Gene

KWMTBOMO00118

Pre Gene Modal

BGIBMGA002131

Annotation

transient_receptor_potential_cation_channel_subfamily_A_member_1_[Bombyx_mori]

Location

Bomo_Chr1(+):3680286-3693994      View in EpiBrowser

Full name

Transient receptor potential cation channel subfamily A member 1       + More
Aspartate aminotransferase      

Alternative Name

Ankyrin-like with transmembrane domains protein 1

Location in the cell

PlasmaMembrane   Reliability : 3.54

CDS

ATGAATGCACCGGACGTCTTATCCGTATCCGTACTTCAAGTGTTTGCGAAGTACAAGTCCTTGTTCAACGTCAACCAAGGTGGCGAACACGGCAGAACGGCTCTTCATTTCGCTGCAATACACGACCACGATCTCTGCGCCAAAATATTGATAACCGATCTGGACGCTGAATGGAAGAAGCCTTGCAACAACGGTTACTATCCCATTCACGAGGCGGCAAAAAATGCTTCATCAAGGACTATAGAAGTGTTCCTGCAGTGGGGCGAACAAAGAGGGTGTACTAGGGAGCAAATGATTTCCCTTTACGACAACGAAGGCAACGTCCCTTTACACTCAGCCGTTCATGGAGGTGATATCAAGGCCGTAGAGCTGTGTCTTCGATCCGGAGCAAAAATATCCACACAGCAACATGATCTGTCAACACCTGTGCACTTAGCTTGCGCTCAAGGAGCACTCGACATCGTGAAGTTAATGTTTACTATGCAACCAAAAGAGAAGCATGCGTGTCTGACATCCTGTGACGTACAGAAAATGACGCCTATTCATTGTGCCGCCATGTTCGACCACCCGGAGATCGTAAACTATTTAATCAACGAAGGCTCTGATATCAACCCTCTGGATAAGGAGCGAAGGTCCCCTTTACTTTTGGCTGCATCTAGGGCGGGATGGCGTACGGTTCACACTTTGATACGCTTGGGTGCTGACATACAACTAAAGGACATAAACAGTCGCAACGTGTTGCATCTGGTCGTCATGAATGGTGGTCGCCTAGAGGATTTCGCTGCGAGCTGCAAGGATCACTGCGAGAAAAGTCTCTTACAACTGTTGAACGAAAAAGACAACACCGGGTGCTCGCCACTACACTACGCGAGTCGTGAAGGTCACATCAGGTCTTTGGAGAACTTGATACGCTTGGGAGCTTGCATCAATCTCAAGAACAATAACAATGAGAGTCCATTGCATTTCGCTGCAAGATACGGACGCTTTCACACCGCCTGTCAACTCCTCGATTCTGATAAAGGCACTTTCATTATCAATGAGAGTGACGGCGAAGGCCTAACTCCTTTACATATAGCTTCACGCGAAGGACATACAAGAGTCGTGCACTTATTATTAAACCGCGGGGCCTTGCTTCATCGAGATCATAATGGAAGAAACCCTTTGCATCTGGCCGCTATGAGTGGATATACAAAAACCATTGAACTGTTGCATTCTGTTCATTCTCATTTGTTGGACCAGATTGATAAGGATGGGAATACTTCTCTTCATTTGGCCACAATGGAGAATAAGCCGTCGTCCATTGCTTTGCTATTGTCTATGGGCTGTCGACTAAGCTATAATAATATGGATATGAGCGCAATAGATTACGCTATATACTACAAGTTCCCTGAAGCCGCTCTTGCTATGGTCACTCATGAGCAAAGAGCCAAAGAAGTTATGGCCTTACGTTCAGATCGCCATCCTTGCGTGACCTTGGCTCTCATCGCCTACATGCCGCGAGTCTTTGAAGCTGTACAAGATAAGTGCATTACCAAAGCCAACTGCAAGAAGGATTCAAAAAGCTTCTATATCAAGTACAGCTTCGAGGCGCTCTGCCCTCAATTGATGGACGAGGACGGAACTAGGAAATCTCAACAGGCCCAGCAAATACCTTTACCGGCTCTCAACGCGATGGTAGCACACGGGCGTGTAGAGCTATTGGCGCATCCCTTGAGCCAAAAATACCTGCAAATGAAGTGGAATTCCTATGGAAAATACTTTCATCTCGTGAATGTGCTGTTCTATTGTATTTTCCTGATCTTCGTCACTGTGTATTCATATCTTCTGATGGAGCACGTGAATCCAATAAATAAAAGGGAAAGGAGTCGGGTTGGTGATGTCTATTACAATTACACCGCTACAAATCGAACACAAACAAACTGGGATATTGATGCAGATTTCGAAGCCATCTTAATTATGTATACAAGCTCTGTGGTTATTATGGTTTATATTTCCGTCTGTATGATGCGGGAAGCATATAATTTAAAGCAGCAAAAATGGCATTACATAGTGGACCCATCTAACCTTGTATCTTGGACATTGTATATTAGTGCCACTATAACAGTATTTCCAACTCTCTATGGACATTATAGTAATTATCAGTTCTCAGCGGCATCGATAACCGTATTCCTGTCTTGGTTCGAACTGTTATTGCTGCTCCAACGTTTCGATCAAGTCGGGATCTACGTTGTGATGTTTCTCGAAATACTCCAGACTCTCATCAAAGTGTTGATGGTTTTCTCCATTCTGATCATCGCGTTCGGCCTGGCCTTTTACATTTTGCTCTCTAAAGGGAATCACCTTTCTTTCAGCAACATCCCTATTGCTTTGATGAGAACATTCGCTATGATGCTTGGTGAATTAGATTTTGTCGGAACTTATGTGCAGCCCTACTACAAGGATGACTCTGATATAATTCTGCCTTTCCCGATACCGACGTTCATAATCCTTGCTCTGTTCATGATTTTGATGCCCATACTTCTAATGAACTTGCTTATTGGTTTGGCCGTTGGTGATATTGAGAGTGTTAGGAGAAACGCTCAGCTGAAACGGCTGGCTATGCAGGTCGTCTTACATACCGAACTTGAAAGAAAACTACCAGCATTCCTATTGGAGAAAGTCGACAAACTAGAACTGATCGAATACCCAAATAATAAGAAATGTAAACTCGGATTTTTGGATTTAATCTTGCATAAATGGTTTTGTAATCCTTTCACAGAAGATACTGGCTTGGACTTAGTTTTGGAGAACAACGACGATTACGTAACGGAACAAATGGAAAAGCAGAAGCGTAAATTCCGTGAGATGCAGAATGTATTGGACCAACAATATTTACTACTCCGGCTAATTGTGCAGAAAATGGAAATCAAAACCGAAGCCGACGATGTGGACGAAGGCGTATCGCCGAATGACACTAAAGTGGTTCCCCGCTGGAGCTCTCATAGGAACCGCAAGAAGTTGCATTCGGCCCGAGCTGCTTCATTTAACAAGTCGACCTGA

