Gene

KWMTBOMO00022

Pre Gene Modal

BGIBMGA002079

Annotation

PREDICTED:_ephrin_type-B_receptor_1-B_[Plutella_xylostella]

Location

Bomo_Chr1(+):564496-567714      View in EpiBrowser

Full name

Receptor protein-tyrosine kinase      

Location in the cell

PlasmaMembrane   Reliability : 1.858

CDS

ATGATTTGGCTGATAGTAGTGACGGCCTTGGCTAGCGTGCATGGCGAACAAGTGCTGCTTCTCGACACTACAGCAGAAGATACTCTAGGCTGGACCCGGTTCTCGTATGGTGCGCAGGCTAGCACTGCCGGCTGGCTCGAAGAATCTTACACTAACTTTGAAAAACAAATAAACTGGCGCTCCTATGTGGTCTGTGACGTCGCCCACCATAATGTGAATAACTGGCTCTGGACCCCGTTCATCGAACGCAGAAATGCCAATAGAATCTACATAGAAATCAAGTTTACTATTCGTGATTGCTCACTTTTCCCAGGAAATGCATTGAGTTGTAAAGAAACATTCAGTCTCTTGTATTATGAATTTGATGTTGCCACTAGAGAACAACCTCCCTGGGAGCCCGAGAGTTACAAGTTAGTTGGCCGCATCGCCGCAGGGGAAGGCAGATTTAACACTAACTCTGAAGTGGACATCAACACTGAAGTGAAGAGTATTGCAGTCACAAAGAAAGGTGTGTATTTTGCATTTAGAGATCAAGGAGCCTGCATATCTATTTTGGCAGTGAAAGTCTATTACATCACATGTCCTGATGTCAACATTAACTTTGCAAGATTCCCTGCCACTCCCACTGGCAGGGAAGTTACGGTTATTGAACAAGCCAATGGAACTTGTGTTGCTAATGCTGAGGTTGCTCCTGGTGAAAAAGCCCCTGTTTATTTATGCAAGGGTGATGGCAAATGGACCCTTCCCAGTGGCTCTTGCAAATGCAGGGCAGGCTTTGAACCTGACCACAACAATCAAATTTGTACAGAATGTGCACCTGGAAAATTTAAATCTCACACTGGTGACGAACACTGCATCCCGTGCCCTGATCATTCTGAGTCAACCATATATGCTGCTGCTGAATGTAAATGTACTCCAAAATACTATAGAGCTAAGAAAGACCCAAAAACCATACCCTGTACTCAACCACCTTCAGCACCTGATAATTTGACTGTAACATTTGCTGATCAGTTTTCTATTTCTCTTACTTGGCAACCGCCACATAATACTGGCGGAAGAAGTGATATTACATATAAGATTTCATGTGCCAATTGCGGCCCCACTGTGGAATTTAGACCAGGAGAGACTGGCCTTAATAGTACACGAGTTACAATTAGTGGTCTAGATCCAGTAACTGAATACAAGTTTCAAGTTTATGCAGAAAATGGAGTATCTGAACTCTCTCCTGATCCTGCAAAACACATAGAAATCACAGCAGTAACTGAAGCCTCTGTAGTGAGTGTAGTGTCAAAATTGAGGATTTTGAACACAGAAAGTGATAGGTTAACAATTGCTTGGAATCCACCACAAGTAGACTTAACTGATCCTGATGACACTATAGAGAGCTATGAAGTGAAATGCTTTCCAAAAGACAGTCAAGACAAGAATACCAACACCACCCTGAGGATTACTAAGGACCCACAGGTCACCATTACAGGATTAAGAAAAGACACTGAATATGGCATTAGGGTCAGAGCCAAGATGAAGAGAGGATGGGGAGAATTCAGTGGAATTGTATATGCTCGAACCAATTCTGTTACTGAAACTTCATTCATTGACGAAGAAGGAGCTCAAGTTAGATTAGTTGCTGGTGTTATGGTGGCAGTAGTTGTCCTCACAGTGATTGCCATCATTGCTACTGTTTTATTTTTGAGATCTCGTGCTGATGATGAATGTGATAAAAAACAACCTAGTGATTGTAATGCTCTTAATTATAGAAATGGAGAAGTTTACACAGGACCTGATCGTCCTGCTAAGACAAGCAGCAATGCTACCACTCCTCTTTTTGCTGGCACTGGTTCCAGGACTTACATAGACCCTCATACATATGAAGACCCCAATCAAGCTGTCAGAGAATTTGCACGTGAGATTGATGCATCATGTATTACTATTGAAGCAATAATAGGTGGTGGTGAATTTGGAGATGTTTGTCGTGGCAAATTGAAACTTCCAGCTAGTTGTGGCCCAGAAATTGATGTTGCCATCAAGACATTAAAACCAGGCTCCACTGAACGAGCTCGACGTGATTTCCTGGCTGAAGCGTCTATAATGGGCCAATTTGAACATCCAAATGTGATATTCTTACAGGGAGTCGTCACAAAATGCAATCCAATCATGATTATTACTGAGTTCATGGAAAATGGATCTTTGGACACTTTCTTACGGGCGAATGATGGAAAATTTAGAGTGCTGCAATTGGTTGGTATGTTACGTGGTATCGCCACTGGAATGCAATATCTTTCAGAGATGAACTACATCCATCGTGACCTAGCTGCACGAAATGTACTTGTCAATTCTCAACTTGTTTGTAAGATAGCTGACTTTGGTCTCTCTCGTGAAATTGAATCTACTGCTGATGGAGCCTATACAACCCGTGGTGGAAAGATTCCAGTGCGATGGACAGCACCAGAAGCAATAGCATTTAGGAAATTTACTTCTGCCAGTGATGTCTGGTCTATGGGAATAGTGTGCTGGGAGGTAATGAGTTTTGGGGAACGACCTTATTGGAACTGGAGCAACCAAGATGTGATTAAATCAATTGAAAAAGGATATCGTCTACCAGCTCCTATGGACTGTCCTGAGGCTGTGTATCAGCTGATGCTTGATTGCTGGCAGAAAGAACGAACACACAGACCAACTTTTTCAAGCATTGTGAAGACACTAGATAAATTAATTCGTTGCCCAGATACATTGAGAAAGATTGCCCAAAACCGTTCAGCAGACCCTTTAGCAGGCGATACTCCAGACTTGATTCAGTTTACATCAGTGGAAGAATGGCTTGAATGCATAAAAATGTCACGGTACATCGAGAAGTTTCGAGCGGCGGGCATTTCCGACATGGATGCGGTGGTCGACTTGACTGTGCATCAGCTGGCATCTCTCGGCGTGACTCTTGTCGGTCATCAGAAGAAGATTATGAATAGTGTGCAGAGCATGCGGGCTCAGATCCGGGGCAGCGGTCCTTACGGATTTCTTGTATAG

