Gene

KWMTBOMO00056

Pre Gene Modal

BGIBMGA002032

Annotation

PREDICTED:_mitogen-activated_protein_kinase_kinase_kinase_12-like_[Bombyx_mori]

Location

Bomo_Chr1(-):1766495-1775110      View in EpiBrowser

Full name

Mitogen-activated protein kinase kinase kinase      

Location in the cell

Cytoplasmic   Reliability : 2.644

CDS

ATGGATGAGCACGAGATTGCAGAGAACGAAGCGGGCGGGTTCTTGTCGAAGACTAGTACCCAAGACTTGCGGTTTCACTTCGAAGACGGGAAGAAGCCACTCTTCTGGATGGTGGGAATGATGGACTGCTTCACAAATATTTTCTCGCTCTTCGCCAACAGCGAAATGAGACCAACAAGAGAGGAAGATTGGGAAGTGCCATTTGAGAGCATCACGGATATGATGTACCTAGGCTCTGGGGCCCAGGGGGTAGTGTACAGCGGCAACCTTAGAGGTGAAATGGTAGCCGTCAAAAAATTACGAGAGAAAGAAGAGACCGACATCATGCACCTGAGGAAACTCAACCACGACAACATAGTTCGTTTCCGTGGCGTCTGCTCGGAAGGAGAAAACTATTGTATTATCATGGAGTTCTGTCAATACGGGCCACTCTACGACTTCCTTCACAGCGGTGCATCTTTTACACCCAGACAGATCATTAGGTGGGCCAAAGATATTGCCCAAGGCATGGTCTATTTGCACAACCGCAAGATTATCCATCGTGATCTGAAAAGCCCCAATGTCCTGGTAGCTGACAATCTTGTCGCAAAGGTGAGTGACTTTGGCACCAGCCGAGAGTGGGACAACGAGAGTGCCGTCATGAGCTTTACTGGCACAGTGGCCTGGATGGCGCCCGAAGTGATTCGCCATGAGCCTTGCTCTGAGCGTGTGGATGTCTGGTCTTTCGGTGTTGTGTTATGGGAGCTGTTGACCCAGGAGATCCCGTACAAGACCTTGGAGACTCATGCTATTCTCTGGGGAGTGGGCACCGAAACTATTTTGCTGCCAGTTCCGAACAGTTGCCCGGAGAGCCTGAAACTCTTGCTGAACCAATGCTGGGACCGTGTGCCTAGGAACAGGCCACCTTTCAAGATAATTTTGGCTCACTTGGACATCGCCGGCGCTGAATTCAGTAGGGTCCTGCCCGACCGTTTTAGCGTGACCCAGGCGACATGGCGTAAAGAGATCGAAAATGAAATGAAGGAGATCTATACGAGGAACAAGGAGAAGTTTGAACAGGCTCAGAAACTGCAGTCAGTTCGTCGCGAGGAGTTGCGCTTGGCTCGCGACACGCGTCTCATCTACGAGCAGCAGCTCTCCCGCGCCAACGAACTATACATGGAGGTCTGCGCCGTCCGCCTCCAGCTCGAACAGAAAGAGAAGCACCTTGACGAGCGCGAGAAAGCTCTGAAACTCTGCCGTTGCGGCCTGCGTAAGACTCTGAAGTACTACCAGCGTCAGAACTCGTCATCGTCGGACGGTAAGTCTCCGCTCGAGGTCATCACGGAGGTGCCTCGCCGTCGCAAGCGCCCGGAGGCCCACGTGATCGTGAGCTACATAGAAGAAGACAGACAGACGGTCACCACCGTCATGGAGGAGTGCGAGTGCATAGACAACTGCAAGAACAACAACTTGGACGTAATACAGACCAGCGTGGTCGAGAGGAACGGTAACATTGAAGAGACCACCTGCGCCTTCCCGTTCGGCAGCAATGACAACTACGCCCCAGGTCAAATCCCAGATGTGGCTCACGTCTAA

