Gene

KWMTBOMO00005

Pre Gene Modal

BGIBMGA002069

Annotation

PREDICTED:_tyrosine-protein_kinase_Abl_isoform_X1_[Bombyx_mori]

Location

Bomo_Chr1(-):86646-118755      View in EpiBrowser

Full name

Tyrosine-protein kinase       + More
Non-specific protein-tyrosine kinase      

Location in the cell

Mitochondrial   Reliability : 1.919

CDS

ATGGGCGCGCAGCAGGCCAAAGAACGCGGCACCGCCAGCGGCGCGTCCATGCGTTCGGCGCGCAGCAAGCCACGGGTGCCGAAGGACCCCCGCATGCTCGGCTCCAACATATTCACTGAACATAGCGGGTGTGTCTCAGCGTGGAGATGGACCTCGAAGGAGAATCTTTTGGCCCATCACGAAGAGGACGATCCCCAGCTGTTCGTAGCCCTCTACGATTTCCAGGCGGGAGGGGAGAACCAGCTCACGCTCAAGAAAGGCGAGCAGGTGCGCATCATGAGCTACAACAAGAGCGGCGAGTGGTGCGAAGCCCACACGCTGACTGGGGCCGTGGGCTGGGTGCCCAGCAACTACGTCACTCCAGTCAACAGTCTCGAGAAGCATTCATGGTACCATGGGCCGATTTCCCGCAACGCGGCGGAGTACCTCCTCTCGTCTGGGATCAATGGCAGCTTCCTGGTCCGCGAATCGGAATCGAGTCCTGGGCAACGCAGCATATCCCTCCGCTACGAAGGGAGAGTTTACCACTACCGCATCAACGAAGACGCCGATGGGAAGGTTTATGTGACCTCCGAGTCGAAGTTCGGAACGTTAGCGGAGCTGGTCCACCATCACTCGGTGGCGGGGGACGGTCTAATTACGCAGCTGCTGTATCCAGCACCGAAGCGCTCGAAGCCTACAGTGTTCCCCCTGGCTCCCCCCGACCACTGGGAGATCGATCGCACGGACATAGTGATGAAGCACAAGCTGGGCGGCGGCCAGTATGGAGACGTTTACGAAGCCGCTTGGAAGCGCGGCAACATCACGGTGGCGGTCAAAACACTCAAGGACGATACGATGGCGCTCAAGGATTTCCTGGAGGAAGCCTCCATAATGAAAGAGATGCGACACCCGAACCTGGTGCAGCTGCTCGGCGTGTGCACACGCGAGCCCCCGTTCTATATTATTACGGAGTTTATGTCCCGCGGAAACCTGCTGGAGTACCTGCGGGCGGGGGCGAGGGAGTGCGTGCCGGGCGCGGTCGTGCTCATGTACATGGCGACGCAGATAGCGTCCGGCATGAGCTACCTCGAGAGCCGCTCCTTCATCCACCGCGACCTCGCCGCCAGGAACTGCCTCGTGGGGGAGAACCATCTGGTCAAGGTGGCCGACTTCGGACTGGCTCGCCTGATGCGCGACGACACATACACGGCCCACGCCGGCGCCAAGTTCCCGATCAAGTGGACGGCGCCGGAGGGTCTGGCCTACAACACTTTCAGCACCAAATCGGATGTCTGGGCTTTCGGGATCCTGCTGTGGGAGATCGCCACGTACGGGATGTCTCCTTACCCCGGAGTGGATCTCGCGGACGTTTACCACATGCTTGAGAAGGGGTACCGCATGGAGTGTCCCCCGGGCTGCCCGGCGCCCGTCTACGAGCTCATGCGCGGCTGCTGGCAGTGGAGCCCCTCCGAGCGGCCCTCCTTCCGCGAGATACACCACGCGCTCGAGCACATGTTCCAGGACAACTCGATCACAGACGAAGTAGAGAAACAACTCCAAGAAGGCAGCGGCGCGCAGGCCGCCGGCACCCCGCTGCTGTCGCTGAAGAAGACGAGCGCCGACCCTCGAGCGGTGCAGATGCGGCGCCCGACCAACCGCCGCGGCAAGCAAGCCCCCACCCCTCCCAAACGCACTAGCCTGCTGTCCTCGTGCAGCTCCTTCCGCGAGTCGCAGTACGCCGCCGACGAGCACGCGCCCGACGACGCGCCCGCCGACGCGCTCGCCGACCTCAACGGTCAGTGTCTCACGCAGCGTCACGCGCCGTCACGCACTCCAACAACCGATATAGTGCAATAG

