Gene

KWMTBOMO00040

Pre Gene Modal

BGIBMGA002043

Annotation

PREDICTED:_probable_3'?5'-cyclic_phosphodiesterase_pde-5_isoform_X3_[Amyelois_transitella]

Location

Bomo_Chr1(-):1271873-1278740      View in EpiBrowser

Full name

Phosphodiesterase       + More
Probable 3',5'-cyclic phosphodiesterase pde-5      

Location in the cell

Cytoplasmic   Reliability : 2.674

CDS

ATGTGGAGAACAAAGGACAGGTTCAAAGTCATCGACGAAGAGATTAGTGGTCACATCGTCGTGTGGGGCAGTGTTGCTCTGCATTACTGTAAGCTGTATGTGGATAAGAAAAGGGAACGTAATATGTCCGATTTTTTATTGGACGTTGTCAAAGCAATTTTCGAAGAGATGGTTTCTTTGGATCAACTGATAAAGAGGATATTAGAGTTCGCCCAGAGGCTTGTGAACGCAGACAGGGCTTCGCTATTCTTAGTCGACTACAGGAATTCTGAGCTGGTCTCCACTGTATTCGATCTTAAATTTGAGCCAGGTCTAGATCTGGATATGGAAAAGAAAGAGATTAGGATGCCGATAAATAGAGGAATTGCCGGTCATGTGGCGTTATCAGGCGAGACTATGAATATTCCTGACGCTTATTCTGATTACAGGTTTAATAGAGACGTGGACGAAGCTACTGGATACAAAACAATAAGCATTCTATGTATGCCCATAAAGGTCGAAGGAAAAGTCATTGGCGTTGTCCAAATGGTTAACAAACGCGACGATAAATATTTCGGTGATGACGATGAGGCGGCCTTCGAGATATTCTCCACGTTTTTCGGCCTAGCCCTCCACCACGCGAGGCTTTATGACAGGATCATGAGGAAAGAGCAGAAGTATCGAGTGGCCCTCGAAGTGCTAAGCTATCACAACACGTGCCGGGAATATGAGGTGCAAGCTATGCTGCTAGACAAAGAACCGTTGAATGTTGACTTCGCAGATTTTTATCTAGATCCGTTTCGTTTTGATGAGTTCGAGAAATGTAAATGTATTATATCAATGTTTCGCGATCTGTTTGATATGACCCAGTTTGATATTACGACGCTGACAAGGTTCACGTTGACTGTCAAGAAGAATTATAGGACGGTGCCGTATCATAACTTCGATCATGGCTGGACCGTCGCTCATGCAATGTACGCCATCTTGAAGAGCGATGTGAAGGAGAGATTTGATTATAACAAGAGACTGGCACTCTTCGTTGCGTGTCTTTGCCACGATTTGGACCACCGAGGGTATACCAATAAATACATGAGCGAAACAGCCTCACCTCTAGCCGCCATGTACACAACATCTACATTAGAGCACCATCATTTCAACATTACGGTCACTATTTTACAACAGGACGGTCACAACATATTCTCACATATTTCAAGCGAAGACTACAAAGAGATTCTCGGCTTCATCAGGCACTGTATTCTGGCAACCGATCTAGCGGCCTTCTTCCCTAATTTAGACAAAATAAGAGAATTGTACAGATCTGATGAAGCACAGTTCAGCTGGGACGATCCGAGTCACAGAGATTTGGCCATGGCCATATCAATGACAGCGGCTGATCTGTCAGCTTCAGCTAAGCCATGGGAGATTCAGATCAAAACAGTGAAGGTTATATTTGAGGAGTTTTATGATCAAGGAGACAAGGAGAGAGCTGCTGGAAGGATACCGATACCGATGATGGATAGGAATAAACCTGAAGAGCAGCCAGCTAGCCAGGTTGGTTTCCTCAGTCAAATATGTATACCGTGTTACGACATGCTGTATCGAATACTTCCGAACACAAAGCCGATGTACGCTATGGCAACAAAAAACCTCAACAGATGGAAAGCGAGAGCTGATAAGATCCTTTTTAAGCAAGACTCGAAGAAAGATAATTCTAAAGATAGCCTTGAACCAAAGGATGGAATCGGAGATGATGATGATGATGTCACAGTTAAAAATGAAGGGAACAAAAGAGTAGAAATCATAAGGCAAGAATCAAAAACTATTATAGGAGAAGCTCAACCCAAACCTGTAGTATGGAATGATGACGAAGAATTTGCGGTTGAACAAACCTTTAGAAGTAACATTTGGAAGGAAATTGATGGAGTCACGTGGATCGAAGAAGAAGGCGTATTAGTTGCTAGTGAAGCGACGAAAAAAGATGATACAGTTTGA

