Gene

KWMTBOMO00076  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA002103

Annotation

PREDICTED:_tubulin_alpha-1_chain-like_[Papilio_polytes]

Location

Bomo_Chr1(+):2275267-2276835      View in EpiBrowser

Full name

Tubulin alpha chain       + More
Tubulin alpha-1 chain      

Location in the cell

Cytoplasmic   Reliability : 3.57

CDS

ATGCGTGAGTGCATATCTATCCACGCGGGCCAGGCTGGTGTGCAAATCGGCAACGCGTGTTGGGAGCTGTATTGTCTCGAACATGGCATCCAACCAGACGGGCAGATGCCCTCGGACAAAACCGTCGGCGGCGGAGACGATTCCTTCAACACATTCTTCAGCGAAACAGGAGCCGGTAAACATGTTCCTAGAGCAGTATTCATAGATCTAGAACCAACAGTAGTGGATGAGGTACGCACGGGTACATACCGCCAACTTTTCCACCCCGAGCAACTGATAACGGGCAAAGAAGACGCTGCCAATAATTACGCTAGAGGACATTACACGATAGGCAAAGAAATTGTCGATTTAGTCTTAGACAGGGTCAGGAAACTCGCTGATCAATGCACCGGACTGCAGGGCTTTCTGATCTTCCATTCGTTCGGTGGCGGCACCGGATCAGGTTTTGCATCACTCCTTATGGAACGTCTCTCCGTCGATTATGGTAAGAAATCCAAACTTGAATTCGCGATATATCCGGCACCACAAATCTCTACTGCGGTTGTGGAGCCTTACAACTCTATCCTCACAACTCACACCACATTGGAACATTCAGATGCAGCATTCATGGTCGATAATGAAGCCATTTATGACATCTGTCGAAGGAACCTAGATATAGAAAGACCTACGTACACGAACTTAAACCGCCTCATTGGTCAGATAGTGTCTTCCATCACTGCGTCACTGCGATTCGACGGAGCACTGAATGTTGATTTAACAGAGTTTCAGACTAATTTAGTGCCATATCCTCGAATTCACTTTCCACTAGTGACCTACGCACCAGTTATTTCTGCCGAGAAGGCGTATCATGAGCAGCTATCTGTCGCCGAGATCACCAATGCTTGCTTCGAACCAGCAAATCAGATGGTTAAATGCGACCCGCGTCACGGGAAATACATGGCGTGCTGTATGCTGTACCGAGGAGACGTGGTTCCTAAGGATGTAAATGCCGCCATTGGCACCATCAAAACGAAACGCACCATTCAGTTTGTAGACTGGTGCCCGACAGGATTCAAGGTGGGGATAAACTATCAGCCACCAACTGTGGTACCGGGTGGAGATTTGGCGAAGGTGCAGCGCGCCGTGTGCATGCTGTCCAATACTACTGCCATAGCAGAGGCGTGGTCTCGCCTCAACCACAAGTTTGATTTGATGTATGCCAAGCGTGCATTCGTGCATTGGTACGTGGGAGAGGGGATGGAGGAAGGCGAGTTTTCAGAAGCCCGTGAGGATCTGGCCGCCCTCGAGAAAGACTACGAAGAGGTGGGAATGGATTCCGGTGAGGGCGAGGGAGAAGGCGGCGAGGAATATTAA

Protein

MRECISIHAGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTVGGGDDSFNTFFSETGAGKHVPRAVFIDLEPTVVDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIVDLVLDRVRKLADQCTGLQGFLIFHSFGGGTGSGFASLLMERLSVDYGKKSKLEFAIYPAPQISTAVVEPYNSILTTHTTLEHSDAAFMVDNEAIYDICRRNLDIERPTYTNLNRLIGQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLVTYAPVISAEKAYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCMLYRGDVVPKDVNAAIGTIKTKRTIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWSRLNHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGMDSGEGEGEGGEEY

Description

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.

Subunit

Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells. Interacts with Ote (PubMed:22751930).

Similarity

Belongs to the tubulin family.

