Silkworm Genome Informatics Database

Gene

KWMTBOMO00004

Pre Gene Modal

BGIBMGA002070

Annotation

PREDICTED:_tyrosine-protein_kinase_Abl_isoform_X3_[Bombyx_mori]

Location

Bomo_Chr1(-):78818-80935 View in EpiBrowser

Full name

Tyrosine-protein kinase

Location in the cell

Nuclear Reliability : 4.606

CDS

ATGATCCGGTCCAACTCCTCGGGCGGAGTGACGGCACCCTCGCCTGCCTCCCCGCGCGCCTCCCGTGCCACCCCTCAGCTGCGATCGTTTACCGGCAGCCCTGCTAAGCCTCGTCCGCGCATAGCGGAGTTGGAATTCCCGCCTCCACCGCCAGACCTACCGCCTCCCCCTGAAGACACCCAACCTCCACCTCCACCTCCGCCGCCGCCCCCCGCAGACCCCGCCGACTCGATCCTCGACCCTCCGCCCCCACTACTCGATAGTCATTTCGACTTCAATGAAAAACCCGCTAAACAAACAATGAAAGAAATGTTAGAGTTAAAACTCGTCGCAGAGATAAAGGAAAGAGCCGATAAAAAGAAGCAAAAGCTAAAAGAATCGCCTCCGTTCGAGGAACAAAATGTAGATTCGCAGCCTTCGTTCGGAGACCCTGTCACCAGATTAGTCTCTGAACTTTCAGAGAGCTTAAATATGGAAGCACTTCGTCGCGTCGATCGCAAACTTGATTCGGCAAAGACAGAAGACGGGAAGGAATCTGTGTCGCCGATTGACTTAAAGGCGAGCTTAAGAAAAACTGCGTACGGTAATAATGCAGAACAGAAAAGATCAGACGCGGAATCCAAAGTGGGTACCGATTTTAAATCGCAATTGAAGAAAGTAGAAGCCAACAAGAAGACTTCCGGAACAAACAAAGAACAAGAGGAGGGCGGTCGTCCGATCATCGACTTTAAGTCCCGTCTACGTAAGGTGGACAGCGGCGCGAATGTTACGAACGGAGCCAAGAAGTTCGAACAGACCTCACCAGATGAGAAAGAAGCTATCAAAAAAGACATTTCAAAGACAGAAGAACTCGACAGGTATCGATCAGAAAGTGGATCTTTGGACACGAGCGGCGGAGACGAGGAAGACAAGCGTCGGAGCACCGGCAGCATCAGTAGCCTAAAGAAACTGTGGGAGAGCAAAGAAACCGAAGAGAGACTCAGTCCCAAGATGAGAGCGCGAGACAACGAGTCCGACGAGGTCTCCCCTGAGGAACGATCCTGCGCGGCGAGGGGCGCGGGGCGGCGCGACGACAAGCCCAGCGTACCCAGCAAGCCCGTCGGGGTGCGGAAGCCGAGCAAGGGCGGTATCTACGCCAGCCCGCAAGTGGGCCCCGAGGAGGCGGAGAGCGGCGCCGCGCTGCGGGAGGTGCGCGGCGCGCTGGAGGCGTGCACGCGGTCCGTGCGGCGCGGCGGGGGGCGCGGCTCGCTGTGGCGGCTGCAGAGCTCGGAGCGGCTGGCGCGGCTCGGCGGGGTGTGCGGGGCGGCGGCCACCGCGTGCTCGCCACACGTGCGCGTGCAGCTGCGGGCCGCCGCCGCGCGACTGGAGGCGCAGGCGCGGGCGCTCGCCTCGCCCGCACCGCACACCCACCACCTCGCCGACGCCGTCGACCACGCGCTGCGGGACCTCGCCGACGTACTCAACCGGTGCTCCTCTTCTTCCTCTCACCCCACCAACAACATCCCGTAA