Protein

MDEHEIAENEAGGFLSKTSTQDLRFHFEDGKKPLFWMVGMMDCFTNIFSLFANSEMRPTREEDWEVPFESITDMMYLGSGAQGVVYSGNLRGEMVAVKKLREKEETDIMHLRKLNHDNIVRFRGVCSEGENYCIIMEFCQYGPLYDFLHSGASFTPRQIIRWAKDIAQGMVYLHNRKIIHRDLKSPNVLVADNLVAKVSDFGTSREWDNESAVMSFTGTVAWMAPEVIRHEPCSERVDVWSFGVVLWELLTQEIPYKTLETHAILWGVGTETILLPVPNSCPESLKLLLNQCWDRVPRNRPPFKIILAHLDIAGAEFSRVLPDRFSVTQATWRKEIENEMKEIYTRNKEKFEQAQKLQSVRREELRLARDTRLIYEQQLSRANELYMEVCAVRLQLEQKEKHLDEREKALKLCRCGLRKTLKYYQRQNSSSSDGKSPLEVITEVPRRRKRPEAHVIVSYIEEDRQTVTTVMEECECIDNCKNNNLDVIQTSVVERNGNIEETTCAFPFGSNDNYAPGQIPDVAHV

Catalytic Activity

ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]

Similarity

Belongs to the protein kinase superfamily. Tyr protein kinase family.
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.

Uniprot

H9IXP9   A0A212F9M5   A0A194Q4S3   A0A194QUD5   A0A2A4K5N2   A0A2W1BSF9   + More
A0A2H1X228   A0A1B6E331   A0A1B6D4I0   A0A2M3ZGW5   A0A2M3ZGY8   B4H9B4   A0A1B6G767   A0A1B6MNK2   A0A1B6M9P6   A0A1B6M2V8   A0A2H8TQA8   A0A1B6M4E0   A0A2S2QI36   A0A2M4CIW3   A0A2M4A534   A0A2M4A599   A0A2M4CR32   A0A2M4CR65   A0A2M4BAZ4   J9K3N1   A0A0R3P786   Q29DE8   A0A0R3P9A3   T1IM54   A0A3B0J4R0   A0A3B0JTE1   A0A182UAC5   Q16RU6   A0A1W4URS3   A0A1W4UE64   A0A182FF86   A0A0L7QZB4   A0A0Q9WIT7   A0A154PAN9   A0A2A3EKD4   A0A1I8QEA1   B4LD14   A0A087ZUA1   A0A1I8QEC4   A0A0P9ALW0   A0A0P8XVS8   B3M6Y7   A0A0Q9WSY3   A0A2C9JZG5   B4N3L7   A0A0P8XVQ1   A0A224XJB4   A0A210Q125   A0A0M8ZUP8   A0A0R1E0S5   B4IY32   A0A0J9RY47   A0A0Q5U5V1   B4QQW6   B4PGD9   A0A069DWV2   B4IIN8   D3DMF6   B3NIG8   A0A0M4EMX5   Q9VW24   A0A3Q0IUJ5   A0A0Q9XQQ6   E2B5X6   A0A0P4VZ37   B4KZB1   Q7PP29   A0A182MUH1   A0A084VAY7   A0A182X909   K7J705   E9ITI2   A0A1Q3G1Y9   A0A1Q3G1P1   A0A232FB58   A0A182PB91   A0A182LKW7   A0A1I8NHG0   A0A1I8NHE5   A0A0A9YND6   A0A0A9XW76   A0A2J7PN35   C3YYZ9   A0A182QZ51   A0A2T7PX45   A0A2R5LBF1   K1QIA3   A0A2J7PN34   A0A1J1IXK6   A0A2J7PN36   A0A067RB91   A0A195D8B1   V5GTG9   A0A0L0C918  

EC Number

2.7.11.25

Pubmed

19121390    22118469    26354079    28756777    17994087    15632085    + More
17510324    18057021    15562597    28812685    17550304    22936249    26334808    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    20798317    27129103    12364791    24438588    20075255    21282665    28648823    20966253    25315136    25401762    26823975    18563158    22992520    24845553    25765539    26108605   

