Gene

KWMTBOMO00006  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA002067

Annotation

PREDICTED:_alpha-tubulin_N-acetyltransferase_1-like_isoform_X2_[Bombyx_mori]

Location

Bomo_Chr1(-):125707-142035      View in EpiBrowser

Full name

Alpha-tubulin N-acetyltransferase      

Alternative Name

Acetyltransferase mec-17 homolog

Location in the cell

Nuclear   Reliability : 2.902

CDS

ATGGCAAGGCGGTATACGCCTGCCAAAGAAAAACTTTATAAATTTGTAGAAATTTGCACTATGGAGTGGATGGTGCCCGTGAATGAGATGTTAAGGGATGAAATCACTCGCATTGACTACAACTTAATGACGGACACTTTTGAAGGAAACATCAGGACCGTGAGGATGCTACAAGATAGTCTGTCAAAGCTGATAGATGTCCTGGGAGAATATTCATCAGCTGCACAAGGCCTCAACCGTGTGATCACTACTGGGGAAAAACTTCGCCTCTGCCCATCGCATGTTGTGTATATCCTTAAAGACAAGGATGCAAAAAACGGTGAGGGCGAGGCAGTCGGCATGCTGAAGATTGGTCGCAAGCACCTGTTTTTGTTCGACGACAAGGAACAAGTGCGCGAGCTGGAGCCGCTCTGCGTCCTCGACTTCTACGTGGTCTGCAACCGCCAGCGCACCGGATGCGGGAAGAAACTTTTCGATTTCATGCTCAAGGACACGGAGAGCGACGTCCACGCACTAGCCATCGACGGGCCCTCGCACAAGATGGAGCAGTTCCTGAAGCGCAACTACGGCGTGGAGCGTCTCGTCCGCCAAAACAACAATTTCGCTGTTTCGCCCAAGTTCTTCACGTTCACCACGGCCGAGCTCAAATTAAAGGCAGTGAATGATCGCCGAGACACGTGCGGGTCGGAGCAGAGCCGCGCCCAGAGCGGGGACAGCAAGGCAGGCCGTCCGGTCTCGTCGCTGCCGCCGGTCATCGGCCGGTTCGCGGCGCCGCGGCGTCCCTCCGCCATCGCCAACGTGATCCACGGCGGGAACGGCCTGGGCTACCGACAGGACTCCCCCAACGGGAACGAATTGGACAAGTTGACGTTCGCTCCTCCGGCCCGAAGCCCCGCTCCAGGCACGGAGCTCGGGCGGGAGCTCGACGACGACGAGGACGAGGAGTCAGATTGGGAAGACGGTGCGGGGGTCGGTCCGGTGCCGACGAGACCGTCCCAGCTCGAGATGGAAGAGGCCTGCGCCGCCCTGTTCGACGAGCCCTCGCCGGCCGGCTCCAGTACGTCGCGTCGCGACTCGCAGCTTACAGATCGCGGAGAAATGTAA

Protein

MARRYTPAKEKLYKFVEICTMEWMVPVNEMLRDEITRIDYNLMTDTFEGNIRTVRMLQDSLSKLIDVLGEYSSAAQGLNRVITTGEKLRLCPSHVVYILKDKDAKNGEGEAVGMLKIGRKHLFLFDDKEQVRELEPLCVLDFYVVCNRQRTGCGKKLFDFMLKDTESDVHALAIDGPSHKMEQFLKRNYGVERLVRQNNNFAVSPKFFTFTTAELKLKAVNDRRDTCGSEQSRAQSGDSKAGRPVSSLPPVIGRFAAPRRPSAIANVIHGGNGLGYRQDSPNGNELDKLTFAPPARSPAPGTELGRELDDDEDEESDWEDGAGVGPVPTRPSQLEMEEACAALFDEPSPAGSSTSRRDSQLTDRGEM

Description

Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released.

Catalytic Activity

acetyl-CoA + L-lysyl-[alpha-tubulin] = CoA + H(+) + N(6)-acetyl-L-lysyl-[alpha-tubulin]

Similarity

Belongs to the acetyltransferase ATAT1 family.

