Gene

KWMTBOMO00167  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA000603

Annotation

PREDICTED:_JNK-interacting_protein_3_isoform_X2_[Bombyx_mori]

Location

Bomo_Chr1(-):5268213-5305556      View in EpiBrowser

Full name

C-Jun-amino-terminal kinase-interacting protein 4      

Alternative Name

JNK-associated leucine-zipper protein
JNK/SAPK-associated protein 2
Mitogen-activated protein kinase 8-interacting protein 4
Sperm-associated antigen 9

Location in the cell

Nuclear   Reliability : 3.454

CDS

ATGAATTTCGACGACAGTGCGAGCAGCGGGTATGTTACCAATGAGACCATATACGGAACTCATGAAGATTCTCACGTAGTTATGTCAGAGAAGGTACAATCTCTTGCTGGAAGTATCTACCAAGAGTTCGAACGTATGATAGCGCGATATGATGAGGATGTAGTAAAAACATTGATGCCACTTCTAGTGAATGTATTAGAGTGCTTGGATTCAGCCTATCAGACGAATCAAGAGCACGAGGTGGAACTAGAGCTATTGCGAGAAGACAACGAGCAGTTAGTTACGCAGTATGAACGCGAGAAGGCAGCCAGGAAGTACGCTGAACAGAAGTTACTGGAAGCTGAGGATCATTATGAAGGAGAAAGAAAAGACTTGACTGGCCGTTTAGAAGCACTGGATAGTATCGTGAGAATGTTAGAACTTAAACACAAGAACTCCTTGGATCATGCTAGTAGACTCGAAGAAAGAGAAAATGAATTGAAAAAAGAATATGCAAAGTTGCATGAAAGGTACACCGAGCTATTTAAAACTCACATGGACTATATGGAAAGAACAAAGCTACTTCTAAGCACAGCAAGTGATAGAAGCGAAGTTCGAGGCCGACTGGGACTCAATCCTGTTGGAAGGTCTAGTGGTCCGATATCGTTTGGTTTCGCATCTCTAGAAAGTTCTATGAACGCGATAGAACAGACCGAAAGTATTCCTGGTAGTCCTGTCAGCTTGTCGTCGTCACCGCCATCGCCGCCCATCGGAGCCGAACTAGCGGCCGTGAGGACGGTCGAAAGAGCTCACCAGACAGATGCCATAACACAACAAAGTCAGGCAACGTCGCCTGTCGCTCTCCCGAATTCAAACATCGGAAAATCTCAGACTAAGAGCGAAAAACGAAGTGGTAACACTTTGTATCAGGAGTTGGCTTTCCATGACACCGATGCGAGCATTGCCGAATCACAAGGCGATGAAGGTGCTGACATCACAGGTAGCTGGGTGCATCCTGGAGAATATGCGTCTTCTGGCATGGGGAAAGAAGTCGAAAACTTGATACTGGAGAACAACGAATTATTGGCCACGAAGAACGCTTTGAACGTTGTCAAGGACGACCTTATAGTGAAGGTGGACGAGTTGACCGGCGAACAGGAGATGCTTCGAGAAGAAGTGGCCAATCTAAGTTCGGCGCGAGAGAAACTTAGAGATCGGGTGACTCAATTGGAGGATGAATTGCGACGTTTGAAGGAGGCGATGAGCAACAACGCCGGCGGTGGGGACAACGAGGAGGAAGCCGACGTCCCGTTGGCGCAGAGACGCCGCTTCACGCGCGTCGAGATGGCACGTGTCCTCATGGAACGTAACCAATATAAGGAACGATTAATGGAGCTTCAAGATGCCGTTCGCTGGACCGAGATGGTTCGTGCCAGTCGCGTGGACAACTCCATCGACAAGAAGAGCAAGCAGAGCATATGGACTTTTTTTAGTAAACTATTCAGTTCGAACGATCGTCCACAAAGACCGCTTTCCACTCCTCATCTAAGAGCCGTGGCCGCCTCACAGCCTACGATGAGACATTCACAAACCCAAGGCGACTTCTTGGAGGCGCAGCTTTCCGACCACCACCAGAAGCGACACGAGAGAACCGAACAATTCCGACAGGTGCGGGTACATGTGCGTAAGGAAGACGGGCGCACGCACGCTTACGGTTGGAGTCTCCCGGGGAAGAACAGCCAGGGACAGAAGGGACCGAGCCCCTCAGCGTCCCTGTCGTCGGGGGGAGTTCCGGTACCAGTTCCGGTTTTTTGTCGCCCGATAGCGGAGAGTGAGCCGCGTATGACTCTGCTGTGTGCGGCCGGCGTAAACCTGAACGGAGGTAGGACTCCGGATGGAGGCTGCATGATTGGTGAGAGCGTTTTCTACGCAAATGAAGACGATAAGACGGAGAACAATATGTCCTTAGCCTACGAGATGAGCAAAGCGCAGTCAGCGCATTCTCCGGAGGTCGAGCAGATCAGCAGACAGCTGCAGTCAACTCAGAGCGTGGAGTACACTGAAAAGAATCTGTCCTCGTTGGTTTGGATATGTGCTAGTACACAGGCTAAAGGAGTGGTTATGATCATCGATGCGAACAATCCGGCGGACGTGATCGAATCCTTTTCAGTGAGCGATAAGCATATTCTCTGTGTAGCTTCAGTGCCTGGTGCCACTTCAGAAGATTATCAAGATTACGAAGAACGAATGTCTGGGGACACCGAAACGAAGCGTCATTCGTCGTTGTTATGCGTGGGAAAGAGTGAGTCTGTGGAGAGCCAACCTAATGGCCCCGTCGAGGACACGAACACGGAGAACACTGAAAACGAAACTGTAATTGGAACTACTAAATTGATAAAGGCAACCCTTCTAACTCCACCGAGTACTCCCGTGAAGGAGCCAGAAGAACCAGCTGCTGATAATGACGAGAATCCCAAAGAATCGATGGTCAAGAATGTTGAAGACGAAGCAGAGAACGACGGTCATGACAGTCCGCCACTAAGCTCCACTCCTAATAATGTAACGGAGCCATCGGTCAGTTCACCGGAGCCCGGATTGGACGCGTTCGCACAGGAACAATCGAACGTCGAGAACCGCGGCGATGTACCGGACCGAAAGATGTCCACCGTGATGGCGACGATGTGGCTAGGAACCAAAAACGGAAACCTATACGTACATTCCGCAATGGGAAACTACAGCAAGTGCTTGGCAAGGATCAAACTGAACGATGCTATATTGGCCATAGTGTCGTGTGCTTCTCGTTGCGTGGTCGCTCTCGCTGATGGAACGGTAGCTATATTTGCCCGACTTGCAGATGGACAGTGGGATTTCACTCAGTATTGGCTCATGACTCTAGGCGATTCTAAATGTTCAGTGCGATGTCTCAGTGCGGTCGGCTGTACGGTTTGGTGCGGTTACCGCAACAAGGTCCAGGTGATCGATCCTCGTACGAGACAACTACTTCACACCCTCGAAGCTCATCCTAGACAAGAGAGTCAAGTGCGACAGATGGCGTGTCACGGCGATGGAGTATGGGTATCGATAAAAATGGACTCCACCCTCGGTCTGTACCACGCGCACACATACAAGAACTTGTGCAACGTCGACATCGAACCGTACGTGAGCAAAATGCTCGGAACGGGCAAACTTGGATTCTCTCTGGTCAGGATCACGGCGCTTCTAATCAGTTCCGGGCGTCTTTGGATCGGAACCAGCAATGGGGTTGTTATATCCGTGCCACTGTCCGAAGCTAATCGAGATCCGATTCATGCAACATTAAATCGAACGAGATCCGCGAGTCCGACTGGGGTTATACCCTGGTGCTCGATGGCTCACGCCCAGCTCAGCTTCCACGGTCACCGGGACGCGGTCAAGTTCTTCGTGGCGGTACCGGGGGCCGCTAGTTCGTCAGCCAGAACACCGGAGTCGCCCCAGCAAGGTTCGAACCAGCCGCCGATGCTGGTCATATCCGGAGGCGAGGGATATATTGACTTTAGAATAGCCGACTCGGAGATGGAGGACAGCGTGGTGGTAGCCGAAGATGGTTCCTCGAGTGGCCACAGCTCGTTAATTGAGAGGGCCTCTAAGAGTCACTTGATAGTGTGGCAAGTAGCGACGGCCTAA