Protein

MIWLIVVTALASVHGEQVLLLDTTAEDTLGWTRFSYGAQASTAGWLEESYTNFEKQINWRSYVVCDVAHHNVNNWLWTPFIERRNANRIYIEIKFTIRDCSLFPGNALSCKETFSLLYYEFDVATREQPPWEPESYKLVGRIAAGEGRFNTNSEVDINTEVKSIAVTKKGVYFAFRDQGACISILAVKVYYITCPDVNINFARFPATPTGREVTVIEQANGTCVANAEVAPGEKAPVYLCKGDGKWTLPSGSCKCRAGFEPDHNNQICTECAPGKFKSHTGDEHCIPCPDHSESTIYAAAECKCTPKYYRAKKDPKTIPCTQPPSAPDNLTVTFADQFSISLTWQPPHNTGGRSDITYKISCANCGPTVEFRPGETGLNSTRVTISGLDPVTEYKFQVYAENGVSELSPDPAKHIEITAVTEASVVSVVSKLRILNTESDRLTIAWNPPQVDLTDPDDTIESYEVKCFPKDSQDKNTNTTLRITKDPQVTITGLRKDTEYGIRVRAKMKRGWGEFSGIVYARTNSVTETSFIDEEGAQVRLVAGVMVAVVVLTVIAIIATVLFLRSRADDECDKKQPSDCNALNYRNGEVYTGPDRPAKTSSNATTPLFAGTGSRTYIDPHTYEDPNQAVREFAREIDASCITIEAIIGGGEFGDVCRGKLKLPASCGPEIDVAIKTLKPGSTERARRDFLAEASIMGQFEHPNVIFLQGVVTKCNPIMIITEFMENGSLDTFLRANDGKFRVLQLVGMLRGIATGMQYLSEMNYIHRDLAARNVLVNSQLVCKIADFGLSREIESTADGAYTTRGGKIPVRWTAPEAIAFRKFTSASDVWSMGIVCWEVMSFGERPYWNWSNQDVIKSIEKGYRLPAPMDCPEAVYQLMLDCWQKERTHRPTFSSIVKTLDKLIRCPDTLRKIAQNRSADPLAGDTPDLIQFTSVEEWLECIKMSRYIEKFRAAGISDMDAVVDLTVHQLASLGVTLVGHQKKIMNSVQSMRAQIRGSGPYGFLV

Catalytic Activity

ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]

Similarity

Belongs to the protein kinase superfamily. Tyr protein kinase family.