Protein

MNAPDVLSVSVLQVFAKYKSLFNVNQGGEHGRTALHFAAIHDHDLCAKILITDLDAEWKKPCNNGYYPIHEAAKNASSRTIEVFLQWGEQRGCTREQMISLYDNEGNVPLHSAVHGGDIKAVELCLRSGAKISTQQHDLSTPVHLACAQGALDIVKLMFTMQPKEKHACLTSCDVQKMTPIHCAAMFDHPEIVNYLINEGSDINPLDKERRSPLLLAASRAGWRTVHTLIRLGADIQLKDINSRNVLHLVVMNGGRLEDFAASCKDHCEKSLLQLLNEKDNTGCSPLHYASREGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRFHTACQLLDSDKGTFIINESDGEGLTPLHIASREGHTRVVHLLLNRGALLHRDHNGRNPLHLAAMSGYTKTIELLHSVHSHLLDQIDKDGNTSLHLATMENKPSSIALLLSMGCRLSYNNMDMSAIDYAIYYKFPEAALAMVTHEQRAKEVMALRSDRHPCVTLALIAYMPRVFEAVQDKCITKANCKKDSKSFYIKYSFEALCPQLMDEDGTRKSQQAQQIPLPALNAMVAHGRVELLAHPLSQKYLQMKWNSYGKYFHLVNVLFYCIFLIFVTVYSYLLMEHVNPINKRERSRVGDVYYNYTATNRTQTNWDIDADFEAILIMYTSSVVIMVYISVCMMREAYNLKQQKWHYIVDPSNLVSWTLYISATITVFPTLYGHYSNYQFSAASITVFLSWFELLLLLQRFDQVGIYVVMFLEILQTLIKVLMVFSILIIAFGLAFYILLSKGNHLSFSNIPIALMRTFAMMLGELDFVGTYVQPYYKDDSDIILPFPIPTFIILALFMILMPILLMNLLIGLAVGDIESVRRNAQLKRLAMQVVLHTELERKLPAFLLEKVDKLELIEYPNNKKCKLGFLDLILHKWFCNPFTEDTGLDLVLENNDDYVTEQMEKQKRKFREMQNVLDQQYLLLRLIVQKMEIKTEADDVDEGVSPNDTKVVPRWSSHRNRKKLHSARAASFNKST