Protein

MNFDDSASSGYVTNETIYGTHEDSHVVMSEKVQSLAGSIYQEFERMIARYDEDVVKTLMPLLVNVLECLDSAYQTNQEHEVELELLREDNEQLVTQYEREKAARKYAEQKLLEAEDHYEGERKDLTGRLEALDSIVRMLELKHKNSLDHASRLEERENELKKEYAKLHERYTELFKTHMDYMERTKLLLSTASDRSEVRGRLGLNPVGRSSGPISFGFASLESSMNAIEQTESIPGSPVSLSSSPPSPPIGAELAAVRTVERAHQTDAITQQSQATSPVALPNSNIGKSQTKSEKRSGNTLYQELAFHDTDASIAESQGDEGADITGSWVHPGEYASSGMGKEVENLILENNELLATKNALNVVKDDLIVKVDELTGEQEMLREEVANLSSAREKLRDRVTQLEDELRRLKEAMSNNAGGGDNEEEADVPLAQRRRFTRVEMARVLMERNQYKERLMELQDAVRWTEMVRASRVDNSIDKKSKQSIWTFFSKLFSSNDRPQRPLSTPHLRAVAASQPTMRHSQTQGDFLEAQLSDHHQKRHERTEQFRQVRVHVRKEDGRTHAYGWSLPGKNSQGQKGPSPSASLSSGGVPVPVPVFCRPIAESEPRMTLLCAAGVNLNGGRTPDGGCMIGESVFYANEDDKTENNMSLAYEMSKAQSAHSPEVEQISRQLQSTQSVEYTEKNLSSLVWICASTQAKGVVMIIDANNPADVIESFSVSDKHILCVASVPGATSEDYQDYEERMSGDTETKRHSSLLCVGKSESVESQPNGPVEDTNTENTENETVIGTTKLIKATLLTPPSTPVKEPEEPAADNDENPKESMVKNVEDEAENDGHDSPPLSSTPNNVTEPSVSSPEPGLDAFAQEQSNVENRGDVPDRKMSTVMATMWLGTKNGNLYVHSAMGNYSKCLARIKLNDAILAIVSCASRCVVALADGTVAIFARLADGQWDFTQYWLMTLGDSKCSVRCLSAVGCTVWCGYRNKVQVIDPRTRQLLHTLEAHPRQESQVRQMACHGDGVWVSIKMDSTLGLYHAHTYKNLCNVDIEPYVSKMLGTGKLGFSLVRITALLISSGRLWIGTSNGVVISVPLSEANRDPIHATLNRTRSASPTGVIPWCSMAHAQLSFHGHRDAVKFFVAVPGAASSSARTPESPQQGSNQPPMLVISGGEGYIDFRIADSEMEDSVVVAEDGSSSGHSSLIERASKSHLIVWQVATA

Description

The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module.

Subunit

Homodimer. The homodimer interacts with ARF6, forming a heterotetramer (By similarity). Homooligomer. Interacts with MAX, MAPK8, MAPK14, MAPK10, MAPK14, MAP3K3, MYC, KNS2, and MAP2K4. Interaction with KNS2 is important in the formation of ternary complex with MAPK8.

Similarity

Belongs to the JIP scaffold family.

Keywords

Acetylation   Alternative splicing   Coiled coil   Complete proteome   Cytoplasm   Phosphoprotein   Reference proteome  

Feature

chain  C-Jun-amino-terminal kinase-interacting protein 4
splice variant  In isoform 6.

Uniprot

H9ITM3   A0A2H1VN22   A0A194Q4Y3   A0A212FMC1   V5GTY7   V5GI32   + More
A0A154PDH8   A0A2A3EP43   A0A0N0U630   A0A195E439   A0A1B6HN80   A0A0L7R9H8   A0A1B6DJ19   A0A195BU43   A0A310SKA3   A0A158P2A9   A0A1B6IUX2   A0A232EYH2   A0A1J1I612   E2AJX5   Q16LZ1   A0A1B6FKZ4   U4U4V0   N6TG04   A0A182H5F5   A0A1B6DA52   A0A1B6E7J4   Q16LZ0   A0A0Q9WUY8   A0A023F2S2   A0A336LP60   A0A0Q9WXB8   A0A0Q9WVQ7   A0A0Q9XMH0   A0A1Q3G3V7   B4LHS0   A0A0C9RUK7   A0A069DXF2   A0A0Q9WJT5   A0A0Q9XJV9   A0A0Q9XEM4   A0A1A9XHV8   B4KUP2   A0A0Q9WKM9   A0A0Q9XPR3   A0A0V0G5K6   A0A0Q9WTS3   A0A1B6MMC8   A0A0Q9WVP6   A0A0Q9XC56   A0A1Q3G3Q0   A0A1B6MDW4   A0A1Q3G3R5   A0A0Q9XCA3   A0A0Q9XC34   A0A1Q3G3Q1   U4TXU9   N6UDF1   A0A0Q9XC33   A0A1A9WCE0   T1IY26   A0A2R5LMW2   A0A131XZH8   V5I520   A0A1L8DLI1   A0A1L8DLF4   A0A224X641   A0A087U4F5   A0A1S3IWE9   A0A1S3HFK4   A0A1S3HIM1   A0A1B6CAD9   R7V594   A0A1S2ZWB5   A0A1S2ZWB6   Q58A65-3   Q58A65-2   Q58A65   A0A1S2ZWC4   Q58A65-5   E9PUD1   A0A287AW88   A0A0R4J196   A0A1S2ZWC3   Q58A65-6   A0A337SBI1  

