Gene

KWMTBOMO00110

Annotation

PREDICTED:_probable_NADH_dehydrogenase_[ubiquinone]_1_alpha_subcomplex_subunit_12_isoform_X2_[Bombyx_mori]

Location

Bomo_Chr1(+):3286556-3296451      View in EpiBrowser

Full name

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12       + More
Serine/threonine-protein phosphatase 2A activator      

Alternative Name

Phosphotyrosyl phosphatase activator

Location in the cell

Mitochondrial   Reliability : 2.483

CDS

ATGTCGTATTTGGCTTTAGATAAATGGGCTCGAGTTATTAGAATGACGATTCAGAACGGTGGACTGTTTAAATCTCTATATAAAATTTGGAGAATGGACACGTTAAAGGAAGGTAAATATATCGGCTGTGATGAGTTCGGTAACAAATACTACGAAAATAAGAATTACATGCTTGGCAGAAGTCGCTGGGTCGAATATAATCCGCAATTCAAATGGGACTACGACGCTTCGCAGGTAACGCCAGAATGGTTCGGCTGGTTACACTACAAGACAGATCGTCTCCCAAGTGAGGACTGCGCGAAGCTGTGCCTGAAGTGCTGCTGTTGGACTCATAGGTGGAGGTTACCTCATACCGAAAACATGAGTGCCACCGAACGCGCTTACTACCCATTCAGGACGACCCGAACTCATATTTCTGTTTGGGATGGTCGTTCGATATGCAATCGTCCTTGCTTCCCACTGTAA

Protein

MSYLALDKWARVIRMTIQNGGLFKSLYKIWRMDTLKEGKYIGCDEFGNKYYENKNYMLGRSRWVEYNPQFKWDYDASQVTPEWFGWLHYKTDRLPSEDCAKLCLKCCCWTHRWRLPHTENMSATERAYYPFRTTRTHISVWDGRSICNRPCFPL

Description

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

Catalytic Activity

[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)

Subunit

Complex I is composed of 45 different subunits.

Similarity

Belongs to the complex I NDUFA12 subunit family.
Belongs to the PTPA-type PPIase family.

Uniprot

A0A2A4JRI7   A0A2H1WS24   A0A212F9S5   A0A194QU93   A0A1B0DHU8   A0A1B0CW92   + More
A0A194QZR7   A0A194PT81   N6TIG4   U4U8H2   S4PTA1   A0A1L8E0M2   A0A1W4XQK1   A0A154NX39   D2A6F4   E0VEB0   A0A2W1BR08   B0XE21   A0A1Y1L422   Q17M02   A0A084VSM7   A0A1Q3FNF6   A0A2H1W2E6   A0A023EGK7   A0A067QUE7   A0A182F371   A0A2M3Z4W2   A0A2M4AEJ5   A0A2A4JNC4   W5J236   A0A2M4C2M4   K7INC9   A0A026WT41   A0A182NGR0   A0A182Q7I9   T1PEY0   H9J151   F4X6K1   A0A2R7W1X2   A0A1I8MJ35   A0A182P1M1   A0A2J7RA20   A0A182JE99   U5ETD9   A0A1B6CJ33   A0A336MVB2   A0A151ILK7   A0A1L8EHE4   A0A1I8PRP1   A0A182RK31   A0A1Y9IW05   A0A195F279   V5GT38   A0A182K1C7   A0A182V659   A0A182X5U8   A0A151XB82   A0A182MD65   A0A1Z5L7P9   A0A158NG18   A0A0P5VUD0   A0A069DW08   A0A182SL98   A0A151I1L3   A0A0L0CMB9   B4KL35   A0A226F330   B7P7E4   A0A0P5N1N4   R4G4M7   A0A0N8B0L1   A0A0P4VQY3   T1HN69   A0A132AM59   A0A1C7CZD0   A0A182U0R9   Q7Q8F5   A0A182IBI1   A0A0N8C2E4   A0A224Y0T7   B4LUR8   E2BN05   A0A131YH11   A0A0V0G8X9   A0A2A3EHQ3   A0A0P6E5D2   A0A162CCQ7   A0A0L7RKB4   A0A0K8RJE5   B4NWR7   A0A0B1PPH1   Q6XHI7   A0A0K8T375   B4I2M3   B4Q8H0   B3NA29   B3N1Y2   A0A0K8TTE2   A0A0A9Z3S6  