Protein

MWRTKDRFKVIDEEISGHIVVWGSVALHYCKLYVDKKRERNMSDFLLDVVKAIFEEMVSLDQLIKRILEFAQRLVNADRASLFLVDYRNSELVSTVFDLKFEPGLDLDMEKKEIRMPINRGIAGHVALSGETMNIPDAYSDYRFNRDVDEATGYKTISILCMPIKVEGKVIGVVQMVNKRDDKYFGDDDEAAFEIFSTFFGLALHHARLYDRIMRKEQKYRVALEVLSYHNTCREYEVQAMLLDKEPLNVDFADFYLDPFRFDEFEKCKCIISMFRDLFDMTQFDITTLTRFTLTVKKNYRTVPYHNFDHGWTVAHAMYAILKSDVKERFDYNKRLALFVACLCHDLDHRGYTNKYMSETASPLAAMYTTSTLEHHHFNITVTILQQDGHNIFSHISSEDYKEILGFIRHCILATDLAAFFPNLDKIRELYRSDEAQFSWDDPSHRDLAMAISMTAADLSASAKPWEIQIKTVKVIFEEFYDQGDKERAAGRIPIPMMDRNKPEEQPASQVGFLSQICIPCYDMLYRILPNTKPMYAMATKNLNRWKARADKILFKQDSKKDNSKDSLEPKDGIGDDDDDVTVKNEGNKRVEIIRQESKTIIGEAQPKPVVWNDDEEFAVEQTFRSNIWKEIDGVTWIEEEGVLVASEATKKDDTV

Description

Redundantly with pde-1, plays a role in the AFD thermosensory neurons to regulate microvilli receptive ending morphology, possibly by regulating cGMP levels.

Catalytic Activity

a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+)

Cofactor

a divalent metal cation

Similarity

Belongs to the cyclic nucleotide phosphodiesterase family.

Keywords

cGMP   Coiled coil   Complete proteome   Hydrolase   Metal-binding   Reference proteome  

Feature

chain  Probable 3',5'-cyclic phosphodiesterase pde-5

Uniprot

H9IXR0   A0A2A4JSA6   A0A2W1C0U8   A0A2H1WFZ1   A0A212EQP0   A0A1W4WYY5   + More
A0A1W4WN66   A0A1W4WN57   Q16HU8   A0A1S4G0Q2   A0A1B0CY76   F6KPR5   D6WFZ7   A0A0A9XBM5   A0A146LDS5   A0A1J1IKS7   A0A0A9XJX4   A0A0A9X9K5   A0A146KLE9   A0A0A9XBN0   A0A1Q3FNA8   A0A146LFP7   A0A0V0GAE4   A0A067RGF4   B0WPM1   A0A0P4VS35   A0A023F0G6   A0A1B6CTP1   A0A2J7PWX5   A0A0A9YAJ3   A0A0A9XF21   A0A0A9X9L0   A0A0A9XCP1   A0A1B6JSE8   A0A1D2ML08   A0A1B6F059   A0A336LSD4   E9GD11   A0A226EF71   A0A0P4ZJF8   A0A0P6A891   A0A0P5D3J8   A0A164XV76   A0A0P5DQ97   A0A0P5YSN8   A0A0P5T289   A0A0P5CTN9   A0A0P5D9M3   A0A0P5C549   A0A0P5EHR2   A0A0P5J7I7   A0A0P5HR42   A0A069DZ88   A0A0P5KKM9   V5IGH5   A0A0P5CXV1   A0A0P6EXF8   B7QBR4   A0A2R5LG71   A0A1Z5KUZ7   A0A1D1W945   A0A1Y1KVY5   A0A2T7NR97   A0A1S3J205   T2M376   V5GNV3   A0A1W0WNA2   B3RPP8   R7UJM9   A0A3M6U3Q3   T1ID25   A0A210R081   K1RHP0   A0A2B4RJR5   A0A369SEH1   A0A1L8DL06   A7RVE3   A0A0N4ZF26   A0A1I7SAH8   A0A2A2K1L2   A0A0P5FQE5   A0A183BM06   A0A158PMK3   P91119   A0A0D6M523   A0A016WJA0   A0A260YPC4   A0A2P4UZC5   A0A158P8A5   A0A261B1I0   A0A1I7U6X5   A0A0B2UZ40   A0A0K0F5E4   A0A158Q616   A0A158QWI5   A0A0N5BIF8   A0A090LEJ3   A0A2G5VLJ5   A0A0K0DWG2  