Pubmed

19121390    26354079    22118469    21347285    28648823    20798317    + More
17510324    23537049    26483478    17994087    25474469    26334808    18057021    25765539    26383154    23254933    12391307    15767678    15368895    16141072    19468303    15489334    15987681    17242355    19131326    21183079    17975172   

EMBL

BABH01006694    ODYU01003434    SOQ42196.1    KQ459463    KPJ00598.1    AGBW02007654    + More
OWR54877.1    GALX01004763    JAB63703.1    GALX01004762    JAB63704.1    KQ434869    KZC09250.1    KZ288202    PBC33487.1    KQ435742    KOX76702.1    KQ979657    KYN19950.1    GECU01031574    JAS76132.1    KQ414625    KOC67530.1    GEDC01011646    JAS25652.1    KQ976408    KYM91134.1    KQ762031    OAD56376.1    ADTU01007051    GECU01016967    JAS90739.1    NNAY01001595    OXU23482.1    CVRI01000042    CRK95704.1    GL440100    EFN66291.1    CH477886    EAT35356.1    GECZ01018914    JAS50855.1    KB631730    ERL85636.1    APGK01039256    KB740969    ENN76688.1    JXUM01004247    KQ560171    KXJ84024.1    GEDC01014798    JAS22500.1    GEDC01003395    JAS33903.1    EAT35357.1    CH940647    KRF85039.1    GBBI01003224    JAC15488.1    UFQS01000097    UFQT01000097    SSW99416.1    SSX19796.1    KRF85040.1    KRF85038.1    CH933809    KRG06110.1    GFDL01000596    JAV34449.1    EDW70645.1    GBYB01011271    JAG81038.1    GBGD01000146    JAC88743.1    KRF85037.1    KRG06106.1    KRG06105.1    EDW18270.1    KRF85042.1    KRG06104.1    GECL01002795    JAP03329.1    KRF85041.1    GEBQ01002879    JAT37098.1    KRF85043.1    KRF85044.1    KRG06107.1    GFDL01000610    JAV34435.1    GEBQ01005850    JAT34127.1    GFDL01000603    JAV34442.1    KRG06108.1    KRG06103.1    KRG06111.1    GFDL01000613    JAV34432.1    ERL85637.1    ENN76687.1    KRG06112.1    JH431669    GGLE01006703    MBY10829.1    GEFM01003377    JAP72419.1    GANP01000740    JAB83728.1    GFDF01006782    JAV07302.1    GFDF01006781    JAV07303.1    GFTR01008479    JAW07947.1    KK118105    KFM72244.1    GEDC01026877    JAS10421.1    AMQN01005076    KB295063    ELU13632.1    AF327451    AY823270    AB047782    AK172961    AK147431    AK147537    AL662838    BC060100    BC094670    AEMK02000080    AANG04003358   

Proteomes

UP000005204    UP000053268    UP000007151    UP000076502    UP000242457    UP000053105    + More
UP000078492    UP000053825    UP000078540    UP000005205    UP000215335    UP000183832    UP000000311    UP000008820    UP000030742    UP000019118    UP000069940    UP000249989    UP000008792    UP000009192    UP000092443    UP000091820    UP000054359    UP000085678    UP000014760    UP000079721    UP000000589    UP000008227    UP000011712   

PRIDE

H9ITM3    Q58A65    E9PUD1    A0A0R4J196   

Pfam

PF16471   JIP_LZII        + More
PF09744   Jnk-SapK_ap_N
PF02779   Transket_pyr
PF02780   Transketolase_C

