Silkworm Genome Informatics Database

Gene

KWMTBOMO00115

Pre Gene Modal

BGIBMGA002131

Annotation

transient_receptor_potential_cation_channel_subfamily_A_member_1_[Bombyx_mori]

Location

Bomo_Chr1(+):3668156-3674008 View in EpiBrowser

Full name

Transient receptor potential cation channel subfamily A member 1 + More
Aspartate aminotransferase

Alternative Name

Ankyrin-like with transmembrane domains protein 1

Location in the cell

Cytoplasmic Reliability : 1.25 Extracellular Reliability : 1.199

CDS

ATGCTAGCTGTTGGGGCTGCTGAAAGCGGAAATGTCGATGACTTCATGCGATTGTACCTCAGTGAGCCTTCTCGTCTTGCTGTGCGCGATGGAAGGGGTCGTACAGCTGCACATCAAGCCTCTGCTCGAAACAACACTAATATATTGCATTTCATCAATAACTACGCTGGAGACCTTAACGCTAAGGATAACGCCGGGAACACACCGCTCCACGTGGCTGTCGAGAATGAAGCCCTCGACGCTATAGAGTATTTGTTGCAGCAACACGTCGAAACTTCTGTCCTCAACGAGAAGTGTCAAGCTCCAATACACATGGCAACTGAACTAAATAAGGCAAATGTTGGAGAGTCTTAA

Protein

MLAVGAAESGNVDDFMRLYLSEPSRLAVRDGRGRTAAHQASARNNTNILHFINNYAGDLNAKDNAGNTPLHVAVENEALDAIEYLLQQHVETSVLNEKCQAPIHMATELNKANVGES

Description

Essential for thermotaxis by sensing environmental temperature. Receptor-activated non-selective cation channel involved in detection of sensations such as temperature. Involved in heat nociception by being activated by warm temperature of about 24-29 degrees Celsius.

Catalytic Activity

2-oxoglutarate + L-aspartate = L-glutamate + oxaloacetate

Subunit

Homotetramer.
Homodimer.

Miscellaneous

In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.

Similarity

Belongs to the transient receptor (TC 1.A.4) family.

Keywords

Alternative splicing ANK repeat Cell membrane Complete proteome Glycoprotein Ion channel Ion transport Membrane Reference proteome Repeat Sensory transduction Transmembrane Transmembrane helix Transport

Feature

chain Transient receptor potential cation channel subfamily A member 1
splice variant In isoform J.

Uniprot

H9IXZ8 W8VUV0 X4YI96 A0A2A4J7J5 A0A2A4J8G5 A0A194QAW8 + More
A0A194QUV6 A0A212F9S1 A0A1A9ZTS1 A0A1Y1M1U7 A0A0Q9X1C4 A0A0Q9WPV3 A0A0Q9WXY6 B4MMD0 A0A0J9RRT9 A0A0J9UHK2 A0A0J9RRT3 Q7Z020-5 H0UST1 Q7Z020 A0A0Q5UHP3 B3NBM3 A0A0Q5U3H8 A0A182HFJ3 B4HK42 A0A0J9RT54 G9L8C4 A0A0J9RS37 H0USS9 A0A0Q5U9M3 A0A0Q5U5B0 M9PBX8 G8IQ59 A0A0M4EIG3 A0A067QW72 A0A0Q9XMU7 A0A0R1DUU3 B4PFH6 A0A0Q9XBB8 A0A0Q9XL17 B4KZG4 U4U429 A0A0P8XTU6 B3M5X8 A0A0P8Y9L5 A0A0P8XTU9 A0A0P9AJX4 A0A0R3P8W6 A0A3B0JXA1 B5DRW8 A0A0R3P941 A0A1W4V0P1 B4LEP7 B4J3L7 A0A2J7RDI1 A0A1B0CK24 D6NLB6 A0A1B0G3C5 A0A2J7RDG6 A0A139WJZ5 A0A1I8PQV0 A0A1I8PQU6 A0A1I8PQU7 A0A1I8PQP5 A0A1S4FME7 A0A1I8NJU2 J9K0X9 A0A1A9V4K4 A0A2S2Q8S0 A0A1W4WSV1 A0A1A9XBH9 A0A1I8QCJ1 A0A1B0BHB3 A0A0R3P7M5 A0A384TFK4 A0A0L0C0A2 A0A1J1HDZ7 A0A182WML1 A0A182HXS5 A0A182WS30 A0A182PV41 A0A182LHX6 A0A182NNL5 A0A182FED1 A0A182M6W7 W5JRE0 A0A182YBU4 A0A182RQE7 B0W5K9 A0A182Q3M9 A0A084W9N1 A0A182UBZ2 Q7Q966 B3G3I7 B0W5K8 E0W214 N6STG4 A0A146KSD5 A0A182JZJ9 A0A182J3R1