EC Number

3.1.4.-
3.1.4.17

Pubmed

19121390    28756777    22118469    17510324    24964065    18362917    + More
19820115    25401762    26823975    24845553    27129103    25474469    27289101    21292972    26334808    25765539    28528879    27649274    28004739    24065732    18719581    23254933    30382153    28812685    22992520    30042472    17615350    21909270    9851916    27062922    25730766    26114425    26394399   

EMBL

BABH01015688    BABH01015689    NWSH01000779    PCG74290.1    KZ149922    PZC77693.1    + More
ODYU01008312    SOQ51792.1    AGBW02013268    OWR43795.1    CH478140    EAT33826.1    AJWK01035539    HQ540429    AEG42080.1    KQ971328    EEZ99770.2    GBHO01026195    GBRD01006051    JAG17409.1    JAG59770.1    GDHC01012974    JAQ05655.1    CVRI01000054    CRL00370.1    GBHO01026189    GBRD01016211    JAG17415.1    JAG49615.1    GBHO01026192    JAG17412.1    GDHC01021680    JAP96948.1    GBHO01026190    JAG17414.1    GFDL01005974    JAV29071.1    GDHC01012404    JAQ06225.1    GECL01001192    JAP04932.1    KK852480    KDR22951.1    DS232027    EDS32424.1    GDKW01001345    JAI55250.1    GBBI01004268    JAC14444.1    GEDC01020705    JAS16593.1    NEVH01020867    PNF20838.1    GBHO01014978    GBRD01007277    JAG28626.1    JAG58544.1    GBHO01026191    JAG17413.1    GBHO01026187    GBRD01007276    JAG17417.1    JAG58545.1    GBHO01026193    JAG17411.1    GECU01005597    JAT02110.1    LJIJ01000955    ODM93561.1    GECZ01026288    JAS43481.1    UFQT01000086    SSX19489.1    GL732539    EFX82772.1    LNIX01000004    OXA56283.1    GDIP01213410    JAJ09992.1    GDIP01033240    JAM70475.1    GDIP01163316    JAJ60086.1    LRGB01000944    KZS14597.1    GDIP01169760    JAJ53642.1    GDIP01053884    JAM49831.1    GDIP01132080    JAL71634.1    GDIP01169759    JAJ53643.1    GDIP01175365    JAJ48037.1    GDIP01175366    JAJ48036.1    GDIP01143116    JAJ80286.1    GDIQ01204134    JAK47591.1    GDIQ01226126    JAK25599.1    GBGD01001065    JAC87824.1    GDIQ01208382    JAK43343.1    GANP01006677    JAB77791.1    GDIP01163915    JAJ59487.1    GDIQ01069142    JAN25595.1    ABJB010075929    ABJB010227318    ABJB010487777    ABJB010522530    ABJB010608325    ABJB010685560    ABJB010940632    ABJB011040192    ABJB011094763    ABJB011096231    DS903006    EEC16286.1    GGLE01004289    MBY08415.1    GFJQ02008070    JAV98899.1    BDGG01000019    GAV08828.1    GEZM01075016    JAV64340.1    PZQS01000010    PVD23694.1    HAAD01000279    CDG66511.1    GANP01012413    JAB72055.1    MTYJ01000071    OQV16694.1    DS985242    EDV27675.1    AMQN01007429    KB300677    ELU06420.1    RCHS01002300    RMX48282.1    ACPB03013655    NEDP02001046    OWF54399.1    JH823218    EKC41025.1    LSMT01000474    PFX17416.1    NOWV01000017    RDD45317.1    GFDF01006952    JAV07132.1    DS469543    EDO44626.1    LIAE01009884    PAV67773.1    GDIQ01253576    JAJ98148.1    UYYA01005321    VDM64508.1    FO080144    KE124835    EPB77491.1    JARK01000245    EYC39676.1    NMWX01000912    OZF75035.1    LFJK02001458    POM30403.1    NIPN01000185    OZG04159.1    JPKZ01002921    KHN74347.1    UYYG01000076    VDN52735.1    UYSL01000080    VDL62631.1    LN609529    CEF66568.1    PDUG01000001    PIC52634.1   

Proteomes

UP000005204    UP000218220    UP000007151    UP000192223    UP000008820    UP000092461    + More
UP000007266    UP000183832    UP000027135    UP000002320    UP000235965    UP000094527    UP000000305    UP000198287    UP000076858    UP000001555    UP000186922    UP000245119    UP000085678    UP000009022    UP000014760    UP000275408    UP000015103    UP000242188    UP000005408    UP000225706    UP000253843    UP000001593    UP000038045    UP000095284    UP000218231    UP000050741    UP000050601    UP000267027    UP000001940    UP000024635    UP000216624    UP000237256    UP000035642    UP000216463    UP000095282    UP000031036    UP000035680    UP000038040    UP000274756    UP000038043    UP000271162    UP000046392    UP000035682    UP000230233    UP000035681   

