Gene

KWMTBOMO00126

Pre Gene Modal

BGIBMGA002137

Annotation

melatonin_receptor-like_[Bombyx_mori]

Location

Bomo_Chr1(+):3813486-3827560      View in EpiBrowser

Full name

Melatonin receptor type 1A      

Location in the cell

PlasmaMembrane   Reliability : 4.752

CDS

ATGCAGCGTTCTGCTGGGGTCGATGCCGCCGCGCCTGTACTCGGTGGCCTCACAGCCCACAACACCTCGAGGGTCTACTCTCCGGTCACTCTGAGCTCAGAGTGGCCAACAGTTGGCAGGCTTTTGTTTGTGGTCTCGTGCTCTTGTCTTGGTACTATCCTCAACGGCTTCTTCGTATCTTCTTTCTTTGTGGAGTTCACCCTGAAGAAAGTTGGTAACGTCTTTCTGGCTTGCGTTGGTCTCGCAGACCTTATTATGACGTCTAGTGTGATGCCTATTTCTGGTGTGGTGTTGCTGTCCGGAGAATGGGATACTCTCGAAGTTTGTCGTGCTCTTCAGTTCCTCGGTCAAGCCTCTACATATTCATACAGCTTGTTCTTTGCTATGGCTGCAATAGAAAACTACTATCGACTATGCCGCTCAAGCGATGAATATGTCATGTTTATCTCGATGCATACTAGCTGCACCTGCGTCTTCATTTTTGCGTTGTCCTTCTGTCTTTCAGCAGTTGGAGTCTTCTTGAATTTAGATTACGATTATTGCTTGCGGACCGACTACGGAAATTTTGCCTTCAGGATTACTACTCTAATAATTTTTCATGCTGTACCTCTTGTTGTAACTTATGTAGGTTTTCTGATATGCGCTATACACATTCGCAATCGCGCTGCTAAAGAGCTCCCCTACAGACGCTCGCACCAGTACGAACGTGATTATTCCAGGACTCATTTGGATATCGCGGTCTATTCACTGCACGTTCTCGCTTGGATTCCCTATCTCATCGTTGTCTACGACTACCCTAACGCCCCCGATTATAAGTTCTACCATAGCACCTGGATCGCGGTGTGCCGTCCCGTCCTCACAAATTTCTTGTACTGCGCTATTAATCGTAACTTCAGACGTGCGTTTGCTCATCTCTACTATTATTGTTGCTGCAAAAGCTCCACAACTCGATCGTTTAGCACCCGCCACCGTCGTATTATTTGTGAGTGCAAGATGCCTATTTCCGATGTCCGCGTTCATATTATGCACCAGGCGCTCAGCTCCAATAGCCCAGCCCGCGGTGCTTCTTCGTGTAGGGAGATGCAGGAATTATGA

Protein

MQRSAGVDAAAPVLGGLTAHNTSRVYSPVTLSSEWPTVGRLLFVVSCSCLGTILNGFFVSSFFVEFTLKKVGNVFLACVGLADLIMTSSVMPISGVVLLSGEWDTLEVCRALQFLGQASTYSYSLFFAMAAIENYYRLCRSSDEYVMFISMHTSCTCVFIFALSFCLSAVGVFLNLDYDYCLRTDYGNFAFRITTLIIFHAVPLVVTYVGFLICAIHIRNRAAKELPYRRSHQYERDYSRTHLDIAVYSLHVLAWIPYLIVVYDYPNAPDYKFYHSTWIAVCRPVLTNFLYCAINRNFRRAFAHLYYYCCCKSSTTRSFSTRHRRIICECKMPISDVRVHIMHQALSSNSPARGASSCREMQEL

Similarity

Belongs to the G-protein coupled receptor 1 family.

Keywords

Cell membrane   Complete proteome   Disulfide bond   G-protein coupled receptor   Glycoprotein   Membrane   Polymorphism   Receptor   Reference proteome   Transducer   Transmembrane   Transmembrane helix  

Feature

chain  Melatonin receptor type 1A
sequence variant  Exhibits significantly reduced B(max) and slightly enhanced affinity; dbSNP:rs1800885.

