTGCAAAATCAATCGACTCGAACACGCTCATTAAGATGTCCCTCTCCATCGCAACTGGACTAGCTCATTTGCATATGGACATTGTCGGCACAAAAGGAAAGCCGGCTATAGCTCATCGGGATCTCAAATCGAAAAACATATTGGTGAAAAGCAACTTGTCTTGCGTGATCGGGGATCTCGGGCTTGCCGTGCGCCACAATGTCTCGAACGACTCTGTTGATGTACCGTCGACCAACCGTGTGGGCACCAAGCGGTACATGGCGCCGGAGGTATTAGATGAAACGATGGACACGCGGCAGTTCGATCCTTACAAGCGTTCGGACGTCTATTCATTCGGCCTAGTGCTGTGGGAGATGGCTCGTCGCTGCGGTAACATGCCGGACGATTACCAGCCTCCTTATTACGACTGCGTGCCACCGGATCCGGCGCTCGAAGACATGAGACGCGTTGTATGCACCGAGAAGCGAAGACCGAACGTACCTAATAGGTGGCACTCTGATCCGGTGCTGTCAGGAATATCAAAGGTAATGAAAGAATGCTGGTACCAAAATCCGGCGGCCAGGTTGACTGCGCTCCGAATCAAGAAAACCCTTGCCAATGTCGGAACAAACGGCGCGGACTACATCAAACTTTGA

Protein

MCNREILQELHPKPPETSPTATAWQVVPWIMGLVVFAICVALSLWWAKKWRADGKRPPRPYPDEDETKHILNTPTTTIRDMIELTTSGSGSGLPLLVQRSIARQIQLVDIIGKGRFGEVWRGRWRGENVAVKIFSSREECSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLITDYHENGSLFDFLTAKSIDSNTLIKMSLSIATGLAHLHMDIVGTKGKPAIAHRDLKSKNILVKSNLSCVIGDLGLAVRHNVSNDSVDVPSTNRVGTKRYMAPEVLDETMDTRQFDPYKRSDVYSFGLVLWEMARRCGNMPDDYQPPYYDCVPPDPALEDMRRVVCTEKRRPNVPNRWHSDPVLSGISKVMKECWYQNPAARLTALRIKKTLANVGTNGADYIKL

Catalytic Activity

[receptor-protein]-L-serine + ATP = [receptor-protein]-O-phospho-L-serine + ADP + H(+)
[receptor-protein]-L-threonine + ATP = [receptor-protein]-O-phospho-L-threonine + ADP + H(+)

Similarity

Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
Belongs to the protein kinase superfamily.

Feature

chain  Serine/threonine-protein kinase receptor

Uniprot

H9ITM1   A0A220QT61   A0A194QVZ3   A0A2A4K181   A0A2A4K0I3   A0A2A4K085   + More
A0A2A4JZI3   A0A2A4K1B7   A0A2A4K052   A0A2A4JZJ2   A0A194Q6G9   A0A212EMN2   A0A2A4K0Z4   A0A2A4JZK3   A0A2A4K0Y3   A0A2A4K0J8   A0A2A4K0K7   A0A2H1V5S4   A0A1Q3G0F9   A0A1B0D486   A0A1W4UY47   A0A1W4UZF9   A0A1W4UKW5   N6W4E6   A0A3B0IZZ5   B4GIN9   A0A1W4UXU3   A0A1I8NCQ2   A0A0R3NNR5   A0A0P8XMK2   B4QGP3   A0A3B0IZP4   A0A0R3NNL0   B4P3F5   A0A1I8PXB6   B4J5D9   A0A0J9R8L6   A0A0R3NNU5   B3N833   A0A0P9ACU6   A0A0R1DTJ7   A0A0Q5WBX1   A0A0J9TWT2   Q28YV2   Q23975   A0A0Q5WKQ1   A0A1I8NCP3   A0A1I8PXB2   A0A0J9R8G5   A0A0Q9XHD7   A1Z7L9   A0A0R1DTF7   A0A1I8NCP7   B3MI97   Q7YU60   A0A3B0JL14   Q17KD7   A0A1I8PXG0   A0A0A1WZ77   A0A0Q9X2Q0   A0A1I8PXC9   A1Z7L8   B4N626   A0A182H9M3   A0A034WMN3   A0A0A1WW58   B4HSC7   A0A1B0ETQ7   A0A0K8WBI6   U5EYZ8   A0A0K8U047   A0A0A1WVW6   B4KLN9   A0A0Q9X7D9   A0A1L8DJT4   A0A1L8DK04   W8AUF0   A0A1A9W2G1   A0A1L8DJN7   A0A1L8DJM3   A0A1A9UZD4   W8B4V7   A0A1A9YEV6   A0A1B0BKH0   A0A0L0CMN7   A0A1B0GA96   A0A084W4S3   B4LLJ2   A0A0Q9WDW8   A0A0Q9W1Y9   A0A1Y9IVJ1   A0A182QTN6   A0A182LTG0   A0A182NU34   A0A1Y9IV94   A0A0Q9W1Y0   A0A1B6FNR6   A0A1B6JF99   A0A2M4ANU6   A0A151IUW5  