PRIDE

H9IXR0    P91119   

Pfam

PF00233   PDEase_I        + More
PF01590   GAF
PF13185   GAF_2
PF00400   WD40
PF12125   Beta-TrCP_D

Interpro

IPR002073   PDEase_catalytic_dom        + More
IPR029016   GAF-like_dom_sf       
IPR003607   HD/PDEase_dom       
IPR036971   PDEase_catalytic_dom_sf       
IPR023174   PDEase_CS       
IPR003018   GAF       
IPR023088   PDEase       
IPR001680   WD40_repeat       
IPR017986   WD40_repeat_dom       
IPR015943   WD40/YVTN_repeat-like_dom_sf       
IPR021977   Beta-TrCP_D       
IPR036322   WD40_repeat_dom_sf       
IPR019775   WD40_repeat_CS       
IPR036047   F-box-like_dom_sf       
IPR020472   G-protein_beta_WD-40_rep       

SUPFAM

SSF50978   SSF50978        + More
SSF81383   SSF81383       

Gene 3D

1.10.1300.10     3.30.450.40     2.130.10.10    

CDD

cd00077  HDc

ProteinModelPortal

H9IXR0   A0A2A4JSA6   A0A2W1C0U8   A0A2H1WFZ1   A0A212EQP0   A0A1W4WYY5   + More
A0A1W4WN66   A0A1W4WN57   Q16HU8   A0A1S4G0Q2   A0A1B0CY76   F6KPR5   D6WFZ7   A0A0A9XBM5   A0A146LDS5   A0A1J1IKS7   A0A0A9XJX4   A0A0A9X9K5   A0A146KLE9   A0A0A9XBN0   A0A1Q3FNA8   A0A146LFP7   A0A0V0GAE4   A0A067RGF4   B0WPM1   A0A0P4VS35   A0A023F0G6   A0A1B6CTP1   A0A2J7PWX5   A0A0A9YAJ3   A0A0A9XF21   A0A0A9X9L0   A0A0A9XCP1   A0A1B6JSE8   A0A1D2ML08   A0A1B6F059   A0A336LSD4   E9GD11   A0A226EF71   A0A0P4ZJF8   A0A0P6A891   A0A0P5D3J8   A0A164XV76   A0A0P5DQ97   A0A0P5YSN8   A0A0P5T289   A0A0P5CTN9   A0A0P5D9M3   A0A0P5C549   A0A0P5EHR2   A0A0P5J7I7   A0A0P5HR42   A0A069DZ88   A0A0P5KKM9   V5IGH5   A0A0P5CXV1   A0A0P6EXF8   B7QBR4   A0A2R5LG71   A0A1Z5KUZ7   A0A1D1W945   A0A1Y1KVY5   A0A2T7NR97   A0A1S3J205   T2M376   V5GNV3   A0A1W0WNA2   B3RPP8   R7UJM9   A0A3M6U3Q3   T1ID25   A0A210R081   K1RHP0   A0A2B4RJR5   A0A369SEH1   A0A1L8DL06   A7RVE3   A0A0N4ZF26   A0A1I7SAH8   A0A2A2K1L2   A0A0P5FQE5   A0A183BM06   A0A158PMK3   P91119   A0A0D6M523   A0A016WJA0   A0A260YPC4   A0A2P4UZC5   A0A158P8A5   A0A261B1I0   A0A1I7U6X5   A0A0B2UZ40   A0A0K0F5E4   A0A158Q616   A0A158QWI5   A0A0N5BIF8   A0A090LEJ3   A0A2G5VLJ5   A0A0K0DWG2  

PDB

3IBJ     E-value=1.71354e-91,     Score=859

KEGG

101741126    K18438 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10 [EC:3.1.4.17 3.1.4.35] | (RefS

GO

GO:0046872   GO:0004114   GO:0007165   GO:0004118   GO:0010754   GO:0030552   GO:0046983   GO:0016787   GO:0007635   GO:0010446   GO:0032528   GO:0008340   GO:0047555   GO:0007602   GO:0010628   GO:0006935   GO:0042542   GO:0005515   GO:0008081   GO:0005524   GO:0048013   GO:0005003   GO:0005887   GO:0007169   GO:0016021  

Length:

656

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.275130000000001

Exp number, first 60 AAs:

0.0819099999999999

Total prob of N-in:

0.01016

outside

1  -  656

 

 

Pi

16.159269

Theta

21.027946

Tajima's D

-0.988573

CLR

0.065179

CSRT

0.138793060346983

Interpretation

Uncertain