Keywords

Acetylation   Complete proteome   Cytoplasm   Cytoskeleton   GTP-binding   Microtubule   Nucleotide-binding   Reference proteome  

Feature

chain  Tubulin alpha-1 chain

Uniprot

A0A194QUQ6   A0A194PTK6   H9IXX0   A0A0L7KUZ4   A0A2W1BIG0   A0A2A4JJT9   + More
A0A220K8K1   A0A2H1WFF5   A0A212EQM6   B4GMN3   A0A2A3ECI2   A0A0N0BGY9   A0A310SJM0   A0A3L8DTU0   K7IX45   A0A1W4VLS5   B4LZC9   B4QYZ8   W8BQW7   B4KDS3   A0A1A9Y408   A0A1X9H7Z9   A0A3B0JUV0   I6T3B1   A0A0K8VM53   A0A1A9VVT4   I6T3B6   A0A1B0BSN7   Q294S5   A0A1S3KF99   I6TYJ7   A0A034WN15   B4PS19   A0A0M4F580   A0A088AKL6   A0A220D6C6   A0A0T6AZS7   A0A1I8Q721   B3LYC5   B4NKL9   A0A0L0BWD3   B4I4N6   B4JHW4   B3P2S7   A0A0A1XPI7   A0A1L8EI06   A0A1A9Z3N0   A0A2L1TGZ4   A0A0K8TTW1   A0A1A9WRU7   A0A2J7QX75   V9I891   Q7YZZ5   T1PH24   D3TQG7   A0A1B2AS19   P06603   F4X8P4   A0A182IR52   A0A2J7PLR5   A0A1B6G946   A0A2P8XUI7   E0VSM7   A0A1Y1M5C8   A0A1L8E538   A0A2R7WCZ9   A0A0C4USD5   T1J7L5   V5GIX6   F4WDI4   D6WBN7   A0A161MFA4   A0A2A3EL84   R4FNL0   R4WD60   E2BLG0   A0A069DUT9   A7UIK9   J3JTA7   H2ZGV1   A0A1Q3FAK3   A0A0J7KZ12   A0A067QTQ0   A0A067RM64   A0A0C9RXB5   A0A182KKE9   Q964U9   E2AGM0   A0A026W2C7   A0A0P6JKY5   B0XE76   Q16JS3   A0A023ETJ9   A0A232F9E2   A7XW51   A0A182RW73   A7XW55   H2ZGV6   R9W3D8   A0A2H1WYZ0  

Pubmed

26354079    19121390    26227816    28756777    28630352    22118469    + More
17994087    30249741    20075255    24495485    15632085    25348373    17550304    28746411    26108605    25830018    26369729    21097902    25315136    20353571    27470169    29403074    3095837    10731132    12537572    22751930    21719571    20566863    28004739    25692689    18362917    19820115    23691247    20798317    26334808    18754809    22516182    24845553    20966253    11489310    24508170    17510324    24945155    26483478    28648823    23777660   

