Gene

KWMTBOMO00052

Pre Gene Modal

BGIBMGA002093

Annotation

PREDICTED:_solute_carrier_family_35_member_C2_[Bombyx_mori]

Location

Bomo_Chr1(+):1490071-1510551      View in EpiBrowser

Full name

Ubiquitin carboxyl-terminal hydrolase      

Location in the cell

PlasmaMembrane   Reliability : 4.934

CDS

ATGTACATACAAATTTTCACAAAAATAAGAATTGTTATTGTTTTATTTTCTCATTGTACTGAGAAGAAGGACTTCAAATACCCATTGACGGTGGTGATGTACCACTTGGTTGTGAAGTGGTTGCTGTCTGTGCTAGTGCGTTCCGTGCTGTACTGCATCACGAAGACCCCTCAGCTGGTGTTGCCTCTCGGGACTAGCATCCGGTCCGTGGCTCCGACCGGCCTGTCCAGCGGCATCGACGTGGGCTTCTCGAATTGGGGCCTGGAGCTCGTCACCATATCGCTGTACACAATGACGAAATCGACAACGATCATTTTCATTCTCGGCTTCGCGATAATTCTCGGTTTGGAAAAGAAGTCTTGGTCTCTCGTGGGCATCGTCCTCATGATCGCGGCGGGCCTTATCATGTTTACTTACAAAGCGACCCAGTTCAACATCGAAGGATTCAGTTTTCTACTCCTAGCGTCTTTTGCGGCGGGTCTACGTTGGACCTTCGCTCAACTTCTCATGCAGAAGGCGAAGCTGGGACTCCATAACCCAGTGGATATGGTGTTTCACGTGCAGCCTTGGATGTTTTTAGCCCTGATACCATTTACAGCAATTTTTGAAGGCCTGGATTGCATCATGTTCCTACTAGGTCTACCCGACGAGTTGTTACTCCCAACTGTCTTGAAGGTGACCGTTGGAGCCACGATCGCATTCGCAATGGAGATCAGCGAGTTCCTGGTCGTAACCTACACTTCGAGTCTGACGCTGTCCATTGCTGGAATATTCAAGGAGATGTGCATACTGGTCTTAGCGGTGAAGGTGAGCGGCGATCAGCTCAGCCTCATAAACGTGGTCGGTCTTGCGGTGTGTCTGCTCGGGATCATTGGCCACATCGTCCATAAGATGTTGATCATTAGAGCCGTCGAGAGTGCCGTTGTTGTCGAAGTCGATAACTTCGAGGCTGTCAAGAACAGGTCCCCGAATAAAGACGAAACAGATGAACCTCTACTGACGGAGAAGAGTTGGCTTAGCGAAGACAGCGACGTAGACGCTAACGTGGTGCTATACGAAGTATTGCAGAGACGCGACGGACATTAA

Protein

MYIQIFTKIRIVIVLFSHCTEKKDFKYPLTVVMYHLVVKWLLSVLVRSVLYCITKTPQLVLPLGTSIRSVAPTGLSSGIDVGFSNWGLELVTISLYTMTKSTTIIFILGFAIILGLEKKSWSLVGIVLMIAAGLIMFTYKATQFNIEGFSFLLLASFAAGLRWTFAQLLMQKAKLGLHNPVDMVFHVQPWMFLALIPFTAIFEGLDCIMFLLGLPDELLLPTVLKVTVGATIAFAMEISEFLVVTYTSSLTLSIAGIFKEMCILVLAVKVSGDQLSLINVVGLAVCLLGIIGHIVHKMLIIRAVESAVVVEVDNFEAVKNRSPNKDETDEPLLTEKSWLSEDSDVDANVVLYEVLQRRDGH

Catalytic Activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Similarity

Belongs to the peptidase C12 family.

Uniprot

A0A2A4IUB8   A0A2A4IUY0   A0A2W1BSH0   A0A1E1W192   A0A212F9M1   A0A194QU69   + More
A0A194Q6A7   H9IXW0   A0A084WKJ4   A0A182HA21   A0A023ESW0   Q16HA4   Q16J20   A0A0K8TQP9   A0A182PP50   A0A182ITB7   A0A182NM34   A0A182Y106   A0A182TYT1   A0A182WQW6   A0A182JY26   A0A182VDG2   A0A182M0I5   A0A2C9GQQ1   Q7PNQ1   U5EVP5   A0A182QZ50   B0WNW5   A0A182X544   A0A1Q3FI62   A0A1Q3FIA8   A0A1Q3FI66   A0A2J7Q3H9   A0A2M4BK32   A0A2M4BKT5   A0A182RN10   A0A067QV19   A0A2M4AIG5   A0A2M3Z6L7   W5J9I1   A0A1A9YS24   A0A1B0AE06   A0A336KUE2   A0A336M8J8   A0A1A9WCR2   A0A1L8DDG8   A0A1B0FR02   A0A1L8DDP3   A0A1L8DDP1   A0A1L8E1M3   A0A1L8E151   A0A1I8P7A5   A0A1I8MXL5   A0A1L8DDG5   A0A182FHX4   A0A1L8E190   B4LH38   A0A1W4X8Z7   A0A0L0BM24   B4KWE7   E0VZY3   A0A1B0B8N5   B4N570   B4IXC6   A0A158NAM5   A0A151I5V5   B4PH41   B3NBX3   A0A0V0G906   E2ANR2   E9IPJ4   A0A1W4W0I8   A0A023F9R1   A0A026WQY0   A0A1Y1KHE0   B3M827   Q960F0   Q9VZP2   E2B5X8   A0A195CJG5   A0A0P4VHU2   B4QPJ6   R4G304   A0A0H3YFJ8   A0A0A1WYV7   B7PD55   A0A1J1ISQ4   D6WIN5   A0A034WBH3   A0A0K8VJC4   A0A1B0GID3   A0A3B0K1P1   A0A232FAT0   A0A1D2NCU3   A0A154P9C4   Q29DQ0   A0A0L7QZ70   K7J704   A0A1W4XIG8   W8CDA6  

