Gene

KWMTBOMO00057  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA002030

Annotation

PREDICTED:_ADP-ribosylation_factor_GTPase-activating_protein_1-like_[Bombyx_mori]

Location

Bomo_Chr1(-):1791902-1833570      View in EpiBrowser

Full name

ADP-ribosylation factor GTPase-activating protein 1      

Alternative Name

ADP-ribosylation factor 1 GTPase-activating protein
ARF1-directed GTPase-activating protein

Location in the cell

Nuclear   Reliability : 3.661

CDS

ATGGCATCACCACGTACCAAACGCAAGTTGAACTCAATCCGCAACCTCGACGAGAACCATAAATGCTTTGAGTGCGGAACTCTGAATCCTCAATGGGTGTCAGTGACGTACGGAGTCTGGATATGCTTGGAGTGCTCGGGCGTGCATCGAAGCCTCGGTGTTCACCTGTCATTCGTTCGCTCCGTCACTATGGACAAGTGGAAGGACGTGGAACTTGAGAAAATGATGGTCGGAGGCAACGCGAAGGCCCGCGAGTTCTTCGAGAGTCAACCGGACATCAGTTCTGGGATGACTATACCACAGAAGTACAATACCAAGGCCGCTGCGATGTACCGCCAAAAGATCGCGGCTTTAGCTGAGGGCCGCCCATGGAGTCCATCGGATTACAAGCCCGAGACGATCGAGAAGCCTCAGGAGTGGCTCCAGTCTCGCGATTTCTACTCTTCGGACAACACGCTGCCGACAAGCGGATCTGATAACAACATTAGCTACCACAGCGAGTATGGAAGCGGCCGCTACACCGGCTTCGGTAACTCCCCAAAGCAATCGCACTCGACTCCGATGTCGCCGATGCACAGCGGGAGCGAGGTCGTCGACAACACGCTCGCGACTCTCGCTTCGGGGTGGTCATTATTCGCGTCTTCTGTCAGTAAAGCAGCTAAGACGGCCACCGATCACGCCGTTCGTTATGGAGGTATTGCGACGCAGAAGGTCTCTGAAATGGCCACAACCGTCACGGAGAAGGTTAATAATCGCGGCGGTTGGAGTTCGCTGGGCGGCAATACTGATGTGCGCCGCGCCAGCAACTATGGCTCGTATCAGTCGCAGAGCTACGGGGCTATGAAGAGCTCGACTTCGGAGCCGTATTCACAGTGGAACGAGCAGACCCAGCCATGGCAGGACTCTGTGGCCACGCGCAACAACTTGGACACCCGCGATCTGTCCCAAGTGGGTGTTTCCAGCCCCCCGCCAGACATCAAGAGTCTCACGATCAAGAAGAAGCGTCGCGACGACGACTCTTGGGATTGGCTCAACAACTAA

Protein

MASPRTKRKLNSIRNLDENHKCFECGTLNPQWVSVTYGVWICLECSGVHRSLGVHLSFVRSVTMDKWKDVELEKMMVGGNAKAREFFESQPDISSGMTIPQKYNTKAAAMYRQKIAALAEGRPWSPSDYKPETIEKPQEWLQSRDFYSSDNTLPTSGSDNNISYHSEYGSGRYTGFGNSPKQSHSTPMSPMHSGSEVVDNTLATLASGWSLFASSVSKAAKTATDHAVRYGGIATQKVSEMATTVTEKVNNRGGWSSLGGNTDVRRASNYGSYQSQSYGAMKSSTSEPYSQWNEQTQPWQDSVATRNNLDTRDLSQVGVSSPPPDIKSLTIKKKRRDDDSWDWLNN

Description

GTPase-activating protein (GAP) for the ADP ribosylation factor 1 (ARF1). Involved in membrane trafficking and /or vesicle transport. Promotes hydrolysis of the ARF1-bound GTP and thus, is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles, a prerequisite for vesicle's fusion with target compartment. Probably regulates ARF1-mediated transport via its interaction with the KDELR proteins and TMED2. Overexpression induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, as when ARF1 is deactivated. Its activity is stimulated by phosphoinosides and inhibited by phosphatidylcholine (By similarity).

Subunit

Interacts with ARF1. Interacts with the COPI coat proteins, KDELR1 and TMED2. The interaction with TMED2 inhibits the GAP activity (By similarity).

Similarity

Belongs to the histidine acid phosphatase family.

Keywords

3D-structure   Acetylation   Alternative splicing   Complete proteome   Cytoplasm   ER-Golgi transport   Golgi apparatus   GTPase activation   Metal-binding   Phosphoprotein   Polymorphism   Protein transport   Reference proteome   Transport   Zinc   Zinc-finger  

Feature

chain  ADP-ribosylation factor GTPase-activating protein 1
splice variant  In isoform 5.
sequence variant  In dbSNP:rs2273499.

