Gene

KWMTBOMO00102

Pre Gene Modal

BGIBMGA002120

Annotation

PREDICTED:_calpain-C_[Bombyx_mori]

Location

Bomo_Chr1(+):3045816-3107821      View in EpiBrowser

Full name

Calpain-C      

Alternative Name

Calcium-activated neutral proteinase homolog C

Location in the cell

Cytoplasmic   Reliability : 1.295 Mitochondrial   Reliability : 1.033 Nuclear   Reliability : 1.035

CDS

ATGGATACATCATACGCAGGCGTATTCAGGTTTCGACTGTGGTGGTGCGGTCAGTGGCTAGAAGTCCTTGTAGATGACCGCCTCCCGACTGTGAATGGGAAACTGGCTTTCTTACAGACCAGTCAAACGGATCAGCTTTGGCCAGCTCTCCTAGAAAAAGCCTACGCCAAATTGCACGGCTCATACGAAGCGTTAAAGTATGGTAGTTTGTTGGACGGATTGGCAGACCTCACCGGCGGCATCACGGAGTCTATCGTTATGCCAGAGTTGTCCGACGGCAGTGCTCTCAGAACTCTACTCGATACGAGCAGTGTGGTCACCGCACATTACTTTCCACCGCCAGCTGAAGATAAAACTGCGACAAGTTTAGAATTAGAAATGAATTATAGGATTTATGATGTACAAAAAGTCGACACAACAAACGAGCCCGTCTACTTGATTCGGTTGCGGCGACCCCTGGGCCACGGGGAAACACCGATATCACACATTGTACTAGATACGGCCTTATGGAAAACGATTCCGCAGTACGAGAGAGACAGACTGATGACCGCGTCTAAAGGCGTCTGGATGCTGTTCAGTGACTTCCAGCGCCTCTTCCCCCGGATCGAGATGGTGCACTTGGACACGGAGACCAGCCGAGCGGAGCTTTCGCTGTCCGAGAAACAGAAGTGGCAGATGAAGATGCACCAAGGCGGCTGGAAGAGGGGCGTATCTGCTGGAGGATGTCGGAATTACGTTAATTTCTTCCACACGAATCCCCAAGTTCAGATCATGTTGAACGAGCCAGACACTGTGATTATATCTCTGAACCAACACAGCATAATGGAGCCTAAAGTAATTGGATTCAGCGTTTATAAAATGCCAAAGTTTCTTACCGAGACCGCCAACCAAATGTTTTTCAAGAGGATCAAAAGCACGATCAACTCGCAGTACACTAATAGCAGACAAGTCAGCCAGAGGTGTCAGTTAGAATCGGGAGCGTACCTCATAATGCCAACGACCTTTGAGCCCCGAGAAGAAGCGCAGTTCACGCTAAGGATCTATTCGAACAAACCACTTAAAATGAAAGTACTGGACGACCCGCCCCAGATGACGAAAGCTGCCTTAGTCAAAGCTCCTCCGGGATCCGATTCGAACGGATTTTTCCAATACGAGACCTTGTTTCTTCAGCTGGCCGACGAACACAGAACCATAGATATATTCGAGCTGCAAGAGCTACTGGACGCGTGCCTCCCGAACGATTACATCAAGAGTTGCGTGTCCATTGACACGTGTCGACAGATTGTTCTGTCTATGGATAAGAAAGGCACGGGTCGGATATGCTTGTCCGACTTCAAGGATCTGATCTGCAGCCTCAAGCATCTGCAGCTCGTGTTCAAGACTCACGCCCGTGAGAAGATGGGGGTGTTGAGGGTGGAGCGCTTGCGGGACGCTCTGAAAGACGTCGGCTTCATTGTACCGGAACGAGTCATATCGTTATTGGTGTTCCGGTATATGAGGAAAGATGGGATGCTGCGTTTCGGGGATTTCGTGTCCGCCGTCATGCACTTGCACAGGGTGTTCGAATTATTTTACACAAACGACGGCCGTCGCCCCGGTTCCGATGCTGTGCAACTAAATCTTTCAGAGTGGCTGAAAAACGCTCTGATGTGCTAG