Feature

chain  Receptor protein-tyrosine kinase

Uniprot

A0A2A4JJG1   Q6VU50   A0A194PT94   A0A0L7LI74   A0A194R3D3   H9IXU6   + More
A0A1B6MMJ9   A0A1Y1NDI2   A0A1B6KV88   A0A0A9XH54   A0A146KLG2   A0A146LRQ2   A0A146KR58   A0A1W4X9Y2   A0A1W4WZ35   A0A0C9PGV0   X1WQ64   A0A3L8E358   A0A158P3E8   Q5D184   A0A151WZE6   A0A2S2PM87   A0A195EZ24   K7IQA3   T1I7Z0   A0A0M9AAF8   A0A2A3ENR8   A0A0P5C6L9   E0W1E4   A0A0N8E0W6   A0A0P4ZRK1   A0A139WE15   A0A0J7L2X8   A0A0P5P411   A0A0P5E3K1   A0A0P5CF79   A0A0P5J8X4   A0A0P5DAF3   A0A0P4ZVS8   A0A0P4XL12   A0A0P4ZR96   A0A0P5N8Z4   A0A0P5GG86   A0A0N8AHC6   A0A0P5YDB9   A0A0P5NAX6   A0A0P6I4L8   A0A0P5XDR9   A0A0P6C1D6   A0A0P5AJG0   A0A1W4WZ30   A0A1W4WZ71   A0A1W4X8H2   A0A0C9PGV6   E9GM17   A0A1W4X9R7   E2C3J5   A0A087ZS47   A0A147BCU0   A0A026W547   A0A0L7RCX9   A0A195BIF7   A0A226E4M0   E9IIL2   A0A0P5Y6S7   A0A0P5BE05   A0A195CCU3   A0A0P5IAT1   A0A0P4Z8N5   A0A0P5VQD8   A0A195DN87   A0A0P6A272   A0A0P5QSN2   A0A0N8A7B5   A0A0N8CXX1   A0A0P4XJK5   A0A0P5IVR6   A0A0P6GDT6   A0A0P6CXK8   A0A0P4XMR5   A0A154P9Y2   T1L496   A0A2J7QUT8   A0A3B0K475   B4H885   B4L7C3   A0A034VY46   B4MF10   D0Z7B1   A0A0A1WQS3   W8BRA0   A0A0L0CNY5   A0A3B0K6U5   A0A0K8TYV5   W8CD17   B7QJ81   B3P9S4   B4PW17   A0A1W4VIH8   A0A0Q9XFB8  

EC Number

2.7.10.1

Pubmed

14684856    26354079    26227816    19121390    28004739    25401762    + More
26823975    30249741    21347285    17443785    20075255    20566863    18362917    19820115    21292972    20798317    24508170    21282665    17994087    25348373    18057021    25830018    24495485    26108605    17550304   