Uniprot

A0A212F9M8   S4P7J7   A0A194Q4S4   A0A194QZQ4   A0A1E1WH26   A0A026WFG1   + More
A0A151JXH8   F4WHR3   A0A151XI51   A0A195B552   A0A158NM30   A0A151IXD1   A0A0L7QPX4   E9IIG2   A0A087ZV68   H9EYY4   V9IKF2   A0A154PC71   A0A2J8RB64   A0A2K6AVJ8   A0A2K5WQR4   A0A1D5Q4U4   A0A2K6AJ96   A0A2I3MFJ5   A0A2K5MDM3   F7FNM2   A0A1U8D2H6   V4AH13   E1ZUZ6   E5RHC5   A0A2J8KN23   A0A2K5EXX7   A0A2A3EP32   G3SC57   A0A2J8RB07   A0A232EQ55   A0A2K5HNW3   A0A2I3NDZ7   A0A2K5EXR3   F7DYA7   A0A2K5QS69   U3DDP3   A0A2R9ATG5   A0A2K5QS58   A0A2J8RB36   A0A2K5WQT9   A0A2K6P086   A0A151NZE4   G3W392   Q53F62   Q8N6T3   A0A091EUC1   G1RG42   A0A1L8ET23   A0A2R9ATI2   K7CBP8   A0A250Y0I4   A0A093IMK7   J3RYD3   F7EQL2   A0A2K6GRY4   Q6DCE5   H0ZB07   A0A2K6AVH0   G7PFI3   F7AMI0   A0A2K6AJE4   A0A3Q0GD42   A0A2I3H2R8   A0A091W5P1   A0A091JJP7   T1DDU4   A0A091N617   A0A1L8ELT9   A0A087VRH1   A0A3L8S5L0   A0A2J8KN27   A0A093FP31   G3U7D9   A0A2Y9G5K8   Q8N6T3-3   A0A3B4TDK3   A0A3Q0GGK3   A0A2Y9G3K2   A0A093GU52   A0A2U3Y2K7   A0A1W5AFF4   A0A0F7ZBB7   A0A087QRQ6   A0A091SR45   A0A099YTS8   H3CPB6   A0A2U3WMG2   A0A3Q0DEI8   A0A2I3N8X8   A0A093IKA0   A0A2K6AJD9  

Pubmed

22118469    23622113    26354079    24508170    30249741    21719571    + More
21347285    21282665    25319552    17431167    23254933    20798317    11780052    16964243    18669648    19690332    19608861    20068231    21269460    23186163    24275569    28648823    25243066    22722832    25362486    22293439    21709235    8125298    9373149    14702039    15489334    17974005    27762356    16136131    28087693    23025625    20360741    22002653    23758969    25727380    30282656    15496914   

EMBL

AGBW02009564    OWR50437.1    GAIX01009885    JAA82675.1    KQ459463    KPJ00538.1    + More
KQ461108    KPJ09071.1    GDQN01004759    JAT86295.1    KK107238    QOIP01000007    EZA54845.1    RLU20269.1    KQ981561    KYN39833.1    GL888167    EGI66270.1    KQ982109    KYQ59995.1    KQ976604    KYM79397.1    ADTU01020208    KQ980813    KYN12705.1    KQ414797    KOC60688.1    GL763491    EFZ19641.1    JU323837    AFE67593.1    JR049941    AEY61132.1    KQ434869    KZC09421.1    NDHI03003717    PNJ05744.1    AQIA01009495    AQIA01009496    JSUE03003924    JU473403    JV047613    AFH30207.1    AFI37684.1    AHZZ02000021    KB201541    ESO96202.1    GL434335    EFN74994.1    AL121827    NBAG03000350    PNI36418.1    KZ288208    PBC33012.1    CABD030117716    PNJ05732.1    PNJ05733.1    PNJ05734.1    NNAY01002828    OXU20483.1    GAMT01005641    GAMS01010977    GAMR01009884    GAMQ01005093    JAB06220.1    JAB12159.1    JAB24048.1    JAB36758.1    AJFE02030760    PNJ05737.1    AKHW03001485    KYO41959.1    AEFK01023386    AEFK01023387    AK223427    BAD97147.1    AK001629    AK027268    AK296351    AK027441    AK303454    CH471077    BC000786    BC006085    BC011876    BC028233    AL137744    AB015340    KK717962    KFO53275.1    ADFV01122540    CM004482    OCT62498.1    AACZ04058741    GABC01008779    GABF01005808    GABD01007093    GABE01008120    JAA02559.1    JAA16337.1    JAA26007.1    JAA36619.1    PNI36407.1    PNI36410.1    PNI36419.1    GFFV01002880    JAV37065.1    KK565285    KFW03940.1    JU173843    AFJ49369.1    BC078102    AAH78102.1    ABQF01028173    CM001285    EHH65170.1    JV527809    CM001262    AFJ70265.1    EHH19521.1    KK734682    KFR10173.1    KK502049    KFP19975.1    GAAZ01000109    GBKC01000149    GBKD01000090    JAA97834.1    JAG45921.1    JAG47528.1    KK842712    KFP84881.1    CM004483    OCT60294.1    KL502929    KFO15213.1    QUSF01000056    RLV97546.1    PNI36415.1    KK398080    KFV58405.1    KL205686    KFV72896.1    GBEX01000140    JAI14420.1    KL225840    KFM03910.1    KK931902    KFQ45457.1    KL886214    KGL73679.1    KK594129    KFW02048.1   