Description

Essential for thermotaxis by sensing environmental temperature. Receptor-activated non-selective cation channel involved in detection of sensations such as temperature. Involved in heat nociception by being activated by warm temperature of about 24-29 degrees Celsius.

Catalytic Activity

2-oxoglutarate + L-aspartate = L-glutamate + oxaloacetate

Subunit

Homotetramer.
Homodimer.

Miscellaneous

In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.

Similarity

Belongs to the transient receptor (TC 1.A.4) family.

Keywords

Alternative splicing   ANK repeat   Cell membrane   Complete proteome   Glycoprotein   Ion channel   Ion transport   Membrane   Reference proteome   Repeat   Sensory transduction   Transmembrane   Transmembrane helix   Transport  

Feature

chain  Transient receptor potential cation channel subfamily A member 1
splice variant  In isoform J.

Uniprot

W8VUV0   H9IXZ8   A0A2A4J8G5   X4YI96   A0A194QUV6   A0A194QAW8   + More
A0A212F9S1   A0A067QW72   A0A1B0CK24   A0A139WJZ5   A0A1I8PQU7   A0A1I8PQP5   A0A384TFK4   A0A0J9RRT3   B3NBM3   A0A1I8PQV0   Q7Z020   A0A1S4FME7   A0A0J9RT54   G9L8C4   A0A0Q5UHP3   A0A0P8XTU9   G8IQ59   A0A0R1DUU3   A0A0P9AJX4   A0A0Q9WPV3   B4MMD0   A0A1B0EWK1   A0A1I8PQU6   B4LEP7   B0W5K9   D6NLB6   B4KZG4   A0A0R3P7M5   B5DRW8   A0A3B0JXA1   A0A084W9N1   B3M5X8   A0A0J9RS37   A0A0J9UHK2   A0A0Q5U3H8   B4PFH6   A0A0P8Y9L5   Q7Z020-5   H0UST1   A0A0Q9WXY6   A0A0Q5U9M3   A0A1W4V0P1   H0USS9   A0A0Q9XL17   A0A0R3P8W6   A0A0R3P941   B3G3I7   A0A182PV41   A0A182WML1   A0A182NNL5   E0W214   B4J3L7   A0A0L0C0A2   A0A0Q5U5B0   A0A0P8XTU6   B4QMM0   M9PBX8   A0A182M6W7   A0A0Q9X1C4   B4HK42   Q7Q966   A0A182KCH3   A0A182FED1   A0A2A4J7J5   A0A1Y1M1U7   A0A182HXS5   A0A182WS30   A0A146KSD5   A0A182YBU4   A0A0J9RRT9   A0A1J1HDZ7   U4U429   A0A0Q9XBB8   N6STG4   J9K0X9   A0A1B6CJX4   A0A0M4EIG3   A0A0Q9XMU7   A0A0J9RRP5   A0A1A9V4K4   A0A1B0BHB3   A0A1B0G3C5   A0A1I8MPV1   Q16VW1   A0A1A9XBH9   A0A2S2Q5Q4   B0W5K8   A0A182RQE7   A0A1W4WSV1   A0A2S2Q8S0   A0A0L7LD88   A0A2S2PHR1  

EC Number

2.6.1.1

Pubmed

24639527    19121390    25827167    26354079    22118469    24845553    + More
18362917    19820115    22936249    17994087    12815418    10731132    12537572    15681611    17510324    22139422    12537568    12537573    12537574    16110336    17569856    17569867    22347718    26109357    26109356    17550304    20237474    18057021    15632085    24438588    18548007    20566863    26108605    12364791    14747013    17210077    28004739    26823975    25244985    23537049    25315136    26227816   