Protein

MDTSYAGVFRFRLWWCGQWLEVLVDDRLPTVNGKLAFLQTSQTDQLWPALLEKAYAKLHGSYEALKYGSLLDGLADLTGGITESIVMPELSDGSALRTLLDTSSVVTAHYFPPPAEDKTATSLELEMNYRIYDVQKVDTTNEPVYLIRLRRPLGHGETPISHIVLDTALWKTIPQYERDRLMTASKGVWMLFSDFQRLFPRIEMVHLDTETSRAELSLSEKQKWQMKMHQGGWKRGVSAGGCRNYVNFFHTNPQVQIMLNEPDTVIISLNQHSIMEPKVIGFSVYKMPKFLTETANQMFFKRIKSTINSQYTNSRQVSQRCQLESGAYLIMPTTFEPREEAQFTLRIYSNKPLKMKVLDDPPQMTKAALVKAPPGSDSNGFFQYETLFLQLADEHRTIDIFELQELLDACLPNDYIKSCVSIDTCRQIVLSMDKKGTGRICLSDFKDLICSLKHLQLVFKTHAREKMGVLRVERLRDALKDVGFIVPERVISLLVFRYMRKDGMLRFGDFVSAVMHLHRVFELFYTNDGRRPGSDAVQLNLSEWLKNALMC

Miscellaneous

Although strongly related to peptidase C2 proteins, it lack the essential Cys, His and Asn residues of the catalytic triad at positions 84, 242 and 267, respectively.

Similarity

Belongs to the peptidase C2 family.

Keywords

Calcium   Complete proteome   Cytoplasm   Metal-binding   Reference proteome  

Feature

chain  Calpain-C

Uniprot

A0A2H1VXZ3   A0A2W1BY18   H9IXY7   A0A212F9S3   S4PES3   A0A195BGC0   + More
A0A195DKH5   A0A151WWI0   A0A0A9ZB15   A0A0J7P2F3   A0A158P119   E2BQT3   A0A146LKX6   E2AP24   A0A146KN76   A0A1V1FIW2   A0A067RT07   A0A026WHH9   A0A3L8E2B9   T1HUB2   A0A1B6CAH4   A0A0V0G726   A0A2A3ELR5   A0A195D7A8   F4WBI5   A0A2H8TF33   A0A2S2NX96   X1WYP2   A0A2S2QC32   K7IW90   A0A1W4X4H0   D6WGY6   E0V9U5   A0A1Y1LG89   A0A1W4X354   A0A154P9C8   A0A1B6L654   A0A1D2NIP3   E9G357   A0A147BMY2   A0A232FKA7   A0A087ZUH1   A0A0L7QZB0   A0A336LVQ1   A0A2R7W550   A0A182NVC8   Q17FB6   A0A1B0D4L1   A0A182T7U1   A0A182K6D8   A0A182JAP6   W5JM84   A0A084W6U6   A0A182W8C0   A0A2M4BFR8   Q5TUE4   T1K732   B0WDU6   A0A182FBL2   A0A0M8ZUZ2   A0A182YE72   A0A182P196   A0A182XFN6   A0A182HX56   A0A1B6EUT4   A0A023ETY8   A0A1S3DR66   A0A1Y1LE10   A0A1Y1LE41   A0A1B6HCL8   A0A2J7PWZ4   A0A1I8MNS5   A0A1I8P7R4   A0A087UT38   A0A1A9WID1   A0A1A9VNG5   A0A182R8X1   A0A1A9XKI4   A0A1B0BU03   A0A1B0AFC5   A0A1B0FQ61   A0A0K8USL1   A0A1W0X9R1   A0A034V743   A0A0A1WKJ6   A0A0L0BQT8   W8BUB8   T2GFF8   Q9VXH6   A0A2P8Y672   A0A0M5J2N8   B4JJC7   B3NX55   B4IF60  