Proteomes

UP000007151    UP000053268    UP000053240    UP000053097    UP000279307    UP000078541    + More
UP000007755    UP000075809    UP000078540    UP000005205    UP000078492    UP000053825    UP000005203    UP000076502    UP000233120    UP000006718    UP000233140    UP000028761    UP000233060    UP000189705    UP000030746    UP000000311    UP000005640    UP000233020    UP000242457    UP000001519    UP000215335    UP000233080    UP000008225    UP000233040    UP000240080    UP000233200    UP000050525    UP000007648    UP000052976    UP000001073    UP000186698    UP000002277    UP000233160    UP000007754    UP000009130    UP000053605    UP000053119    UP000276834    UP000007646    UP000248481    UP000261420    UP000053584    UP000245341    UP000192224    UP000053286    UP000053641    UP000007303    UP000245340    UP000189704   

PRIDE

E5RHC5    Q53F62    Q8N6T3   

Pfam

PF01412   ArfGap

Interpro

IPR037278   ARFGAP/RecO        + More
IPR001164   ArfGAP_dom       
IPR038508   ArfGAP_dom_sf       
IPR029033   His_PPase_superfam       
IPR000560   His_Pase_clade-2       

SUPFAM

SSF57863   SSF57863        + More
SSF53254   SSF53254       

Gene 3D

3.30.40.160     3.40.50.1240    

CDD

cd07061  HP_HAP_like

ProteinModelPortal

A0A212F9M8   S4P7J7   A0A194Q4S4   A0A194QZQ4   A0A1E1WH26   A0A026WFG1   + More
A0A151JXH8   F4WHR3   A0A151XI51   A0A195B552   A0A158NM30   A0A151IXD1   A0A0L7QPX4   E9IIG2   A0A087ZV68   H9EYY4   V9IKF2   A0A154PC71   A0A2J8RB64   A0A2K6AVJ8   A0A2K5WQR4   A0A1D5Q4U4   A0A2K6AJ96   A0A2I3MFJ5   A0A2K5MDM3   F7FNM2   A0A1U8D2H6   V4AH13   E1ZUZ6   E5RHC5   A0A2J8KN23   A0A2K5EXX7   A0A2A3EP32   G3SC57   A0A2J8RB07   A0A232EQ55   A0A2K5HNW3   A0A2I3NDZ7   A0A2K5EXR3   F7DYA7   A0A2K5QS69   U3DDP3   A0A2R9ATG5   A0A2K5QS58   A0A2J8RB36   A0A2K5WQT9   A0A2K6P086   A0A151NZE4   G3W392   Q53F62   Q8N6T3   A0A091EUC1   G1RG42   A0A1L8ET23   A0A2R9ATI2   K7CBP8   A0A250Y0I4   A0A093IMK7   J3RYD3   F7EQL2   A0A2K6GRY4   Q6DCE5   H0ZB07   A0A2K6AVH0   G7PFI3   F7AMI0   A0A2K6AJE4   A0A3Q0GD42   A0A2I3H2R8   A0A091W5P1   A0A091JJP7   T1DDU4   A0A091N617   A0A1L8ELT9   A0A087VRH1   A0A3L8S5L0   A0A2J8KN27   A0A093FP31   G3U7D9   A0A2Y9G5K8   Q8N6T3-3   A0A3B4TDK3   A0A3Q0GGK3   A0A2Y9G3K2   A0A093GU52   A0A2U3Y2K7   A0A1W5AFF4   A0A0F7ZBB7   A0A087QRQ6   A0A091SR45   A0A099YTS8   H3CPB6   A0A2U3WMG2   A0A3Q0DEI8   A0A2I3N8X8   A0A093IKA0   A0A2K6AJD9  

PDB

3O47     E-value=4.10499e-49,     Score=491

KEGG

101736132    K12492 ADP-ribosylation factor GTPase-activating protein 1 | (RefSeq) ADP-ribosylation factor GTPase

PATHWAY

04144    Endocytosis - Bombyx mori (domestic silkworm)

GO

GO:0046872   GO:0005096   GO:0016021   GO:0014069   GO:0030100   GO:0032012   GO:0005829   GO:0000139   GO:0015031   GO:0006890   GO:0006888   GO:0036498   GO:0045202   GO:0006468   GO:0005524   GO:0008081   GO:0048013   GO:0005003   GO:0005887   GO:0007169  

Subcellular location

Cytoplasm   Associates with the Golgi complex.   With evidence from 9 publications.
Golgi apparatus   Associates with the Golgi complex.   With evidence from 9 publications.

Length:

346

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.05451

Exp number, first 60 AAs:

0.04979

Total prob of N-in:

0.05495

outside

1  -  346

 

 

Pi

15.038778

Theta

17.444781

Tajima's D

-1.058569

CLR

0.156448

CSRT

0.124543772811359

Interpretation

Uncertain