SGID Silkworm Genome Informatics Database
Gene
KWMTBOMO00169
Pre Gene Modal
BGIBMGA000602
Annotation
PREDICTED:_epidermal_growth_factor_receptor_isoform_X2_[Amyelois_transitella]
Full name
Receptor protein-tyrosine kinase       + More
Epidermal growth factor receptor      
Location in the cell
Extracellular   Reliability : 2.183
 

Sequence

CDS
ATGTCAGTCCCGTCGAATCGCGACACCCACTACCGGAATCTTCGCGATCGCTTCACCAACTGTACCTACGTAGACGGGAACCTCGAGCTGACATGGCTGGAGAACGAGTCAATGGATTTGTCGTTCCTGAAGTACATACGAGAGGTGACAGGTTACGTCCTAATATCGCATGTGAAAGTTCACAAAATCGTCCTGCCCCAGCTGCAAATAATTCGTGGGCGGACTCTTTTCAAATTGAACGTGAGAGAAGAAGAATTCGCACTCTTGGTTACTATGTCCACGGCTTTCACCCTGGAGTTACCGGCTCTACGAGATGTACTCCAAGGAAGCGTGGGTATATATAGTAACTTTAATCTTTGCCACGTCAAAACTATTAATTGGGACGAAATAATATCAGGACCTAACGCAAGTTACGTTTACGTTTATAATTTTGCCACTCGGGAAAGGGAATGCCCGCGTTGTCACCCAGCCTGCAAGATGGGCTGCTGGGGAGAAGGTATTGAAAATTGCCAGAAATTCTCTAAAACAATTTGCAGTCCACAGTGTGCGCAGGGACGCTGCTTTGGACCCAATCCGAGAGACTGTTGTAATACGTTCTGTGCAGGTGGATGCACCGGCCCATTGCCCACTCAATGTCTAGCTTGCCGAAACTTTTACGATGAAGGAACATGCTCACAAGAATGCCCTTCAATGCAAATATACAATCCCACCACTTATTCGTGGGAGCCTAACCCCAATGGAAAATATGCATACGGTGCGACATGTGTAAGGAATTGCCCTGAGCATCTCTTAAAAGATAACGGCGCTTGTGTTCGAAGCTGCCCTCCGAATAAAACTGCCGTGAATGGAGAATGTATACCTTGCGTTGGTACTTGTCCCAAGACTTGTCGAGCTGAAAAACCAATTCATTCCGGAAACATTGATTCCTTTAAAGACTGTACTATAATAGATGGTTCTATTGAAATTTTGGAAATGACATTTACTGGATTCCAGCAAGTGAATCAGGACTATTCTTTTGGTGAACGATATCCAAAAATGGAACCAGATGCTTTAGAAGTATTCAGCACTGTTCGCGAAGTCACCGGCTATCTAAATGTTCAAGCACATCATCCGAATTTCACAAGTCTATCTTACTTCCGGAACCTAGAAGTAATAGGAGGACGCCAAGTCGTTGAAAACCTATTTGCATCTCTCTACATAGTCAAAACATCTTTGAAGTCTCTCGGATTAAAATCCTTGAAGAAAGTTAACTCAGGTGCAATAGCCATAATGGAAAACAGAAATCTTTGTTACGCTGACAAAATAGCATGGAATAAACTTGTGAAATCTAAGGACCATAAACAGATCATACAGAAGAACGGCGATCCAAGACAGTGTGAAAAAAACAATTTGGTATGTGATCCACAATGCTCTGCGGATGGGTGCTGGGGCCCGGGGCCTGATCAGTGCCTCTCCTGTCAAAACTACAATTTCGGCGAAATCTGTATCGATAACTGCAGCGTTCATCCAGGATTGTACAAGGCTGACCACAAAAGCTGTAAGCAATGTCACTCGGAGTGCCTTGACGGATGCACTGGAGCAAGTCGGGCGAACTGCACCTCCTGTAAGCATGTCCGAGATGGCCCTTACTGTGTTGCCCAGTGTCCTGAATCAAGATATGCCTCAGAAAATGGAACGTGTCACCCATGTCATCCTAATTGCAATAATGGTTGCACGGGTCCTGCGAACACTGTCGGAGAAGGCGGATGTAATTCCTGCAATAAAGCTATAATAAGTGTTGAAGCCACAGTTGAAAGCTGTCTCAAGGAAGACGAACCGTGTCCAGACGGGTATTATAACGAGTGGGTCGGTAACGTTAAACCTTTAGAAGGAAAAGTGAAAATAGCGTGCAGAAAATGCCATCCCCTATGTATTAAATGTGTAGGATTTGGAATCCATGAACAAGTATGTCAAGTATGTAACGGTTTCAAAAGAGGGGATCAATGTGAGGATGAGTGTCCATCAGATCATTTCACTGATGAAATCGGCAGAAATTGTACACCTTGTCACTCAGAATGTAAAGGCTGTACTGGACCTGGTCCCACAGATTGCATCAAATGTAAAAATCTAAAGATATTCTTGGGTGGTTCTGATGCGAGCGACGAAAACGCTCCATTCAACTGCACTGATACATGTCCAGATAATATTCCTAATAAAATATATTTTGATGAACAATTACAAGACCCAATCGAAGAGCCGTATTGTTCTGAACACGCCAATGATATCCCAACCGCAACTGCAAGAACATCAACAGTTTTAGTTATAATTCTGGTCATAGCTTCCTTGTTCTTGGCGGTTCTTGCCATAATTGGATATAATTTCCGTCAAAAAGCAAAAGCAAAGAAAGAAGCTGTCAAAATGACGATGGTGTTGACAGGGTGTGAAGACAACGAACCACTGCGTCCAACTAACGTCAAACCAAATCTTGCCAAATTAAGAATAGTAAAGGAAGCTGAGCTTCGCAGGGGTGGTATGTTAGGATTTGGTGCTTTTGGAAAAGTATACAAGGGCGTATGGGTTCCTGAGGGAGAAAACGTTAAAATACCTGTCGCTATAAAAGTGCTAAAAGAGACAACAGGTGCGAACACTAGTAAAGAATTTTTAGAAGAAGCTTACATAATGGCTAGCGTCGAACATCCAAACCTATTACAACTTCTAGCTGTATGCATGACCAATCAAATGATGCTCATCACTCAGTTAATGCCGTTGGGGTGCTTAGTTGACTATGTGAGAACACATAAAGAGAAAATAGGATCGAAAGCATTCCTTAACTGGTGCACACAAATAGCTAGAGGAATGGCATACTTAGAAGAAAAAAGATTAGTGCACAGGGATTTGGCAGCCCGTAATGTTTTAGTACAAACTCCCAACTCAGTTAAAATAACTGATTTTGGACTAGCCAAGCTATTAGATATAAATGAAGACGAGTACAAAGCAGCTGGAGGTAAAATGCCAATAAAATGGTTGGCACTAGAATGTATACAACATAGAATTTTCACCCACAAAAGTGATGTTTGGGCTTTTGGTGTTACAATTTGGGAGATTCTCAGTTATGGCGCCCGACCTTACGAGAATATCTCAGCACGAAATGTACCCGAACTAATTGAAAATGGATTGAAATTACCGCAACCGAGTATTTGCACGTTGGACATTTATTGTGTTATGGTATCATGTTGGATGTTAGATGCGGATAGCAGACCGACCTTCAAACAACTAGCTGATACATTCGCTGAAATGGCGAGAGACCCTGGTAGATATCTTGTTATTCCTGGAGACAAGTTTATGCGCCTTCCATCCTACTCGACACAGGATGAAAAGGAAATGATAAGAAATTTGTCATCGGCTATGGAAGGTCCAGAATCACTAGTTGATGCCGACGAATATCTACAACCTAAATTCAAAAGTATGACAGGTACAGTGACGACCAACTCCGCTCTCAGTGCGGGCATGGAAACCCAAACCAGCTCACTGAAACCCTGTACATCTTCTTCGTGGCCTAATAATGCTGGTCAAGACGGGGTCCCCGACCCATCTACTAAGCCTGAAAATTGGGATCACGAAATGTTGCGATACAACAATCAACTGAATCCCGATGGCTCAGAAGTACGTCATTACTATAATAACGGCGTATGCGCGTCTGACACTTCGAGTTCGAGATATTGCAGCGATCCTATGAAAACGAGAACCGAAGTATCTTTGGAAGATAACTTCGACGGCATGTCCAAGGCAAAAGAAGCTCAAGTCGGTAATTTAAAACTGAACTTACCGTTGGACGAAGATGACTACTTGATGCCTTCCCCACAACATACTCAGAACGCTTCGACGTATATGGATCTGATCAGCGAAGGCTGCGAAGGACAAGACGTTAACGACATCCGTTTCGGGGAATTCGTGAGTTCTAAACGTTGCATCGACAACCCTGAATACTTAATGTCAGAAGAAAGCGTACCGCCTCAGACGTTGGGTATCCCGACCGAACCAGTTCCACTGGAGTCACTGTCCGCGAGCGAAGAAAGCGCCGATACCACACCTCGTCCAGGTACTAGCAATTATATGCCGCAGCGTTCTGTAGAGGAGGAGTCCATGTCAGACCACGAGTACTACAATGATCTGCAACGAGAGCTCCAACCTCTACGACGGAATGAAACGACCGTCTGA
Protein
MSVPSNRDTHYRNLRDRFTNCTYVDGNLELTWLENESMDLSFLKYIREVTGYVLISHVKVHKIVLPQLQIIRGRTLFKLNVREEEFALLVTMSTAFTLELPALRDVLQGSVGIYSNFNLCHVKTINWDEIISGPNASYVYVYNFATRERECPRCHPACKMGCWGEGIENCQKFSKTICSPQCAQGRCFGPNPRDCCNTFCAGGCTGPLPTQCLACRNFYDEGTCSQECPSMQIYNPTTYSWEPNPNGKYAYGATCVRNCPEHLLKDNGACVRSCPPNKTAVNGECIPCVGTCPKTCRAEKPIHSGNIDSFKDCTIIDGSIEILEMTFTGFQQVNQDYSFGERYPKMEPDALEVFSTVREVTGYLNVQAHHPNFTSLSYFRNLEVIGGRQVVENLFASLYIVKTSLKSLGLKSLKKVNSGAIAIMENRNLCYADKIAWNKLVKSKDHKQIIQKNGDPRQCEKNNLVCDPQCSADGCWGPGPDQCLSCQNYNFGEICIDNCSVHPGLYKADHKSCKQCHSECLDGCTGASRANCTSCKHVRDGPYCVAQCPESRYASENGTCHPCHPNCNNGCTGPANTVGEGGCNSCNKAIISVEATVESCLKEDEPCPDGYYNEWVGNVKPLEGKVKIACRKCHPLCIKCVGFGIHEQVCQVCNGFKRGDQCEDECPSDHFTDEIGRNCTPCHSECKGCTGPGPTDCIKCKNLKIFLGGSDASDENAPFNCTDTCPDNIPNKIYFDEQLQDPIEEPYCSEHANDIPTATARTSTVLVIILVIASLFLAVLAIIGYNFRQKAKAKKEAVKMTMVLTGCEDNEPLRPTNVKPNLAKLRIVKEAELRRGGMLGFGAFGKVYKGVWVPEGENVKIPVAIKVLKETTGANTSKEFLEEAYIMASVEHPNLLQLLAVCMTNQMMLITQLMPLGCLVDYVRTHKEKIGSKAFLNWCTQIARGMAYLEEKRLVHRDLAARNVLVQTPNSVKITDFGLAKLLDINEDEYKAAGGKMPIKWLALECIQHRIFTHKSDVWAFGVTIWEILSYGARPYENISARNVPELIENGLKLPQPSICTLDIYCVMVSCWMLDADSRPTFKQLADTFAEMARDPGRYLVIPGDKFMRLPSYSTQDEKEMIRNLSSAMEGPESLVDADEYLQPKFKSMTGTVTTNSALSAGMETQTSSLKPCTSSSWPNNAGQDGVPDPSTKPENWDHEMLRYNNQLNPDGSEVRHYYNNGVCASDTSSSRYCSDPMKTRTEVSLEDNFDGMSKAKEAQVGNLKLNLPLDEDDYLMPSPQHTQNASTYMDLISEGCEGQDVNDIRFGEFVSSKRCIDNPEYLMSEESVPPQTLGIPTEPVPLESLSASEESADTTPRPGTSNYMPQRSVEEESMSDHEYYNDLQRELQPLRRNETTV