EMBL

BABH01015735    AGBW02009564    OWR50434.1    KQ459463    KPJ00542.1    KQ461108    + More
KPJ09077.1    NWSH01000103    PCG79537.1    KZ149952    PZC76584.1    ODYU01012411    SOQ58704.1    GEDC01004983    JAS32315.1    GEDC01016696    JAS20602.1    GGFM01007033    MBW27784.1    GGFM01007010    MBW27761.1    CH479227    EDW35338.1    GECZ01011520    JAS58249.1    GEBQ01002542    JAT37435.1    GEBQ01007336    JAT32641.1    GEBQ01009712    JAT30265.1    GFXV01004384    MBW16189.1    GEBQ01009204    JAT30773.1    GGMS01008174    MBY77377.1    GGFL01001011    MBW65189.1    GGFK01002558    MBW35879.1    GGFK01002666    MBW35987.1    GGFL01003614    MBW67792.1    GGFL01003615    MBW67793.1    GGFJ01001068    MBW50209.1    ABLF02033339    CH379070    KRT08977.1    EAL30466.2    KRT08976.1    JH430968    OUUW01000002    SPP76617.1    SPP76616.1    CH477696    EAT37138.1    KQ414683    KOC63896.1    CH940647    KRF84637.1    KQ434846    KZC08444.1    KZ288223    PBC31954.1    EDW69895.1    CH902618    KPU78814.1    KPU78815.1    EDV40852.1    CH964095    KRF99033.1    EDW79222.1    KPU78816.1    GFTR01007744    JAW08682.1    NEDP02005293    OWF42369.1    KQ435835    KOX71515.1    CM000159    KRK02366.1    CH916366    EDV97575.1    CM002912    KMZ00584.1    CH954178    KQS44254.1    CM000363    EDX11104.1    KMZ00582.1    EDW95298.2    GBGD01000702    JAC88187.1    CH480844    EDW49809.1    BT100072    AE014296    ACX61613.1    ADV37568.1    EDV52393.1    CP012525    ALC45135.1    AY094787    AAF49129.3    AAM11140.1    CH933809    KRG06424.1    GL445887    EFN88945.1    GDKW01001789    JAI54806.1    EDW18937.2    AAAB01008960    EAA11125.5    AXCM01017424    ATLV01004756    ATLV01004757    ATLV01004758    KE524238    KFB35131.1    GL765555    EFZ16110.1    GFDL01001254    JAV33791.1    GFDL01001318    JAV33727.1    NNAY01000580    OXU27567.1    GBHO01011012    GBHO01011011    GDHC01019943    GDHC01018164    GDHC01000698    JAG32592.1    JAG32593.1    JAP98685.1    JAQ00465.1    JAQ17931.1    GBHO01019963    GBHO01011009    GDHC01000094    JAG23641.1    JAG32595.1    JAQ18535.1    NEVH01023957    PNF17751.1    GG666565    EEN54507.1    AXCN02000458    AXCN02000459    AXCN02000460    PZQS01000001    PVD37995.1    GGLE01002696    MBY06822.1    JH817910    EKC28565.1    PNF17752.1    CVRI01000063    CRL04450.1    PNF17750.1    KK852811    KDR15928.1    KQ976750    KYN08679.1    GANP01010758    JAB73710.1    JRES01000836    KNC27874.1   

Proteomes

UP000005204    UP000007151    UP000053268    UP000053240    UP000218220    UP000008744    + More
UP000007819    UP000001819    UP000268350    UP000075902    UP000008820    UP000192221    UP000069272    UP000053825    UP000008792    UP000076502    UP000242457    UP000095300    UP000005203    UP000007801    UP000007798    UP000076420    UP000242188    UP000053105    UP000002282    UP000001070    UP000008711    UP000000304    UP000001292    UP000000803    UP000092553    UP000079169    UP000009192    UP000008237    UP000007062    UP000075883    UP000030765    UP000076407    UP000002358    UP000215335    UP000075885    UP000075882    UP000095301    UP000235965    UP000001554    UP000075886    UP000245119    UP000005408    UP000183832    UP000027135    UP000078542    UP000037069   

PRIDE

H9IXP9   

Pfam

PF07714   Pkinase_Tyr        + More
PF00041   fn3
PF07679   I-set
PF01412   ArfGap