EMBL

KQ461108    KPJ09054.1    KQ459593    KPI96746.1    BABH01015770    JTDY01005364    + More
KOB67077.1    KZ150024    PZC74842.1    NWSH01001179    PCG72231.1    MF319697    ASJ26411.1    ODYU01007973    SOQ51194.1    AGBW02013268    OWR43779.1    CH479185    EDW38107.1    KZ288285    PBC29447.1    KQ435768    KOX75272.1    KQ760551    OAD59858.1    QOIP01000004    RLU23319.1    AAZX01000600    AAZX01006238    CH940650    EDW68164.1    CM000364    EDX11938.1    GAMC01014636    JAB91919.1    CH933806    EDW14920.1    KX099611    ANA52573.1    OUUW01000008    SPP84172.1    JQ866747    AFM80098.1    GDHF01012343    JAI39971.1    JQ866752    AFM80103.1    JXJN01019798    CM000070    EAL28889.1    JQ866758    AFM80109.1    GAKP01003387    JAC55565.1    CM000160    EDW96419.1    CP012526    ALC46657.1    KY558640    ARQ84036.1    LJIG01022464    KRT80443.1    CH902617    EDV41788.1    CH964272    EDW85191.1    JRES01001243    KNC24340.1    CH480821    EDW55179.1    CH916369    EDV92872.1    CH954181    EDV48099.1    GBXI01001517    JAD12775.1    GFDG01000514    JAV18285.1    KY707326    AVF19943.1    GDAI01000027    JAI17576.1    NEVH01020936    NEVH01009388    PNF20592.1    PNF33185.1    JR036023    JR036024    AEY56866.1    AEY56867.1    AF465692    FN653015    FN654394    AAP80594.1    CBY20619.1    CBY43752.1    KA647435    AFP62064.1    CCAG010010324    EZ423669    ADD19945.1    KX228233    PYGN01000366    ANY30847.1    PSN47598.1    M14643    AE014297    BT012506    GL888932    EGI57313.1    NEVH01024424    PNF17259.1    GECZ01010976    JAS58793.1    PYGN01001324    PSN35673.1    DS235751    EEB16383.1    GEZM01042508    JAV79810.1    GFDF01000308    JAV13776.1    KK854476    PTY16175.1    KJ534554    AIY54295.1    JH431936    GALX01004467    JAB63999.1    GL888087    EGI67764.1    KQ971311    EEZ99348.1    GEMB01003839    JAR99415.1    KZ288219    PBC32254.1    GAHY01000548    JAA76962.1    AK417244    BAN20459.1    GL449017    EFN83512.1    GBGD01001437    JAC87452.1    EU073050    KU521361    ABU24274.1    ANS71241.1    BT126463    AEE61427.1    GFDL01010431    JAV24614.1    LBMM01001763    KMQ95792.1    KK853027    KDR12287.1    KK852590    KDR20722.1    GBYB01013740    JAG83507.1    AF272829    AAK58683.1    GL439334    EFN67417.1    KK107467    EZA50232.1    GDIQ01051546    GDIQ01051545    GDIQ01050155    GDIQ01050154    GDIQ01048651    GDIQ01048650    GDIQ01047206    GDIQ01003930    JAN90807.1    DS234244    DS232809    EDS33374.1    EDS45909.1    CH477994    EAT34538.1    JXUM01090583    GAPW01001408    GAPW01001407    KQ563850    JAC12191.1    KXJ73172.1    NNAY01000601    OXU27456.1    EU100017    ABU94678.1    EU100018    ABU94679.1    KC149906    AGN90966.1    ODYU01012101    SOQ58217.1   

Proteomes

UP000053240    UP000053268    UP000005204    UP000037510    UP000218220    UP000007151    + More
UP000008744    UP000242457    UP000053105    UP000279307    UP000002358    UP000192221    UP000008792    UP000000304    UP000009192    UP000092443    UP000268350    UP000078200    UP000092460    UP000001819    UP000085678    UP000002282    UP000092553    UP000005203    UP000095300    UP000007801    UP000007798    UP000037069    UP000001292    UP000001070    UP000008711    UP000092445    UP000091820    UP000235965    UP000095301    UP000092444    UP000245037    UP000000803    UP000007755    UP000075880    UP000009046    UP000007266    UP000008237    UP000007875    UP000036403    UP000027135    UP000075882    UP000000311    UP000053097    UP000002320    UP000008820    UP000069940    UP000249989    UP000215335    UP000075900   

PRIDE

H9IXX0    Q7YZZ5    P06603    E0VSM7   

Pfam

PF00091   Tubulin        + More
PF03953   Tubulin_C
PF00005   ABC_tran
PF00664   ABC_membrane