Pubmed

28756777    19121390    22118469    23622113    25401762    21347285    + More
20798317    26823975    28410430    24845553    24508170    30249741    21719571    20075255    18362917    19820115    20566863    28004739    27289101    21292972    28648823    17510324    20920257    23761445    24438588    12364791    14747013    17210077    25244985    24945155    25315136    25348373    25830018    26108605    24495485    12646209    10731132    12537572    12537569    29403074    17994087   

EMBL

ODYU01005124    SOQ45683.1    KZ149901    PZC78514.1    BABH01015860    BABH01015861    + More
BABH01015862    AGBW02009564    OWR50473.1    GAIX01004362    JAA88198.1    KQ976488    KYM83642.1    KQ980765    KYN13351.1    KQ982691    KYQ52198.1    GBHO01004599    JAG39005.1    LBMM01000305    KMR01443.1    ADTU01006018    ADTU01006019    GL449799    EFN81958.1    GDHC01009968    JAQ08661.1    GL441439    EFN64856.1    GDHC01020645    JAP97983.1    FX985381    BAX07394.1    KK852480    KDR22954.1    KK107242    EZA54534.1    QOIP01000001    RLU26870.1    ACPB03000725    GEDC01027048    JAS10250.1    GECL01002218    JAP03906.1    KZ288223    PBC31971.1    KQ976749    KYN08761.1    GL888063    EGI68464.1    GFXV01000880    MBW12685.1    GGMR01008697    MBY21316.1    ABLF02035453    GGMS01006085    MBY75288.1    KQ971321    EFA01443.2    DS234996    EEB10151.1    GEZM01058120    JAV71891.1    KQ434846    KZC08427.1    GEBQ01020775    JAT19202.1    LJIJ01000029    ODN05130.1    GL732531    EFX86047.1    GEGO01003285    JAR92119.1    NNAY01000123    OXU30757.1    KQ414683    KOC63877.1    UFQS01000233    UFQT01000233    SSX01747.1    SSX22126.1    KK854342    PTY14857.1    CH477272    EAT45230.1    AJVK01024648    AJVK01024649    ADMH02000713    ETN65261.1    ATLV01020953    KE525310    KFB45940.1    GGFJ01002754    MBW51895.1    AAAB01008849    EAL41029.2    CAEY01001799    DS231901    EDS44883.1    KQ435835    KOX71497.1    APCN01005139    GECZ01028092    GECZ01010113    JAS41677.1    JAS59656.1    GAPW01000753    JAC12845.1    GEZM01058121    JAV71889.1    GEZM01058123    GEZM01058122    GEZM01058119    GEZM01058118    JAV71893.1    GECU01035367    JAS72339.1    NEVH01020867    PNF20844.1    KK121469    KFM80527.1    JXJN01020416    CCAG010006706    GDHF01022635    JAI29679.1    MTYJ01000007    OQV24279.1    GAKP01019816    JAC39136.1    GBXI01014945    JAC99346.1    JRES01001597    KNC21604.1    GAMC01013836    GAMC01013835    JAB92719.1    BT150312    AGW24094.1    AJ538040    AE014298    AY061567    AAF48591.2    AAL29115.1    CAD61271.1    PYGN01000878    PSN39760.1    CP012528    ALC48186.1    CH916370    EDV99679.1    CH954180    EDV46884.1    CH480832    EDW46114.1   

Proteomes

UP000005204    UP000007151    UP000078540    UP000078492    UP000075809    UP000036403    + More
UP000005205    UP000008237    UP000000311    UP000027135    UP000053097    UP000279307    UP000015103    UP000242457    UP000078542    UP000007755    UP000007819    UP000002358    UP000192223    UP000007266    UP000009046    UP000076502    UP000094527    UP000000305    UP000215335    UP000005203    UP000053825    UP000075884    UP000008820    UP000092462    UP000075901    UP000075881    UP000075880    UP000000673    UP000030765    UP000075920    UP000007062    UP000015104    UP000002320    UP000069272    UP000053105    UP000076408    UP000075885    UP000076407    UP000075840    UP000079169    UP000235965    UP000095301    UP000095300    UP000054359    UP000091820    UP000078200    UP000075900    UP000092443    UP000092460    UP000092445    UP000092444    UP000037069    UP000000803    UP000245037    UP000092553    UP000001070    UP000008711    UP000001292   