EC Number

2.7.11.30

Pubmed

19121390    26354079    22118469    15632085    17994087    25315136    + More
22936249    17550304    8289834    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    17510324    25830018    26483478    25348373    24495485    26108605    24438588   

EMBL

BABH01006725    BABH01006726    BABH01006727    KY328721    ASK12089.1    KQ461108    + More
KPJ09135.1    NWSH01000326    PCG77430.1    PCG77428.1    PCG77426.1    PCG77425.1    PCG77432.1    PCG77429.1    PCG77431.1    KQ459463    KPJ00600.1    AGBW02013811    OWR42744.1    PCG77433.1    PCG77427.1    PCG77423.1    PCG77424.1    PCG77434.1    ODYU01000800    SOQ36126.1    GFDL01001768    JAV33277.1    AJVK01011278    CM000071    ENO01712.1    OUUW01000001    SPP73925.1    CH479183    EDW36359.1    KRT02631.1    CH902619    KPU75898.1    CM000362    CM002911    EDX06268.1    KMY92389.1    SPP73924.1    KRT02632.1    CM000157    EDW89428.1    CH916367    EDW01781.1    KMY92391.1    KRT02633.1    CH954177    EDV59446.1    KPU75897.1    KRJ98433.1    KQS70828.1    KMY92390.1    EAL25863.3    U04692    AAA18959.1    KQS70827.1    KMY92392.1    CH933808    KRG04222.1    AE013599    AAF59011.1    KRJ98432.1    EDV35942.2    BT009976    AAQ22445.1    ACZ94371.1    SPP73926.1    CH477225    EAT47154.1    GBXI01009943    JAD04349.1    CH964154    KRF99165.1    AAM71094.1    EDW79815.2    JXUM01030571    JXUM01030572    JXUM01030573    KQ560889    KXJ80467.1    GAKP01003914    JAC55038.1    GBXI01011185    JAD03107.1    CH480816    EDW47022.1    AJWK01011290    GDHF01003793    JAI48521.1    GANO01001696    JAB58175.1    GDHF01032624    JAI19690.1    GBXI01011719    JAD02573.1    EDW08675.2    KRG04223.1    GFDF01007403    JAV06681.1    GFDF01007404    JAV06680.1    GAMC01018222    JAB88333.1    GFDF01007406    JAV06678.1    GFDF01007405    JAV06679.1    GAMC01018224    JAB88331.1    JXJN01015940    JRES01000182    KNC33546.1    CCAG010018535    ATLV01020378    ATLV01020379    ATLV01020380    KE525299    KFB45217.1    CH940648    EDW59897.1    KRF79147.1    KRF79145.1    AXCN02000776    AXCM01003318    KRF79146.1    GECZ01017970    JAS51799.1    GECU01009841    JAS97865.1    GGFK01009106    MBW42427.1    KQ980945    KYN11252.1   

Proteomes

UP000005204    UP000053240    UP000218220    UP000053268    UP000007151    UP000092462    + More
UP000192221    UP000001819    UP000268350    UP000008744    UP000095301    UP000007801    UP000000304    UP000002282    UP000095300    UP000001070    UP000008711    UP000009192    UP000000803    UP000008820    UP000007798    UP000069940    UP000249989    UP000001292    UP000092461    UP000091820    UP000078200    UP000092443    UP000092460    UP000037069    UP000092444    UP000030765    UP000008792    UP000075920    UP000075886    UP000075883    UP000075884    UP000078492   

PRIDE

H9ITM1    Q23975    A1Z7L9    A1Z7L8   

Pfam

PF07714   Pkinase_Tyr        + More
PF08515   TGF_beta_GS
PF01064   Activin_recp
PF00069   Pkinase

Interpro

IPR003605   GS_dom        + More
IPR000719   Prot_kinase_dom       
IPR008271   Ser/Thr_kinase_AS       
IPR001245   Ser-Thr/Tyr_kinase_cat_dom       
IPR011009   Kinase-like_dom_sf       
IPR017441   Protein_kinase_ATP_BS       
IPR000333   TGFB_receptor       
IPR000472   Activin_recp       
IPR017194   Transform_growth_fac-b_typ-2       

