SGID Silkworm Genome Informatics Database
Gene
KWMTBOMO00057  Validated by peptides from experiments
Pre Gene Modal
BGIBMGA002030
Annotation
PREDICTED:_ADP-ribosylation_factor_GTPase-activating_protein_1-like_[Bombyx_mori]
Full name
ADP-ribosylation factor GTPase-activating protein 1      
Alternative Name
ADP-ribosylation factor 1 GTPase-activating protein
ARF1-directed GTPase-activating protein
Location in the cell
Nuclear   Reliability : 3.661
 

Sequence

CDS
ATGGCATCACCACGTACCAAACGCAAGTTGAACTCAATCCGCAACCTCGACGAGAACCATAAATGCTTTGAGTGCGGAACTCTGAATCCTCAATGGGTGTCAGTGACGTACGGAGTCTGGATATGCTTGGAGTGCTCGGGCGTGCATCGAAGCCTCGGTGTTCACCTGTCATTCGTTCGCTCCGTCACTATGGACAAGTGGAAGGACGTGGAACTTGAGAAAATGATGGTCGGAGGCAACGCGAAGGCCCGCGAGTTCTTCGAGAGTCAACCGGACATCAGTTCTGGGATGACTATACCACAGAAGTACAATACCAAGGCCGCTGCGATGTACCGCCAAAAGATCGCGGCTTTAGCTGAGGGCCGCCCATGGAGTCCATCGGATTACAAGCCCGAGACGATCGAGAAGCCTCAGGAGTGGCTCCAGTCTCGCGATTTCTACTCTTCGGACAACACGCTGCCGACAAGCGGATCTGATAACAACATTAGCTACCACAGCGAGTATGGAAGCGGCCGCTACACCGGCTTCGGTAACTCCCCAAAGCAATCGCACTCGACTCCGATGTCGCCGATGCACAGCGGGAGCGAGGTCGTCGACAACACGCTCGCGACTCTCGCTTCGGGGTGGTCATTATTCGCGTCTTCTGTCAGTAAAGCAGCTAAGACGGCCACCGATCACGCCGTTCGTTATGGAGGTATTGCGACGCAGAAGGTCTCTGAAATGGCCACAACCGTCACGGAGAAGGTTAATAATCGCGGCGGTTGGAGTTCGCTGGGCGGCAATACTGATGTGCGCCGCGCCAGCAACTATGGCTCGTATCAGTCGCAGAGCTACGGGGCTATGAAGAGCTCGACTTCGGAGCCGTATTCACAGTGGAACGAGCAGACCCAGCCATGGCAGGACTCTGTGGCCACGCGCAACAACTTGGACACCCGCGATCTGTCCCAAGTGGGTGTTTCCAGCCCCCCGCCAGACATCAAGAGTCTCACGATCAAGAAGAAGCGTCGCGACGACGACTCTTGGGATTGGCTCAACAACTAA
Protein
MASPRTKRKLNSIRNLDENHKCFECGTLNPQWVSVTYGVWICLECSGVHRSLGVHLSFVRSVTMDKWKDVELEKMMVGGNAKAREFFESQPDISSGMTIPQKYNTKAAAMYRQKIAALAEGRPWSPSDYKPETIEKPQEWLQSRDFYSSDNTLPTSGSDNNISYHSEYGSGRYTGFGNSPKQSHSTPMSPMHSGSEVVDNTLATLASGWSLFASSVSKAAKTATDHAVRYGGIATQKVSEMATTVTEKVNNRGGWSSLGGNTDVRRASNYGSYQSQSYGAMKSSTSEPYSQWNEQTQPWQDSVATRNNLDTRDLSQVGVSSPPPDIKSLTIKKKRRDDDSWDWLNN

