SGID Silkworm Genome Informatics Database
Gene
KWMTBOMO00006  Validated by peptides from experiments
Pre Gene Modal
BGIBMGA002067
Annotation
PREDICTED:_alpha-tubulin_N-acetyltransferase_1-like_isoform_X2_[Bombyx_mori]
Full name
Alpha-tubulin N-acetyltransferase      
Alternative Name
Acetyltransferase mec-17 homolog
Location in the cell
Nuclear   Reliability : 2.902
 

Sequence

CDS
ATGGCAAGGCGGTATACGCCTGCCAAAGAAAAACTTTATAAATTTGTAGAAATTTGCACTATGGAGTGGATGGTGCCCGTGAATGAGATGTTAAGGGATGAAATCACTCGCATTGACTACAACTTAATGACGGACACTTTTGAAGGAAACATCAGGACCGTGAGGATGCTACAAGATAGTCTGTCAAAGCTGATAGATGTCCTGGGAGAATATTCATCAGCTGCACAAGGCCTCAACCGTGTGATCACTACTGGGGAAAAACTTCGCCTCTGCCCATCGCATGTTGTGTATATCCTTAAAGACAAGGATGCAAAAAACGGTGAGGGCGAGGCAGTCGGCATGCTGAAGATTGGTCGCAAGCACCTGTTTTTGTTCGACGACAAGGAACAAGTGCGCGAGCTGGAGCCGCTCTGCGTCCTCGACTTCTACGTGGTCTGCAACCGCCAGCGCACCGGATGCGGGAAGAAACTTTTCGATTTCATGCTCAAGGACACGGAGAGCGACGTCCACGCACTAGCCATCGACGGGCCCTCGCACAAGATGGAGCAGTTCCTGAAGCGCAACTACGGCGTGGAGCGTCTCGTCCGCCAAAACAACAATTTCGCTGTTTCGCCCAAGTTCTTCACGTTCACCACGGCCGAGCTCAAATTAAAGGCAGTGAATGATCGCCGAGACACGTGCGGGTCGGAGCAGAGCCGCGCCCAGAGCGGGGACAGCAAGGCAGGCCGTCCGGTCTCGTCGCTGCCGCCGGTCATCGGCCGGTTCGCGGCGCCGCGGCGTCCCTCCGCCATCGCCAACGTGATCCACGGCGGGAACGGCCTGGGCTACCGACAGGACTCCCCCAACGGGAACGAATTGGACAAGTTGACGTTCGCTCCTCCGGCCCGAAGCCCCGCTCCAGGCACGGAGCTCGGGCGGGAGCTCGACGACGACGAGGACGAGGAGTCAGATTGGGAAGACGGTGCGGGGGTCGGTCCGGTGCCGACGAGACCGTCCCAGCTCGAGATGGAAGAGGCCTGCGCCGCCCTGTTCGACGAGCCCTCGCCGGCCGGCTCCAGTACGTCGCGTCGCGACTCGCAGCTTACAGATCGCGGAGAAATGTAA
Protein
MARRYTPAKEKLYKFVEICTMEWMVPVNEMLRDEITRIDYNLMTDTFEGNIRTVRMLQDSLSKLIDVLGEYSSAAQGLNRVITTGEKLRLCPSHVVYILKDKDAKNGEGEAVGMLKIGRKHLFLFDDKEQVRELEPLCVLDFYVVCNRQRTGCGKKLFDFMLKDTESDVHALAIDGPSHKMEQFLKRNYGVERLVRQNNNFAVSPKFFTFTTAELKLKAVNDRRDTCGSEQSRAQSGDSKAGRPVSSLPPVIGRFAAPRRPSAIANVIHGGNGLGYRQDSPNGNELDKLTFAPPARSPAPGTELGRELDDDEDEESDWEDGAGVGPVPTRPSQLEMEEACAALFDEPSPAGSSTSRRDSQLTDRGEM

Summary

Description
Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released.
Catalytic Activity
acetyl-CoA + L-lysyl-[alpha-tubulin] = CoA + H(+) + N(6)-acetyl-L-lysyl-[alpha-tubulin]
Similarity
Belongs to the acetyltransferase ATAT1 family.
EC Number
2.3.1.108
Pfam
PF05301   Acetyltransf_16
Interpro
IPR007965   GNAT_ATAT        + More
IPR038746   Atat       
IPR016181   Acyl_CoA_acyltransferase       
SUPFAM
SSF55729   SSF55729       
PDB
4PK3     E-value=1.37961e-31,     Score=340

Ontologies

Topology

Length:
367
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0.02417
Exp number, first 60 AAs:
0.02335
Total prob of N-in:
0.06306
outside
1  -  367
 
 

Population Genetic Test Statistics

Pi
0.790887
Theta
2.793458
Tajima's D
-1.931691
CLR
0.345663
CSRT
0.0137993100344983
Interpretation
Uncertain
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