Summary

Description
Upon binding to its ligands, transduces the signal through the ras-raf-MAPK pathway and is involved in a myriad of developmental decisions (By similarity). Involved in the determination of adult size, ovary development, and development timing, especially during queen determination of honeybee larvae. May have an important role in the prolongation of longevity in queens.
Catalytic Activity
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]
Similarity
Belongs to the protein kinase superfamily. Tyr protein kinase family.
Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
Keywords
ATP-binding   Complete proteome   Developmental protein   Glycoprotein   Kinase   Membrane   Nucleotide-binding   Phosphoprotein   Receptor   Reference proteome   Transferase   Transmembrane   Transmembrane helix   Tyrosine-protein kinase  
Feature
chain  Receptor protein-tyrosine kinase
EC Number
2.7.10.1
EMBL
BABH01006695    JTDY01001461    KOB73812.1    KZ149901    PZC78508.1    KQ461108    + More
KPJ09202.1    AGBW02007654    OWR54879.1    NWSH01001050    PCG72920.1    KQ459594    KPI96184.1    KQ435816    KOX72629.1    KQ981523    KYN40202.1    KK852768    KDR16947.1    LN623701    CEG62429.1    QOIP01000002    RLU25658.1    KQ976530    KYM81713.1    GL444289    EFN60989.1    KQ434772    KZC03931.1    KQ414736    KOC62098.1    ADTU01007302    KQ982753    KYQ51232.1    KQ976885    KYN07395.1    AAZX01003361    AAZX01005802    GBYB01001130    GBYB01001133    JAG70897.1    JAG70900.1    GBYB01001132    JAG70899.1    GEZM01096444    JAV54909.1    GEZM01096443    JAV54910.1    GDIP01203761    JAJ19641.1    GDIQ01269859    JAJ81865.1    GDIP01218056    JAJ05346.1    GDIQ01137057    GDIQ01137056    JAL14669.1    GDIP01203713    JAJ19689.1    GDIP01062782    JAM40933.1    GDIQ01174598    JAK77127.1    GDIQ01116367    GDIQ01080224    GDIQ01061731    JAN14513.1    LRGB01001764    KZS10602.1    GDIQ01159557    JAK92168.1    GDIP01081726    JAM21989.1    GDIQ01230988    JAK20737.1    GDIP01160466    JAJ62936.1    GDIQ01083225    JAN11512.1    GDIQ01192189    JAK59536.1    GDIP01167414    JAJ55988.1    GDIQ01109123    JAL42603.1    GDIP01168513    JAJ54889.1    GDIP01224813    JAI98588.1    GDIP01081725    JAM21990.1    GDIP01166716    JAJ56686.1    GDIQ01193942    JAK57783.1    GDIQ01174599    JAK77126.1    GDIQ01174597    GDIQ01057233    JAK77128.1    GDIQ01059734    JAN35003.1    GDIP01121367    JAL82347.1    GDIP01121365    JAL82349.1    GDIP01119368    JAL84346.1    GDIP01176359    JAJ47043.1    GDIQ01186685    JAK65040.1    GDIQ01236478    JAK15247.1    GDIQ01026550    JAN68187.1    GDIP01212261    JAJ11141.1    GDIP01205914    JAJ17488.1    GDIQ01148953    JAL02773.1    GDIP01205913    JAJ17489.1    GDIP01053344    JAM50371.1    GDIQ01050447    JAN44290.1    GDIP01230668    JAI92733.1    KQ765917    OAD53778.1    GDIQ01069330    JAN25407.1    GDIP01125070    JAL78644.1    KT355580    ALV82499.1    GDIP01122969    JAL80745.1    GDIQ01110871    JAL40855.1    GDIP01121366    JAL82348.1    GBGD01000112    JAC88777.1    DS235873    EEB19606.1    ADMH02001307    ETN63066.1    GGFK01001407    MBW34728.1    GGFK01001436    MBW34757.1    GGFJ01000422    MBW49563.1    GGFM01001250    MBW22001.1    GGFJ01000455    MBW49596.1    KQ971334    EFA01355.2    CH477299    EAT44302.1    GDIQ01139506    JAL12220.1    KK107069    EZA60762.1    GDIQ01165257    JAK86468.1    AB300616    BAG65666.1    GL888096    EGI67610.1    GDIP01102669    JAM01046.1    GDIQ01041249    JAN53488.1    GDIQ01201391    JAK50334.1    GDIP01239660    JAI83741.1    ATLV01016146    KE525057    KFB41066.1    LJIG01022823    KRT78532.1    GDIP01220758    JAJ02644.1    GANP01015190    JAB69278.1    GANP01004642    JAB79826.1    GDIP01102667    JAM01048.1   
Pfam
PF14843   GF_recep_IV        + More
PF01030   Recep_L_domain
PF00757   Furin-like
PF07714   Pkinase_Tyr
Interpro
IPR008266   Tyr_kinase_AS        + More
IPR006212   Furin_repeat       
IPR001245   Ser-Thr/Tyr_kinase_cat_dom       
IPR011009   Kinase-like_dom_sf       
IPR020635   Tyr_kinase_cat_dom       
IPR017441   Protein_kinase_ATP_BS       
IPR006211   Furin-like_Cys-rich_dom       
IPR000494   Rcpt_L-dom       
IPR016245   Tyr_kinase_EGF/ERB/XmrK_rcpt       
IPR032778   GF_recep_IV       
IPR000719   Prot_kinase_dom       
IPR009030   Growth_fac_rcpt_cys_sf       
IPR036941   Rcpt_L-dom_sf       
IPR017896   4Fe4S_Fe-S-bd       
SUPFAM
SSF57184   SSF57184        + More
SSF56112   SSF56112       
Gene 3D
PDB
3LTG     E-value=0,     Score=1803

Ontologies

Topology

Subcellular location
Membrane  
Length:
1398
Number of predicted TMHs:
2
Exp number of AAs in TMHs:
41.31794
Exp number, first 60 AAs:
0.02329
Total prob of N-in:
0.01905
outside
1  -  764
TMhelix
765  -  787
inside
788  -  893
TMhelix
894  -  916
outside
917  -  1398
 
 

Population Genetic Test Statistics

Pi
20.000915
Theta
21.478596
Tajima's D
-0.801423
CLR
0.026249
CSRT
0.180740962951852
Interpretation
Uncertain
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