EC Number

5.2.1.8

Pubmed

22118469    26354079    23537049    23622113    18362917    19820115    + More
20566863    28756777    28004739    17510324    24438588    24945155    26483478    24845553    20920257    23761445    20075255    24508170    19121390    21719571    25315136    28528879    21347285    26334808    26108605    17994087    27129103    26555130    20966253    12364791    14747013    17210077    20798317    26830274    17550304    14525923    22936249    26369729    25401762   

EMBL

NWSH01000713    PCG74647.1    ODYU01010572    SOQ55776.1    AGBW02009564    OWR50478.1    + More
KQ461108    KPJ09093.1    AJVK01034172    AJWK01032044    KQ460890    KPJ10947.1    KQ459593    KPI96522.1    APGK01036659    KB740941    ENN77598.1    KB632225    ERL90224.1    GAIX01012398    JAA80162.1    GFDF01001888    JAV12196.1    KQ434777    KZC04229.1    KQ971347    EFA05745.1    DS235088    EEB11716.1    KZ150065    PZC74173.1    DS232798    EDS45793.1    GEZM01065539    JAV68432.1    CH477209    EAT47742.1    ATLV01016091    KE525057    KFB40971.1    GFDL01005981    JAV29064.1    ODYU01005900    SOQ47265.1    JXUM01151927    GAPW01005659    KQ571331    JAC07939.1    KXJ68202.1    KK852999    KDR12671.1    GGFM01002784    MBW23535.1    GGFK01005821    MBW39142.1    NWSH01001044    PCG72943.1    ADMH02002210    ETN57796.1    GGFJ01010421    MBW59562.1    KK107109    EZA59103.1    AXCN02002079    KA647352    AFP61981.1    BABH01031374    BABH01031375    GL888818    EGI57961.1    KK854197    PTY12940.1    NEVH01006580    PNF37688.1    GANO01002818    JAB57053.1    GEDC01023792    GEDC01016160    JAS13506.1    JAS21138.1    UFQS01000326    UFQS01002785    UFQT01000326    UFQT01002785    SSX02904.1    SSX34060.1    KQ977104    KYN05767.1    GFDG01000734    JAV18065.1    KQ981864    KYN34194.1    GALX01003659    JAB64807.1    KQ982335    KYQ57604.1    AXCM01005884    GFJQ02003896    JAW03074.1    ADTU01014889    GDIP01109714    JAL94000.1    GBGD01003390    JAC85499.1    KQ976580    KYM79897.1    JRES01000186    KNC33493.1    CH933807    EDW12785.1    LNIX01000001    OXA63824.1    ABJB010750526    ABJB010875182    DS651463    EEC02516.1    GDIQ01159743    JAK91982.1    GAHY01001225    JAA76285.1    GDIQ01224571    JAK27154.1    GDKW01001677    JAI54918.1    ACPB03020358    JXLN01017427    KPM11530.1    AAAB01008944    EAA10156.3    APCN01000703    GDIQ01121507    JAL30219.1    GFTR01002387    JAW14039.1    CH940649    EDW64245.1    GL449382    EFN82909.1    GEDV01011171    JAP77386.1    GECL01002285    JAP03839.1    KZ288253    PBC30994.1    GDIQ01082170    JAN12567.1    LRGB01000996    KZS14222.1    KQ414578    KOC71181.1    GADI01003164    JAA70644.1    CM000157    EDW87409.1    KN538412    KHJ41730.1    AY232196    AAR10219.1    GBRD01005975    JAG59846.1    CH480820    EDW54018.1    CM000361    CM002910    EDX03487.1    KMY87694.1    CH954177    EDV57492.1    CH902667    EDV30592.1    GDAI01000172    JAI17431.1    GBHO01005606    JAG37998.1   