EMBL

AB243445    AB703646    BAO53207.1    BAO53211.1    BABH01015908    BABH01015909    + More
BABH01015910    NWSH01002531    PCG68056.1    KF827820    AHV83756.1    KQ461108    KPJ09099.1    KQ459463    KPJ00566.1    AGBW02009564    OWR50481.1    KK853297    KDR08794.1    AJWK01015649    AJWK01015650    KQ971334    KYB28252.1    KX249692    AOR81469.1    CM002912    KMY98493.1    CH954178    EDV50619.2    AY302598    AE014296    KMY98494.1    JQ015263    AEU17952.1    KQS43402.1    CH902618    KPU78145.1    JN814911    AET41695.1    AGB94295.1    CM000159    KRK00950.1    KPU78146.1    CH963847    KRF97727.1    EDW73275.2    AJVK01027805    AJVK01027806    CH940647    EDW69132.2    DS231843    EDS35492.1    GU566733    ADG84994.1    GU566732    CH933809    ADG84993.1    EDW17891.2    CH379070    KRT09070.1    EDY74257.2    OUUW01000002    SPP77351.1    ATLV01021842    KE525324    KFB46925.1    EDV39668.2    KMY98497.1    KMY98495.1    KQS43403.1    EDW93102.2    KPU78144.1    JN836988    AEU17863.1    KRF97726.1    KQS43405.1    JN400354    AEU04534.1    AGB94296.1    KRG05826.1    KRT09071.1    KRT09069.1    EU624401    ACC86138.1    AAZO01007075    DS235873    EEB19608.1    CH916366    EDV96219.1    JRES01001077    KNC25718.1    KQS43404.1    KPU78147.1    CM000363    EDX09774.1    AGB94297.1    AXCM01005377    AXCM01005378    KRF97725.1    CH480815    EDW40778.1    AAAB01008905    EAA09726.4    PCG68055.1    GEZM01044333    JAV78305.1    APCN01005343    GDHC01019225    JAP99403.1    KMY98498.1    CVRI01000001    CRK86167.1    KB631620    ERL84735.1    KRG05824.1    APGK01057546    APGK01057547    KB741280    ENN70974.1    ABLF02031858    ABLF02031860    GEDC01023529    JAS13769.1    CP012525    ALC43651.1    KRG05825.1    KMY98496.1    JXJN01014254    CCAG010013762    CCAG010013763    CH477580    EAT38698.1    GGMS01003841    MBY73044.1    EDS35491.1    GGMS01004409    MBY73612.1    JTDY01001575    KOB73483.1    GGMR01016315    MBY28934.1   

Proteomes

UP000005204    UP000218220    UP000053240    UP000053268    UP000007151    UP000027135    + More
UP000092461    UP000007266    UP000095300    UP000008711    UP000000803    UP000007801    UP000002282    UP000007798    UP000092462    UP000008792    UP000002320    UP000009192    UP000001819    UP000268350    UP000030765    UP000192221    UP000075885    UP000075920    UP000075884    UP000009046    UP000001070    UP000037069    UP000000304    UP000075883    UP000001292    UP000007062    UP000075881    UP000069272    UP000075840    UP000076407    UP000076408    UP000183832    UP000030742    UP000019118    UP000007819    UP000092553    UP000078200    UP000092460    UP000092444    UP000095301    UP000008820    UP000092443    UP000075900    UP000192223    UP000037510   

PRIDE

H9IXZ8    Q7Z020   

Pfam

PF12796   Ank_2        + More
PF00520   Ion_trans
PF00023   Ank
PF00168   C2
PF16165   Ferlin_C
PF00089   Trypsin
PF00155   Aminotran_1_2
PF03619   Solute_trans_a

Interpro

IPR005821   Ion_trans_dom        + More
IPR036770   Ankyrin_rpt-contain_sf       
IPR020683   Ankyrin_rpt-contain_dom       
IPR002110   Ankyrin_rpt       
IPR037725   C2F_Ferlin       
IPR035892   C2_domain_sf       
IPR037724   C2E_Ferlin       
IPR037721   Ferlin       
IPR032362   Ferlin_C       
IPR000008   C2_dom       
IPR001254   Trypsin_dom       
IPR009003   Peptidase_S1_PA       
IPR015422   PyrdxlP-dep_Trfase_dom1       
IPR004838   NHTrfase_class1_PyrdxlP-BS       
IPR000796   Asp_trans       
IPR004839   Aminotransferase_I/II       
IPR015424   PyrdxlP-dep_Trfase       
IPR015421   PyrdxlP-dep_Trfase_major       
IPR005178   Ostalpha/TMEM184C       