Protein

MGAQQAKERGTASGASMRSARSKPRVPKDPRMLGSNIFTEHSGCVSAWRWTSKENLLAHHEEDDPQLFVALYDFQAGGENQLTLKKGEQVRIMSYNKSGEWCEAHTLTGAVGWVPSNYVTPVNSLEKHSWYHGPISRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINEDADGKVYVTSESKFGTLAELVHHHSVAGDGLITQLLYPAPKRSKPTVFPLAPPDHWEIDRTDIVMKHKLGGGQYGDVYEAAWKRGNITVAVKTLKDDTMALKDFLEEASIMKEMRHPNLVQLLGVCTREPPFYIITEFMSRGNLLEYLRAGARECVPGAVVLMYMATQIASGMSYLESRSFIHRDLAARNCLVGENHLVKVADFGLARLMRDDTYTAHAGAKFPIKWTAPEGLAYNTFSTKSDVWAFGILLWEIATYGMSPYPGVDLADVYHMLEKGYRMECPPGCPAPVYELMRGCWQWSPSERPSFREIHHALEHMFQDNSITDEVEKQLQEGSGAQAAGTPLLSLKKTSADPRAVQMRRPTNRRGKQAPTPPKRTSLLSSCSSFRESQYAADEHAPDDAPADALADLNGQCLTQRHAPSRTPTTDIVQ

Catalytic Activity

ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]

Similarity

Belongs to the protein kinase superfamily. Tyr protein kinase family.

Uniprot

A0A2W1BXZ4   A0A212EXN4   A0A194QLS4   A0A194PFC7   A0A1B6CDF7   A0A1B6DYH9   + More
A0A1W4WJG9   A0A1W4WUB1   A0A1W4WVJ8   A0A1B6HCF1   A0A139WK02   A0A1Y1KNK4   A0A1Y1KMS3   A0A1Y1KK61   A0A1Y1KKE9   A0A1B6JBG0   A0A0L7R834   A0A139WJS9   A0A1Y1KQR3   A0A1Y1KK43   A0A1Y1KQS3   A0A1Y1KK48   A0A3L8DM09   A0A026W235   A0A0C9PHZ8   A0A0P4VT99   A0A0M9AB24   A0A088AT87   A0A069DY91   A0A224X5G0   A0A2A3EUP4   F4WV60   K7J766   A0A158NUM9   A0A151WUC9   A0A195DS06   A0A195EXC2   A0A232ES62   A0A195C704   J9K2P5   A0A1W4WJI7   A0A1Y1KK51   A0A1Y1KK32   A0A1Y1KNJ1   A0A1W4WVB9   A0A195BS54   A0A1Y1KQ07   A0A067RM58   A0A1Y1KK29   A0A0K8SX23   A0A0K8TEK1   A0A1Y1KSD4   A0A0J7L3V4   A0A1Y1KQ17   A0A1Y1KKC9   A0A1Y1KQ27   A0A0K8SVW5   A0A1Y1KMH7   A0A1B6D953   A0A1B6DM49   A0A1B6EB12   A0A1B6C175   A0A1Y1KK27   E0VZT3   T1HWB4   A0A1Y1KK49   A0A336KXW8   A0A1Q3F495   A0A146KZU4   A0A0K8TF41   A0A0K8T914   A0A0K8SVV8   A0A0K8TET8   A0A1W7R720   Q16XS6   A0A1S4FKD3   A0A2S2P7F6   A0A0K8SVW2   A0A2M3Z2A4   W4VRS5   B0WAD3   A0A336MRU8   A0A1I8N9R0   A0A1I8N9R1   A0A1I8N9Q8   A0A1I8NNX1   A0A1I8N9S0   A0A1B0BMW2   A0A146LW71   A0A1I8NNX9   A0A1I8NNX8   A0A1I8NNX3   A0A1I8NNZ3   A0A336LL25   A0A0A1X0T2   A0A2M4BFH1   W5J694   A0A2M3Z6K3   A0A2M4CG35   A0A2M4AMJ2  

