Gene

KWMTBOMO00007

Pre Gene Modal

BGIBMGA002066

Annotation

PREDICTED:_adenylate_cyclase_type_6_[Bombyx_mori]

Location

Bomo_Chr1(-):152176-201965      View in EpiBrowser

Full name

Adenylate cyclase       + More
Adenylate cyclase type 5      

Alternative Name

ATP pyrophosphate-lyase 5
Adenylate cyclase type V
Adenylyl cyclase 5
Ca(2+)-inhibitable adenylyl cyclase

Location in the cell

PlasmaMembrane   Reliability : 3.636

CDS

ATGGTTGTTGTAGAGAGCCGGGCGGAAGGCGCGGCCGGCACGAGCACCGCGCTGGTGCCCGACGACGAGGAGCAGCGGACCTGCTTCAAGCAGTGCGTCAGCTCCTGTCCTCCGCCGGTCCGCGCCATGTGTGCCTCCAACCGATTTGACAACTTACATGTGGAGATGTTGTACCAACGCTACTTTCTCCGCATGAACCAGACGAACATGACGCACCTGCTGGGGTTGCTGTTGACCGTCGCCGTCGGCCTCATGGTGGTGCAAGTTCGGACGCTACTCCTTGCTCAGAACTTCCTGGGAGAACTCATACCGTTCCCATTCGTATTGAGCAGTACGGAACCTAATCTAGAGCCGCTGGAGTTCTTCACGCAGTACCCGCGCTCGGGCACGCTCAGCGACTCGCAGTCCTTCGACGACACCGACCCGTCCCACTACAAGCGGATCTACTACGAGAAGGAGCGGGTCGCGCACATCATCAACGTCATCGTGCTCGGACTCAGCGCTCTGGTCTTTGCCTGCCTGCTGGCGTGTCTGAGCCGTCCCGCCATGAATGAGATCTACCTGCTCACCATCTCTTATGTGGTGCTCGTCGCATTCCTGCTCATTGAATTCTCATTTGCCGGAACTTCAGTACTGCGGTCGTTAACAGTGAGCACGGGAGCATGTTCGCTGTTCACGTATGTGACGTACGCGACGCTCCCGGTGCGACTCCACGAGGCCACCATCGGCGGTCTGGCGCTGGCCGCCGTCAACATCGGCGCGCATCTGCTACTCGACAACTCATCTGACATGCAGCTGTACTGCACGATCGCGACGCTGATCGCGTGCAACGCGGCCGGCATGCTGACGCACCAGCCGCGTGAGCTCGCCCAGCGCCGCGCCTTCCTCGAGACCCGAGACTGCGTCGAGGCGCGCCTCCTCACGCAGCGCGAGAACCAGCAGCAGGAGCGGCTGCTGCTGTCCGTGCTGCCGCGCCACGTCGCTATGGAGATGAAAGCGGACATCGCGAGCCAACCACGCCACGAGCAGTTCCACAAGATCTACATTCAGCGCTACGAGAATGTCAGCATCCTGTTCGCGGACATCTGCGGCTTCACCTCCCTCTCGGACCAGTGCACGGCCGAGGAGCTAGTGCGGCTGCTCAACGAGCTGTTCGCCAGGTTCGACCGGCTGGCGGCGGAGCACCACTGCCTGCGCATCAAGCTGCTCGGCGACTGCTACTACTGCGTGTCCGGGCTGCCCGAGGCGCGCGACGACCACGCCAAGTGCTGCGTCGAGATGGGACTCGACATGATCGACGCCATTGCGCTGGTGCGCGAGGTGATGGCGGTGAACGTGAACATGCGCGTCGGCATCCACACCGGCCGCGTGCACTGCGTCGTGCTCGGCCTCCGCAAGTGGCAGTTCGACGTGTGGTCCAACGACGTCACCCTCGCCAACTACATGGAGAGCGGAGGAGTGGCCGGCCGCGTGCACATCACGAAGGAGACGCTCTGTTGCCTCGGCGACGACTACAAGGTGGAGCCGGGACATGGCGGCTATCGGAACGCATACCTCAAGGACCACAACATCGAGACCTACCTCATCGTGCCTGACGACACCAGCCGAGTGGACAAGAAGCCGCAGCACTCGTTCGCTGTGAACGGGAACGTGTCGAAGGAGATGCGCGTCATGGGACACGGCTCGCAGCACGGCAAGCACTCCTCCAAGATGGGCGCGGACGCGGGCGCCGACAACAAGAAGCCCGAGGACGAAGTTAACGAGTACCTGATGAAGGCGATCGACGCGCGCTCCATCGACCGCCTGCGCGCCGAGCACTGCCGCCCCTTCACGCTCACCTTCCGCGACGCCCACCTCGAGAGGAAGTACACGGCGGAGCGCGACCGCATGCTGAAGGTGTACTTCTCGTGCTCGCTGGTCGTGTACACCGCCGTGCTCATCGTGCAGCTGCTCGCCTTCAACATGACTCCGATTGGCATCGCGACCATGATCCTGTGCGGAATTATTGTTGTATCTGTTACGTACTTGATTTTCGCCATTGACTTGAAGTTCGCTGGTGGCAAGTTGAAGAGGATATCGAAACGCGTGCACAACAACCGCACTCTCGCTCAGCTGATGTCGTTCATCGTGGTCGGCGCGGTCATCCTGCAGATACAGGTCGTCATGGTGCAAGAGGTGCTCGGCGTCACCAACAACACGAACGTCCCGTCGTACGAGAACAGCGGCGGCAACTGTCCCTACGACATGAACGAGCATTACTTGCAAGTGACCCTGATGGCGATGTTCCTGTGCGCGGTGCACCAGATACTGATCACGATGGTGAAGGTGCTCCTGCTGCTGGTCGTGTGCGTCACGTACGTGGCGGTCACCACGCAGGAACATCTCTATTACCGGAACCATTTCTACGACTATCAGCACCGGTGCGGCCTGGACTGGAATCAGCAGTGGACCAACATCGCCATAGCGCTGGGCGCCACCGTCGCGCTGCTGCTGCACTCGCAACAAACAGAGAGCACCTACAGACTCGACTTCATCTGGAAGCTGCAGGCCAATGAAGAGAAAGAGGACATGGAGCACCTGCAGGCGTACAACCGCAAGCTGCTGGCCAACATCCTGCCCGAGCACGTCGCGCAGCACTTCCTCTGCAGCGACAAGAACATCGACCAATTCGACGCGCAGGAGCTCTACCACGAGCAGTGCGACTCCGTCTGCGTCATGTTCGCCTCCATCCCGAACTTCTCCGAGTTCTACGTGGAGCTGGAGGGGAACAACGAGGGCGTCGAGTGTCTCCGCCTCCTCAACGAGATCATCGCAGACTTCGACGAGATCCTCGCCGAGGAGCCGTTCAAGTACATCGAGAAAATTAAGAGCACCGGAGCTACATACATGGCTGCTTCAGGCCTCACCAACTCCACTCAGGACCTGGTCGGGTACCGGCACGTGACCGCCATGGCGGACTACGCGCTGCGTCTCCGCGAGCAGCTGCAATACGTCAACGAACATTCGTTCAACTGCTTCCGCATCCGGATAGGCATCAACATCGGGCCCGTGGTGGCGGGGGTGATCGGCGCCCGCAAGCCGCAGTACGACATCTGGGGCAACGCTGTGAACGTCGCCTCCAGGATGGACTCCACCGGACTGCTGGATCACATTCAGGTGACGCAGGAAGTGTACGACATCCTGTCGGCGCGCGGGTACAAGCTTCGTTGCCGCGGCACAGTCGACGTCAAAGGCAAAGGGAACATGGTCACGTACTTCCTCGAGGGAGTCGGCGACTCCATCCCCGACGACATATACAATAATCCCATTCCATCAACATCAAGCGAGGGCGCCGTGCCTCCCCGTCCTGAACACCGCCCTCTGGACACTCTGTCGGAGGCACACACCGATGAGGACGGCGGCCCCTCTCCGAGAGCTTCCATCCCTATGGAGGTTGCAGAGAGCGAGACGGCGTCGTCGTCGGCCCGCGTGGCGTCCCGTTCCCGCGAGAGTGTGAGCAGCGCGGCGAGCGCGGTGCGGGAGCGAGTGCGCCGACGACTGCAGCGCCCTCTCTCTCTCGCGGACGACGACGCCTTCCCCAGCCTCATCTCACTCGTTAACGCTAAGGCTTACTCCGCCGACTTCGACTCGGCCTTCCGCCACGAAGAAACTCTACGCGAGAGGCCCTCGCAGCCCCGCACCAGCAAGGCGACCAGTCTCGCCGACTTCATCTTCAAGAGGAGGCCCAACAAGTCGCAATTGAACGCTGTCCACGTCATCGAGAACCCGATGAATGCCATGGACGACTTCGACTCGAACTGCTCCGCGACCACTACATTCTCTCCCGTCTAA