SUPFAM

SSF48403   SSF48403        + More
SSF50494   SSF50494       
SSF53383   SSF53383       

Gene 3D

1.25.40.20     2.60.40.150     3.40.640.10     3.90.1150.10    

CDD

cd00204  ANK
cd08374  C2F_Ferlin
cd04037  C2E_Ferlin

ProteinModelPortal

W8VUV0   H9IXZ8   A0A2A4J8G5   X4YI96   A0A194QUV6   A0A194QAW8   + More
A0A212F9S1   A0A067QW72   A0A1B0CK24   A0A139WJZ5   A0A1I8PQU7   A0A1I8PQP5   A0A384TFK4   A0A0J9RRT3   B3NBM3   A0A1I8PQV0   Q7Z020   A0A1S4FME7   A0A0J9RT54   G9L8C4   A0A0Q5UHP3   A0A0P8XTU9   G8IQ59   A0A0R1DUU3   A0A0P9AJX4   A0A0Q9WPV3   B4MMD0   A0A1B0EWK1   A0A1I8PQU6   B4LEP7   B0W5K9   D6NLB6   B4KZG4   A0A0R3P7M5   B5DRW8   A0A3B0JXA1   A0A084W9N1   B3M5X8   A0A0J9RS37   A0A0J9UHK2   A0A0Q5U3H8   B4PFH6   A0A0P8Y9L5   Q7Z020-5   H0UST1   A0A0Q9WXY6   A0A0Q5U9M3   A0A1W4V0P1   H0USS9   A0A0Q9XL17   A0A0R3P8W6   A0A0R3P941   B3G3I7   A0A182PV41   A0A182WML1   A0A182NNL5   E0W214   B4J3L7   A0A0L0C0A2   A0A0Q5U5B0   A0A0P8XTU6   B4QMM0   M9PBX8   A0A182M6W7   A0A0Q9X1C4   B4HK42   Q7Q966   A0A182KCH3   A0A182FED1   A0A2A4J7J5   A0A1Y1M1U7   A0A182HXS5   A0A182WS30   A0A146KSD5   A0A182YBU4   A0A0J9RRT9   A0A1J1HDZ7   U4U429   A0A0Q9XBB8   N6STG4   J9K0X9   A0A1B6CJX4   A0A0M4EIG3   A0A0Q9XMU7   A0A0J9RRP5   A0A1A9V4K4   A0A1B0BHB3   A0A1B0G3C5   A0A1I8MPV1   Q16VW1   A0A1A9XBH9   A0A2S2Q5Q4   B0W5K8   A0A182RQE7   A0A1W4WSV1   A0A2S2Q8S0   A0A0L7LD88   A0A2S2PHR1  

PDB

3J9P     E-value=4.82732e-160,     Score=1452

KEGG

101744290    K04984 transient receptor potential cation channel subfamily A member 1 | (RefSeq) TRPA1; transient

GO

GO:0005216   GO:0016021   GO:0097604   GO:0006812   GO:0050850   GO:0005261   GO:0015276   GO:0023041   GO:0046957   GO:0007638   GO:0043052   GO:0050960   GO:0040040   GO:0009416   GO:0010378   GO:0009408   GO:0034703   GO:0005262   GO:0006816   GO:0005886   GO:0050968   GO:0001580   GO:0007602   GO:0034605   GO:0050965   GO:0004252   GO:0004069   GO:0009058   GO:0006520   GO:0030170   GO:0005515   GO:0006811   GO:0016020   GO:0015074   GO:0048013   GO:0005003   GO:0005887   GO:0007169   GO:0055085  

PANTHER

PTHR12546   PTHR11879  

Subcellular location

Cell membrane  

Length:

1012

Number of predicted TMHs:

6

Exp number of AAs in TMHs:

147.37645

Exp number, first 60 AAs:

0.016

Total prob of N-in:

0.40153

inside

1  -  586

TMhelix

587  -  609

outside

610  -  649

TMhelix

650  -  667

inside

668  -  687

TMhelix

688  -  710

outside

711  -  713

TMhelix

714  -  733

inside

734  -  752

TMhelix

753  -  775

outside

776  -  826

TMhelix

827  -  849

inside

850  -  1012

 

 

Pi

29.315593

Theta

23.468162

Tajima's D

-1.60967

CLR

0.000219

CSRT

0.0453477326133693

Interpretation

Uncertain