EC Number

3.4.19.12

Pubmed

28756777    22118469    26354079    19121390    24438588    26483478    + More
24945155    17510324    26369729    25244985    12364791    14747013    17210077    24845553    20920257    23761445    25315136    17994087    26108605    18057021    20566863    21347285    17550304    20798317    21282665    25474469    24508170    30249741    28004739    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    27129103    22936249    26057828    25830018    18362917    19820115    25348373    28648823    27289101    15632085    23185243    20075255    24495485   

EMBL

NWSH01006238    PCG63577.1    PCG63575.1    KZ149952    PZC76575.1    GDQN01010352    + More
JAT80702.1    AGBW02009564    OWR50430.1    KQ461108    KPJ09073.1    KQ459463    KPJ00540.1    BABH01015712    ATLV01024123    KE525349    KFB50738.1    JXUM01121934    KQ566552    KXJ70039.1    GAPW01001221    JAC12377.1    CH478188    EAT33620.1    CH478036    EAT34267.1    GDAI01000916    JAI16687.1    AXCM01013109    APCN01004280    APCN01004281    AAAB01008960    EAA11804.4    GANO01003316    JAB56555.1    AXCN02002327    DS232016    EDS31970.1    GFDL01007798    JAV27247.1    GFDL01007767    JAV27278.1    GFDL01007810    JAV27235.1    NEVH01019067    PNF23148.1    GGFJ01004266    MBW53407.1    GGFJ01004267    MBW53408.1    KK852982    KDR12889.1    GGFK01007216    MBW40537.1    GGFM01003422    MBW24173.1    ADMH02001883    ETN60656.1    UFQS01000972    UFQT01000972    SSX08095.1    SSX28235.1    UFQT01000553    SSX25219.1    GFDF01009588    JAV04496.1    CCAG010001599    GFDF01009587    JAV04497.1    GFDF01009589    JAV04495.1    GFDF01001612    JAV12472.1    GFDF01001611    JAV12473.1    GFDF01009583    JAV04501.1    GFDF01001613    JAV12471.1    CH940647    EDW69528.1    JRES01001656    KNC21101.1    CH933809    EDW18554.1    KRG06245.1    DS235854    EEB18939.1    JXJN01010019    CH964101    EDW79509.1    CH916366    EDV97458.1    ADTU01010381    KQ976413    KYM90357.1    CM000159    EDW93278.1    CH954178    EDV50790.1    GECL01001606    JAP04518.1    GL441305    EFN64930.1    GL764522    EFZ17518.1    GBBI01001049    JAC17663.1    KK107145    QOIP01000010    EZA57504.1    RLU17423.1    RLU17644.1    GEZM01083974    JAV60889.1    CH902618    EDV39935.1    AY052095    AAK93519.1    AE014296    BT133405    AAF47777.1    AFH55504.1    GL445887    EFN88947.1    KQ977642    KYN00881.1    GDKW01002358    JAI54237.1    CM000363    CM002912    EDX09089.1    KMY97369.1    ACPB03001509    GAHY01002121    JAA75389.1    KT163697    AKN21647.1    GBXI01010048    JAD04244.1    ABJB010047318    ABJB010332044    ABJB010641635    ABJB010825748    ABJB010886116    DS688408    EEC04527.1    CVRI01000059    CRL03160.1    KQ971321    EFA00757.1    GAKP01006026    JAC52926.1    GDHF01013325    JAI38989.1    AJWK01013699    AJWK01013700    AJWK01013701    AJWK01013702    AJWK01013703    AJWK01013704    AJWK01013705    AJWK01013706    OUUW01000012    SPP87233.1    NNAY01000580    OXU27569.1    LJIJ01000095    ODN02816.1    KQ434846    KZC08441.1    CH379070    EAL30364.1    KRT08861.1    KQ414683    KOC63893.1    GAMC01002281    JAC04275.1   