PRIDE

H9IXY7    Q9VXH6   

Pfam

PF00648   Peptidase_C2        + More
PF01067   Calpain_III

Interpro

IPR038765   Papain-like_cys_pep_sf        + More
IPR022684   Calpain_cysteine_protease       
IPR033883   C2_III       
IPR001300   Peptidase_C2_calpain_cat       
IPR022683   Calpain_III       
IPR022682   Calpain_domain_III       
IPR036213   Calpain_III_sf       
IPR002048   EF_hand_dom       
IPR011992   EF-hand-dom_pair       

SUPFAM

SSF49758   SSF49758        + More
SSF54001   SSF54001       
SSF47473   SSF47473       

CDD

cd00214  Calpain_III
cd00044  CysPc

ProteinModelPortal

A0A2H1VXZ3   A0A2W1BY18   H9IXY7   A0A212F9S3   S4PES3   A0A195BGC0   + More
A0A195DKH5   A0A151WWI0   A0A0A9ZB15   A0A0J7P2F3   A0A158P119   E2BQT3   A0A146LKX6   E2AP24   A0A146KN76   A0A1V1FIW2   A0A067RT07   A0A026WHH9   A0A3L8E2B9   T1HUB2   A0A1B6CAH4   A0A0V0G726   A0A2A3ELR5   A0A195D7A8   F4WBI5   A0A2H8TF33   A0A2S2NX96   X1WYP2   A0A2S2QC32   K7IW90   A0A1W4X4H0   D6WGY6   E0V9U5   A0A1Y1LG89   A0A1W4X354   A0A154P9C8   A0A1B6L654   A0A1D2NIP3   E9G357   A0A147BMY2   A0A232FKA7   A0A087ZUH1   A0A0L7QZB0   A0A336LVQ1   A0A2R7W550   A0A182NVC8   Q17FB6   A0A1B0D4L1   A0A182T7U1   A0A182K6D8   A0A182JAP6   W5JM84   A0A084W6U6   A0A182W8C0   A0A2M4BFR8   Q5TUE4   T1K732   B0WDU6   A0A182FBL2   A0A0M8ZUZ2   A0A182YE72   A0A182P196   A0A182XFN6   A0A182HX56   A0A1B6EUT4   A0A023ETY8   A0A1S3DR66   A0A1Y1LE10   A0A1Y1LE41   A0A1B6HCL8   A0A2J7PWZ4   A0A1I8MNS5   A0A1I8P7R4   A0A087UT38   A0A1A9WID1   A0A1A9VNG5   A0A182R8X1   A0A1A9XKI4   A0A1B0BU03   A0A1B0AFC5   A0A1B0FQ61   A0A0K8USL1   A0A1W0X9R1   A0A034V743   A0A0A1WKJ6   A0A0L0BQT8   W8BUB8   T2GFF8   Q9VXH6   A0A2P8Y672   A0A0M5J2N8   B4JJC7   B3NX55   B4IF60  

PDB

1QXP     E-value=3.57163e-74,     Score=709

KEGG

101743425    no KO assigned | (RefSeq) calpain-C

GO

GO:0004198   GO:0005509   GO:0016021   GO:0005737   GO:0007586   GO:0005622   GO:0006508   GO:0015074   GO:0048013   GO:0005003   GO:0005887   GO:0007169  

Subcellular location

Cytoplasm  

Length:

551

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.06424

Exp number, first 60 AAs:

0.00128

Total prob of N-in:

0.00187

outside

1  -  551

 

 

Pi

24.036523

Theta

20.389252

Tajima's D

-1.295816

CLR

0.02196

CSRT

0.0891955402229889

Interpretation

Uncertain