Protein

MVVVESRAEGAAGTSTALVPDDEEQRTCFKQCVSSCPPPVRAMCASNRFDNLHVEMLYQRYFLRMNQTNMTHLLGLLLTVAVGLMVVQVRTLLLAQNFLGELIPFPFVLSSTEPNLEPLEFFTQYPRSGTLSDSQSFDDTDPSHYKRIYYEKERVAHIINVIVLGLSALVFACLLACLSRPAMNEIYLLTISYVVLVAFLLIEFSFAGTSVLRSLTVSTGACSLFTYVTYATLPVRLHEATIGGLALAAVNIGAHLLLDNSSDMQLYCTIATLIACNAAGMLTHQPRELAQRRAFLETRDCVEARLLTQRENQQQERLLLSVLPRHVAMEMKADIASQPRHEQFHKIYIQRYENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAAEHHCLRIKLLGDCYYCVSGLPEARDDHAKCCVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCVVLGLRKWQFDVWSNDVTLANYMESGGVAGRVHITKETLCCLGDDYKVEPGHGGYRNAYLKDHNIETYLIVPDDTSRVDKKPQHSFAVNGNVSKEMRVMGHGSQHGKHSSKMGADAGADNKKPEDEVNEYLMKAIDARSIDRLRAEHCRPFTLTFRDAHLERKYTAERDRMLKVYFSCSLVVYTAVLIVQLLAFNMTPIGIATMILCGIIVVSVTYLIFAIDLKFAGGKLKRISKRVHNNRTLAQLMSFIVVGAVILQIQVVMVQEVLGVTNNTNVPSYENSGGNCPYDMNEHYLQVTLMAMFLCAVHQILITMVKVLLLLVVCVTYVAVTTQEHLYYRNHFYDYQHRCGLDWNQQWTNIAIALGATVALLLHSQQTESTYRLDFIWKLQANEEKEDMEHLQAYNRKLLANILPEHVAQHFLCSDKNIDQFDAQELYHEQCDSVCVMFASIPNFSEFYVELEGNNEGVECLRLLNEIIADFDEILAEEPFKYIEKIKSTGATYMAASGLTNSTQDLVGYRHVTAMADYALRLREQLQYVNEHSFNCFRIRIGINIGPVVAGVIGARKPQYDIWGNAVNVASRMDSTGLLDHIQVTQEVYDILSARGYKLRCRGTVDVKGKGNMVTYFLEGVGDSIPDDIYNNPIPSTSSEGAVPPRPEHRPLDTLSEAHTDEDGGPSPRASIPMEVAESETASSSARVASRSRESVSSAASAVRERVRRRLQRPLSLADDDAFPSLISLVNAKAYSADFDSAFRHEETLRERPSQPRTSKATSLADFIFKRRPNKSQLNAVHVIENPMNAMDDFDSNCSATTTFSPV

Description

Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
Isoform 1: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling (PubMed:1618857, PubMed:8428899, PubMed:10427002, PubMed:11087399, PubMed:15591060, PubMed:16766715, PubMed:19243146). Mediates signaling downstream of ADRB1. Regulates the increase of free cytosolic Ca(2+) in response to increased blood glucose levels and contributes to the regulation of Ca(2+)-dependent insulin secretion (By similarity).
Isoform 2: Lacks catalytic activity by itself, but can associate with isoform 1 to form active adenylyl cyclase.