Uniprot

H9IXT4   A0A212EXJ3   S4PS37   A0A2W1BE19   A0A154PJU1   A0A195FP56   + More
A0A158NTS1   A0A195BMH7   A0A151JNJ2   A0A151WX11   A0A195CTR1   D6WEE9   F4WJ15   N6T7F5   E2AJ00   A0A0K8TK85   A0A310SCQ8   A0A088ADU4   A0A0L7R9A0   A0A2A3E0V6   A0A1B6H6G6   A0A026WAW1   A0A3L8DCI9   A0A232F3V2   E2C5Y5   A0A1B6EEY5   A0A2M3ZB71   A0A1B6D665   A0A1W4VM95   A0A2M4ATF1  

EC Number

2.3.1.108

Pubmed

19121390    22118469    23622113    28756777    21347285    18362917    + More
19820115    21719571    23537049    20798317    26369729    24508170    30249741    28648823   

EMBL

BABH01015592    BABH01015593    AGBW02011730    OWR46216.1    GAIX01014203    JAA78357.1    + More
KZ150173    PZC72591.1    KQ434938    KZC12095.1    KQ981382    KYN42345.1    ADTU01026119    ADTU01026120    KQ976435    KYM87093.1    KQ978878    KYN27862.1    KQ982673    KYQ52442.1    KQ977279    KYN04055.1    KQ971318    EFA00356.2    GL888181    EGI65785.1    APGK01049674    APGK01049675    APGK01049676    KB741156    ENN73593.1    GL439921    EFN66589.1    GDAI01002906    JAI14697.1    KQ769940    OAD52746.1    KQ414627    KOC67455.1    KZ288497    PBC25174.1    GECU01037420    GECU01026672    JAS70286.1    JAS81034.1    KK107348    EZA52144.1    QOIP01000010    RLU17843.1    NNAY01001046    OXU25355.1    GL452875    EFN76644.1    GEDC01000813    JAS36485.1    GGFM01004947    MBW25698.1    GEDC01016135    JAS21163.1    GGFK01010764    MBW44085.1   

Proteomes

UP000005204    UP000007151    UP000076502    UP000078541    UP000005205    UP000078540    + More
UP000078492    UP000075809    UP000078542    UP000007266    UP000007755    UP000019118    UP000000311    UP000005203    UP000053825    UP000242457    UP000053097    UP000279307    UP000215335    UP000008237    UP000192221   

PRIDE

H9IXT4   

Pfam

PF05301   Acetyltransf_16

Interpro

IPR007965   GNAT_ATAT        + More
IPR038746   Atat       
IPR016181   Acyl_CoA_acyltransferase       

SUPFAM

SSF55729   SSF55729       

ProteinModelPortal

H9IXT4   A0A212EXJ3   S4PS37   A0A2W1BE19   A0A154PJU1   A0A195FP56   + More
A0A158NTS1   A0A195BMH7   A0A151JNJ2   A0A151WX11   A0A195CTR1   D6WEE9   F4WJ15   N6T7F5   E2AJ00   A0A0K8TK85   A0A310SCQ8   A0A088ADU4   A0A0L7R9A0   A0A2A3E0V6   A0A1B6H6G6   A0A026WAW1   A0A3L8DCI9   A0A232F3V2   E2C5Y5   A0A1B6EEY5   A0A2M3ZB71   A0A1B6D665   A0A1W4VM95   A0A2M4ATF1  

PDB

4PK3     E-value=1.37961e-31,     Score=340

KEGG

101741407    K19573 alpha-tubulin N-acetyltransferase 1 [EC:2.3.1.108] | (RefSeq) alpha-tubulin N-acetyltransfera

GO

GO:0071929   GO:0005874   GO:0019799   GO:0048666   GO:0070507   GO:0006468   GO:0005515   GO:0004713   GO:0005215   GO:0006810  

PANTHER

PTHR12327  

Length:

367

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.02417

Exp number, first 60 AAs:

0.02335

Total prob of N-in:

0.06306

outside

1  -  367

 

 

Pi

0.790887

Theta

2.793458

Tajima's D

-1.931691

CLR

0.345663

CSRT

0.0137993100344983

Interpretation

Uncertain