Uniprot

B3XXL2   H9IY04   A0A2H1VUM5   A0A2A4JLC2   A0A194Q4V5   A0A212F9T3   + More
D6WGL7   A0A067RGQ9   T1I5Q4   A0A2J7PWX1   A0A1B6CH00   E0VXG7   A0A1B0GKM6   A0A087ZYH0   A0A026WKA3   A0A1S4EFB0   A7UTN2   A0A182R2M0   A0A182Q712   A0A182KW30   A0A0L7QWS8   W5J2I3   A0A087ZM17   J9JJK7   A0A2S2QL41   U4U8U4   A0A2S2NUX4   A0A1B6EBR1   A0A151XFJ6   A0A182PB70   A0A195D6Y1   A0A195E9J2   A0A0C9RR05   A0A182XD17   A0A158NFD9   A0A195BIA7   E2BF24   A0A182FGT1   K7JTF3   B0WY66   A0A2P8XJZ5   A0A2A3E5G3   A0A232FMC5   A0A151JZ78   E2A6A2   A0A182J7E0   T1IYG9   A0A182U1X7   A0A182WAM1   A0A1B0D4N3   A0A182KH48   A0A1J1IC75   A0A182GWC2   A0A310SHQ8   A0A182LVW2   A0A1V9XCQ0   A0A224YY32   L7MCZ0   A0A0K0PVN4   T1KGL9   B7PYV6   A0A3B4TZ70   A0A3P8YTB5   A0A287B9N3   G3R7Q0   H2QQJ5   P48039   A0A2R8ZWV5   S9YDM5   A0A3B4XJR5   A0A287B0N4   H3CUA2   Q4SJQ7   B7X945   S4V4B1   A0A2I4B1D8   A0A3P9HZ72   Q9ESJ3   A0A3B4TXT1   H2LVT7   A0A3P9KY41   C8KI32   A0A3B4GIG5  

Pubmed

18725956    19121390    26354079    22118469    18362917    19820115    + More
24845553    20566863    24508170    30249741    12364791    14747013    17210077    20966253    20920257    23537049    21347285    20798317    20075255    29403074    28648823    26483478    28327890    28797301    25576852    26190115    25069045    16136131    7946354    10471411    15489334    22722832    23149746    15496914    15057822    15632090    19340560    23661545    17554307    12133595   

EMBL

AB330420    BAG68398.1    BABH01015925    ODYU01004530    SOQ44513.1    NWSH01001185    + More
PCG72212.1    KQ459463    KPJ00572.1    AGBW02009564    OWR50488.1    KQ971321    EFA00583.2    KK852480    KDR22962.1    ACPB03000702    NEVH01020867    PNF20835.1    GEDC01024658    GEDC01002543    JAS12640.1    JAS34755.1    DS235832    EEB18073.1    AJWK01030720    KK107199    QOIP01000009    EZA55529.1    RLU18578.1    AAAB01008960    EDO63653.1    AXCN02000898    KQ414710    KOC63021.1    ADMH02002185    ETN57946.1    ABLF02037338    GGMS01009241    MBY78444.1    KB632169    ERL89472.1    GGMR01008371    MBY20990.1    GEDC01001937    JAS35361.1    KQ982182    KYQ59172.1    KQ976750    KYN08626.1    KQ979440    KYN21489.1    GBYB01004363    GBYB01010970    JAG74130.1    JAG80737.1    ADTU01014311    ADTU01014312    ADTU01014313    KQ976464    KYM84560.1    GL447910    EFN85702.1    DS232182    EDS36943.1    PYGN01001886    PSN32338.1    KZ288400    PBC26311.1    NNAY01000040    OXU31659.1    KQ981410    KYN41906.1    GL437123    EFN70987.1    JH431683    AJVK01024709    AJVK01024710    CVRI01000047    CRK97803.1    JXUM01004293    KQ560172    KXJ84005.1    KQ766175    OAD53729.1    AXCM01001258    MNPL01015232    OQR71173.1    GFPF01008375    MAA19521.1    GACK01003342    JAA61692.1    KP293972    AKQ63026.1    CAEY01000067    ABJB010171490    DS822291    EEC11778.1    AEMK02000103    CABD030035399    AACZ04005261    U14108    AB029933    EU432127    BC074946    BC074947    BC126297    BC126299    AJFE02082772    AJFE02082773    AJFE02082774    KB016652    EPY85616.1    CAAE01014573    CAF99125.1    AABR07025784    AB377274    CH473995    BAH03529.1    EDL78848.1    JX524510    AGO03819.1    AF130341    AAG18471.1    AB492766    BAI39600.1   