EMBL

NWSH01001255    PCG71969.1    AY327249    AAQ67231.1    KQ459599    KPI94355.1    + More
JTDY01001079    KOB74936.1    KQ460953    KPJ10351.1    BABH01015624    BABH01015625    GEBQ01002844    JAT37133.1    GEZM01007759    GEZM01007758    JAV94950.1    GEBQ01024618    JAT15359.1    GBHO01023552    JAG20052.1    GDHC01021225    JAP97403.1    GDHC01009529    JAQ09100.1    GDHC01019741    JAP98887.1    GBYB01000098    JAG69865.1    ABLF02038853    ABLF02038859    ABLF02038862    ABLF02038869    QOIP01000001    RLU26962.1    ADTU01007737    ADTU01007738    ADTU01007739    ADTU01007740    ADTU01007741    ADTU01007742    ADTU01007743    ADTU01007744    AY921579    AAX14899.1    KQ982649    KYQ53071.1    GGMR01017885    MBY30504.1    KQ981905    KYN33555.1    ACPB03012482    ACPB03012483    ACPB03012484    KQ435714    KOX79159.1    KZ288204    PBC33154.1    GDIP01175125    GDIQ01036299    JAJ48277.1    JAN58438.1    DS235870    EEB19450.1    GDIQ01072740    JAN21997.1    GDIP01209014    JAJ14388.1    KQ971357    KYB26081.1    LBMM01001046    KMQ97021.1    GDIQ01154805    JAK96920.1    GDIP01147330    GDIQ01160807    JAJ76072.1    JAK90918.1    GDIP01175126    JAJ48276.1    GDIQ01209341    JAK42384.1    GDIP01175127    GDIQ01184451    JAJ48275.1    JAK67274.1    GDIP01209012    JAJ14390.1    GDIP01240374    JAI83027.1    GDIP01209013    JAJ14389.1    GDIQ01148266    JAL03460.1    GDIP01147328    GDIQ01242824    JAJ76074.1    JAK08901.1    GDIP01147329    JAJ76073.1    GDIP01073645    JAM30070.1    GDIQ01148265    JAL03461.1    GDIQ01009418    JAN85319.1    GDIP01073644    JAM30071.1    GDIP01010921    JAM92794.1    GDIP01198125    JAJ25277.1    GBYB01000103    JAG69870.1    GL732552    EFX79285.1    GL452320    EFN77533.1    GEGO01006835    JAR88569.1    KK107447    EZA50746.1    KQ414615    KOC68645.1    KQ976467    KYM84152.1    LNIX01000007    OXA51974.1    GL763494    EFZ19580.1    GDIQ01244028    GDIP01063745    JAK07697.1    JAM39970.1    GDIP01185868    JAJ37534.1    KQ977935    KYM98679.1    GDIQ01239879    JAK11846.1    GDIP01217917    GDIQ01029110    JAJ05485.1    JAN65627.1    GDIP01096885    JAM06830.1    KQ980713    KYN14291.1    GDIQ01132673    GDIP01036243    JAL19053.1    JAM67472.1    GDIQ01110127    JAL41599.1    GDIP01175417    JAJ47985.1    GDIP01088079    GDIQ01084635    JAM15636.1    JAN10102.1    GDIP01240373    JAI83028.1    GDIQ01209340    JAK42385.1    GDIQ01036298    JAN58439.1    GDIQ01086187    JAN08550.1    GDIP01240372    JAI83029.1    KQ434853    KZC08637.1    CAEY01001080    NEVH01010480    PNF32350.1    OUUW01000017    SPP89004.1    CH479221    EDW34885.1    CH933813    EDW10917.2    GAKP01010751    JAC48201.1    CH940665    EDW71111.2    KRF85367.1    CM000831    ACY70479.1    GBXI01013291    JAD01001.1    GAMC01002725    JAC03831.1    JRES01000108    KNC34063.1    SPP89003.1    GDHF01032667    GDHF01027214    GDHF01017643    GDHF01000863    JAI19647.1    JAI25100.1    JAI34671.1    JAI51451.1    GAMC01002727    GAMC01002726    JAC03830.1    ABJB010182879    ABJB010388182    ABJB010401843    ABJB010475459    ABJB010801537    ABJB010836030    ABJB010973941    DS950795    EEC18904.1    CH954184    EDV45237.1    CM000161    EDW99322.2    KRK04916.1    KRG07276.1   

Proteomes

UP000218220    UP000053268    UP000037510    UP000053240    UP000005204    UP000192223    + More
UP000007819    UP000279307    UP000005205    UP000075809    UP000078541    UP000002358    UP000015103    UP000053105    UP000242457    UP000009046    UP000007266    UP000036403    UP000000305    UP000008237    UP000005203    UP000053097    UP000053825    UP000078540    UP000198287    UP000078542    UP000078492    UP000076502    UP000015104    UP000235965    UP000268350    UP000008744    UP000009192    UP000008792    UP000037069    UP000001555    UP000008711    UP000002282    UP000192221   

PRIDE

H9IXU6    B7QJ81   

Pfam

PF00536   SAM_1        + More
PF07714   Pkinase_Tyr
PF01404   Ephrin_lbd
PF14575   EphA2_TM
PF00041   fn3
PF07699   Ephrin_rec_like
PF07647   SAM_2