SUPFAM

SSF56112   SSF56112       

ProteinModelPortal

H9ITM1   A0A220QT61   A0A194QVZ3   A0A2A4K181   A0A2A4K0I3   A0A2A4K085   + More
A0A2A4JZI3   A0A2A4K1B7   A0A2A4K052   A0A2A4JZJ2   A0A194Q6G9   A0A212EMN2   A0A2A4K0Z4   A0A2A4JZK3   A0A2A4K0Y3   A0A2A4K0J8   A0A2A4K0K7   A0A2H1V5S4   A0A1Q3G0F9   A0A1B0D486   A0A1W4UY47   A0A1W4UZF9   A0A1W4UKW5   N6W4E6   A0A3B0IZZ5   B4GIN9   A0A1W4UXU3   A0A1I8NCQ2   A0A0R3NNR5   A0A0P8XMK2   B4QGP3   A0A3B0IZP4   A0A0R3NNL0   B4P3F5   A0A1I8PXB6   B4J5D9   A0A0J9R8L6   A0A0R3NNU5   B3N833   A0A0P9ACU6   A0A0R1DTJ7   A0A0Q5WBX1   A0A0J9TWT2   Q28YV2   Q23975   A0A0Q5WKQ1   A0A1I8NCP3   A0A1I8PXB2   A0A0J9R8G5   A0A0Q9XHD7   A1Z7L9   A0A0R1DTF7   A0A1I8NCP7   B3MI97   Q7YU60   A0A3B0JL14   Q17KD7   A0A1I8PXG0   A0A0A1WZ77   A0A0Q9X2Q0   A0A1I8PXC9   A1Z7L8   B4N626   A0A182H9M3   A0A034WMN3   A0A0A1WW58   B4HSC7   A0A1B0ETQ7   A0A0K8WBI6   U5EYZ8   A0A0K8U047   A0A0A1WVW6   B4KLN9   A0A0Q9X7D9   A0A1L8DJT4   A0A1L8DK04   W8AUF0   A0A1A9W2G1   A0A1L8DJN7   A0A1L8DJM3   A0A1A9UZD4   W8B4V7   A0A1A9YEV6   A0A1B0BKH0   A0A0L0CMN7   A0A1B0GA96   A0A084W4S3   B4LLJ2   A0A0Q9WDW8   A0A0Q9W1Y9   A0A1Y9IVJ1   A0A182QTN6   A0A182LTG0   A0A182NU34   A0A1Y9IV94   A0A0Q9W1Y0   A0A1B6FNR6   A0A1B6JF99   A0A2M4ANU6   A0A151IUW5  

PDB

1PY5     E-value=8.29143e-137,     Score=1248

KEGG

101742113    K04674 TGF-beta receptor type-1 [EC:2.7.11.30] | (RefSeq) TGF-beta receptor type-1

PATHWAY

04068    FoxO signaling pathway - Bombyx mori (domestic silkworm)
04144    Endocytosis - Bombyx mori (domestic silkworm)
04350    TGF-beta signaling pathway - Bombyx mori (domestic silkworm)
04933    AGE-RAGE signaling pathway in diabetic complications - Bombyx mori (domestic silkworm)

GO

GO:0046872   GO:0016021   GO:0005524   GO:0004675   GO:0007179   GO:0043235   GO:0048179   GO:0008340   GO:0007476   GO:0007411   GO:0030513   GO:0007455   GO:0048185   GO:0010862   GO:0016319   GO:0032924   GO:0007405   GO:0009411   GO:0007346   GO:0010507   GO:0046332   GO:0005025   GO:0019838   GO:0005887   GO:0007389   GO:0048813   GO:0007165   GO:0004672   GO:0004703   GO:0016361   GO:0005024   GO:0048666   GO:0006468   GO:0005886   GO:0016020   GO:0004713   GO:0003707   GO:0007169  

PANTHER

PTHR23255  

Subcellular location

Membrane  

Length:

403

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

22.20615

Exp number, first 60 AAs:

21.85738

Total prob of N-in:

0.34797

POSSIBLE N-term signal

sequence

outside

1  -  23

TMhelix

24  -  46

inside

47  -  403

 

 

Pi

0.425956

Theta

2.377599

Tajima's D

-1.939355

CLR

1.623493

CSRT

0.0126993650317484

Interpretation

Possibly Positive selection