Proteomes

UP000005204    UP000218220    UP000053268    UP000007151    UP000007266    UP000027135    + More
UP000015103    UP000235965    UP000009046    UP000092461    UP000005203    UP000053097    UP000279307    UP000079169    UP000007062    UP000075900    UP000075886    UP000075882    UP000053825    UP000000673    UP000007819    UP000030742    UP000075809    UP000075885    UP000078542    UP000078492    UP000076407    UP000005205    UP000078540    UP000008237    UP000069272    UP000002358    UP000002320    UP000245037    UP000242457    UP000215335    UP000078541    UP000000311    UP000075880    UP000075902    UP000075920    UP000092462    UP000075881    UP000183832    UP000069940    UP000249989    UP000075883    UP000192247    UP000015104    UP000001555    UP000261420    UP000265140    UP000008227    UP000001519    UP000002277    UP000005640    UP000240080    UP000261360    UP000007303    UP000002494    UP000192220    UP000265200    UP000001038    UP000265180    UP000261460   

PRIDE

B3XXL2    H9IY04    B7PYV6    P48039   

Pfam

PF00001   7tm_1

Interpro

IPR000276   GPCR_Rhodpsn        + More
IPR017452   GPCR_Rhodpsn_7TM       
IPR001878   Znf_CCHC       
IPR002280   Mel_rcpt_1X       
IPR000025   Melatonin_rcpt       
IPR002279   Mel_rcpt_1C       
IPR002278   Mel_1A/1B_rcpt       
IPR001504   Brdyknn_2_rcpt       
IPR000496   Brdyknn_rcpt       

ProteinModelPortal

B3XXL2   H9IY04   A0A2H1VUM5   A0A2A4JLC2   A0A194Q4V5   A0A212F9T3   + More
D6WGL7   A0A067RGQ9   T1I5Q4   A0A2J7PWX1   A0A1B6CH00   E0VXG7   A0A1B0GKM6   A0A087ZYH0   A0A026WKA3   A0A1S4EFB0   A7UTN2   A0A182R2M0   A0A182Q712   A0A182KW30   A0A0L7QWS8   W5J2I3   A0A087ZM17   J9JJK7   A0A2S2QL41   U4U8U4   A0A2S2NUX4   A0A1B6EBR1   A0A151XFJ6   A0A182PB70   A0A195D6Y1   A0A195E9J2   A0A0C9RR05   A0A182XD17   A0A158NFD9   A0A195BIA7   E2BF24   A0A182FGT1   K7JTF3   B0WY66   A0A2P8XJZ5   A0A2A3E5G3   A0A232FMC5   A0A151JZ78   E2A6A2   A0A182J7E0   T1IYG9   A0A182U1X7   A0A182WAM1   A0A1B0D4N3   A0A182KH48   A0A1J1IC75   A0A182GWC2   A0A310SHQ8   A0A182LVW2   A0A1V9XCQ0   A0A224YY32   L7MCZ0   A0A0K0PVN4   T1KGL9   B7PYV6   A0A3B4TZ70   A0A3P8YTB5   A0A287B9N3   G3R7Q0   H2QQJ5   P48039   A0A2R8ZWV5   S9YDM5   A0A3B4XJR5   A0A287B0N4   H3CUA2   Q4SJQ7   B7X945   S4V4B1   A0A2I4B1D8   A0A3P9HZ72   Q9ESJ3   A0A3B4TXT1   H2LVT7   A0A3P9KY41   C8KI32   A0A3B4GIG5  

PDB

6IBL     E-value=0.00306679,     Score=95

KEGG

100174942    no KO assigned | (RefSeq) Mtnr; melatonin receptor-like

GO

GO:0016021   GO:0008502   GO:0007186   GO:0008020   GO:0005887   GO:0007602   GO:0071482   GO:0008270   GO:0003676   GO:0004930   GO:0043235   GO:0042562   GO:0007193   GO:0097159   GO:0007623   GO:0005886   GO:0007617   GO:0007187   GO:0042310   GO:0006939   GO:0004947   GO:0016020   GO:0015074   GO:0048013   GO:0005003   GO:0007169  

PANTHER

PTHR24228:SF56  

Subcellular location

Cell membrane  

Length:

364

Number of predicted TMHs:

7

Exp number of AAs in TMHs:

152.98029

Exp number, first 60 AAs:

20.71788

Total prob of N-in:

0.05779

POSSIBLE N-term signal

sequence

outside

1  -  41

TMhelix

42  -  64

inside

65  -  76

TMhelix

77  -  99

outside

100  -  113

TMhelix

114  -  136

inside

137  -  156

TMhelix

157  -  176

outside

177  -  195

TMhelix

196  -  218

inside

219  -  238

TMhelix

239  -  261

outside

262  -  275

TMhelix

276  -  298

inside

299  -  364

 

 

Pi

24.701852

Theta

24.702869

Tajima's D

0.142993

CLR

0.015558

CSRT

0.415329233538323

Interpretation

Uncertain