Interpro

IPR002452   Alpha_tubulin        + More
IPR017975   Tubulin_CS       
IPR003008   Tubulin_FtsZ_GTPase       
IPR008280   Tub_FtsZ_C       
IPR037103   Tubulin/FtsZ_C_sf       
IPR023123   Tubulin_C       
IPR000217   Tubulin       
IPR018316   Tubulin/FtsZ_2-layer-sand-dom       
IPR036525   Tubulin/FtsZ_GTPase_sf       
IPR017871   ABC_transporter_CS       
IPR003439   ABC_transporter-like       
IPR036640   ABC1_TM_sf       
IPR027417   P-loop_NTPase       
IPR011527   ABC1_TM_dom       
IPR003593   AAA+_ATPase       
IPR000719   Prot_kinase_dom       
IPR011009   Kinase-like_dom_sf       

SUPFAM

SSF55307   SSF55307        + More
SSF52490   SSF52490       
SSF52540   SSF52540       
SSF90123   SSF90123       
SSF56112   SSF56112       

Gene 3D

1.10.287.600     3.30.1330.20     3.40.50.1440     1.20.1560.10    

ProteinModelPortal

A0A194QUQ6   A0A194PTK6   H9IXX0   A0A0L7KUZ4   A0A2W1BIG0   A0A2A4JJT9   + More
A0A220K8K1   A0A2H1WFF5   A0A212EQM6   B4GMN3   A0A2A3ECI2   A0A0N0BGY9   A0A310SJM0   A0A3L8DTU0   K7IX45   A0A1W4VLS5   B4LZC9   B4QYZ8   W8BQW7   B4KDS3   A0A1A9Y408   A0A1X9H7Z9   A0A3B0JUV0   I6T3B1   A0A0K8VM53   A0A1A9VVT4   I6T3B6   A0A1B0BSN7   Q294S5   A0A1S3KF99   I6TYJ7   A0A034WN15   B4PS19   A0A0M4F580   A0A088AKL6   A0A220D6C6   A0A0T6AZS7   A0A1I8Q721   B3LYC5   B4NKL9   A0A0L0BWD3   B4I4N6   B4JHW4   B3P2S7   A0A0A1XPI7   A0A1L8EI06   A0A1A9Z3N0   A0A2L1TGZ4   A0A0K8TTW1   A0A1A9WRU7   A0A2J7QX75   V9I891   Q7YZZ5   T1PH24   D3TQG7   A0A1B2AS19   P06603   F4X8P4   A0A182IR52   A0A2J7PLR5   A0A1B6G946   A0A2P8XUI7   E0VSM7   A0A1Y1M5C8   A0A1L8E538   A0A2R7WCZ9   A0A0C4USD5   T1J7L5   V5GIX6   F4WDI4   D6WBN7   A0A161MFA4   A0A2A3EL84   R4FNL0   R4WD60   E2BLG0   A0A069DUT9   A7UIK9   J3JTA7   H2ZGV1   A0A1Q3FAK3   A0A0J7KZ12   A0A067QTQ0   A0A067RM64   A0A0C9RXB5   A0A182KKE9   Q964U9   E2AGM0   A0A026W2C7   A0A0P6JKY5   B0XE76   Q16JS3   A0A023ETJ9   A0A232F9E2   A7XW51   A0A182RW73   A7XW55   H2ZGV6   R9W3D8   A0A2H1WYZ0  

PDB

5KX5     E-value=0,     Score=2280

KEGG

101745545    K07374 tubulin alpha | (RefSeq) tubulin alpha-1 chain-like

PATHWAY

04145    Phagosome - Bombyx mori (domestic silkworm)

GO

GO:0007017   GO:0005874   GO:0005525   GO:0003924   GO:0005737   GO:0005200   GO:0042626   GO:0005524   GO:0016021   GO:0019730   GO:0005813   GO:0048471   GO:0000235   GO:0032418   GO:0000278   GO:0000226   GO:0005634   GO:0005819   GO:0048013   GO:0005003   GO:0005887   GO:0007169  

PANTHER

PTHR11588  

Subcellular location

  

Length:

450

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

2.66841

Exp number, first 60 AAs:

0.0023

Total prob of N-in:

0.12000

outside

1  -  450

 

 

Pi

15.048643

Theta

7.532604

Tajima's D

0.402334

CLR

0.001345

CSRT

0.504974751262437

Interpretation

Uncertain