Protein

MIRSNSSGGVTAPSPASPRASRATPQLRSFTGSPAKPRPRIAELEFPPPPPDLPPPPEDTQPPPPPPPPPPADPADSILDPPPPLLDSHFDFNEKPAKQTMKEMLELKLVAEIKERADKKKQKLKESPPFEEQNVDSQPSFGDPVTRLVSELSESLNMEALRRVDRKLDSAKTEDGKESVSPIDLKASLRKTAYGNNAEQKRSDAESKVGTDFKSQLKKVEANKKTSGTNKEQEEGGRPIIDFKSRLRKVDSGANVTNGAKKFEQTSPDEKEAIKKDISKTEELDRYRSESGSLDTSGGDEEDKRRSTGSISSLKKLWESKETEERLSPKMRARDNESDEVSPEERSCAARGAGRRDDKPSVPSKPVGVRKPSKGGIYASPQVGPEEAESGAALREVRGALEACTRSVRRGGGRGSLWRLQSSERLARLGGVCGAAATACSPHVRVQLRAAAARLEAQARALASPAPHTHHLADAVDHALRDLADVLNRCSSSSSHPTNNIP

Catalytic Activity

ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]

Similarity

Belongs to the protein kinase superfamily. Tyr protein kinase family.

Uniprot

H9IXT7 A0A212EXN4 A0A2H1W5F9 A0A194QLS4 A0A194PFC7 A0A2J7RK06 + More
A0A067RM58 A0A2P8XNB6 A0A026W235 A0A3L8DM09 A0A195DS06 A0A158NUM9 F4WV60 A0A151WUC9 A0A2A3EUP4 A0A088AT87

EC Number

2.7.10.2

Pubmed

19121390 22118469 26354079 24845553 29403074 24508170 + More
30249741 21347285 21719571

EMBL

BABH01015589 AGBW02011730 OWR46217.1 ODYU01006332 SOQ48082.1 KQ461196 + More
KPJ06314.1 KQ459605 KPI91987.1 NEVH01002981 PNF41160.1 KK852591 KDR20715.1 PYGN01001664 PSN33486.1 KK107485 EZA50127.1 QOIP01000006 RLU21464.1 KQ980530 KYN15631.1 ADTU01026625 GL888384 EGI61948.1 KQ982745 KYQ51367.1 KZ288185 PBC34936.1

Proteomes

UP000005204 UP000007151 UP000053240 UP000053268 UP000235965 UP000027135 + More
UP000245037 UP000053097 UP000279307 UP000078492 UP000005205 UP000007755 UP000075809 UP000242457 UP000005203

PRIDE

H9IXT7

Pfam

PF07714   Pkinase_Tyr        + More
PF00017   SH2
PF00018   SH3_1
PF08919   F_actin_bind

Interpro

IPR001245   Ser-Thr/Tyr_kinase_cat_dom        + More
IPR011009   Kinase-like_dom_sf
IPR036028   SH3-like_dom_sf
IPR000719   Prot_kinase_dom
IPR035837   ABL_SH2
IPR001452   SH3_domain
IPR020635   Tyr_kinase_cat_dom
IPR017441   Protein_kinase_ATP_BS
IPR000980   SH2
IPR036860   SH2_dom_sf
IPR033221   ABL1
IPR008266   Tyr_kinase_AS
IPR015015   F-actin_binding

SUPFAM

SSF56112   SSF56112        + More
SSF50044   SSF50044
SSF55550   SSF55550

Gene 3D

3.30.505.10

CDD

cd09935 SH2_ABL

ProteinModelPortal

H9IXT7 A0A212EXN4 A0A2H1W5F9 A0A194QLS4 A0A194PFC7 A0A2J7RK06 + More
A0A067RM58 A0A2P8XNB6 A0A026W235 A0A3L8DM09 A0A195DS06 A0A158NUM9 F4WV60 A0A151WUC9 A0A2A3EUP4 A0A088AT87

KEGG

101739479 K06619 abelson tyrosine-protein kinase 1 [EC:2.7.10.2] | (RefSeq) tyrosine-protein kinase Abl

GO

GO:0004672 GO:0004715 GO:0005524

PANTHER

PTHR24418:SF88

Length:

502

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00625

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00183

outside

1 - 502

Pi

2.038455

Theta

5.6387

Tajima's D

-1.649298

CLR

0.019546

CSRT

0.0368981550922454

Interpretation

Possibly Positive selection

Sequence

Summary

Ontologies

Topology

Population Genetic Test Statistics