Catalytic Activity

ATP = 3',5'-cyclic AMP + diphosphate

Cofactor

Mg(2+)

Subunit

Interacts with GNAS (PubMed:9417641, PubMed:10427002, PubMed:11087399, PubMed:15591060, PubMed:16766715, PubMed:19243146). Interacts with GNB1 and GNG2 (By similarity). Part of a complex containing AKAP5, ADCY6, PDE4C and PKD2 (By similarity). Interacts with RAF1 (By similarity).

Similarity

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.

Keywords

3D-structure   Alternative splicing   ATP-binding   cAMP biosynthesis   Cell membrane   Cell projection   Cilium   Complete proteome   Glycoprotein   Lyase   Magnesium   Membrane   Metal-binding   Methylation   Nucleotide-binding   Phosphoprotein   Reference proteome   Repeat   Transmembrane   Transmembrane helix  

Feature

chain  Adenylate cyclase
splice variant  In isoform 2.

Uniprot

A0A2H1W4R0   A0A194QXY7   A0A194PT75   A0A2A4JCS1   A0A139WHS6   A0A158NKR7   + More
A0A1B6DUR8   A0A195BA02   A0A3L8D9N2   A0A067RF30   A0A195EI24   A0A151X717   A0A1W4UFV0   B4LI53   B4J0W3   B4HJP0   A0A0C9R618   B4MMH3   A8JNU1   B4QMU3   A0A3B0JYF2   A0A0Q9XH14   B4L9J0   W5J6K4   A0A0M3QWE1   A0A0M4EYI5   A0A182RNT2   A0A182HU61   A0A182Y490   Q7QD83   A0A182W045   A0A182WRL7   A0A182Q6E9   A0A0P5DHS5   A0A0P6HEP8   A0A0P5VY21   A0A0P5DYS2   A0A0P5TTT3   A0A0P4XUR4   A0A0P5B3Y9   A0A0P5WCY0   A0A0P5SH86   A0A195FBQ9   A0A1J1J6G1   E2C9M5   A0A0P5DFM0   A0A0P4XI81   A0A0P5ZZH9   A0A0P4WWN7   A0A336M5G7   A0A0P5D4F2   A0A0P4Y1R0   A0A0P5YBW1   A0A0P5TQ67   A0A0P5ZXK3   A0A0P5KQU1   A0A0P6D9B2   J9JND4   A0A0P5QXZ5   A0A1Z5LEN6   A0A293N4J5   A0A1S3J9E5   A0A147A3P3   M3ZEX5   A0A3B5QHH9   A0A3P9N4B7   A0A210PVG6   A0A0S7G3J3   A0A383ZKM3   A0A340WQ40   A0A340WJJ6   A0A3B3XW93   A0A3P9N459   A0A3B3QTD0   A0A340WRR1   W5M3J7   A0A3B3QRY3   A0A3B3UIX8   P30803   F1PAJ9   S7PMB9   R7T3T8   A0A3P8ZN85   D2HJU4   K7FCE2   A0A341CEC8   A0A2T7PC30  

EC Number

4.6.1.1

Pubmed

26354079    18362917    19820115    21347285    30249741    24845553    + More
17994087    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    22936249    20920257    23761445    25244985    12364791    20798317    28528879    26383154    23542700    28812685    29240929    1618857    8428899    9417641    10427002    11087399    15591060    16766715    19243146    16341006    23254933    25069045    20010809    17381049   