Interpro

IPR000719   Prot_kinase_dom        + More
IPR011009   Kinase-like_dom_sf       
IPR001245   Ser-Thr/Tyr_kinase_cat_dom       
IPR008271   Ser/Thr_kinase_AS       
IPR013098   Ig_I-set       
IPR036116   FN3_sf       
IPR003961   FN3_dom       
IPR003599   Ig_sub       
IPR007110   Ig-like_dom       
IPR013783   Ig-like_fold       
IPR003598   Ig_sub2       
IPR036179   Ig-like_dom_sf       
IPR017419   MAP3K12_MAP3K13       
IPR037278   ARFGAP/RecO       
IPR038508   ArfGAP_dom_sf       
IPR001164   ArfGAP_dom       
IPR017896   4Fe4S_Fe-S-bd       

SUPFAM

SSF56112   SSF56112        + More
SSF49265   SSF49265       
SSF48726   SSF48726       
SSF57863   SSF57863       

Gene 3D

2.60.40.10     3.30.40.160    

CDD

cd00063  FN3

ProteinModelPortal

H9IXP9   A0A212F9M5   A0A194Q4S3   A0A194QUD5   A0A2A4K5N2   A0A2W1BSF9   + More
A0A2H1X228   A0A1B6E331   A0A1B6D4I0   A0A2M3ZGW5   A0A2M3ZGY8   B4H9B4   A0A1B6G767   A0A1B6MNK2   A0A1B6M9P6   A0A1B6M2V8   A0A2H8TQA8   A0A1B6M4E0   A0A2S2QI36   A0A2M4CIW3   A0A2M4A534   A0A2M4A599   A0A2M4CR32   A0A2M4CR65   A0A2M4BAZ4   J9K3N1   A0A0R3P786   Q29DE8   A0A0R3P9A3   T1IM54   A0A3B0J4R0   A0A3B0JTE1   A0A182UAC5   Q16RU6   A0A1W4URS3   A0A1W4UE64   A0A182FF86   A0A0L7QZB4   A0A0Q9WIT7   A0A154PAN9   A0A2A3EKD4   A0A1I8QEA1   B4LD14   A0A087ZUA1   A0A1I8QEC4   A0A0P9ALW0   A0A0P8XVS8   B3M6Y7   A0A0Q9WSY3   A0A2C9JZG5   B4N3L7   A0A0P8XVQ1   A0A224XJB4   A0A210Q125   A0A0M8ZUP8   A0A0R1E0S5   B4IY32   A0A0J9RY47   A0A0Q5U5V1   B4QQW6   B4PGD9   A0A069DWV2   B4IIN8   D3DMF6   B3NIG8   A0A0M4EMX5   Q9VW24   A0A3Q0IUJ5   A0A0Q9XQQ6   E2B5X6   A0A0P4VZ37   B4KZB1   Q7PP29   A0A182MUH1   A0A084VAY7   A0A182X909   K7J705   E9ITI2   A0A1Q3G1Y9   A0A1Q3G1P1   A0A232FB58   A0A182PB91   A0A182LKW7   A0A1I8NHG0   A0A1I8NHE5   A0A0A9YND6   A0A0A9XW76   A0A2J7PN35   C3YYZ9   A0A182QZ51   A0A2T7PX45   A0A2R5LBF1   K1QIA3   A0A2J7PN34   A0A1J1IXK6   A0A2J7PN36   A0A067RB91   A0A195D8B1   V5GTG9   A0A0L0C918  

KEGG

101741691    K04422 mitogen-activated protein kinase kinase kinase 13 [EC:2.7.11.25] | (RefSeq) mitogen-activated

GO

GO:0005524   GO:0004672   GO:0016021   GO:0004709   GO:0046777   GO:0007616   GO:0007283   GO:0030424   GO:2000331   GO:0048674   GO:0007030   GO:0046872   GO:0005096   GO:0072375   GO:0006468   GO:0048682   GO:0008081   GO:0048013   GO:0005003   GO:0005887   GO:0007169  

Length:

525

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

1.759

Exp number, first 60 AAs:

1.68751

Total prob of N-in:

0.07018

outside

1  -  525

 

 

Pi

21.623573

Theta

27.431769

Tajima's D

-0.529058

CLR

0.021236

CSRT

0.235838208089596

Interpretation

Uncertain