Interpro

IPR036322   WD40_repeat_dom_sf        + More
IPR032486   JIP_LZII       
IPR034744   RH2       
IPR034743   RH1       
IPR039911   JIP3/JIP4       
IPR015943   WD40/YVTN_repeat-like_dom_sf       
IPR019143   JNK/Rab-associated_protein-1_N       
IPR011047   Quinoprotein_ADH-like_supfam       
IPR005475   Transketolase-like_Pyr-bd       
IPR009014   Transketo_C/PFOR_II       
IPR029061   THDP-binding       
IPR033248   Transketolase_C       
IPR011044   Quino_amine_DH_bsu       
IPR002119   Histone_H2A       
IPR009072   Histone-fold       

SUPFAM

SSF50978   SSF50978        + More
SSF50998   SSF50998       
SSF52922   SSF52922       
SSF52518   SSF52518       
SSF50969   SSF50969       
SSF47113   SSF47113       

Gene 3D

2.130.10.10     3.40.50.920     1.10.20.10    

ProteinModelPortal

H9ITM3   A0A2H1VN22   A0A194Q4Y3   A0A212FMC1   V5GTY7   V5GI32   + More
A0A154PDH8   A0A2A3EP43   A0A0N0U630   A0A195E439   A0A1B6HN80   A0A0L7R9H8   A0A1B6DJ19   A0A195BU43   A0A310SKA3   A0A158P2A9   A0A1B6IUX2   A0A232EYH2   A0A1J1I612   E2AJX5   Q16LZ1   A0A1B6FKZ4   U4U4V0   N6TG04   A0A182H5F5   A0A1B6DA52   A0A1B6E7J4   Q16LZ0   A0A0Q9WUY8   A0A023F2S2   A0A336LP60   A0A0Q9WXB8   A0A0Q9WVQ7   A0A0Q9XMH0   A0A1Q3G3V7   B4LHS0   A0A0C9RUK7   A0A069DXF2   A0A0Q9WJT5   A0A0Q9XJV9   A0A0Q9XEM4   A0A1A9XHV8   B4KUP2   A0A0Q9WKM9   A0A0Q9XPR3   A0A0V0G5K6   A0A0Q9WTS3   A0A1B6MMC8   A0A0Q9WVP6   A0A0Q9XC56   A0A1Q3G3Q0   A0A1B6MDW4   A0A1Q3G3R5   A0A0Q9XCA3   A0A0Q9XC34   A0A1Q3G3Q1   U4TXU9   N6UDF1   A0A0Q9XC33   A0A1A9WCE0   T1IY26   A0A2R5LMW2   A0A131XZH8   V5I520   A0A1L8DLI1   A0A1L8DLF4   A0A224X641   A0A087U4F5   A0A1S3IWE9   A0A1S3HFK4   A0A1S3HIM1   A0A1B6CAD9   R7V594   A0A1S2ZWB5   A0A1S2ZWB6   Q58A65-3   Q58A65-2   Q58A65   A0A1S2ZWC4   Q58A65-5   E9PUD1   A0A287AW88   A0A0R4J196   A0A1S2ZWC3   Q58A65-6   A0A337SBI1  

PDB

4PXJ     E-value=1.66662e-09,     Score=155

KEGG

101738756    K20317 c-Jun-amino-terminal kinase-interacting protein 4 | (RefSeq) JNK-interacting protein 3

GO

GO:0005078   GO:0003824   GO:0016301   GO:0030140   GO:0008088   GO:0043005   GO:0019894   GO:0016192   GO:0000786   GO:0003677   GO:0005634   GO:0046982   GO:0005737   GO:0000187   GO:0051260   GO:0005829   GO:0042147   GO:0048273   GO:0005815   GO:0008432   GO:0007257   GO:0030159   GO:0090074   GO:0043410   GO:0030335   GO:0045666   GO:0048471   GO:0051146   GO:0016021   GO:0005515   GO:0003676   GO:0000413   GO:0016020   GO:0043565   GO:0043401   GO:0003707   GO:0007169  

PANTHER

PTHR13886  

Subcellular location

Cytoplasm  
Perinuclear region  

Length:

1213

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.0955000000000001

Exp number, first 60 AAs:

7e-05

Total prob of N-in:

0.00001

outside

1  -  1213

 

 

Pi

23.039178

Theta

20.859029

Tajima's D

-1.593878

CLR

0.022806

CSRT

0.0485975701214939

Interpretation

Uncertain