EMBL

ODYU01006332    SOQ48085.1    KQ460953    KPJ10337.1    KQ459599    KPI94335.1    + More
NWSH01002101    PCG69193.1    KQ971342    KYB27523.1    ADTU01018731    ADTU01018732    ADTU01018733    ADTU01018734    ADTU01018735    ADTU01018736    GEDC01007929    JAS29369.1    KQ976537    KYM81363.1    QOIP01000011    RLU17054.1    KK852675    KDR18711.1    KQ978881    KYN27806.1    KQ982472    KYQ56100.1    CH940647    EDW68597.2    CH916366    EDV95784.1    CH480815    EDW41767.1    GBYB01011734    JAG81501.1    CH963847    EDW73318.2    AE014296    ABW08553.2    CM000363    CM002912    EDX10735.1    KMZ00061.1    OUUW01000012    SPP87107.1    CH933816    KRG07756.1    EDW17365.2    ADMH02002131    ETN58480.1    CP012525    ALC43989.1    ALC43575.1    APCN01000608    AAAB01008859    EAA07942.5    AXCN02000196    GDIP01156021    JAJ67381.1    GDIQ01020221    JAN74516.1    GDIP01093574    JAM10141.1    GDIP01167164    JAJ56238.1    GDIP01121666    JAL82048.1    GDIP01237510    JAI85891.1    GDIP01190059    JAJ33343.1    GDIP01087925    JAM15790.1    GDIQ01095770    JAL55956.1    KQ981693    KYN37647.1    CVRI01000074    CRL07995.1    GL453868    EFN75364.1    GDIP01160516    JAJ62886.1    GDIP01250556    JAI72845.1    GDIP01037089    JAM66626.1    GDIP01250959    JAI72442.1    UFQS01000586    UFQT01000586    SSX05153.1    SSX25514.1    GDIP01161114    JAJ62288.1    GDIP01235959    JAI87442.1    GDIP01059882    JAM43833.1    GDIP01123166    JAL80548.1    GDIP01037940    JAM65775.1    GDIQ01181990    JAK69735.1    GDIQ01082327    JAN12410.1    ABLF02037758    ABLF02037765    ABLF02037766    ABLF02037769    ABLF02037770    ABLF02037772    GDIQ01114114    JAL37612.1    GFJQ02001101    JAW05869.1    GFWV01022949    MAA47676.1    GCES01013511    JAR72812.1    NEDP02005461    OWF40483.1    GBYX01460838    JAO20730.1    AHAT01011606    AHAT01011607    M88649    M97886    AAEX03017035    AAEX03017036    AAEX03017037    AAEX03017038    AAEX03017039    KE163428    EPQ11983.1    AMQN01003620    KB312312    ELT87487.1    ACTA01098695    ACTA01106695    GL192925    EFB14421.1    AGCU01193434    AGCU01193435    AGCU01193436    AGCU01193437    AGCU01193438    AGCU01193439    AGCU01193440    AGCU01193441    AGCU01193442    AGCU01193443    PZQS01000005    PVD30969.1   

Proteomes

UP000053240    UP000053268    UP000218220    UP000007266    UP000005205    UP000078540    + More
UP000279307    UP000027135    UP000078492    UP000075809    UP000192221    UP000008792    UP000001070    UP000001292    UP000007798    UP000000803    UP000000304    UP000268350    UP000009192    UP000000673    UP000092553    UP000075900    UP000075840    UP000076408    UP000007062    UP000075920    UP000076407    UP000075886    UP000078541    UP000183832    UP000008237    UP000007819    UP000085678    UP000002852    UP000242638    UP000242188    UP000261681    UP000265300    UP000261480    UP000261540    UP000018468    UP000261500    UP000002254    UP000014760    UP000265140    UP000008912    UP000007267    UP000252040    UP000245119   

PRIDE

A8JNU1    P30803   

Pfam

PF06327   DUF1053        + More
PF16214   AC_N
PF00211   Guanylate_cyc

Interpro

IPR018297   A/G_cyclase_CS        + More
IPR001054   A/G_cyclase       
IPR030672   Adcy       
IPR029787   Nucleotide_cyclase       
IPR032628   AC_N       
IPR009398   Adcy_conserved_dom       