Interpro

IPR011009   Kinase-like_dom_sf        + More
IPR016257   Tyr_kinase_ephrin_rcpt       
IPR001090   Ephrin_rcpt_lig-bd_dom       
IPR036116   FN3_sf       
IPR001245   Ser-Thr/Tyr_kinase_cat_dom       
IPR001660   SAM       
IPR003961   FN3_dom       
IPR027936   Eph_TM       
IPR009030   Growth_fac_rcpt_cys_sf       
IPR017441   Protein_kinase_ATP_BS       
IPR013783   Ig-like_fold       
IPR013761   SAM/pointed_sf       
IPR008979   Galactose-bd-like_sf       
IPR020635   Tyr_kinase_cat_dom       
IPR008266   Tyr_kinase_AS       
IPR001426   Tyr_kinase_rcpt_V_CS       
IPR000719   Prot_kinase_dom       
IPR011641   Tyr-kin_ephrin_A/B_rcpt-like       

SUPFAM

SSF49785   SSF49785        + More
SSF47769   SSF47769       
SSF49265   SSF49265       
SSF56112   SSF56112       
SSF57184   SSF57184       

Gene 3D

2.60.120.260     2.60.40.10    

CDD

cd00063  FN3

ProteinModelPortal

A0A2A4JJG1   Q6VU50   A0A194PT94   A0A0L7LI74   A0A194R3D3   H9IXU6   + More
A0A1B6MMJ9   A0A1Y1NDI2   A0A1B6KV88   A0A0A9XH54   A0A146KLG2   A0A146LRQ2   A0A146KR58   A0A1W4X9Y2   A0A1W4WZ35   A0A0C9PGV0   X1WQ64   A0A3L8E358   A0A158P3E8   Q5D184   A0A151WZE6   A0A2S2PM87   A0A195EZ24   K7IQA3   T1I7Z0   A0A0M9AAF8   A0A2A3ENR8   A0A0P5C6L9   E0W1E4   A0A0N8E0W6   A0A0P4ZRK1   A0A139WE15   A0A0J7L2X8   A0A0P5P411   A0A0P5E3K1   A0A0P5CF79   A0A0P5J8X4   A0A0P5DAF3   A0A0P4ZVS8   A0A0P4XL12   A0A0P4ZR96   A0A0P5N8Z4   A0A0P5GG86   A0A0N8AHC6   A0A0P5YDB9   A0A0P5NAX6   A0A0P6I4L8   A0A0P5XDR9   A0A0P6C1D6   A0A0P5AJG0   A0A1W4WZ30   A0A1W4WZ71   A0A1W4X8H2   A0A0C9PGV6   E9GM17   A0A1W4X9R7   E2C3J5   A0A087ZS47   A0A147BCU0   A0A026W547   A0A0L7RCX9   A0A195BIF7   A0A226E4M0   E9IIL2   A0A0P5Y6S7   A0A0P5BE05   A0A195CCU3   A0A0P5IAT1   A0A0P4Z8N5   A0A0P5VQD8   A0A195DN87   A0A0P6A272   A0A0P5QSN2   A0A0N8A7B5   A0A0N8CXX1   A0A0P4XJK5   A0A0P5IVR6   A0A0P6GDT6   A0A0P6CXK8   A0A0P4XMR5   A0A154P9Y2   T1L496   A0A2J7QUT8   A0A3B0K475   B4H885   B4L7C3   A0A034VY46   B4MF10   D0Z7B1   A0A0A1WQS3   W8BRA0   A0A0L0CNY5   A0A3B0K6U5   A0A0K8TYV5   W8CD17   B7QJ81   B3P9S4   B4PW17   A0A1W4VIH8   A0A0Q9XFB8  

PDB

2HEL     E-value=4.827e-137,     Score=1254

KEGG

101742469    K05110 Eph receptor B1 [EC:2.7.10.1] | (RefSeq) ephrin type-B receptor 1-B

GO

GO:0005887   GO:0005003   GO:0005524   GO:0016021   GO:0004714   GO:0007169   GO:0005005   GO:0043005   GO:0007411   GO:0043235   GO:0004568   GO:0007422   GO:0016319   GO:0035011   GO:0004713   GO:0006468   GO:0005515   GO:0004672   GO:0048013  

SignalP

Position:   1 - 15,         Likelihood:  0.994029

 

 

Length:

1006

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

27.98596

Exp number, first 60 AAs:

0.0714100000000001

Total prob of N-in:

0.03566

outside

1  -  541

TMhelix

542  -  564

inside

565  -  1006

 

 

Pi

4.910585

Theta

4.002788

Tajima's D

0.626516

CLR

0.113201

CSRT

0.584370781460927

Interpretation

Uncertain