Summary

Description
GTPase-activating protein (GAP) for the ADP ribosylation factor 1 (ARF1). Involved in membrane trafficking and /or vesicle transport. Promotes hydrolysis of the ARF1-bound GTP and thus, is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles, a prerequisite for vesicle's fusion with target compartment. Probably regulates ARF1-mediated transport via its interaction with the KDELR proteins and TMED2. Overexpression induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, as when ARF1 is deactivated. Its activity is stimulated by phosphoinosides and inhibited by phosphatidylcholine (By similarity).
Subunit
Interacts with ARF1. Interacts with the COPI coat proteins, KDELR1 and TMED2. The interaction with TMED2 inhibits the GAP activity (By similarity).
Similarity
Belongs to the histidine acid phosphatase family.
Keywords
3D-structure   Acetylation   Alternative splicing   Complete proteome   Cytoplasm   ER-Golgi transport   Golgi apparatus   GTPase activation   Metal-binding   Phosphoprotein   Polymorphism   Protein transport   Reference proteome   Transport   Zinc   Zinc-finger  
Feature
chain  ADP-ribosylation factor GTPase-activating protein 1
splice variant  In isoform 5.
sequence variant  In dbSNP:rs2273499.
EMBL
AGBW02009564    OWR50437.1    GAIX01009885    JAA82675.1    KQ459463    KPJ00538.1    + More
KQ461108    KPJ09071.1    GDQN01004759    JAT86295.1    KK107238    QOIP01000007    EZA54845.1    RLU20269.1    KQ981561    KYN39833.1    GL888167    EGI66270.1    KQ982109    KYQ59995.1    KQ976604    KYM79397.1    ADTU01020208    KQ980813    KYN12705.1    KQ414797    KOC60688.1    GL763491    EFZ19641.1    JU323837    AFE67593.1    JR049941    AEY61132.1    KQ434869    KZC09421.1    NDHI03003717    PNJ05744.1    AQIA01009495    AQIA01009496    JSUE03003924    JU473403    JV047613    AFH30207.1    AFI37684.1    AHZZ02000021    KB201541    ESO96202.1    GL434335    EFN74994.1    AL121827    NBAG03000350    PNI36418.1    KZ288208    PBC33012.1    CABD030117716    PNJ05732.1    PNJ05733.1    PNJ05734.1    NNAY01002828    OXU20483.1    GAMT01005641    GAMS01010977    GAMR01009884    GAMQ01005093    JAB06220.1    JAB12159.1    JAB24048.1    JAB36758.1    AJFE02030760    PNJ05737.1    AKHW03001485    KYO41959.1    AEFK01023386    AEFK01023387    AK223427    BAD97147.1    AK001629    AK027268    AK296351    AK027441    AK303454    CH471077    BC000786    BC006085    BC011876    BC028233    AL137744    AB015340    KK717962    KFO53275.1    ADFV01122540    CM004482    OCT62498.1    AACZ04058741    GABC01008779    GABF01005808    GABD01007093    GABE01008120    JAA02559.1    JAA16337.1    JAA26007.1    JAA36619.1    PNI36407.1    PNI36410.1    PNI36419.1    GFFV01002880    JAV37065.1    KK565285    KFW03940.1    JU173843    AFJ49369.1    BC078102    AAH78102.1    ABQF01028173    CM001285    EHH65170.1    JV527809    CM001262    AFJ70265.1    EHH19521.1    KK734682    KFR10173.1    KK502049    KFP19975.1    GAAZ01000109    GBKC01000149    GBKD01000090    JAA97834.1    JAG45921.1    JAG47528.1    KK842712    KFP84881.1    CM004483    OCT60294.1    KL502929    KFO15213.1    QUSF01000056    RLV97546.1    PNI36415.1    KK398080    KFV58405.1    KL205686    KFV72896.1    GBEX01000140    JAI14420.1    KL225840    KFM03910.1    KK931902    KFQ45457.1    KL886214    KGL73679.1    KK594129    KFW02048.1   
Pfam
PF01412   ArfGap
Interpro
IPR037278   ARFGAP/RecO        + More
IPR001164   ArfGAP_dom       
IPR038508   ArfGAP_dom_sf       
IPR029033   His_PPase_superfam       
IPR000560   His_Pase_clade-2       
SUPFAM
SSF57863   SSF57863        + More
SSF53254   SSF53254       
Gene 3D
PDB
3O47     E-value=4.10499e-49,     Score=491

Ontologies

Topology

Subcellular location
Cytoplasm   Associates with the Golgi complex.   With evidence from 9 publications.
Golgi apparatus   Associates with the Golgi complex.   With evidence from 9 publications.
Length:
346
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0.05451
Exp number, first 60 AAs:
0.04979
Total prob of N-in:
0.05495
outside
1  -  346
 
 

Population Genetic Test Statistics

Pi
15.038778
Theta
17.444781
Tajima's D
-1.058569
CLR
0.156448
CSRT
0.124543772811359
Interpretation
Uncertain
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