EC Number

2.7.10.2

Pubmed

28756777    22118469    26354079    18362917    19820115    28004739    + More
30249741    24508170    27129103    26334808    21719571    20075255    21347285    28648823    24845553    20566863    26823975    17510324    25315136    25830018    20920257    23761445   

EMBL

KZ149922    PZC77690.1    AGBW02011730    OWR46217.1    KQ461196    KPJ06314.1    + More
KQ459605    KPI91987.1    GEDC01025811    JAS11487.1    GEDC01006577    JAS30721.1    GECU01035414    JAS72292.1    KQ971331    KYB28309.1    GEZM01081231    GEZM01081216    JAV61780.1    GEZM01081222    GEZM01081217    JAV61771.1    GEZM01081225    GEZM01081206    JAV61793.1    GEZM01081215    GEZM01081205    JAV61794.1    GECU01011192    JAS96514.1    KQ414637    KOC67004.1    KYB28308.1    GEZM01081228    GEZM01081218    JAV61776.1    GEZM01081226    GEZM01081221    JAV61773.1    GEZM01081211    GEZM01081207    JAV61786.1    GEZM01081232    GEZM01081213    JAV61783.1    QOIP01000006    RLU21464.1    KK107485    EZA50127.1    GBYB01000512    GBYB01000513    GBYB01000515    JAG70279.1    JAG70280.1    JAG70282.1    GDKW01000146    JAI56449.1    KQ435694    KOX80895.1    GBGD01000157    JAC88732.1    GFTR01008691    JAW07735.1    KZ288185    PBC34936.1    GL888384    EGI61948.1    AAZX01007534    ADTU01026625    KQ982745    KYQ51367.1    KQ980530    KYN15631.1    KQ981953    KYN32529.1    NNAY01002531    OXU21126.1    KQ978164    KYM96644.1    ABLF02012147    GEZM01081208    JAV61789.1    GEZM01081224    JAV61769.1    GEZM01081223    JAV61770.1    KQ976417    KYM89862.1    GEZM01081227    JAV61765.1    KK852591    KDR20715.1    GEZM01081229    JAV61763.1    GBRD01008376    JAG57445.1    GBRD01001829    JAG63992.1    GEZM01081210    JAV61787.1    LBMM01000867    KMQ97331.1    GEZM01081219    JAV61775.1    GEZM01081220    JAV61774.1    GEZM01081212    JAV61785.1    GBRD01008374    JAG57447.1    GEZM01081209    JAV61788.1    GEDC01015116    JAS22182.1    GEDC01010576    JAS26722.1    GEDC01002162    JAS35136.1    GEDC01030279    JAS07019.1    GEZM01081230    JAV61762.1    DS235854    EEB18889.1    ACPB03013644    ACPB03013645    GEZM01081214    JAV61782.1    UFQS01001061    UFQT01001061    SSX08755.1    SSX28667.1    GFDL01012727    JAV22318.1    GDHC01018409    JAQ00220.1    GBRD01001830    JAG63991.1    GBRD01003789    JAG62032.1    GBRD01008383    JAG57438.1    GBRD01001827    JAG63994.1    GEHC01000725    JAV46920.1    CH477533    EAT39429.1    GGMR01012772    MBY25391.1    GBRD01008378    JAG57443.1    GGFM01001817    MBW22568.1    GANO01000206    JAB59665.1    DS231870    EDS41023.1    SSX08756.1    SSX28668.1    JXJN01017066    GDHC01006736    JAQ11893.1    UFQS01000040    UFQT01000040    SSW98280.1    SSX18666.1    GBXI01009937    JAD04355.1    GGFJ01002659    MBW51800.1    ADMH02002077    ETN59521.1    GGFM01003405    MBW24156.1    GGFL01000128    MBW64306.1    GGFK01008694    MBW42015.1   

Proteomes

UP000007151    UP000053240    UP000053268    UP000192223    UP000007266    UP000053825    + More
UP000279307    UP000053097    UP000053105    UP000005203    UP000242457    UP000007755    UP000002358    UP000005205    UP000075809    UP000078492    UP000078541    UP000215335    UP000078542    UP000007819    UP000078540    UP000027135    UP000036403    UP000009046    UP000015103    UP000008820    UP000002320    UP000095301    UP000095300    UP000092460    UP000000673   