EC Number

2.6.1.1

Pubmed

19121390 24639527 25827167 26354079 22118469 28004739 + More
17994087 22936249 12815418 10731132 12537572 15681611 26483478 22139422 12537568 12537573 12537574 16110336 17569856 17569867 22347718 26109357 26109356 24845553 17550304 18057021 20237474 23537049 15632085 18362917 19820115 17510324 25315136 26108605 20966253 20920257 23761445 25244985 24438588 12364791 14747013 17210077 18548007 20566863 26823975

EMBL

BABH01015908 BABH01015909 BABH01015910 AB243445 AB703646 BAO53207.1 + More
BAO53211.1 KF827820 AHV83756.1 NWSH01002531 PCG68055.1 PCG68056.1 KQ459463 KPJ00566.1 KQ461108 KPJ09099.1 AGBW02009564 OWR50481.1 GEZM01044333 JAV78305.1 CH963847 KRF97725.1 KRF97727.1 KRF97726.1 EDW73275.2 CM002912 KMY98498.1 KMY98495.1 KMY98493.1 AY302598 AE014296 JN836988 AEU17863.1 CH954178 KQS43402.1 EDV50619.2 KQS43403.1 JXUM01037084 KQ561116 KXJ79660.1 CH480815 EDW40778.1 KMY98494.1 JQ015263 AEU17952.1 KMY98497.1 JN400354 AEU04534.1 AGB94296.1 KQS43405.1 KQS43404.1 AGB94297.1 JN814911 AET41695.1 AGB94295.1 CP012525 ALC43651.1 KK853297 KDR08794.1 CH933809 KRG05825.1 CM000159 KRK00950.1 EDW93102.2 KRG05824.1 KRG05826.1 GU566732 ADG84993.1 EDW17891.2 KB631620 ERL84735.1 CH902618 KPU78147.1 EDV39668.2 KPU78144.1 KPU78145.1 KPU78146.1 CH379070 KRT09071.1 OUUW01000002 SPP77351.1 EDY74257.2 KRT09069.1 CH940647 EDW69132.2 CH916366 EDV96219.1 NEVH01005290 PNF38881.1 AJWK01015649 AJWK01015650 GU566733 ADG84994.1 CCAG010013762 CCAG010013763 PNF38879.1 KQ971334 KYB28252.1 ABLF02031858 ABLF02031860 GGMS01004409 MBY73612.1 JXJN01014254 KRT09070.1 KX249692 AOR81469.1 JRES01001077 KNC25718.1 CVRI01000001 CRK86167.1 APCN01005343 AXCM01005377 AXCM01005378 ADMH02000689 ETN65314.1 DS231843 EDS35492.1 AXCN02001921 ATLV01021842 KE525324 KFB46925.1 AAAB01008905 EAA09726.4 EU624401 ACC86138.1 EDS35491.1 AAZO01007075 DS235873 EEB19608.1 APGK01057546 APGK01057547 KB741280 ENN70974.1 GDHC01019225 JAP99403.1

Proteomes

UP000005204 UP000218220 UP000053268 UP000053240 UP000007151 UP000092445 + More
UP000007798 UP000000803 UP000008711 UP000069940 UP000249989 UP000001292 UP000092553 UP000027135 UP000009192 UP000002282 UP000030742 UP000007801 UP000001819 UP000268350 UP000192221 UP000008792 UP000001070 UP000235965 UP000092461 UP000092444 UP000007266 UP000095300 UP000095301 UP000007819 UP000078200 UP000192223 UP000092443 UP000092460 UP000037069 UP000183832 UP000075920 UP000075840 UP000076407 UP000075885 UP000075882 UP000075884 UP000069272 UP000075883 UP000000673 UP000076408 UP000075900 UP000002320 UP000075886 UP000030765 UP000075902 UP000007062 UP000009046 UP000019118 UP000075881 UP000075880

PRIDE

H9IXZ8 Q7Z020

Pfam

PF00520   Ion_trans        + More
PF12796   Ank_2
PF00023   Ank
PF03619   Solute_trans_a
PF00155   Aminotran_1_2
PF00168   C2
PF16165   Ferlin_C
PF00089   Trypsin