Proteomes

UP000218220    UP000007151    UP000053240    UP000053268    UP000005204    UP000030765    + More
UP000069940    UP000249989    UP000008820    UP000075885    UP000075880    UP000075884    UP000076408    UP000075902    UP000075920    UP000075881    UP000075903    UP000075883    UP000075840    UP000007062    UP000075886    UP000002320    UP000076407    UP000235965    UP000075900    UP000027135    UP000000673    UP000092443    UP000092445    UP000091820    UP000092444    UP000095300    UP000095301    UP000069272    UP000008792    UP000192223    UP000037069    UP000009192    UP000009046    UP000092460    UP000007798    UP000001070    UP000005205    UP000078540    UP000002282    UP000008711    UP000000311    UP000192221    UP000053097    UP000279307    UP000007801    UP000000803    UP000008237    UP000078542    UP000000304    UP000015103    UP000001555    UP000183832    UP000007266    UP000092461    UP000268350    UP000215335    UP000094527    UP000076502    UP000001819    UP000053825    UP000002358   

PRIDE

H9IXW0    Q960F0   

Pfam

PF03151   TPT        + More
PF18031   UCH_C
PF01088   Peptidase_C12
PF13967   RSN1_TM
PF02714   RSN1_7TM
PF14703   PHM7_cyt

Interpro

IPR004853   Sugar_P_trans_dom        + More
IPR036959   Peptidase_C12_UCH_sf       
IPR001578   Peptidase_C12_UCH       
IPR041507   UCH_C       
IPR038765   Papain-like_cys_pep_sf       
IPR012340   NA-bd_OB-fold       
IPR026957   TMEM63A       
IPR027815   PHM7_cyt       
IPR003864   RSN1_7TM       
IPR032880   Csc1_N       

SUPFAM

SSF54001   SSF54001        + More
SSF50249   SSF50249       

Gene 3D

3.40.532.10    

ProteinModelPortal

A0A2A4IUB8   A0A2A4IUY0   A0A2W1BSH0   A0A1E1W192   A0A212F9M1   A0A194QU69   + More
A0A194Q6A7   H9IXW0   A0A084WKJ4   A0A182HA21   A0A023ESW0   Q16HA4   Q16J20   A0A0K8TQP9   A0A182PP50   A0A182ITB7   A0A182NM34   A0A182Y106   A0A182TYT1   A0A182WQW6   A0A182JY26   A0A182VDG2   A0A182M0I5   A0A2C9GQQ1   Q7PNQ1   U5EVP5   A0A182QZ50   B0WNW5   A0A182X544   A0A1Q3FI62   A0A1Q3FIA8   A0A1Q3FI66   A0A2J7Q3H9   A0A2M4BK32   A0A2M4BKT5   A0A182RN10   A0A067QV19   A0A2M4AIG5   A0A2M3Z6L7   W5J9I1   A0A1A9YS24   A0A1B0AE06   A0A336KUE2   A0A336M8J8   A0A1A9WCR2   A0A1L8DDG8   A0A1B0FR02   A0A1L8DDP3   A0A1L8DDP1   A0A1L8E1M3   A0A1L8E151   A0A1I8P7A5   A0A1I8MXL5   A0A1L8DDG5   A0A182FHX4   A0A1L8E190   B4LH38   A0A1W4X8Z7   A0A0L0BM24   B4KWE7   E0VZY3   A0A1B0B8N5   B4N570   B4IXC6   A0A158NAM5   A0A151I5V5   B4PH41   B3NBX3   A0A0V0G906   E2ANR2   E9IPJ4   A0A1W4W0I8   A0A023F9R1   A0A026WQY0   A0A1Y1KHE0   B3M827   Q960F0   Q9VZP2   E2B5X8   A0A195CJG5   A0A0P4VHU2   B4QPJ6   R4G304   A0A0H3YFJ8   A0A0A1WYV7   B7PD55   A0A1J1ISQ4   D6WIN5   A0A034WBH3   A0A0K8VJC4   A0A1B0GID3   A0A3B0K1P1   A0A232FAT0   A0A1D2NCU3   A0A154P9C4   Q29DQ0   A0A0L7QZ70   K7J704   A0A1W4XIG8   W8CDA6  

KEGG

101744817    K15280 solute carrier family 35, member C2 | (RefSeq) solute carrier family 35 member C2

GO

GO:0016021   GO:0015297   GO:0005793   GO:0015786   GO:0005794   GO:0005801   GO:0022857   GO:0004843   GO:0006511   GO:0000138  

PANTHER

PTHR10589   PTHR13018:SF24  

Length:

361

Number of predicted TMHs:

7

Exp number of AAs in TMHs:

155.57462

Exp number, first 60 AAs:

20.45578

Total prob of N-in:

0.93021

POSSIBLE N-term signal

sequence

inside

1  -  28

TMhelix

29  -  51

outside

52  -  91

TMhelix

92  -  114

inside

115  -  120

TMhelix

121  -  138

outside

139  -  147

TMhelix

148  -  170

inside

171  -  189

TMhelix

190  -  212

outside

213  -  231

TMhelix

232  -  254

inside

255  -  274

TMhelix

275  -  294

outside

295  -  361

 

 

Pi

25.280549

Theta

29.310522

Tajima's D

-0.713909

CLR

0.017631

CSRT

0.190140492975351

Interpretation

Uncertain