Pfam

PF00018   SH3_1        + More
PF07714   Pkinase_Tyr
PF00017   SH2
PF08919   F_actin_bind

Interpro

IPR008266   Tyr_kinase_AS        + More
IPR035837   ABL_SH2       
IPR036860   SH2_dom_sf       
IPR033221   ABL1       
IPR036028   SH3-like_dom_sf       
IPR000719   Prot_kinase_dom       
IPR017441   Protein_kinase_ATP_BS       
IPR011009   Kinase-like_dom_sf       
IPR001452   SH3_domain       
IPR000980   SH2       
IPR020635   Tyr_kinase_cat_dom       
IPR001245   Ser-Thr/Tyr_kinase_cat_dom       
IPR015015   F-actin_binding       

SUPFAM

SSF50044   SSF50044        + More
SSF55550   SSF55550       
SSF56112   SSF56112       

Gene 3D

3.30.505.10    

CDD

cd09935  SH2_ABL

ProteinModelPortal

A0A2W1BXZ4   A0A212EXN4   A0A194QLS4   A0A194PFC7   A0A1B6CDF7   A0A1B6DYH9   + More
A0A1W4WJG9   A0A1W4WUB1   A0A1W4WVJ8   A0A1B6HCF1   A0A139WK02   A0A1Y1KNK4   A0A1Y1KMS3   A0A1Y1KK61   A0A1Y1KKE9   A0A1B6JBG0   A0A0L7R834   A0A139WJS9   A0A1Y1KQR3   A0A1Y1KK43   A0A1Y1KQS3   A0A1Y1KK48   A0A3L8DM09   A0A026W235   A0A0C9PHZ8   A0A0P4VT99   A0A0M9AB24   A0A088AT87   A0A069DY91   A0A224X5G0   A0A2A3EUP4   F4WV60   K7J766   A0A158NUM9   A0A151WUC9   A0A195DS06   A0A195EXC2   A0A232ES62   A0A195C704   J9K2P5   A0A1W4WJI7   A0A1Y1KK51   A0A1Y1KK32   A0A1Y1KNJ1   A0A1W4WVB9   A0A195BS54   A0A1Y1KQ07   A0A067RM58   A0A1Y1KK29   A0A0K8SX23   A0A0K8TEK1   A0A1Y1KSD4   A0A0J7L3V4   A0A1Y1KQ17   A0A1Y1KKC9   A0A1Y1KQ27   A0A0K8SVW5   A0A1Y1KMH7   A0A1B6D953   A0A1B6DM49   A0A1B6EB12   A0A1B6C175   A0A1Y1KK27   E0VZT3   T1HWB4   A0A1Y1KK49   A0A336KXW8   A0A1Q3F495   A0A146KZU4   A0A0K8TF41   A0A0K8T914   A0A0K8SVV8   A0A0K8TET8   A0A1W7R720   Q16XS6   A0A1S4FKD3   A0A2S2P7F6   A0A0K8SVW2   A0A2M3Z2A4   W4VRS5   B0WAD3   A0A336MRU8   A0A1I8N9R0   A0A1I8N9R1   A0A1I8N9Q8   A0A1I8NNX1   A0A1I8N9S0   A0A1B0BMW2   A0A146LW71   A0A1I8NNX9   A0A1I8NNX8   A0A1I8NNX3   A0A1I8NNZ3   A0A336LL25   A0A0A1X0T2   A0A2M4BFH1   W5J694   A0A2M3Z6K3   A0A2M4CG35   A0A2M4AMJ2  

KEGG

101739479    K06619 abelson tyrosine-protein kinase 1 [EC:2.7.10.2] | (RefSeq) tyrosine-protein kinase Abl

GO

GO:0004715   GO:0005524   GO:0042127   GO:0038083   GO:0030154   GO:0004672   GO:0006468   GO:0005515   GO:0004713   GO:0005215   GO:0006810  

PANTHER

PTHR24418:SF88  

Length:

612

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.16742

Exp number, first 60 AAs:

0.00135

Total prob of N-in:

0.00630

outside

1  -  612

 

 

Pi

1.044689

Theta

2.188746

Tajima's D

-2.162168

CLR

0.2745

CSRT

0.00264986750662467

Interpretation

Possibly Positive selection