Interpro

IPR020683   Ankyrin_rpt-contain_dom        + More
IPR036770   Ankyrin_rpt-contain_sf
IPR005821   Ion_trans_dom
IPR002110   Ankyrin_rpt
IPR005178   Ostalpha/TMEM184C
IPR028320   iASPP
IPR015422   PyrdxlP-dep_Trfase_dom1
IPR004838   NHTrfase_class1_PyrdxlP-BS
IPR000796   Asp_trans
IPR004839   Aminotransferase_I/II
IPR015424   PyrdxlP-dep_Trfase
IPR015421   PyrdxlP-dep_Trfase_major
IPR035892   C2_domain_sf
IPR037724   C2E_Ferlin
IPR037721   Ferlin
IPR032362   Ferlin_C
IPR000008   C2_dom
IPR037725   C2F_Ferlin
IPR001254   Trypsin_dom
IPR009003   Peptidase_S1_PA

SUPFAM

SSF48403   SSF48403        + More
SSF53383   SSF53383
SSF50494   SSF50494

Gene 3D

1.25.40.20 3.40.640.10 3.90.1150.10 2.60.40.150

CDD

cd00204  ANK
cd08374  C2F_Ferlin
cd04037  C2E_Ferlin

ProteinModelPortal

H9IXZ8 W8VUV0 X4YI96 A0A2A4J7J5 A0A2A4J8G5 A0A194QAW8 + More
A0A194QUV6 A0A212F9S1 A0A1A9ZTS1 A0A1Y1M1U7 A0A0Q9X1C4 A0A0Q9WPV3 A0A0Q9WXY6 B4MMD0 A0A0J9RRT9 A0A0J9UHK2 A0A0J9RRT3 Q7Z020-5 H0UST1 Q7Z020 A0A0Q5UHP3 B3NBM3 A0A0Q5U3H8 A0A182HFJ3 B4HK42 A0A0J9RT54 G9L8C4 A0A0J9RS37 H0USS9 A0A0Q5U9M3 A0A0Q5U5B0 M9PBX8 G8IQ59 A0A0M4EIG3 A0A067QW72 A0A0Q9XMU7 A0A0R1DUU3 B4PFH6 A0A0Q9XBB8 A0A0Q9XL17 B4KZG4 U4U429 A0A0P8XTU6 B3M5X8 A0A0P8Y9L5 A0A0P8XTU9 A0A0P9AJX4 A0A0R3P8W6 A0A3B0JXA1 B5DRW8 A0A0R3P941 A0A1W4V0P1 B4LEP7 B4J3L7 A0A2J7RDI1 A0A1B0CK24 D6NLB6 A0A1B0G3C5 A0A2J7RDG6 A0A139WJZ5 A0A1I8PQV0 A0A1I8PQU6 A0A1I8PQU7 A0A1I8PQP5 A0A1S4FME7 A0A1I8NJU2 J9K0X9 A0A1A9V4K4 A0A2S2Q8S0 A0A1W4WSV1 A0A1A9XBH9 A0A1I8QCJ1 A0A1B0BHB3 A0A0R3P7M5 A0A384TFK4 A0A0L0C0A2 A0A1J1HDZ7 A0A182WML1 A0A182HXS5 A0A182WS30 A0A182PV41 A0A182LHX6 A0A182NNL5 A0A182FED1 A0A182M6W7 W5JRE0 A0A182YBU4 A0A182RQE7 B0W5K9 A0A182Q3M9 A0A084W9N1 A0A182UBZ2 Q7Q966 B3G3I7 B0W5K8 E0W214 N6STG4 A0A146KSD5 A0A182JZJ9 A0A182J3R1

PDB

5OOY E-value=5.68698e-09, Score=138

KEGG

101744290 K04984 transient receptor potential cation channel subfamily A member 1 | (RefSeq) TRPA1; transient

GO

GO:0005216 GO:0016021 GO:0050960 GO:0043052 GO:0040040 GO:0009416 GO:0006812 GO:0050850 GO:0005261 GO:0097604 GO:0023041 GO:0015276 GO:0046957 GO:0007638 GO:0050965 GO:0034605 GO:0007602 GO:0034703 GO:0010378 GO:0009408 GO:0006816 GO:0005886 GO:0005262 GO:0050968 GO:0001580 GO:0004069 GO:0009058 GO:0006520 GO:0030170 GO:0004252 GO:0005515 GO:0022857 GO:0043565 GO:0015074 GO:0048013 GO:0005003 GO:0005887 GO:0007169

PANTHER

PTHR24164 PTHR11879 PTHR12546

Subcellular location

Cell membrane

Length:

117

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0

Exp number, first 60 AAs:

0

Total prob of N-in:

0.06783

outside

1 - 117

Pi

23.416388

Theta

32.191618

Tajima's D

-0.866627

CLR

0.01798

CSRT

0.16249187540623

Interpretation

Uncertain

Sequence

Summary

Ontologies

Topology

Population Genetic Test Statistics