SUPFAM

SSF55073   SSF55073       

Gene 3D

3.30.70.1230    

ProteinModelPortal

A0A2H1W4R0   A0A194QXY7   A0A194PT75   A0A2A4JCS1   A0A139WHS6   A0A158NKR7   + More
A0A1B6DUR8   A0A195BA02   A0A3L8D9N2   A0A067RF30   A0A195EI24   A0A151X717   A0A1W4UFV0   B4LI53   B4J0W3   B4HJP0   A0A0C9R618   B4MMH3   A8JNU1   B4QMU3   A0A3B0JYF2   A0A0Q9XH14   B4L9J0   W5J6K4   A0A0M3QWE1   A0A0M4EYI5   A0A182RNT2   A0A182HU61   A0A182Y490   Q7QD83   A0A182W045   A0A182WRL7   A0A182Q6E9   A0A0P5DHS5   A0A0P6HEP8   A0A0P5VY21   A0A0P5DYS2   A0A0P5TTT3   A0A0P4XUR4   A0A0P5B3Y9   A0A0P5WCY0   A0A0P5SH86   A0A195FBQ9   A0A1J1J6G1   E2C9M5   A0A0P5DFM0   A0A0P4XI81   A0A0P5ZZH9   A0A0P4WWN7   A0A336M5G7   A0A0P5D4F2   A0A0P4Y1R0   A0A0P5YBW1   A0A0P5TQ67   A0A0P5ZXK3   A0A0P5KQU1   A0A0P6D9B2   J9JND4   A0A0P5QXZ5   A0A1Z5LEN6   A0A293N4J5   A0A1S3J9E5   A0A147A3P3   M3ZEX5   A0A3B5QHH9   A0A3P9N4B7   A0A210PVG6   A0A0S7G3J3   A0A383ZKM3   A0A340WQ40   A0A340WJJ6   A0A3B3XW93   A0A3P9N459   A0A3B3QTD0   A0A340WRR1   W5M3J7   A0A3B3QRY3   A0A3B3UIX8   P30803   F1PAJ9   S7PMB9   R7T3T8   A0A3P8ZN85   D2HJU4   K7FCE2   A0A341CEC8   A0A2T7PC30  

PDB

3MAA     E-value=2.11894e-93,     Score=878

KEGG

101739615    K08045 adenylate cyclase 5 [EC:4.6.1.1] | (RefSeq) adenylate cyclase type 6

PATHWAY

00230    Purine metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)
04213    Longevity regulating pathway - multiple species - Bombyx mori (domestic silkworm)

GO

GO:0005524   GO:0005886   GO:0016021   GO:0035556   GO:0006171   GO:0046872   GO:0004016   GO:0000166   GO:0007189   GO:0005887   GO:0004383   GO:0001932   GO:0045471   GO:0007204   GO:0061178   GO:1904322   GO:0005929   GO:0007191   GO:0001973   GO:0045111   GO:0007626   GO:0046982   GO:0008179   GO:0007195   GO:0050885   GO:0097110   GO:0009190   GO:0016849   GO:0005215   GO:0006810  

Subcellular location

Cell membrane  
Cell projection  
Cilium  

Length:

1276

Number of predicted TMHs:

9

Exp number of AAs in TMHs:

214.26779

Exp number, first 60 AAs:

1e-05

Total prob of N-in:

0.91504

inside

1  -  71

TMhelix

72  -  94

outside

95  -  155

TMhelix

156  -  178

inside

179  -  184

TMhelix

185  -  207

outside

208  -  239

TMhelix

240  -  258

inside

259  -  630

TMhelix

631  -  653

outside

654  -  657

TMhelix

658  -  680

inside

681  -  700

TMhelix

701  -  723

outside

724  -  768

TMhelix

769  -  791

inside

792  -  811

TMhelix

812  -  834

outside

835  -  1276

 

 

Pi

18.46945

Theta

4.06373

Tajima's D

-1.959836

CLR

0.058974

CSRT

0.0107494625268737

Interpretation

Possibly Positive selection