Proteomes

UP000218220    UP000007151    UP000053240    UP000092462    UP000092461    UP000053268    + More
UP000019118    UP000030742    UP000192223    UP000076502    UP000007266    UP000009046    UP000002320    UP000008820    UP000030765    UP000069940    UP000249989    UP000027135    UP000069272    UP000000673    UP000002358    UP000053097    UP000075884    UP000075886    UP000005204    UP000007755    UP000095301    UP000075885    UP000235965    UP000075880    UP000078542    UP000095300    UP000075900    UP000075920    UP000078541    UP000075881    UP000075903    UP000076407    UP000075809    UP000075883    UP000005205    UP000075901    UP000078540    UP000037069    UP000009192    UP000198287    UP000001555    UP000015103    UP000075882    UP000075902    UP000007062    UP000075840    UP000008792    UP000008237    UP000242457    UP000076858    UP000053825    UP000002282    UP000001292    UP000000304    UP000008711    UP000007801   

PRIDE

H9J151   

Pfam

PF05071   NDUFA12        + More
PF00412   LIM
PF03095   PTPA

Interpro

IPR007763   NDUFA12        + More
IPR001781   Znf_LIM       
IPR004327   Phstyr_phstse_ac       
IPR037218   PTPA_sf       

SUPFAM

SSF140984   SSF140984       

CDD

cd04087  PTPA

ProteinModelPortal

A0A2A4JRI7   A0A2H1WS24   A0A212F9S5   A0A194QU93   A0A1B0DHU8   A0A1B0CW92   + More
A0A194QZR7   A0A194PT81   N6TIG4   U4U8H2   S4PTA1   A0A1L8E0M2   A0A1W4XQK1   A0A154NX39   D2A6F4   E0VEB0   A0A2W1BR08   B0XE21   A0A1Y1L422   Q17M02   A0A084VSM7   A0A1Q3FNF6   A0A2H1W2E6   A0A023EGK7   A0A067QUE7   A0A182F371   A0A2M3Z4W2   A0A2M4AEJ5   A0A2A4JNC4   W5J236   A0A2M4C2M4   K7INC9   A0A026WT41   A0A182NGR0   A0A182Q7I9   T1PEY0   H9J151   F4X6K1   A0A2R7W1X2   A0A1I8MJ35   A0A182P1M1   A0A2J7RA20   A0A182JE99   U5ETD9   A0A1B6CJ33   A0A336MVB2   A0A151ILK7   A0A1L8EHE4   A0A1I8PRP1   A0A182RK31   A0A1Y9IW05   A0A195F279   V5GT38   A0A182K1C7   A0A182V659   A0A182X5U8   A0A151XB82   A0A182MD65   A0A1Z5L7P9   A0A158NG18   A0A0P5VUD0   A0A069DW08   A0A182SL98   A0A151I1L3   A0A0L0CMB9   B4KL35   A0A226F330   B7P7E4   A0A0P5N1N4   R4G4M7   A0A0N8B0L1   A0A0P4VQY3   T1HN69   A0A132AM59   A0A1C7CZD0   A0A182U0R9   Q7Q8F5   A0A182IBI1   A0A0N8C2E4   A0A224Y0T7   B4LUR8   E2BN05   A0A131YH11   A0A0V0G8X9   A0A2A3EHQ3   A0A0P6E5D2   A0A162CCQ7   A0A0L7RKB4   A0A0K8RJE5   B4NWR7   A0A0B1PPH1   Q6XHI7   A0A0K8T375   B4I2M3   B4Q8H0   B3NA29   B3N1Y2   A0A0K8TTE2   A0A0A9Z3S6  

PDB

6G72     E-value=1.786e-15,     Score=195

KEGG

101737036    K11352 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 12 | (RefSeq) probable NADH dehydr

PATHWAY

00190    Oxidative phosphorylation - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0005743   GO:0070469   GO:0008137   GO:0009055   GO:0046872   GO:0006979   GO:0005747   GO:0016020   GO:0019211   GO:0005737   GO:0003755   GO:0016021   GO:0006508   GO:0015074   GO:0048013   GO:0005003   GO:0005887   GO:0007169  

PANTHER

PTHR12910   PTHR10012  

Subcellular location

Mitochondrion inner membrane  
Cytoplasm  

Length:

154

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.04554

Exp number, first 60 AAs:

0.04554

Total prob of N-in:

0.11319

outside

1  -  154

 

 

Pi

3.336477

Theta

22.119234

Tajima's D

-1.203307

CLR

0.100095

CSRT

0.103844807759612

Interpretation

Uncertain